Gvoke HypoPen (glucagon injection) is premixed and ready-to-use for low blood sugar emergencies

Posted: October 05, 2022 | Word Count: 940

Michelle Trites, her husband and their 3-year-old daughter all have Type 1 diabetes. Diabetes is an ever-present part of their lives and ensuring that they have tools in their tool kits to handle low blood sugar emergencies is a top priority.

Ever since Michelle was diagnosed at 13 years old, the Glucagon Emergency Kit has been a constant presence — at school, at work, and on her person at all times. But not anymore. After learning about ready-to-use glucagon, Michelle made sure that everyone in her family replaced the old red kit with Gvoke HypoPen®, a ready-to-use rescue pen for treatment of very low blood sugar in adults and kids ages 2 and older.

Michelle believes the emergency glucagon kit is cumbersome to use due to its 12-step administration process. “That was a lot to ask from non-medical professionals who could get squeamish just looking at a needle, much less completing so many steps in a high-stakes emergency,” Michelle said. In a usability study, only 31% of users could use the glucagon injection kit correctly.

Eli Lilly and Company, a producer of the GEK kit, recently announced that it is discontinuing distribution of the kit on December 31, 2022. The decision was reportedly made due to innovations in the glucagon market and highlights the importance of providing patients with products that enable simpler administration during critical moments of need.

As a result of this news, all patients that currently have a prescription for Eli Lilly’s GEK will need to be transitioned to another option.

The Trites recommend that people with diabetes and their caregivers ask their physician for Gvoke HypoPen®. “Everyone should have Gvoke HypoPen in their tool kit,” said Michelle. “It can help you confidently manage a low blood sugar emergency.”

Gvoke HypoPen®, the simple solution you can count on:

  • Ready-to-use: Premixed and ready-to-go1
  • Simple to administer: Simple 2-step administration. Pull red. Push yellow
  • Reliable method of delivery: 99% of people (trained and untrained) were able to give correctly in usability studies1
  • Proven to work: >99% of adults and pediatrics patients had their blood glucose raised to safe levels

Talk to your doctor about adding Gvoke HypoPen® to your diabetes toolkit and visit GvokeGlucagon.com to learn more.

“We are focused on making our treatments simple for patients or caregivers to administer,” said Ken Johnson, senior vice president for Global Development and Medical Affairs at Xeris Pharmaceuticals. “Xeris is committed to offering historically hard-to-administer and potentially life-saving medications in innovative ready-to-use injectables.”

GVOKE is a prescription medicine used to treat very low blood sugar (severe hypoglycemia) in adults and kids with diabetes ages 2 years and above. It is not known if GVOKE is safe and effective in children under 2 years of age.


Do not use GVOKE if:

  • you have a tumor in the gland on top of your kidneys (adrenal gland), called a pheochromocytoma.
  • you have a tumor in your pancreas called an insulinoma.
  • you are allergic to glucagon or any other inactive ingredient in GVOKE.


High blood pressure. GVOKE can cause high blood pressure in certain people with tumors in their adrenal glands.

Low blood sugar. GVOKE can cause low blood sugar in certain people with tumors in their pancreas called insulinomas by making too much insulin in their bodies.

Serious allergic reaction. Call your doctor or get medical help right away if you have a serious allergic reaction including:

  • rash
  • difficulty breathing
  • low blood pressure


The most common side effects of GVOKE in adults include:

  • nausea
  • vomiting
  • swelling at the injection site
  • headache

The most common side effects of GVOKE in children include:

  • nausea
  • low blood sugar
  • high blood sugar
  • vomiting
  • abdominal pain
  • headache
  • pain or redness at the injection site
  • itching

These are not all the possible side effects of GVOKE. For more information, ask your doctor.

Call your doctor for medical advice about side effects. You are encouraged to report side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.


Before using GVOKE, tell your doctor about all your medical conditions, including if you:

  • have adrenal gland problems
  • have a tumor in your pancreas
  • have not had food or water for a long time (prolonged fasting or starvation)
  • have low blood sugar that does not go away (chronic hypoglycemia)
  • are pregnant or plan to become pregnant
  • are breastfeeding or plan to breastfeed

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.


  • Read the detailed Instructions for Use that come with GVOKE.
  • Use GVOKE exactly how your healthcare provider tells you to use it
  • Make sure your relatives, close friends, and caregivers know where you store GVOKE and how to use it the right way before you need their help.
  • Act quickly. Having very low blood sugar for a period of time may be harmful.
  • Your healthcare provider will tell you how and when to use GVOKE.
  • After giving GVOKE, your caregiver should call for emergency medical help right away.
  • If you do not respond after 15 minutes, your caregiver may give you another dose, if available. Tell your healthcare provider each time you use GVOKE. Low blood sugar may happen again after receiving an injection of GVOKE. Your diabetes medicine may need to be changed.


  • Keep GVOKE in the foil pouch until you are ready to use it.
  • Store GVOKE at temperatures between 68°F and 77°F.
  • Do not keep it in the refrigerator or let it freeze.

Keep GVOKE and all medicines out of the reach of children.

For more information, call 1-877-937-4737 or go to https://gvokeglucagon.com/

Please see the Full Prescribing Information for Gvoke: https://gvokeglucagon.com/pdf/gvoke-prescribing-information.pdf

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