Walking is one of the most effective, accessible and sustainable forms of exercise you can do. This low-intensity movement can support heart health, boost energy, reduce stress and help build long-term healthy habits. Below are just a few reasons why walking may be the key to moving more, feeling better and supporting your overall health.

Accessible and approachable

For many people, walking is a simple, flexible way to move more and support their health. It's a low- to no-cost activity that doesn't require special equipment or a high skill level. Whether it's taking a quick walk during your lunch break or choosing the stairs, small moments of movement throughout the day can add up.

Supports heart health

Consistent movement can play an important role in supporting cardiovascular health. According to the American Heart Association, physical activity like a daily 20-minute walk may help reduce cardiovascular health disparities.

The good news? Those minutes don't have to happen all at once. Short walks throughout the day can help people gradually build healthier habits and incorporate more movement into everyday routines.

Supports overall well-being

Beyond the physical benefits, walking may also help reduce symptoms of depression and anxiety and improve your quality of life and sense of overall well-being. Even a short walk around the neighborhood can be a great way to recharge during a hectic day.

How much movement do you need?

So, how much should you walk? The American Heart Association recommends getting at least 150 minutes (2.5 hours) of heart-pumping physical activity per week. That may sound intimidating, but you don't have to do it all at once!

Throughout your week, you can get in a few minutes of walking here and there. That could mean taking a 10-minute walk during your lunch break, walking to the park with your dog or grabbing a coffee with a friend and taking a stroll around the neighborhood.

Take the next step

Are you ready to start walking? Set yourself up for success by joining the American Heart Association's Heart on the Move Challenge. The free 21-day movement challenge encourages participants to move more and build heart-healthy habits through simple daily activities like walking.

As you move, you can earn points that you can redeem for fun rewards along the way. Plus, you'll join thousands of others across the country who are moving more to feel better.

Remember, walking for your health isn't about perfection. It's about consistent movement and progress. To learn more and join the challenge, visit Heart.org.

What are omega-3s and why do they matter so much? Here's what to know, and a new, simple, value-add way to get more of them in your daily routine to support your health and wellness goals.*

What are omega-3s and why are they so important?

Omega-3 fatty acids are key nutrients that support overall health. The omega-3s EPA and DHA are among the few nutrients that support every single cell in the body. And, essentially, whatever your body does or doesn't do well greatly depends on the health of your cells, making omega-3s critical to your heart health, brain function, immune system and overall everyday well-being.* Basically, they show up everywhere in your body, doing important work.

Unfortunately, current research shows that more than 80% of Americans aren't getting enough omega-3s through their diet.^† Americans simply aren't consuming enough omega-3-rich foods. For example, you would need to eat at least 3 ounces of salmon every single day or 76,000 chia seeds each day to get a common daily serving of 1,000 mg of EPA and DHA, which are the most critical omega-3s bodies need. But you have to rely on your diet because the human body can't efficiently make EPA and DHA on its own. Omega-3s EPA and DHA are primarily found in cold-water fatty fish (e.g., salmon, sardines, mackerel) and algae — foods that typically aren't an abundant part of the everyday American diet.

How can you get more omega-3s?

Meeting your daily omega-3 needs is vital to reaping the full benefits of your other healthy lifestyle efforts. Eating foods rich in the omega-3s EPA and DHA is a great place to start. This can include cold-water fatty fish like salmon, anchovies and sardines. But, as studies have shown, it's incredibly difficult to get enough omega-3s through food sources alone.

This is why adding a high-quality omega-3 supplement to your daily routine can help ensure you're meeting your omega-3 needs to get all of those whole-body benefits.

For shoppers looking for both quality and value, there's good news. For the first time, Nordic Naturals Ultimate Omega^® Minis are available in Costco stores nationwide. To learn more, visit https://www.costco.com/p/-/nordic-naturals-ultimate-omega-fish-oil-110-mini-softgels-lemon-flavor/4201002165?langId=-1.

What should you look for in an omega-3 supplement?

Not all omega-3 supplements are created equal. Quality, freshness and absorption are all important factors to consider. A trusted brand like Nordic Naturals — the No. 1 selling omega-3 company in the U.S.^‡ — sets high standards for purity, strength and freshness.

"Every Nordic Naturals fish oil product is rigorously tested for purity, strength and freshness to confirm virtually undetectable levels of environmental contaminants such as PCBs and heavy metals; that active ingredient amounts always match what's shown on the label; and that oxidation values are well below international standards to ensure great taste with no fishy aftertaste," said Kate Turner, MA, RD, CPT, nutrition specialist at Nordic Naturals.

As part of Nordic Naturals' commitment to transparency, the brand offers a Certificate of Analysis (COA) for every product, which you can access by scanning a QR code on the box, so you can see exactly what you're getting.

If you've avoided fish oil in the past due to a fishy taste, smell or "fishy burps," it simply means the fish oil you took was exposed to oxygen, making it go rancid and creating that awful experience. Nordic Naturals addresses this by carefully purifying and concentrating its fish oils in an oxygen-controlled environment, helping ensure exceptional freshness and a clean taste.

As with starting any new supplement, it's important to speak to your healthcare provider first.

A new way to get omega-3s

With more accessible options, closing the omega-3 gap doesn't have to be complicated. Check out Nordic Naturals Ultimate Omega^® Minis now in Costco stores nationwide, giving consumers access to a premium omega-3 product at a great value. To learn more, visit https://www.costco.com/p/-/nordic-naturals-ultimate-omega-fish-oil-110-mini-softgels-lemon-flavor/4201002165?langId=-1.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

†Murphy RA, et al. BMJ Open. 2021.11

‡Based on Stackline, Nielsen and SPINS annual sales data in the U.S.

"I noticed that I needed to stop and rest more often as work began on the house, which I just attributed to getting older," says Dave. "But it seemed like my physical capabilities reduced a little bit quicker than I expected."

What he initially dismissed as signs of aging slowly escalated. Annual blood work revealed minor abnormalities, placing Dave on a cautious watchlist with his primary care doctor. The true alarm sounded when he was turned away from a local blood drive due to low hemoglobin levels. This prompted another doctor's visit, a new round of blood tests, and ultimately, a referral to an oncologist.

Dave remembered feeling anxious after the initial consultation. It took months for a definite answer to emerge, as his blood counts continued their troubling decline. Finally, a bone marrow biopsy delivered a definitive diagnosis: Myelodysplastic syndromes (MDS)-related anemia.

MDS is a group of disorders in which the bone marrow fails to make enough healthy red blood cells (RBCs), white blood cells (WBCs) or platelets.¹ The resulting low red blood cells cause anemia, leading to common symptoms such as feeling tired, weak and dizzy. These symptoms are often overlooked, frequently mistaken for normal signs of aging and many can get in the way of daily activities.^1,2 Left untreated, anemia can worsen over time, potentially affecting vital organs like the brain, heart and lungs.³

Dave remembers his diagnosis feeling like a "curveball," threatening not only his health but also the shared dream he had with his wife, Diana, of building their ideal home. Despite the shock, this shared adversity strengthened Dave and Diana's bond, and they were determined to navigate their new reality together.

Dave discussed his treatment options with his oncologist. While some people may require RBC transfusions, they weren't the required initial approach for his specific case yet. Healthcare providers may recommend treating anemia with RBC transfusions based on symptom severity and hemoglobin levels.¹ His oncologist recommended Reblozyl (luspatercept-aamt), a prescription medicine for injection used to treat adults with anemia associated with MDS, and together they decided to move forward with the treatment.

____________________________________________________________________________________

REBLOZYL (luspatercept-aamt) is a prescription medicine for injection, and is used to treat anemia (low red blood cells) in adults with⁴:

• MDS who may need regular RBC transfusions and have never received an erythropoiesis-stimulating agent (ESA).

It is not known if REBLOZYL is safe or effective in children under 18 years of age. REBLOZYL is not for use as a substitute for RBC transfusions in people who need immediate treatment for anemia.

REBLOZYL may cause serious side effects, including blood clots (also known as thrombosis or thromboembolism) and high blood pressure (also known as hypertension). The most common side effects of REBLOZYL include tiredness, headache, back, joint, muscle or bone pain, joint pain, dizziness, nausea, diarrhea, cough, stomach (abdominal) pain, trouble breathing, swelling of your hands, legs, or feet, high blood pressure, and allergic reactions. Please see additional Important Safety Information for REBLOZYL below and at www.REBLOZYL.com.

____________________________________________________________________________________

Dave says he experienced a noticeable difference early in his treatment. He reported lower gastrointestinal side effects, though he acknowledges that each person's experience can vary. Now, Dave and Diana are getting back to planning for their future.

Dave offers poignant advice to others facing similar health circumstances: "Don't just sit there and listen to a one-way conversation. Ask your doctor questions so that you can make decisions about your own treatment. Autonomy is empowering and may change the way you look at the path forward." For more information, visit www.reblozyl.com.

What is REBLOZYL^® (luspatercept-aamt)?

REBLOZYL is a prescription medicine used to treat anemia (low red blood cells) in adults with:

• myelodysplastic syndromes who may need regular red blood cell transfusions (RBC transfusions) and have never received an erythropoiesis stimulating agent (ESA).
• myelodysplastic syndromes with ring sideroblasts (MDS-RS) or myelodysplastic/myeloproliferative neoplasms with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T) who need 2 or more RBC units over 8 weeks and have not responded well to an erythropoiesis-stimulating agent (ESA).

REBLOZYL is not for use as a substitute for RBC transfusions in people who need immediate treatment for anemia. It is not known if REBLOZYL is safe or effective in children.

Before receiving REBLOZYL, tell your healthcare provider about all of your medical conditions, including if you:

• have or have had blood clots
• take hormone replacement therapy or birth control pills (oral contraceptives)
• have had your spleen removed (splenectomy)
• smoke
• have or have had high blood pressure (hypertension)
• are pregnant or plan to become pregnant. REBLOZYL may harm your unborn baby. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with REBLOZYL.
  For females who are able to become pregnant:

• • Your healthcare provider should do a pregnancy test before you start treatment with REBLOZYL.
  • You should use effective birth control (contraception) during treatment with REBLOZYL and for at least 3 months after the last dose.
• are breastfeeding or plan to breastfeed. It is not known if REBLOZYL passes into your breast milk.
  • Do not breastfeed during treatment with REBLOZYL and for 3 months after the last dose. Talk to your healthcare provider about the best way to feed your baby during this time.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of REBLOZYL? REBLOZYL may cause serious side effects, including:

• Blood clots. Blood clots in the arteries, veins, brain, and lungs have happened in people with beta thalassemia during treatment with REBLOZYL. The risk of blood clots may be higher in people who have had their spleen removed or who take hormone replacement therapy or birth control (oral contraceptives). Call your healthcare provider or get medical help right away if you have any of these symptoms:
  • chest pain
  • trouble breathing or shortness of breath
  • pain in your leg, with or without swelling
  • a cold or pale arm or leg
  • sudden numbness or weakness that are both short-term or continue to happen over a long period of time, especially on one side of the body
  • severe headache or confusion
  • sudden problems with vision, speech, or balance (such as trouble speaking, difficulty walking, or dizziness)
• High blood pressure. REBLOZYL may cause an increase in your blood pressure. Your healthcare provider will check your blood pressure before you receive your REBLOZYL dose. Your healthcare provider may prescribe you medicine to treat high blood pressure or increase the dose of medicine you already take to treat high blood pressure, if you develop high blood pressure during treatment with REBLOZYL

The most common side effects of REBLOZYL include:

• tiredness
• headache
• back, joint, muscle or bone pain
• joint pain
• dizziness
• nausea
• diarrhea
• cough
• stomach (abdominal) pain
• trouble breathing
• swelling of your hands, legs, or feet
• high blood pressure
• allergic reactions

REBLOZYL may cause fertility problems in females. This could affect your ability to become pregnant. Talk to your healthcare provider if this is a concern for you.

These are not all of the possible side effects of REBLOZYL. Call your doctor for medical advice about side effects. You are encouraged to report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please see accompanying US Full Prescribing Information and Patient Information for REBLOZYL.

(BPT) - Parasite season is in full swing. As temperatures rise, ticks and mosquitoes emerge, increasing the risk of serious diseases like Lyme disease and heartworm disease. These threats, along with intestinal worms, pose significant threats to our furry friends.

Speaking with your veterinarian about comprehensive parasite coverage is one of the most important things you can do for your dog's health.

Ask your veterinarian about Credelio Quattro™ (lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets), the broadest parasite coverage of its kind* covering 6 kinds of parasites§ in one chewable tablet.

Join Quattro Dogs across the country and keep your pup covered all year long.

Visit QuattroDog.com and follow @CredelioQuattroUS on Instagram.

*Based on label comparison of the number of parasite types covered in a chewable that targets ticks

§Credelio Quattro protects dogs against ticks, fleas, heartworm disease, roundworms, hookworms and tapeworms.

For complete safety information, please see the Credelio Quattro product label or ask your veterinarian.

The trusted home comfort experts at Lennox, a leader in reliable, efficient climate-control solutions, offer guidance on what you should worry about when it comes to your home's air quality, and simple steps to put those worries to rest.

No Fresh Air? To maximize efficiency of air conditioning, homeowners often keep homes tightly sealed up, with no open windows all summer long. This lack of ventilation traps volatile organic compounds (VOCs) in homes. VOCs are gases emitted from various household products and include a number of chemicals, some of which may have negative health effects like eye, nose and throat irritation, dizziness, headaches, fatigue and more. VOCs are ten times as concentrated indoors, making them a key factor in your home's air quality.

The No Worries Fix. To reduce the potential negative impacts of VOCs, you can open windows at night or during early morning hours to allow for better ventilation without inviting the day's worst heat inside.

How can you know if your home has a high level of VOCs? Beyond experiencing symptoms at home such as those mentioned above, be aware of persistent odors from things like new paint, furniture or carpet. For a clearer picture of what's in your indoor air, homeowners can reach out to a local Lennox dealer to perform an Indoor Air Quality test to help identify potential concerns.

To improve your home's ventilation overall, consider a whole home ventilator. These units are your worry-free solution to delivering the fresh-air feeling you crave into your home.

Humidity? Many regions of the country are especially humid during the summer months, which can create problems for people with respiratory conditions like asthma or COPD, weakened immune systems or certain allergies. Because summer humidity can promote mold growth in homes, this can cause symptoms such as nasal congestion, coughing or eye irritation, to name a few.

The No Worries Fix. To improve humidity levels in your home, use exhaust fans in bathrooms and kitchens to reduce moisture in the air. You'll also want to fix leaks or seepage, preventing moisture from coming in from the ground by putting a plastic cover over dirt in crawlspaces, and bolstering landscaping so the ground slopes away from your home.

How can you tell if there's too much humidity in your home? Look for window condensation or warped wood. You may also notice a musty smell, mold growth or weakened structural elements.

If your home could benefit from additional humidity control, you may want to invest in a reliable dehumidification system. Balanced humidity levels from a system like this can help make your home environment healthier and worry-free year-round, and can also save energy.

Pollen? Spring coming to a close doesn't mean your allergies get a break. Sneezing, coughing and itchy eyes are caused by pollen outside that invades your home. While tree pollen flares in the spring, summertime is when grass pollen is at its highest. It can be hard to avoid allergens in the summer, even when you're indoors.

The No Worries Fix. To help keep pollen outside where it belongs, leave shoes at the door and then shower and change clothes immediately when you return home, especially if you've just spent time enjoying the great outdoors. Keep windows closed when the pollen count is high.

If you or a family member suffers from frequent allergies, choose a high-efficiency HEPA or MERVE 13+ HVAC filter, or upgrade to a whole-home purification system for a worry-free way to clean the air inside your home. Healthy Climate^® air purification and filtration systems from Lennox are designed to work with your central heating and cooling system to improve the air quality throughout your entire home, not just individual rooms.

Not Sure if Your Indoor Air Quality Needs Help? No Worries!

You can take this online quiz to help determine what's going on with the air in your home. Or contact your local Lennox dealer to perform an air quality check to assess your home's levels of VOCs, humidity, carbon dioxide, carbon monoxide and more. Learn more about IAQ products Lennox offers at Lennox.com.

Main image caption: With warmer days ahead, poor indoor air quality can impact your home. Getty Images

Misconceptions about ED, coupled with the deeply personal nature of sexual health, may prevent many men from discussing it, which could lead to feelings of isolation and shame. The hesitation to discuss ED, even with their partner, may profoundly impact a man's sexual confidence and relationships. This is especially relevant if they don't fully understand the medical condition and the potential causes.

ED occurs when blood flow to the penis is limited or when nerves are damaged. There are many factors that can contribute to ED, including age and medical conditions like diabetes, cardiovascular disease and neurological disorders.²

For men experiencing ED, it's important to seek care from a healthcare professional. A complete examination, usually with a urologist, can be an important first step in determining the cause and extent of ED and identifying appropriate treatment options. Additionally, lifestyle changes such as increasing physical activity, quitting smoking, limiting alcohol, dieting and reducing stress can also help improve symptoms.²

Treatment advances offer safe and effective options

A variety of options are readily available and can be pursued based on each patient's needs. For most men, the first line of treatment often involves oral medications, which can be taken an hour or two before intercourse or as a low, daily dose to maintain a consistent level of medication in the body.

Oral medications may not always be an effective treatment since they may increase blood flow to other tissues of the body.³ Some may experience side effects like headaches, facial flushing or muscle aches.³ Other users may dislike the need to plan sexual activity around their medication as it can take away from spontaneity. It is important for men to continue talking to their urologist, who may recommend alternative treatments such as penile injections, vacuum devices or a long-term treatment, like a penile implant.

Exploring a discreet approach to treatment

For men who don't respond to initial treatment options, a penile implant may be an effective long-term treatment. Implanted surgically, a penile implant can enable a man with ED to achieve and maintain an erection whenever desired, for as long as desired. A penile implant allows direct control of both the timing and duration of an erection.

One type of penile implant is the AMS 700™ Inflatable Penile Prosthesis, which is designed to closely mimic a natural erection, providing rigidity when inflated and a natural, flaccid appearance when deflated. When deflated, the device can't be seen from the outside, allowing men with a penile implant to maintain discretion. The implant is also designed to feel natural, which can be a key feature. A natural feel design combined with the spontaneity of achieving an erection on demand can enable intimacy with partners.

Taking the first step to ED treatment

For men experiencing ED, an important step is to initiate a conversation with a healthcare professional who understands the condition and available treatments. Know that you are not alone: ED is a common, treatable medical condition and there are safe and effective treatment options available.

If you think a penile implant might be an option for you or to learn more, ask your doctor about the AMS 700 penile implant. To find a specialist who offers penile implants, visit EDCure.com.

Important Safety Information

The AMS 700™ Inflatable Penile Prosthesis (IPP) is intended for use in the treatment of chronic, organic male erectile dysfunction (impotence).

With all medical procedures, there are risks associated with the procedure and the use of the device, including long term implantation.

Implanting a penile prosthesis will damage or destroy any remaining ability to have a natural erection, as well as make other treatment options (oral medications, vacuum devices or injections) impossible. Men with diabetes, spinal cord injuries or skin infections may have an increased risk of infection. Implantation may result in penile curvature or scarring. The device is not suitable for patients with active urinary tract, genital or skin infections in the region of surgery. Some AMS 700 devices contain an antibiotic (InhibiZone™ Antibiotic Surface Treatment). AMS 700 with InhibiZone is not suitable for patients who are allergic to the antibiotics contained within the device (rifampin and minocycline HCl) or other tetracyclines, or for patients with systemic lupus, so devices that do not contain InhibiZone should be considered for these patients.

The risks include but are not limited to: device malfunction/failure leading to additional surgery, device migration potentially leading to exposure through tissues, wearing away/loss of tissue (device/tissue erosion), infection, unintended-inflation of the device, pain/soreness, redness or rash near the incision or scrotum, swelling near the incision, scrotum or penis, hives, fever, problems with urination, device in an inappropriate position (device malposition), a second surgery may be required to reposition or remove the reservoir (reservoir revision or removal).

The device can be MRI scanned under specific conditions. Scanning under other conditions may result in injury or device malfunction. Be sure to talk to your doctor before undergoing MRI scanning.

Be sure to talk with your doctor so that you thoroughly understand all of the risks and benefits associated with the use of the device.

CAUTION: U.S. Federal law restricts this device to sale by or on the order of a physician.

This article is sponsored by Boston Scientific.

References

1. Selvin E, Burnett AL, Platz EA. Prevalence and risk factors for erectile dysfunction in the US. Am J Med. 2007 Feb;120(2):151-7. doi: 10.1016/j.amjmed.2006.06.010.
2. Leslie SW, Sooriyamoorthy T. Erectile dysfunction. In: StatPearls [Internet]. StatPearls Publishing; 2024. Updated January 9, 2024. Accessed May 20, 2026.
3. "Erectile Dysfunction (Ed)." Erectile Dysfunction (ED): Symptoms, Diagnosis & Treatment - Urology Care Foundation. www.urologyhealth.org/urology-a-z/e/erectile-dysfunction-(ed)#Treatment. Accessed April 2026.

According to the latest GeneSight^® Mental Health Monitor national survey from Myriad Genetics^®, even in today's highly customizable environment, many Americans feel that mental health treatment isn't designed with them in mind.

The survey found that 41% of those diagnosed with depression and/or anxiety, and who are currently taking a mental health medication, think it feels "one-size-fits-all," and 74% of those who are still finding a medication that works for them say that mental health treatment feels "one-size-fits-all." Of those diagnosed with depression and/or anxiety, just over two-thirds (67%) say their mental health is a daily struggle, and more than half (52%) feel the healthcare system treats them like part of an "assembly line" more than an individual.

"People today expect to experience personalization everywhere they go, but many of my patients feel like their mental health treatment is a lengthy, uncertain trial-and-error process," said Dr. Crystal Nelson, board-certified psychiatrist and CEO of Blueprint Psychiatry in Atlanta. "It's crucial to find ways to tailor mental health medication treatment to each individual so they can feel better, sooner."

How lack of personalization impacts treatment

Many patients feel their mental healthcare isn't tailored to them, which may shape their confidence in their treatment plan. In fact, a majority (roughly 70%) of those diagnosed with depression and/or anxiety think various aspects of their mental healthcare are "only somewhat," "not very" or "not at all" personalized to them, and most of the same group (88%) say they would be more confident in their mental healthcare plan if it were personalized to them.

This lack of confidence is especially important when it comes to mental health medication. Among those diagnosed with depression and/or anxiety and currently taking a prescribed mental health medication, nearly two-thirds (65%) are not confident their medication was selected specifically for them. At the same time, patients are signaling that personalization could make a meaningful difference: Nearly three-quarters (74%) indicated that personalization would make them more likely to stay committed to a prescribed mental health medication.

This is important, as mental health medication treatment can involve a degree of trial and error. According to the national survey, only 13% of those diagnosed with anxiety and/or depression who have taken mental health medication previously said the first medication they tried worked for them, meaning many spend time trying multiple medications before finding one that works. However, 78% of the same group said they felt more like themselves after finding a medication that worked for them, highlighting the value of a more personalized approach to mental health medication treatment.

A tool to help personalize treatment: genetic testing

For clinicians, genetic testing can be a useful tool to help them offer more personalized mental health treatment. For example, the GeneSight Test from Myriad Genetics is a simple cheek swab that analyzes how a patient's genes may affect medication outcomes. The GeneSight Test looks at clinically important genetic variations in each patient's DNA, providing results that may inform clinicians about how a patient may break down or respond to over 60 FDA-approved medications commonly prescribed for depression, anxiety, ADHD and other psychiatric conditions.

These insights supplement other key information, like your medical history, to help your clinician create a comprehensive medical assessment and treatment plan. With this additional information, clinicians can better understand if you may need dose adjustments, if certain medications may be less likely to work for them, or if they may have an increased risk of side effects based on your genetics. Nearly two-thirds (65%) of survey respondents were unaware that genetic testing may help inform mental health medication decisions, but after learning about this option, more than half (55%) say they would have preferred their clinician to offer it as part of their care.

"The GeneSight Test is a valuable tool in my practice," said Nelson. "Many of my patients are surprised to learn that genetic testing may help inform mental health medication decisions and often wish they had known about it sooner. The test provides additional insights about each person as an individual, helping me make more informed decisions about prescribing mental health medications and better tailoring each patient's treatment plan."

Learn more about how genetic testing can help personalize mental health treatment at GeneSight.com.

*The GeneSight^® Mental Health Monitor is a nationwide survey conducted online by ACUPOLL Precision Research, Inc. between February 23-March 6, 2026, among a representative sample (n=1002) of U.S. adults age 18+. The margin of error in survey results for the total base population at a 95% confidence interval is +/- 4%. A nationally representative sample of adults aged 18 years or older was recruited and balanced to match U.S. Census quotas across five primary metrics (i.e., age, gender, income, education and ethnicity). In addition to the nationally representative sample, a statistically reliable sample was achieved of respondents who were self-reported as being diagnosed by a medical professional with depression or anxiety. ACUPOLL has more than 30 years of experience conducting statistically valid research through careful recruiting and quality control measures.

• Digital twins and using AI to answer health questions are trends gaining momentum this year.
• Experts point out that AI should not replace a conversation with a doctor.
• Tech like AI-assisted wearables could help identify early warning signs.

Healthcare technology entered 2026 smarter, faster and more connected than ever. From creating digital twins of real people to artificial intelligence (AI) gaining momentum, here are trends experts at health-tech company Medtronic say could define this year.

How digital twins help clinicians personalize care

You're one of a kind. But someday, you could have a digital twin — a virtual version of you that helps clinicians personalize care and predict health outcomes.

How? By combining clinical, physiological and lifestyle data, a digital twin can mirror the unique characteristics of individual patients.

While a comprehensive human digital twin hasn't been created yet, patients are already beginning to benefit from this technology. Doctors can now "rehearse" a heart valve replacement using a digital replica of the patient's heart, predicting how the body may respond to the procedure.

Medtronic is also exploring how digital twins could help develop safe therapies faster.

"A digital twin can help us accelerate research, reduce the need for animal testing and avoid exposing humans to unnecessary risks," said Dr. Nathalie Virag, Vice President and General Manager at the Medtronic Bakken Research Center. "Many early-stage experiments can be conducted on a computer before moving to animal or human testing."

What's next? Digital twins will become smarter and help clinicians move from reacting to patient health challenges to predicting individual health risks before symptoms appear.

Are you using AI to answer health questions?

You've likely asked "Dr. Google" medical questions. But how we find answers is changing. More people are using generative AI to learn about their health concerns, turning to AI overviews and chatbots before seeing a doctor.

While AI can offer quick, personalized answers, it should be used as a tool for learning rather than diagnosing. This is especially true for health conditions like heart disease, which can present differently in women than in men.

"AI can be a great starting point, but it should never replace a conversation with a healthcare professional," said Dr. Kendra Grubb, Vice President and Chief Medical Officer of Structural Heart at Medtronic. "It doesn't understand your lifestyle, family history or clinical signs the way a physician does."

What's next? AI could become more connected to wearable devices.

By tracking real-time health data like heart rate and blood pressure, AI-assisted wearables could help identify early warning signs before symptoms start. This could empower patients to seek care sooner and give clinicians insights to personalize treatment.

As the weather warms and people head outdoors, most folks think about vacations, barbecues and long days in the sun. In trauma care, we think about something else: Summer is our busiest season, which many of us recognize as "trauma season." Every year, as outdoor activity increases, so do preventable injuries, including bleeding emergencies. Car crashes, falls, boating mishaps, power tool and DIY injuries — the kinds of events that turn ordinary days into those that can change our lives.

The goal for many of us, including trauma surgeons and others in the wide range of roles contributing to injury prevention, survival and recovery, is not to dampen summer plans. Instead, we want to prepare people for the reality that when something goes wrong, the first person on scene is rarely a professional healthcare worker. It's a family member, a friend or a bystander who may be able to help; what they do in those first moments matters.

This is why the American College of Surgeons created the ACS Stop the Bleed program. It's a simple, practical program that teaches anyone how to control life-threatening bleeding (bleeding that is spurting or pooling). After calling 911, the steps are simple:

1. Press directly on the wound (direct pressure)
2. Pack the wound with gauze or cloth (wound packing)
3. Place a tourniquet just above the serious bleeding (tourniquet application)

These skills are intentionally designed so that almost anyone can perform them. Severe bleeding can be fatal in minutes, and in many parts of the country, especially in rural areas, EMS response times can be longer than expected. This gap between injury and interventions is where lives are lost or saved. Stop the Bleed exists to close that gap.

It is important to remind ourselves that emergencies don't wait for the perfect time. They happen in driveways, on lakes, in backyards and on highways. They happen to people who never imagined they'd need to act.

Anyone on the scene can do more than just call for help. A friend's quick thinking saved a high school student's life after a serious car crash. A Minnesota woman saved her husband's life after a severe injury in their rural backyard. These aren't unusual stories; they're examples of what's possible when someone nearby knows what to do. Anyone can be a lifesaver by becoming trained in Stop the Bleed.

As you prepare for summer plans, add a quick and easy item for the entire family: attend a Stop the Bleed class near you. Hospitals, fire and police departments, community centers and other programs host them regularly. We also offer a convenient online course to help you get started on what to do in a bleeding emergency. Keep a bleeding control kit in your home and car. The training takes less than an hour and can save a life.

When summer fun takes a turn, minutes matter. And in those minutes, you matter.

David S. Shapiro, MD, MHCM, FCCM, FACS, is Chair of the American College of Surgeons Stop the Bleed Committee and a trauma surgeon based in West Hartford, Connecticut.

What many people may not realize is that the latest technological advancements, like artificial intelligence (AI), are already helping to improve the healthcare experience for everyone: patients, caregivers and providers alike.

Forward-thinking companies like NextGen Healthcare are constantly evolving and adapting, discovering new ways to use AI and intelligent automation to reshape outpatient healthcare services.

What does this mean for families and their healthcare providers? Streamlined services that improve the patient experience and take some of the burden of excess paperwork off the hands of healthcare providers.

Here's how NextGen Healthcare uses Clinical AI and intelligent automation to offer improved patient solutions and streamlined processes that make healthcare less painful for everyone.

1. Reduced wait time to see a doctor

2. Faster referrals to a specialist

NextGen's Closed Loop™ approach means there's one seamless platform to integrate the entire patient experience. For providers, there's no more switching between systems or hunting for patient data. This also leads to a quicker referral loop from one doctor to another (such as a specialist) — taking half the time of standard referral methods.

3. Fewer missed appointments

There's nothing worse than forgetting an appointment you set long ago, both for you and for your healthcare provider. With intelligent automation, NextGen Healthcare sets automatic patient reminders, resulting in a 40% reduction in missed appointments.

4. More accurate billing and claim resolution

Automating systems efficiently also leads to much more accurate billing processes, plus better cost and payment transparency. NextGen's system sees 45% faster health insurance claim resolutions for patients.

5. Improved health outcomes

AI integration across a single platform offers improvement across the patient journey. From enhanced communication with providers and faster access to medical information, to virtual visits, better care coordination and remote patient monitoring, today's tech tools empower patients throughout their entire experience. It also gives healthcare professionals the ability to focus more on what matters: providing the best care for you and your family.

"Families shouldn't have to act as full-time coordinators of their own healthcare," said Dr. Robert Murry, MD, Ph.D., chief medical officer at NextGen Healthcare and a practicing family medicine physician. "The best healthcare technology works quietly in the background — making care easier to access, easier to understand, and easier to manage across the entire family."

AI has changed the world of healthcare, but one thing that stays the same is NextGen Healthcare's mission to simplify the care process with the most intelligent, purpose-built solutions available. NextGen Healthcare uses the best of AI and intelligent automation to maximize efficiency for all practices, so they can offer the best possible patient experience.

Learn more about how healthcare processes are improving through the smart use of AI and intelligent automation at NextGen.com.

(BPT) - More Americans than ever are living longer. As of 2024, nearly 24% of the U.S. population is age 60 or older, making healthy aging increasingly important for individuals, families and communities. Everyday habits like eating well, staying active, keeping up with preventive care and staying connected can meaningfully support long-term health, independence and quality of life.

Each May, communities across the country recognize Older Americans Month, an observance led by the Administration for Community Living (ACL) to celebrate the contributions of older adults and promote healthy aging.

"This year's Older Americans Month theme, 'Champion Your Health,' encourages people to take an active role in their health and well-being," said Mary Lazare, principal deputy administrator at ACL. "Simple habits like staying active, managing stress and keeping up with preventive care can help people stay healthy and independent over time."

This Older Americans Month, look for simple ways to support health and connection in your daily life and community.

Simple Tips for Healthy Aging

• Stay up to date on checkups and screenings to help prevent health problems.
• Spend time with friends, family and community groups to stay socially connected.
• Eat nutritious foods and stay active to maintain strength and balance.
• Support your mental health by managing stress and getting enough sleep.

Ways to Support Older Adults in Your Community

• Check in on older neighbors, friends or family members to help them stay connected.
• Support caregivers by offering encouragement and help when you can.
• Support local programs that serve older adults by volunteering or helping raise awareness.

How Communities and Organizations Can Help

• Share resources and tips that support healthy habits and preventive care.
• Highlight local programs and events that help older adults stay healthy and connected.
• Organize volunteer activities or donation drives for older adults.

For more ideas and information, visit acl.gov/oam.

"While the shock of a brain tumor diagnosis is often acknowledged, the practical and emotional support families need in those early days doesn't always follow," says Regina. "Many families are left searching for someone who can slow down, answer questions and help them process what this diagnosis means for daily life."

pLGG is the most common type of brain tumor in children. It is considered slow-growing, but its effects can be significant, depending on where the tumor develops in the brain. Some children experience vision problems, loss of balance or changes in energy levels. Others may face mood disorders or seizures.¹

From a clinical standpoint, the course of pLGG varies as well. Some tumors remain stable and are monitored through routine imaging. Others require surgery or targeted treatment.¹ But the one constant across all of those impacted is that the experience extends far beyond what happens in a hospital or clinic.

"What many people don't realize," Regina explains, "is that this is often a long-term condition. Families aren't just dealing with a diagnosis. They're learning how to live with ongoing uncertainty."

Much of the pLGG experience happens between appointments. There are the waiting periods between scans, when anxiety can quietly build. There are school days missed for appointments, and the challenge of helping teachers and classmates understand what a child is going through. There are shifts at home, as parents balance caregiving with work and siblings adjust to changes in attention and routine.²

For children, the emotional impact can be just as significant as the physical.²

"Even when children are able to return to school or social activities, many continue to struggle to make sense of something that's hard for even adults to process," Regina says. "Challenges aren't always visible, but they can affect friendships, participation in class and how children see themselves."

This is where support and resources become essential. In addition to needing help to process the emotional weight of diagnosis, families also need practical support. That can include financial resources, coordination with schools or having conversations with children about their condition in an age-appropriate way. These needs constantly change as a child's journey continues.

That's why it's critical that patients and families have access to a care team — not just a single point of contact. Social workers, Child Life Specialists and other care team members often collaborate closely with doctors and nurses to provide holistic care for the child and their family. In addition to treatment, the broader team focuses on helping children understand and cope with medical experiences and support the emotional and logistical needs of the entire family.³

Together, this network helps families navigate not just treatment, but the realities of everyday life with pLGG.

One of the most common challenges families face is isolation. Because pLGG can be a long-term condition, families may feel like others don't fully understand what they are going through.²

Access to resources can help bridge that gap. Educational materials can make it easier for parents to explain the diagnosis in a way their child can understand. Support communities offer a sense of connection with others on a similar path.

Additional tools are designed specifically for children and families, including books that help explain pLGG in age-appropriate ways and provide guidance for navigating uncertainty.

"I've seen how much it helps when families feel that they're not alone," Regina says. "Even small moments of understanding and connection can ease the burden. I encourage anyone navigating a pLGG diagnosis to seek out trusted resources and support networks that can help them feel informed, supported and less isolated."

For more information on pLGG and resources for families, visit rethinkplgg.com.

Sources:

1. What is pediatric low-grade glioma (pLGG)?. rethink pLGG from Day One Biopharmaceuticals. (2026). https://www.rethinkplgg.com/about-plgg
2. Pediatric Brain Tumor Foundation. (2024, July 17). Voice of the Patient Report. Cure the Kids. https://curethekids.org/wp-content/uploads/2024/08/PBTF-pLGG-Voice-of-the-Patient-Report.pdf
3. Scialla, M. A., Canter, K. S., Chen, F. F., Kolb, E. A., Sandler, E., Wiener, L., & Kazak, A. E. (2017). Implementing the psychosocial standards in pediatric cancer: Current staffing and services available. Pediatric Blood & Cancer, 64(11). https://doi.org/10.1002/pbc.26634

• Summer with pets is fun, but can bring additional safety and health worries.
• A recent Rover survey found pet parents are willing to put in the effort and expense to protect their pets.
• Pet parents need confidence that pet sitters and dog walkers are reliable and knowledgeable about summer safety risks.
• Rover provides trusted care, for peace of mind that pets are living their best lives while pet parents are, too.

Summer travel season is ramping up, and for many pet parents, plans are increasingly shaped around one priority: keeping pets safe from seasonal risks.

A new 2026 Summer Safety Survey from Rover found that 88% of pet parents plan summer activities around whether their pets can join them. But alongside more outdoor adventures and travel comes increased concern about seasonal risks, particularly heat-related illness (32%) and exposure to fleas and ticks (38%).

Those concerns are personal for many pet parents. Nearly half of pet parents say their dog or cat has experienced heat exhaustion or dehydration, yet 64% admit they are not fully confident they know exactly what warning signs to look for.

Safeguard against fleas and ticks

Heading into the summer months, make sure your pet is up to date on your veterinarian's recommended flea and tick prevention to alleviate this concern. Also keep your yard clear of organic matter, including leaves and clippings, where fleas might hide. If your dog often explores grassy or wooded areas, learn methods for safe tick removal.

How to keep pets safe during summer heat

Heat-related illness remains one of the biggest summer risks for pets. Despite widespread concern, many pet parents still struggle to identify the early signs of overheating. According to the survey, nearly half (46%) of pet parents report their pet has experienced heat exhaustion or dehydration at some point.

Early warning signs include:

• Dogs: Excessive panting, lethargy, confusion or drooling. Severe signs are pale gums, foaming at the mouth or seizures.
• Cats: Excessive pacing, panting, grooming, drooling or atypical vocalizations. Severe signs include stumbling, vomiting, loss of consciousness or collapsing.

For early warning signs, give your pet cool (not iced) water to drink, get them in the shade/air conditioning and apply wet towels or cool water to their head or neck. For concerns about your pet's symptoms, consult your veterinarian.

Ways pet parents care for their dogs and cats

Almost all pet parents (96%) will go to great lengths to keep their dogs and cats safe from heat-related risks. Their most common practices include:

• Keeping indoor temperatures as cool as possible (73%)
• Not leaving pets in unattended vehicles, even on cooler days (58%)
• Limiting outdoor time to shady or heat-protected areas only (57%)

Other heat-safety best practices include adjusting outdoor time to cooler parts of the day, avoiding strenuous or excessive activity in general on hot days, and swapping outdoor time for more indoor enrichment activities.

When out and about, nearly half (45%) of pet parents bring portable pet bowls and water, and 23% use booties or paw wax to protect paws from the hot pavement. In addition, 19% of pet parents have their pets groomed specifically to prevent sunburn and overheating.

The survey also highlighted the lengths many pet parents are willing to go financially to keep pets comfortable. Nearly 80% said they would sacrifice personal comforts to prioritize their pet's safety during the summer months. More than half said they would spend up to $100 extra per month on cooling costs, 37% would purchase a new air conditioner specifically for their pet, and 31% said they would even cancel an expensive vacation in favor of their pet's well-being.

Where to find someone to care for your pet when you're traveling

Summer is also one of the busiest travel seasons of the year, leading many pet parents to seek reliable care while they are away.

If you need someone to care for your pet when you're on a trip, use a reputable platform like Rover, the world's largest online marketplace for pet care. Rover enables safer, more personalized pet care by connecting pet parents with trusted sitters who understand each pet's unique needs.

Sitters offering pet care services on Rover receive safety guidance related to summer care, including monitoring for signs of overheating and ensuring pets receive adequate hydration and breaks from the heat. Sitters on the platform are also required to complete enhanced background checks and safety quizzes.

Pet care experts recommend scheduling a meet and greet with potential sitters before booking their services, particularly during busy travel periods. Planning ahead can help pet parents feel more confident that their pet's routines, comfort and individual care needs will be maintained while they're away.

Whether pets are joining summer adventures or staying home with a sitter, experts say preparation and heat awareness can go a long way toward helping pets stay safe and comfortable throughout the season. For more tips on how to enjoy summer with your pets in mind, visit Rover.com.

(BPT) - Bladder cancer happens when cells in the bladder start to grow out of control. These cells can form a tumor and, over time, can spread to other parts of the body.

Bladder cancer isn't always easy to detect, so it's important to know what your chances (or risk) of getting bladder cancer may be and what to look for.

Do you want to better understand your risk for bladder cancer? Here are 3 things you should know:

1. The signs and symptoms of bladder cancer

Blood in urine (pee) is usually the first and most common sign of bladder cancer. Blood in your urine may:

• Look orange, pink or dark red in color
• Go away and then come back from time-to-time

Blood in your urine does not always mean cancer, but it's important to see and talk to your doctor to rule out other causes like a bladder or kidney stone, an infection or kidney disease.

When should I talk to my doctor?
Always talk with your doctor about any changes in your urine or bladder habits, such as:

• Having to go more often than usual
• Pain or burning while you urinate
• Feeling like you have to urinate right away, even when your bladder isn't full
• Having trouble going or having a weak urine stream
• Getting up to go often during the night

Your may recommend exams or tests to learn the cause of the blood in your urine or changes in bladder habits.

2. Some people may have a higher chance of developing bladder cancer

The chances of developing bladder cancer increase with age. In the U.S., about 9 in 10 people with bladder cancer are over the age of 55. Bladder cancer is also about twice as likely to occur in white people compared to Black and Hispanic people, and it affects men more than women.

Smoking is a major risk factor for bladder cancer. People who smoke are at least three times as likely to get bladder cancer as people who don't.

Does bladder cancer run in families?
Bladder cancer does not usually run in families. This means it's not usually inherited from your parents.

What are some causes of bladder cancer?
Bladder cancer can be caused by changes in your genes (called gene mutations). These changes can cause cells to become cancerous and grow out of control.

These changes are not usually something a person is born with, and may develop later in life, possibly due to factors such as:

• A person's environment or lifestyle, such as using tobacco, especially if they smoke cigarettes
• Not drinking enough fluids
• Being exposed to certain chemicals at work
• A history of radiation to the pelvis to treat other cancers

3. Certain jobs may put people at a higher risk of bladder cancer

Some people have jobs that may expose them to certain chemicals linked to a higher chance of bladder cancer, including industrial chemicals used in making rubber, leather, textiles and paint products. People who work as painters, firefighters, hairdressers and truck drivers can similarly be exposed to certain chemicals and fumes that might increase their risk of bladder cancer.

If your work might expose you to chemicals that could raise your risk of bladder cancer, be sure to follow good work safety practices.

Even if someone has one or more risk factors, it doesn't mean that you will get bladder cancer.

Talk with your doctor about changes in your health.

If you notice changes in your urine or bladder habits, don't ignore them – tell your doctor.

Ask your doctor if you have a higher chance of developing bladder cancer. This conversation may help you and your doctor catch bladder cancer earlier.

For more information and resources about bladder cancer, visit Merck.com.

Copyright © 2026 Merck & Co., Inc., Rahway, NJ, USA and its affiliates. All rights reserved.

Key Takeaways

• Americans are prioritizing adding protein into their daily diets, and snacking could be another opportunity to increase protein intake.
• 86% of Americans are adding protein to their daily diet, and 63% say they would choose snacks with added protein over regular ones.*
• Americans are looking for added protein in both salty and sweet snack options.
• New Quaker^® Protein Rice Crisps, available in Chocolate Caramel and Tangy Barbecue flavors, are great options.

When your days are packed with meetings, errands, chores and all of life's daily chaos, it can be challenging to find convenient ways to meet your daily diet goals, including protein intake. With Quaker, you can enjoy the flavors of the delicious snacks you love and have functional ingredients like added protein.

The protein snacks market has grown over 11% from 2025 to 2026, showing that the demand is no longer just a trend. In fact, 86% of Americans are adding more protein to their daily diet, and 63% say they would choose snacks with added protein over regular ones. In addition, more than half of Americans (54%) prioritize protein during snacking occasions.

Here are some easy ways to help you meet your snacking goals.

New snacking options with added protein shake up the usual routine

Do you want added protein in your favorite snacks? Quaker has got your back, with tasty new snack options that make it convenient to add protein into your routine. New Quaker Protein Rice Crisps are airy, crunchy mini rice cakes with a light texture offering 6 grams of protein and 9 grams of whole grains per serving. They're easy to pack in a lunch, take to work or just enjoy at home.

How to find gluten-free snack options

For anyone seeking gluten-free choices, Quaker Protein Rice Crisps are also gluten-free (see specially marked packages). They're popped and never fried, with no artificial preservatives or flavors added.

Other gluten-free snack options containing protein that are easy to pack when you're on-the-go include nuts, seeds and edamame. Some meat sticks and most cheese sticks are gluten-free, but some are not. It's best to check the product packaging to be sure.

• It's a great time to refresh your daily routines. Start with making informed personal care choices.
• Step one is to take stock of current products and declutter. Then focus on more intentional and transparent options.
• Empower smart shopping aligned with your health and values by understanding terms like B Corp and "free from" claims.

A changing season is the perfect opportunity to refresh. As you clear out closets and swap heavy layers for lighter ones, don't forget to freshen up the bathroom shelf. Personal care options can feel endless but knowing what to look for can help you feel more confident about what you're choosing.

1. How to organize your bathroom shelf

Before diving in, do a quick check of what you already have. Check expiration dates. Toothpaste, deodorant and other daily staples may lose effectiveness over time.

In many cases, the most intentional choice is simply using up what you already own before reaching for something new.

2. Is your daily routine working?

Once you've checked expiration dates and confirmed everything is still good to use, take a closer look at what you have.

• Which products are part of your daily routine?
• Which ones have been sitting untouched and taking up space?
• What ingredients are used in them?
• And are they free from the ingredients that are important for you to avoid?

This quick look can help you identify what's working, what's not and where it might be time to make a change, without overhauling everything at once.

3. How to choose the best products and brands

Once you know what you need, the next step is reviewing your options. As you evaluate a new product, consider not just what's in it, but the brand behind it — whether they are transparent about how they operate and the impact they have.

One of the clearest indicators of a brand's accountability is B Corp Certification, overseen by the nonprofit B Lab, which evaluates a company across governance, workers, customers, community and environment — and audits it every three years. This shows that a brand holds itself to a social and environmental standard, not just a product one.

Tom's of Maine is a certified B Corp and it's a distinction the brand takes seriously.

"Tom's of Maine's B Corp certification is a reflection of 50 years of deliberate choices," said Michelle Waring, Steward for Sustainability and Everyday Good at Tom's of Maine. "From sourcing naturally derived ingredients to dedicating 10% of our annual profits to protecting nature, we hold ourselves to the high standards B Lab sets because we believe business should be a genuine force for good."

4. Tips to navigate the meaning of "free from" claims

From there, labels can help you refine your decision even further. "Free from" claims communicate that a product has been intentionally formulated without specific ingredients. Think of them as cues to understand what a brand prioritizes and how a product was made.

Brands like Tom's of Maine take a consistent approach, putting their ingredient philosophy into practice across everything they make — every product is free from artificial flavors, synthetic fragrances, artificial colors, artificial sweeteners and preservatives.

Ultimately, the goal is to know your own needs and preferences and choose based on what matters to you.

To learn more about Tom's of Maine's ingredient sourcing, safety standards and sustainability commitments, visit www.tomsofmaine.com and www.tomsofmaine.com/pages/our-mission.

From brightening white laundry and refreshing old household items to helping flowers stay fresher longer, Clorox^® Disinfecting Bleach can play a practical role in all kinds of daily cleaning and lifestyle moments. With the right know-how, that bottle of bleach tucked away in the laundry room can become a go-to solution throughout the home — one that helps make regular cleaning easy, effective and more approachable.

"Many people think of bleach as something you only use for the biggest cleaning challenges, but it can be an incredibly versatile product for everyday use throughout the home," said Clorox's Principal Scientist, Heather Day. "Clorox^® Disinfecting Bleach has hundreds of different uses to help people clean with more confidence and make everyday routines a little easier, from refreshing your favorite old T-shirt and cleaning outdoor furniture to tackling unexpected messes."

Common Uses Around the Home

When used as directed, Clorox^® Disinfecting Bleach can clean, disinfect, sanitize, whiten, and deodorize surfaces throughout your home. Common applications include brightening white laundry, sanitizing cutting boards and hard surfaces like plastic children's toys, deodorizing trash cans, and refreshing white clothing and linens that have lost their brightness. It can also tackle odor-causing bacteria in laundry and refresh plastic shower curtains and liners.

Unexpected Ways to Use Bleach

Beyond everyday cleaning, Clorox^® Disinfecting Bleach offers surprising solutions in places you might not think to use it. For example, adding 1/4 teaspoon of Clorox^® Disinfecting Bleach for every 1/3 gallon of water can help keep cut flowers fresher longer — a simple trick that prolongs the life of your bouquets. It can also be used to restore dull or cloudy drinking glasses to brilliance by soaking them for 2 minutes in a diluted bleach solution of one gallon of water and two teaspoons of bleach and rinsing thoroughly.

Using Bleach with Confidence

Clorox is encouraging households to start seeing bleach as a trusted, routine cleaning companion. By spotlighting bleach's unexpected versatility, Clorox is helping consumers reframe its role in the home — not as something reserved only for tough jobs but as a dependable and effective go-to for everyday tasks.

As with any cleaning product, it's important to use bleach as directed and follow product label instructions for safe and effective use. For complete directions and usage information, consumers should always refer to the label.

You reach for your phone to check if there's a blackout in your area, only to find the battery at 3%. Not only are you physically uncomfortable from the rising heat inside your home, but you also feel incredibly vulnerable without your connection to the outside world.

When it comes to backup power, it's critical to take a proactive approach, much like you would with your health and wellness. Waiting until you get sick or need to go to the doctor is more difficult to recover from in the long run than building everyday habits, like eating leafy greens for gut health or practicing mindfulness to avoid stress and burnout.

In short, preparing for an emergency like a power outage is more than just a practicality; it's a critical facet of wellness.

Power readiness as self-care

Having a reliable backup power source and other emergency preparedness measures were once associated mainly with doomsday thinking. However, emergency preparedness is gaining traction as an essential lifestyle habit.

According to the Federal Emergency Management Agency (FEMA), a 2023 survey found 51% of adults believed they were prepared for a disaster — a 9% increase from 42% in 2017. During this same time frame, the survey found that more adults were taking preparedness action, suggesting that Americans have become more proactive and better informed about their risks.

In a world of rising incidences of unpredictable weather and an aging power grid, power readiness is a form of self-care. Just as you invest time and resources in improving your sleep routine, diet and emotional wellness to feel secure and stable, having reliable backup power offers you security and peace of mind.

Backup power solutions for all lifestyles

Backup power has come a long way. Cumbersome, loud gas generators are no longer the only option. Instead, homeowners and renters can choose from a variety of renewable energy solutions, such as solar generators.

For example, Jackery — a global leader in home backup, innovative solar generators and clean off-grid energy solutions — offers a full spectrum of power solutions, from whole-home backup systems that connect directly to home circuits to apartment-ready portable units. Because these generators run on solar power, homeowners and renters alike can generate their own electricity — no gas, no fumes, no noise and safe for indoor use.

Homeowners looking for a true gas generator alternative that powers home circuits via a transfer switch should consider a whole-home backup option like the Jackery HomePower 3600 Plus, the company's flagship essential home backup unit. This is a serious backup power solution for seamless whole-home coverage without a permanent generator installation.

Need something more powerful? Opt for the company's Explorer 5000 Plus. This high-capacity whole-home backup powerhouse can power essential home circuits and is ideal for single-family homeowners.

Apartment residents can stay ready for a rolling blackout with the Explorer 2000 v2 or the Explorer 2000 Plus. These compact and portable units are perfect for apartment living — no installation required, no HOA issues, no building permissions needed. If the power goes out, you'll know that you can keep the essentials, like your refrigerator, phones, laptops and fans, running.

For households that need a power source that marries power with portability, check out the Jackery HomePower 3000. This versatile unit bridges the gap between apartment-ready and whole-home capacity — powerful enough for homeowners but compact enough for larger apartment setups or condos.

Preparedness is empowerment

Being prepared for an emergency isn't just about survival. Having reliable backup power offers you energy independence. It's this independence that empowers you to weather a disaster with confidence, knowing that you can control your environment and protect your health and well-being.

Jackery's backup power solutions are available at Amazon, Costco, Best Buy, Walmart and directly from the company. To learn more about power solutions and discover which best suits your needs, visit Jackery.com.

Why Chilean salmon earns the top spot

Salmon from Chile is more than just a flavorful addition to the grill — it's a nutritional powerhouse. Each serving is packed with high-quality, complete protein that keeps you satisfied during busy summer days. It's also naturally rich in omega-3 fatty acids, essential nutrients known to support heart, brain, skin and immune health.

"As a registered dietitian, salmon is one of my top protein recommendations during the summer," says Kayla Farrell, RDN. "Chilean salmon delivers a unique combination of high-quality protein and omega-3s that support whole-body health, while also being incredibly versatile and easy to prepare."

Chilean salmon is low in mercury, making it a smart, family-friendly choice for everyone, including children and pregnant women. In fact, the U.S. Food and Drug Administration (FDA) includes salmon on its list of foods that meet its updated definition of "healthy," reinforcing its role as a nutrient-dense staple.

A sustainable seafood choice you can feel good about

Sustainability is top of mind for today's shoppers, and salmon from Chile delivers. Farm-raised under strict environmental standards in the pristine waters of Chile's Coastal Patagonia, it's one of the most efficient animal proteins, with a high edible yield and low feed conversion ratio. Responsible aquaculture practices and strong third-party partnerships help ensure accountability and protect ocean ecosystems, making Chilean salmon a reliable, sustainable choice for today and the future.

Made for summer grilling (and beyond)

When it comes to summer meals, salmon from Chile naturally shines on the grill. Its naturally rich flavor and firm texture hold up well to high heat, making it ideal for everything from simple fillets to skewers and cedar plank preparations. Whether seasoned with fresh herbs, citrus or bold marinades, it pairs effortlessly with seasonal produce and vibrant summer sides.

For effortless entertaining, Chilean salmon is easily prepped and cooked in less than 15 minutes, making it perfect for weeknight dinners or backyard gatherings. It's also just as versatile off the grill — delicious baked, pan-seared or added to salads, grain bowls and tacos.

Simple tips for grilling salmon like a pro

• Start with the skin on: It helps hold the fish together and prevents sticking
• Don't overcook: Salmon is best when it flakes easily but remains moist
• Add flavor fast: A quick marinade or dry rub can elevate taste in minutes

Look for 'Sourced from Chile'

As you plan your summer menus, keep an eye out for Chilean salmon at the seafood counter or in the freezer aisle. Look for "Sourced from Chile" on packaging to ensure you're getting a high-quality product that delivers on taste, nutrition and sustainability.

This summer, make Chilean salmon your go-to protein for grilling season and enjoy a simple, delicious way to nourish your body while supporting responsible seafood practices.

For many parents and caregivers, concerns often start with small changes. A child who once loved school may begin refusing to go. A normally social teen may withdraw from friends. Headaches or stomachaches may start appearing with no clear medical cause.

It can be hard to know what is part of growing up and what might be something more.

That uncertainty has become more common as youth mental health concerns continue to rise across the United States.

According to the Centers for Disease Control and Prevention, 40% of high school students report persistent feelings of sadness or hopelessness, and nearly 1 in 5 say they have seriously considered attempting suicide. At the same time, organizations like the American Academy of Pediatrics have declared a national emergency in child and adolescent mental health.

About 1 in 5 children in the U.S. has been diagnosed with a mental, emotional or behavioral health condition, yet only about half receive treatment. Suicide is now the second leading cause of death among young people.

This is showing up in everyday moments at home, often well before families reach a crisis point.

"Mental Health Awareness Month is an important moment to pause and check in on how kids are really doing," said Dr. Monika Roots, child, adolescent and adult psychiatrist and co-founder of Bend Health. "But awareness alone isn't enough. Many families still struggle to access support until things feel urgent. We need to make it easier to recognize early signs and get help sooner, and that has to happen year-round."

So what should parents actually be paying attention to?

Clinicians say early signs often show up in everyday ways:

1. Changes in behavior or mood

A child who was once engaged may start withdrawing from friends or activities. Others may seem more irritable, anxious or overwhelmed than usual.

2. Shifts in sleep, appetite or physical health

Trouble sleeping, eating more or less than usual, or frequent headaches or stomachaches can be signs of underlying stress.

3. Changes at school or in daily functioning

A drop in grades, difficulty concentrating or reluctance to go to school can signal something deeper going on.

These signs don't always mean something serious, but they are worth paying attention to.

Parents and caregivers are often the first to notice these shifts, but they don't have to figure it out on their own. Pediatricians, teachers and school counselors can help make sense of what is happening and guide families toward next steps.

In many cases, early screening helps clarify what's going on and what kind of support could make a difference. If changes persist, worsen or start to affect daily life, it may be time to seek additional support.

Some children benefit from skills-based coaching or short-term therapy focused on building coping strategies. Others may need more comprehensive support, including therapy, psychiatry or coordinated care across providers. The right approach depends on the child, their symptoms and their environment.

Providers like Bend Health work with families to assess these needs and connect children to appropriate care, ranging from coaching and therapy to psychiatry and more integrated support when needed.

"Awareness should be a starting point, not the only time we focus on mental health," Dr. Roots said. "Kids do better when support is accessible early and consistently, not just when things become urgent."

For families, the first step is often simple but not always easy: trusting your instincts. If something about a child's behavior or emotional well-being feels different, starting a conversation with a trusted adult or healthcare provider can help clarify what to do next.

Early support can make a meaningful difference, helping children build resilience and navigate challenges before they become more serious.

For more information or to schedule an appointment, visit www.bendhealth.com.

Hearing loss is one of the most common conditions associated with aging, affecting nearly one in three adults over 65. Still, it often goes unaddressed. Cost concerns, stigma and the belief that "it's not that bad yet" can delay action for years. In the meantime, missed words can turn into missed connections, which can gradually erode confidence and independence.

"We hear from older adults every day who don't realize how much hearing loss is shaping their independence until they start avoiding conversations altogether," said Mike Strecker, Chief Regulatory and Compliance Officer of ClearCaptions. "When communication becomes difficult, people often withdraw — not because they want to, but because it feels exhausting or embarrassing. Addressing hearing loss is really about preserving connection, dignity and autonomy."

Communication is foundational to aging well

Research consistently shows that staying socially and cognitively engaged is a key pillar of healthy aging. Phone conversations, in particular, play an outsized role. They're how many seniors schedule transportation, refill prescriptions, connect with care teams and stay emotionally connected to loved ones.

But standard phones aren't designed with hearing loss in mind. Background noise, unclear audio and fast-paced conversations can make even short calls exhausting — or impossible.

Captioned phones offer a different reality. By displaying near real-time captions of what the caller says, they allow people with hearing loss to read along while listening, reducing strain and helping ensure nothing important is missed.

Why "free" raises eyebrows

When people first hear about phones with captioning services that are available at no cost, skepticism is natural. In a world of robocalls and too-good-to-be-true offers, older adults and their families are rightly cautious.

So how can a specialized phone be free?

According to Strecker, a federally certified Internet Protocol Captioned Telephone Service (IP CTS) provider, the answer lies in federal accessibility policy, not marketing gimmicks or predatory schemes. Captioned telephone service is funded through the Federal Communications Commission (FCC) via the Telecommunications Relay Service (TRS) Fund. This federal fund was created to allow persons who are deaf, hard of hearing, deafblind, or have speech disabilities to communicate by telephone in a manner that is functionally equivalent to telephone services used by persons without such disabilities.

For individuals whose hearing loss prevents them from using their telephone and who certify under penalty of perjury, the phone, captioning service and user support are at no-cost to the customer thanks to the FCC's TRS Fund. There's no requirement to provide a credit card, no subscription fee and no obligation to purchase additional products.

Advocates note that skepticism is understandable given how many scams target older adults — but this captioning service (IP CTS) is free because it is part of a government-backed service that is funded in order to increase accessibility under Title IV of the Americans with Disabilities Act (ADA), similar in spirit to closed captions on television.

What to look for to avoid scams

Still, not all offers are created equal. Advocates recommend examining a few key details to confirm legitimacy:

• Check FCC registration: Legitimate captioned phone providers are registered with the FCC and can be found at fcc.gov.
• No pressure tactics: Reputable services don't rush decisions or use scare tactics.
• Clear eligibility explanation: You should be told why you qualify and what certification is required.
• No payment requests: There should be no upfront or hidden fees for eligible users for the service.

Trusted providers also offer transparent user support and clear privacy policies, helping users feel confident that their information — and conversations — are protected.

A small change with outsized impact

For many older adults, using a captioned phone isn't about adopting new technology so much as it's about removing a barrier.

"[Using a captioned phone] was the first time I called my sister who lives 2,000 miles away, and I didn't miss anything she said. I was so happy I cried," said Lynn T., a user who embraced this technology.

Captioned phone users often describe feeling more confident making calls on their own, less dependent on family members to "translate," and eager to be socially engaged.

That sense of autonomy matters. Studies link untreated hearing loss to higher risks of social isolation, depression and cognitive decline. Tools that support clearer communication can help interrupt that cycle, reinforcing independence rather than diminishing it.

Reframing help as empowerment

As the population ages, conversations about independence in aging are evolving. The focus is shifting away from "getting by" toward proactively supporting quality of life. Meaningfully addressing hearing loss is part of that shift.

Captioned phones won't solve every challenge associated with aging, but they can make everyday communication easier and more dignified. When they're made free and accessible through a legitimate, federally funded program, there's no catch, just a public resource.

For older adults who value staying connected on their own terms, clearer conversations may be one of the simplest ways to support independence.

To learn more about captioning services, visit https://clearcaptions.com/lp-mat/.

Intended for US audiences only

At her second birthday party, Skylar was picking chocolate candies out of a bowl of trail mix when she suddenly broke out in full-body hives — the first sign of a peanut allergy that would shape much of her life. Today, she's channeling two decades of food vigilance into a career in allergy medicine.

By the time she was four, Skylar was already advocating for herself. When a well-meaning family member offered her a snack containing peanuts, she immediately turned it down before her parents could step in. "Speaking up was how I stayed safe, and I knew this from an early age," Skylar said.

She also found ways to view the daily challenges with food allergies with an optimistic lens. In elementary school, she proudly called the "nut-free table" the "VIP table." She could even bring a friend. "I thought it was the coolest table in the room," she said.

As Skylar got older, food became a bigger part of her social life, bringing her allergy into even sharper focus.

Birthday parties, school events, dinners with friends — situations many kids navigate without a second thought — required extra planning.

She specifically remembers being invited to a friend's birthday dinner as a child. "My friend's mom promised that the restaurant could handle my allergy," Skylar recalled. "I ended up having a reaction to food I was accidentally exposed to and had to leave immediately to receive treatment."

As a teenager, dating brought new challenges. "There were times when a date ended with a trip to the emergency room. Definitely not the ending I had in mind!" she said with a laugh.

Still, she built a supportive community and found ways to safely participate in activities she cared about.

"My friends have always been amazing. But there are times I skip events if I'm not sure the food is safe," she explained. "Certain restaurants use nuts more often, so I call ahead and ask questions. If I'm not comfortable with the answers, I'll just stay home or meet up with friends after."

Years later, while working in allergy research, Skylar began learning about how food allergy science has evolved.

She's currently applying to medical schools to become a board-certified allergist so she can help others like herself.

What is a food allergy?

About 17 million people in the U.S. have a food allergy, which is a serious disease where the body's immune system overreacts to certain foods[1],[2]. Food allergies are either immunoglobulin E (IgE)–mediated or non–IgE-mediated[3].

Symptoms of an IgE-mediated food allergy, ranging from mild itching to serious reactions like anaphylaxis, usually occur minutes to hours after exposure to the allergen[4]. The gastrointestinal symptoms of non-IgE-mediated allergies usually occur up to several hours after exposure[5].

There are more than 160 foods that can cause IgE-mediated food allergies, but the most common food allergens in the U.S. are peanuts, milk, tree nuts, shellfish, eggs, fish, wheat, soy, and sesame. Food allergies can develop at any age but often begin in the first two years of life[6].

More than 40% of children and more than half of adults with food allergies have experienced a severe reaction at least once[7],[8]. It is estimated that food-related anaphylaxis results in 30,000 medical events treated in emergency rooms in the U.S. each year[9],[10],[11].

Treatment advances for food allergies

While avoiding those food allergens is still required, there are treatments such as Xolair^® (omalizumab) that may be used to help reduce the risk of allergic reactions in the event of accidental exposure.

In February 2024, the FDA approved Xolair for the reduction of IgE-mediated allergic reactions, including anaphylaxis, that may occur with accidental exposure to one or more foods[12].

While taking Xolair, you should continue to avoid all foods to which you are allergic. It is not known if Xolair is safe and effective in children with food allergy under one year of age. Xolair should not be used for the emergency treatment of any allergic reactions, including anaphylaxis.

The importance of speaking with an allergist

Right after the FDA approval of Xolair for food allergies, Skylar spoke with her allergist about the evolving treatment landscape, and together they decided it was a good treatment option for her.

"I still avoid my allergens and carry epinephrine, but Xolair has changed the way I look at my food allergy," Skylar said. "Seeing how treatments are evolving is also part of what motivates me to become an allergist — so I can help others manage their food allergies too."

If you or a loved one have been diagnosed with food allergies, talk to your allergist and ask about Xolair. You can also find more information at Xolair.com.

Indication:

What is XOLAIR?

XOLAIR^® (omalizumab) for subcutaneous use is an injectable prescription medicine used to treat food allergy in people 1 year of age and older to reduce allergic reactions that may occur after accidentally eating one or more foods to which you are allergic. While taking XOLAIR you should continue to avoid all foods to which you are allergic. It is not known if XOLAIR is safe and effective in people with food allergy under 1 year of age.

XOLAIR should not be used for the emergency treatment of any allergic reactions, including anaphylaxis.

IMPORTANT SAFETY INFORMATION & INDICATION

What is the most important information I should know about XOLAIR?

Severe allergic reaction. A severe allergic reaction called anaphylaxis can happen when you receive XOLAIR. The reaction can occur after the first dose, or after many doses. It may also occur right after a XOLAIR injection or days later. Anaphylaxis is a life-threatening condition and can lead to death. Go to the nearest emergency room right away if you have any of these symptoms of an allergic reaction:

• wheezing, shortness of breath, cough, chest tightness, or trouble breathing
• low blood pressure, dizziness, fainting, rapid or weak heartbeat, anxiety, or feeling of "impending doom"
• flushing, itching, hives, or feeling warm
• swelling of the throat or tongue, throat tightness, hoarse voice, or trouble swallowing

Your healthcare provider will monitor you closely for symptoms of an allergic reaction while you are receiving XOLAIR and for a period of time after treatment is initiated. Your healthcare provider should talk to you about getting medical treatment if you have symptoms of an allergic reaction.

Do not receive and use XOLAIR if you are allergic to omalizumab or any of the ingredients in XOLAIR.

Before receiving XOLAIR, tell your healthcare provider about all of your medical conditions, including if you:

• have a latex allergy or any other allergies (such as seasonal allergies). The needle cap on the XOLAIR prefilled syringe contains a type of natural rubber latex.
• have sudden breathing problems (bronchospasm)
• have ever had a severe allergic reaction called anaphylaxis
• have or have had a parasitic infection
• have or have had cancer
• are pregnant or plan to become pregnant. It is not known if XOLAIR may harm your unborn baby
• are breastfeeding or plan to breastfeed. It is not known if XOLAIR passes into your breast milk. Talk with your healthcare provider about the best way to feed your baby while you receive and use XOLAIR

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How should I receive and use XOLAIR?

• When starting treatment, XOLAIR should be given by your healthcare provider in a healthcare setting.
• If your healthcare provider decides that you or a caregiver may be able to give your own XOLAIR prefilled syringe or autoinjector injections, you should receive training on the right way to prepare and inject XOLAIR.
• Do not try to inject XOLAIR until you have been shown the right way to give XOLAIR prefilled syringe or autoinjector injections by a healthcare provider. Use XOLAIR exactly as prescribed by your healthcare provider.
• The XOLAIR autoinjector (all doses) is intended for use only in adults and adolescents aged 12 years and older. For children 12 years of age and older, XOLAIR prefilled syringe or autoinjector may be self-injected under adult supervision. For children 1 to 11 years of age, XOLAIR prefilled syringe should be injected by a caregiver.
• See the detailed Instructions for Use that comes with XOLAIR for information on the right way to prepare and inject XOLAIR.
• XOLAIR is given in 1 or more injections under the skin (subcutaneous), 1 time every 2 or 4 weeks.
• In people with food allergy, a blood test for a substance called IgE must be performed before starting XOLAIR to determine the appropriate dose and dosing frequency.
• Do not decrease or stop taking any of your food allergy medicine or allergen immunotherapy, unless your healthcare providers tell you to.
• You may not see improvement in your symptoms right away after XOLAIR treatment. If your symptoms do not improve or get worse, call your healthcare provider.
• If you inject more XOLAIR than prescribed, call your healthcare provider right away.

What are the possible side effects of XOLAIR?

XOLAIR may cause serious side effects, including:

• Cancer. Cases of cancer were observed in some people who received XOLAIR.
• Fever, muscle aches, and rash. Some people get these symptoms 1 to 5 days after receiving a XOLAIR injection. If you have any of these symptoms, tell your healthcare provider.
• Parasitic infection. Some people who are at a high risk for parasite (worm) infections, get a parasite infection after receiving XOLAIR. Your healthcare provider can test your stool to check if you have a parasite infection.
• Heart and circulation problems. Some people who receive XOLAIR have had chest pain, heart attack, blood clots in the lungs or legs, or temporary symptoms of weakness on one side of the body, slurred speech, or altered vision. It is not known whether these are caused by XOLAIR.

The most common side effects of XOLAIR in people with food allergy: injection site reactions and fever.

These are not all the possible side effects of XOLAIR. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at (800) FDA-1088 or www.fda.gov/medwatch.

You may also report side effects to Genentech at (888) 835-2555 or Novartis Pharmaceuticals Corporation at (888) 669-6682.

Please see full Prescribing Information, including Medication Guide, for additional Important Safety Information and Instructions for Use.

According to the Centers for Disease Control and Prevention, strokes are common and can be devastating for patients and their families. In the United States, a stroke occurs every 40 seconds,ⁱⁱ and someone dies from one about every three minutes.ⁱⁱⁱ Each year, more than 795,000 Americans have a stroke, making it a leading cause of serious long-term disability.^iv In fact, more than half of survivors aged 65 and older have ongoing difficulty with movement afterward. Beyond the personal toll, strokes cost the U.S. nearly $56.2 billion in healthcare expenses and lost productivity from 2019 to 2020.^v

Common risk factors for stroke include high blood pressure, diabetes, smoking and obesity — many of which are manageable with lifestyle changes and medical care. Even though risk goes up with age, more younger adults are being affected as these issues become more widespread.^vi

Recognizing stroke symptoms: Think B.E. F.A.S.T.

For all of these reasons, early recognition of a stroke is critical. The sooner treatment begins, the greater the chances of survival and meaningful recovery. Health experts recommend the B.E. F.A.S.T. acronym as a simple, effective tool for identifying the most common warning signs:

• B for Balance Loss: Sudden dizziness, loss of coordination, or trouble walking.
• E for Eye (Vision) Changes: Sudden blurred, double or lost vision in one or both eyes.
• F for Face Drooping: One side of the face droops or feels numb — ask the person to smile and look for unevenness.
• A for Arm Weakness: One arm feels weak or numb — ask the person to raise both arms and watch for one drifting downward.
• S for Speech Difficulty: Slurred or confused speech — ask the person to repeat a simple sentence.
• T for Time to Call 911: Call emergency services immediately. When in doubt, act — the cost of waiting is far greater than the cost of a false alarm.

Additional warning signs include sudden confusion, a severe headache with no known cause, and numbness or weakness on one side of the body.

Finding a stroke center before an emergency

Beyond recognizing symptoms, one of the most valuable steps individuals and families can take is identifying the nearest certified stroke center before an emergency occurs as it could save critical minutes when a stroke happens.

Comprehensive Stroke Centers are hospitals specially equipped to provide the highest level of stroke care. Certified by organizations like The Joint Commission, they offer 24/7 care and are equipped with the tools needed to diagnose and treat strokes quickly. Many regions also have Primary Stroke Centers or Thrombectomy-Capable Stroke Centers that provide specialized, timely treatment.

To find a nearby stroke-ready hospital:

• Use hospital locator tools provided by the The Joint Commission (www.jointcommission.org) or the American Stroke Association (www.stroke.org)
• Check with your local health department or major hospital systems
• Ask your primary care provider about the closest certified facility

While emergency medical services will typically transport patients to the nearest appropriate hospital, knowing the closest certified stroke center in advance empowers families to advocate quickly when every second matters.

Latest advancements offer new hope

While prevention and rapid response are critical, advances in treatment are improving survival and recovery rates — particularly for acute ischemic stroke, the most common type of stroke.

One of the latest advancements is mechanical thrombectomy, which is a minimally invasive procedure that removes blood clots from the brain to restore circulation. A type of mechanical thrombectomy is aspiration thrombectomy, done with products such as Penumbra's RED Reperfusion Catheters, which uses a vacuum to remove clots from blocked blood vessels and restores blood flow quickly.

Clinical studies show mechanical thrombectomy works faster and is more likely to restore blood flow compared to other treatments such as thrombolysis — a procedure that uses clot-busting medication (such as tPA) to dissolve dangerous blood clots in arteries or veins and restore blood flow.^vii

With a stroke occurring somewhere in the United States every 40 seconds, the message is clear: Recognizing the symptoms, calling 911 and knowing where to go as well as your treatment options aren't just good practices — they're lifesaving ones.

Sponsored by GSK. Schari is a patient with endometrial cancer who will be discussing her experience; individual experiences may vary. Schari has been compensated by GSK for her participation in this article.

Cancer doesn't wait for the right moment, and it doesn't always announce itself loudly. Even when you're paying attention, symptoms can come and go or feel less urgent than everything else life throws your way.

For Schari, this is exactly what happened.

A few years after she entered menopause — typically defined as 12 straight months without a period — she experienced unexpected vaginal bleeding. Alarmed, she called her doctor and underwent testing. The results showed a thickened endometrial lining in her uterus, but she was told there was no immediate cause for alarm. The bleeding stopped, and life moved on.

She experienced abnormal bleeding twice more. The second time, her doctor performed a biopsy and found a nodule that turned out to be benign. Four years later, the bleeding returned again — but by then, Schari was dealing with the aftermath of a serious fall that reignited intense back pain. Compared to the pain she was experiencing, the bleeding felt like something that could wait.

"I remember thinking, 'The bleeding is probably nothing. This has happened before, and my tests were benign.' I was lulled into thinking this time it would be more of the same," she said.

Months later, she returned to her gynecologist for an exam, ultrasound, and biopsy. Schari remembers she was sitting in the bath when her doctor called with unexpected news: the findings showed endometrial carcinosarcoma, an aggressive type of endometrial cancer. She had recently gotten engaged to her partner, Patrick, and was busy planning their life together. The thought struck her in an instant: would she live to see her wedding, let alone the rest of her life plans?

Looking back, Schari sees that phone call as a turning point — and wonders how different things might have been if she had gotten an answer sooner. Her experience reflects a reality many women face: quieter symptoms can be overshadowed by bigger, louder problems. It's also a reminder of what postmenopausal bleeding can signal.

What Is Endometrial Cancer?

Endometrial cancer is a type of uterine cancer. It starts in the inner lining of the uterus, known as the endometrium. Uterine cancer and endometrial cancer are often used interchangeably, since endometrial cancer makes up the majority — about 90% — of cancers in the body of the uterus. Endometrial cancer is the most commonly diagnosed type of cancer that affects the gynecologic organs in the United States and it is estimated that more than 68,000 people will be diagnosed in 2026.

Common symptoms of endometrial cancer can include unusual vaginal bleeding or spotting, other vaginal discharge, pelvic pain, and unexplained weight loss. Because there is no routine screening test for endometrial cancer, regular gynecologic checkups are especially important — even after menopause. Any vaginal bleeding after menopause is never considered normal and should always be evaluated.

A family history of endometrial cancer increases one's risk, but women with no family history can also develop it. Additional risk factors for endometrial cancer can include obesity, polycystic ovary syndrome (PCOS), advancing age, and the use of postmenopausal estrogen therapy without progestin.

A Diagnosis — and a New Era of Treatment

After her diagnosis, Schari's gynecologic oncologist outlined an aggressive treatment plan. Surgery would involve removing her uterus, cervix, ovaries, fallopian tubes, surrounding lymph nodes, and omentum (fatty tissue in the abdomen). After recovery, she would begin six rounds of chemotherapy with the medicines carboplatin and paclitaxel.

After her surgery, the pathology revealed her cancer was stage 3C1 and that her tumor was a certain biomarker called mismatch repair–deficient (dMMR). dMMR describes cancers that have an MMR system that is not working properly to correct errors in the genes. dMMR is an important biomarker in endometrial cancer.

Her doctor also introduced another treatment option that they thought she could be a good candidate for: an immunotherapy called JEMPERLI (dostarlimab-gxly for injection 500 mg). JEMPERLI is an immunotherapy designed to work with the body's immune system to help find and attack cancer cells.

Approved Uses

JEMPERLI is a prescription medicine used to treat adults with a kind of uterine cancer called endometrial cancer (EC)

• JEMPERLI may be used in combination with the chemotherapy medicines, carboplatin and paclitaxel, and then after that JEMPERLI may be used alone:
  • when your cancer has spread outside your uterus (advanced) or,
  • your cancer has returned.
• JEMPERLI may be used alone:
  • when a laboratory test shows that your tumor is mismatch repair deficient (dMMR), and
  • your cancer has returned, or it has spread (advanced EC), and
  • you have received chemotherapy that contains platinum and it did not work or is no longer working, and
  • your cancer cannot be treated by surgery or radiation.
• It is not known if JEMPERLI is safe and effective in children.

JEMPERLI, in combination with the chemotherapy medicines carboplatin and paclitaxel, is the first and only FDA-approved immunotherapy combination proven to help patients with newly diagnosed advanced or returned endometrial cancer live longer.

A clinical trial compared JEMPERLI + CP (carboplatin and paclitaxel) vs CP alone in 494 people with endometrial cancer that had spread outside the uterus (newly diagnosed advanced) or returned, also known as the overall study population. The overall study population included people whose tumors were either dMMR/MSI-H (microsatellite instability-high) or MMRp/MSS (mismatch repair proficient)/(microsatellite stable). The clinical trial tested the effectiveness and safety of adding JEMPERLI to CP. The trial treated some patients with JEMPERLI + CP and others with a placebo (an inactive substance) + CP and then compared the results.

In the overall study population, median overall survival (OS) with JEMPERLI + CP was 45 months vs 28 months with CP alone. This difference is statistically significant, which means that the difference between the two treatment groups is greater than what might be expected by chance alone. Results varied among different biomarker groups within the overall population. Median is the middle value in a set of measurements. OS measures the average length of time patients are alive after the start of treatment. JEMPERLI + CP was not studied in comparison to other immunotherapy combinations.

Based on the results of this trial, this combination of medications was approved by the U.S. Food and Drug Administration (FDA) for healthcare providers to prescribe to appropriate patients. In patients receiving JEMPERLI + CP, 19% stopped taking JEMPERLI completely and 37% had their treatment interrupted due to side effects.

Immunotherapy like JEMPERLI may be used in certain people with advanced or recurrent endometrial cancer whose tumors have specific characteristics, such as dMMR. Based on those results, her oncologist believed JEMPERLI was right for her.

Schari's doctor discussed with her how JEMPERLI could affect her when reviewing treatment options. Because JEMPERLI is an immunotherapy, it can cause someone's immune system to attack normal organs and tissues in any area of the body. These problems can become severe or life-threatening and lead to death. More than one of these problems can occur at the same time, which may happen during or after treatment. It is important to call or see a doctor right away for any new or worsening signs or symptoms. Immune system problems can include lung problems, intestinal problems, liver problems, hormone gland problems, kidney problems, skin problems, and problems in other organs and tissues. JEMPERLI can also cause severe or life-threatening infusion reactions, rejection of a transplanted organ, and complications in people who received a bone marrow transplant that uses donor stem cells.

The most common side effects of JEMPERLI when given with carboplatin and paclitaxel include nerve problems in your arms, hands, legs, and feet; tiredness; nausea; hair loss; joint pain; rash; constipation; diarrhea; stomach-area (abdomen) pain; shortness of breath; decreased appetite; urinary tract infections; vomiting.

These are not all the potential side effects that can occur with JEMPERLI; please review the Important Safety Information below and the full Prescribing Information, including Medication Guide, to learn more. Learn more about additional trial results at JEMPERLI.com and ask your doctor if JEMPERLI may be right for you or a loved one.

After completing six rounds of chemotherapy plus JEMPERLI, she transitioned to JEMPERLI alone. Every six weeks, she receives a 30-minute infusion. She's experienced some fatigue and headaches. She works closely with her doctor on her treatment schedule, including any additional appointments for monitoring. Maintaining this coordination is key.

Over time, her scans showed she was in remission, or what they call no evidence of disease — meaning they don't see any cancer in her body — words she never imagined she would hear after such an advanced diagnosis. She continues to be monitored by her doctor and is still receiving JEMPERLI.

This was Schari's experience, and everyone's experience is different. But the results gave her something she hadn't felt in a long time: hope.

Balancing Urgency With Hope

Schari is clear about what she wants other women to take from her experience: urgency, without fear. "I often say to other women: Don't ignore those 'womanly' symptoms. I carried extra weight for years and brushed off bleeding and other signs that I now know mattered. I wish I'd been more proactive. If that's happening to you, do something now, talk to your doctor."

At the same time, her story offers hope. Advances in genetic testing, targeted therapies, and immunotherapy are expanding what's possible for people diagnosed with endometrial cancer, even at later stages.

"I used to believe that if cancer ever came for me, I wouldn't be able to handle it. However, here I am, battle-weary, but still standing. It hasn't been easy. My life is forever changed. Now I live with a new reality: the beast called cancer still lurks at the edge of the woods, always watching, always waiting. But I no longer face it empty-handed. And for that, I am thankful."

Her journey is a reminder that awareness can lead to earlier evaluation, that science is reshaping treatment, and that even when diagnosis comes late, progress in care is giving patients and families something powerful to hold onto: possibility.

To learn more about endometrial cancer and potential treatment options, including JEMPERLI, talk to your doctor and visit www.JEMPERLI.com.

IMPORTANT SAFETY INFORMATION

JEMPERLI is a medicine that may treat certain cancers by working with your immune system. JEMPERLI can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You can have more than one of these problems at the same time. These problems may happen anytime during treatment or even after your treatment has ended.

Call or see your healthcare provider (HCP) right away if you develop any new or worsening signs or symptoms, including:

Lung problems. Signs and symptoms may include cough, shortness of breath, or chest pain.

Intestinal problems. Signs and symptoms may include diarrhea or more bowel movements than usual; stools that are black, tarry, sticky, or have blood or mucus; or severe stomach-area (abdomen) pain or tenderness.

Liver problems. Signs and symptoms may include yellowing of your skin or the whites of your eyes, severe nausea or vomiting, pain on the right side of your stomach area (abdomen), dark urine (tea colored), or bleeding or bruising more easily than usual.

Hormone gland problems. Signs and symptoms may include headaches that will not go away or unusual headaches, eye sensitivity to light, eye problems, rapid heartbeat, increased sweating, extreme tiredness, weight gain or weight loss, feeling more hungry or thirsty than usual, urinating more often than usual, hair loss, feeling cold, constipation, your voice gets deeper, dizziness or fainting, changes in mood or behavior such as decreased sex drive, irritability, or forgetfulness.

Kidney problems. Signs and symptoms may include change in the amount or color of your urine, blood in your urine, swelling in your ankles, or loss of appetite.

Skin problems. Signs and symptoms may include rash; itching; skin blistering or peeling; swollen lymph nodes; painful sores or ulcers in your mouth or in your nose, throat, or genital area; fever or flu-like symptoms.

Problems can also happen in other organs and tissues. These are not all of the signs and symptoms of immune system problems that can happen with JEMPERLI. Call or see your HCP right away for any new or worse signs or symptoms. Signs and symptoms may include chest pain, irregular heartbeat, shortness of breath, swelling of ankles; confusion, sleepiness, memory problems, changes in mood or behavior, stiff neck, balance problems, tingling or numbness of the arms or legs; double vision, blurry vision, sensitivity to light, eye pain, changes in eyesight; persistent or severe muscle pain or weakness, muscle cramps; low red blood cells, bruising.

Infusion reactions that can sometimes be severe or life-threatening. Signs and symptoms of infusion reactions may include chills or shaking, itching or rash, flushing, shortness of breath or wheezing, dizziness, feel like passing out, fever, back or neck pain.

Rejection of a transplanted organ. Your HCP should tell you what signs and symptoms you should report and monitor you, depending on the type of organ transplant that you have had.

Complications, including graft-versus-host-disease (GVHD), in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). These complications can be serious and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with JEMPERLI. Your HCP will monitor you for these complications.

Getting medical treatment right away may help keep these problems from becoming more serious. Your HCP will check you for these problems during treatment with JEMPERLI and may treat you with corticosteroid or hormone replacement medicines. If you have severe side effects, your HCP may also need to delay or completely stop treatment with JEMPERLI.

Before receiving JEMPERLI, tell your HCP about all of your medical conditions, including immune system problems such as Crohn's disease, ulcerative colitis, or lupus; received an organ transplant; have received or plan to receive a stem cell transplant that uses donor stem cells (allogeneic); have received radiation treatment to your chest area; have a condition that affects your nervous system, such as myasthenia gravis or Guillain-Barré syndrome.

If you are pregnant or plan to become pregnant, tell your HCP. JEMPERLI can harm your unborn baby. If you are able to become pregnant, your HCP will give you a pregnancy test before you start treatment. Use an effective birth control method during treatment and for 4 months after your last dose of JEMPERLI. Tell your HCP right away if you become pregnant or think you may be pregnant during treatment with JEMPERLI.

If you are breastfeeding or plan to breastfeed, tell your HCP. It is not known if JEMPERLI passes into your breast milk. Do not breastfeed during treatment with JEMPERLI and for 4 months after your last dose.

Tell your HCP about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

The most common side effects of JEMPERLI when given with carboplatin and paclitaxel include nerve problems in your arms, hands, legs, and feet; tiredness; nausea; hair loss; joint pain; rash; constipation; diarrhea; stomach-area (abdomen) pain; shortness of breath; decreased appetite; urinary tract infections; vomiting.

The most common side effects of JEMPERLI when used alone include tiredness and weakness, low red blood cell count (anemia), diarrhea, nausea, constipation, vomiting.

These are not all of the possible side effects of JEMPERLI. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call by 1-800-FDA-1088. You may also report negative side effects to GSK at https://gsk.public.reportum.com or 1-888-825-5249.

Please see full Prescribing Information, including Medication Guide for patients.

Trademarks are owned by or licensed to the GSK group of companies.
©2026 GSK or licensor.
PMUS-DSTCOCO260002 April 2026
Produced in USA.

Here are tips from Chef Tiffany Derry, MasterChef Judge and Eggland's Best partner, to help you enhance your culinary efforts, just in time for summer entertaining.

Focus on ingredients

To build confidence in the kitchen, begin with a foundation of high-quality ingredients that deliver on both flavor and performance, like farm-fresh vegetables, fresh herbs and Eggland's Best eggs. Check grocery store produce for optimal freshness, or grow your own herbs or veggies to ensure you start with fresh ingredients that pack more flavor into every bite.

Master the basics

Once you've got fresh ingredients, Derry recommends focusing on mastering a few core techniques. You can learn about balancing flavors through acid and seasoning. For example, if a dish is too rich, sweet or salty, adding a little acid like lemon juice or vinegar makes all the difference. You can also commit to learning how to properly saute and layer ingredients. These techniques give you the freedom to experiment and make recipes your own.

Stay seasonal

Let the season guide you by incorporating fresh, vibrant ingredients when they're at peak ripeness. Shopping for locally grown ingredients is one of the best ways to ensure the produce you use is at its best. Keep your preparations simple, allowing the natural flavors of seasonal ingredients to shine.

Trust your palate

Stay flexible as you cook. Learn to trust your instincts by tasting as you go and adjusting along the way. This process helps you build confidence with each step. Derry suggests trying recipes with a critical eye, and letting your taste buds be your best guide. You may be surprised how much of your personality and preferences you can add to any dish!

Elevate family favorites

Every family has tried-and-true meals they always enjoy. When you're ready, take a favorite and experiment a little, adding unexpected combinations and fun ingredients. For example, try this twist on a classic pasta dish from Eggland's Best, Carbonara with Blue Cheese, Broccoli and Hazelnuts.

Eggland's Best, America's #1 branded egg, is teaming up with FOX's hit culinary competition series MasterChef Season 16, a high-stakes season inspired by the world's biggest international soccer tournament.

Eggland's Best eggs contain more than double the Vitamin B12 of ordinary eggs, helping provide a natural energy boost so you can stay energized and creative in the kitchen. They also have more than double the Omega-3s compared to ordinary eggs, helping support brain function and overall wellness as part of a balanced diet.

Carbonara with Blue Cheese, Broccoli and Hazelnuts

Ingredients

• 2 Eggland's Best eggs, large
• 1/2 cup hazelnuts
• 1 1/3 cups penne or other pasta of your choice
• 3/4 cup broccolini, finely chopped
• 1/2 cup blue cheese, crumbled
• Freshly ground black pepper
• 1/2 cup arugula, finely chopped
• 1/2 lemon, juice only
• 1 tablespoon honey
• Extra virgin olive oil, sea salt and freshly ground black pepper to serve

Preparation

1. Preheat oven to 350°F.

2. Tip the hazelnuts onto a baking tray, then transfer to the oven to toast for 7-10 minutes. Once cool enough to handle, roughly chop into large pieces.

3. Meanwhile, bring large pan of salted water to boil, and add pasta. Cook according to packet instructions, adding the broccoli one minute before the pasta is ready.

4. Drain well, reserving 3 ounces of the cooking water, then return to the pan and stir through a tablespoon of extra virgin olive oil.

5. While the pasta is cooking, whisk eggs with the crumbled blue cheese and season well with freshly ground black pepper.

6. Add the blue cheese sauce to the pasta and stir vigorously to coat.

7. Add reserved cooking water one tablespoon at a time until the sauce clings to the pasta, then stir through the arugula, 3/4 of the chopped hazelnuts, lemon juice, honey and a little more extra virgin olive oil.

8. Taste and adjust the salt, lemon juice and honey as needed.

9. Serve immediately, topped with remaining chopped hazelnuts.

To extend the excitement beyond the screen, the Eggland's Best x MasterChef "Ultimate Summer Entertaining Sweepstakes" is encouraging fans to embrace global flavors and summer entertaining for a chance to win premium prizes. Now through June 30, consumers can enter daily at EBFamilySweeps.com for a chance to win $5,000 toward a kitchen upgrade, MasterChef-branded cookware and an Eggland's Best prize pack. Additionally, seven weekly winners will receive a $250 gift card, cookware and more to elevate their entertaining experiences.

Find more recipes and products to inspire your culinary creativity at EgglandsBest.com.

Represented internationally by Banijay Entertainment, MasterChef is the world's most successful cookery television format (Guinness World Records). Commissioned across 72 markets, the life-changing show has aired over 700 seasons and more than 16,000 episodes to date. Created by Franc Roddam and first launched in 1990, the super brand is known and enjoyed across the globe.

NO PURCHASE NECESSARY TO ENTER OR WIN IN THE EGGLAND'S BEST X MASTERCHEF "ULTIMATE SUMMER ENTERTAINING" SWEEPSTAKES. Open to legal residents of the 50 US & DC, 18 or older and have reached the age of majority in state of jurisdiction. Void where prohibited. Sweepstakes starts 5/12/26 at 9:00 AM ET and ends 6/30/26 at 11:59 PM ET. For Official Rules, which govern, click here. Sponsor: Eggland's Best, LLC.

In states across the country, the demand for nurses continues to grow as healthcare systems adapt to population growth, an aging demographic and increasing patient needs. These trends are placing added pressure on providers and reinforcing the importance of preparing a new generation of skilled nursing professionals.

With the country's population aging, plus chronic diseases and public health emergencies on the rise, nurses are vital for keeping the healthcare system running smoothly, providing much-needed patient access and reducing wait times for quality care. The nursing profession is also evolving, merging compassionate care with technological advances like telehealth, remote patient monitoring and AI tools.

"Today's nursing careers require a growing range of skills and expertise, including bedside care, clinical assessment and technological proficiency, plus leadership qualities, teamwork, communication and critical thinking," said Dr. Karen Fuss-Sommer, associate provost of Nursing at Carrington College. "The profession also offers numerous work settings, from clinics and hospitals to home care, nursing facilities, schools and more."

For those considering a career in nursing or advancing their career in the healthcare field, National Nurses Month in May is the perfect time to learn about educational programs providing training, knowledge and experience to help you take the next step toward reaching your career goals.

Preparing the next generation of nurses

If you're interested in pursuing the satisfying field of nursing, consider exploring the career-focused nursing programs at Carrington College, an institution dedicated to preparing the next generation of nurses to meet the healthcare demands of their local communities. Programs are offered at campuses in California, Idaho, New Mexico, Arizona, Nevada and Oregon. Program availability varies by campus, but here are some of the options that can help you reach your goals.

Entering the field: Vocational Nursing and Practical Nursing

If you're new to nursing or have been working as a Certified Nursing Assistant (CNA), you can prepare for or advance your career through Carrington College's Vocational Nursing program, which provides hands-on training and clinical experience to prepare you for entry-level employment under the guidance of a Registered Nurse (RN) or licensed physician in various healthcare settings. This program is available in Bakersfield, Rancho Mirage, Sacramento, Santa Maria, San Jose and Visalia. Students can earn a Vocational Nursing certificate in as few as 12 months, or an associate degree in as few as 15 months.

One alternative is the similar Practical Nursing certificate Carrington College offers in Boise and Albuquerque, offering a quick path to becoming a practical nurse working under the guidance of RNs and physicians, in as few as 12 months. Upon graduation, you'll be well positioned to take the National Council Licensure Examination for Practical Nurses (NCLEX-PN).[1] Depending on the state where you're licensed to practice, Licensed Practical Nurse (LPN) or Licensed Vocational Nurse (LVN) duties may vary.

"Students need more than textbook knowledge. They need to feel confident in real-world scenarios," said Dr. Fuss-Sommer. "We focus on simulation-based learning and clinical experiences that reflect what they'll encounter on the job, including monitoring patient health, administering basic patient care and keeping patient health records."

Becoming a Registered Nurse

Further along the nursing career path, Carrington College's Registered Nurse Degree program trains students to work within the healthcare delivery system as providers and managers of care, communicators and collaborators, as well as client advocates and educators. The curriculum covers medical-surgical nursing, geriatric and pediatric care, obstetric and neonatal nursing and mental healthcare. An Associate Degree in Nursing (ADN) can be completed in as few as 23 months.

Carrington College also offers Nursing Bridge options to help students transition from an LVN or LPN to become an RN. The program can be completed in as few as 8-12 months and is available in Boise and Sacramento.

"Today's nursing students must be prepared for a healthcare environment that's more complex and technology-driven than ever before," said Dr. Fuss-Sommer. "In addition to clinical knowledge, they need hands-on experience, critical thinking skills and the ability to communicate effectively with patients and care teams."

How to earn a BS in Nursing

For licensed RNs seeking higher-level roles, a Bachelor of Science in Nursing (BSN) program builds on your experience, expanding your skills in leadership, research, patient care and evidence-based practice. A BSN degree can be earned in as few as 15 months, and the program is conveniently available online. As an RN with a BSN, your advanced skills and knowledge can widen your career opportunities.

"Nursing is a rewarding, impactful profession that offers many opportunities for career advancement, and further education is key to that mobility," said Dr. Fuss-Sommer. "With hands-on labs and an evidence-based curriculum, our students gain the skills and expertise they need to take the next step in their careers."

Your next step

With nursing positions available across a wide range of settings nationwide, individuals can pursue paths that align with their interests, while making a meaningful impact in their communities and the lives of others. The healthcare field is more vital than ever, with nurses at the forefront of meeting local healthcare demands.

"Nursing continues to stand out as a career that combines stability with a strong sense of purpose," Dr. Fuss-Sommer said. "If you're motivated, passionate and enjoy helping others, a nursing career may be right for you."

Those interested in exploring nursing career paths can learn more about available programs at Carrington.edu.

Visit Carrington.edu/student-consumer-information for important information on program outcomes.

These symptoms might seem like "just part of life," but they don't have to be. Here are five things everyone should know about dry eye disease, and how to take control of it.

1. Dry eye disease is more common than you may realize

Did you know that dry eye disease affects more than 38 million people in the U.S.? You also may not know that dry eye disease is more than just the symptoms that you feel. It is an underlying condition that can have different causes.

2. Too much tear evaporation is a leading cause of dry eye disease

Everyone's tears evaporate, but too much evaporation can lead to problems for your eyes. So how does this work?

The tear film that exists on the outside of the eye is made up of 3 layers: the oily layer on top, and the watery layer of tears which is mixed with the inner mucus layer. In healthy eyes, the oily layer helps to keep the tears from drying out. With evaporative dry eye, the oily layer isn't effective, allowing too many tears to evaporate too quickly, which can leave the eyes feeling dry, rough and gritty.

3. Everyday factors can make dry eye worse

From blasting air conditioning on a hot day, to long hours in front of a screen, or even taking antihistamines during allergy season — these are all factors that can make your dry eye symptoms worse. Additionally, there are the factors that can't be controlled at all, like getting older or living with certain inflammatory conditions, that may make dry eye even more likely.

As symptoms continue and worsen, they may start to take a toll. Many people with dry eye say they're aware of how their eyes feel. People with dry eye report that they often cut back on things they enjoy just to find some relief, whether it's time on their devices, being outdoors or even wearing makeup.*

4. The good news: There's something you can do about it

Everyone's experience with dry eye is unique. You may feel like you've tried everything when it comes to over-the-counter (OTC) eye drops, but they may not be providing lasting relief. If tear evaporation is driving your symptoms, a prescription treatment option — such as MIEBO^® (perfluorohexyloctane ophthalmic solution), used to treat the signs and symptoms of dry eye disease — may be right for you. MIEBO is the first and only prescription eye drop that directly targets tear evaporation and it works by forming a protective layer on the surface of the eye, helping you retain more of your own tears. The exact way MIEBO works is unknown. Do not use if you are allergic to MIEBO.

5. The first step is to talk to your eye doctor

Early diagnosis and ongoing care may prevent symptoms from getting worse. To learn more about the role that tear evaporation plays in dry eye disease, visit MIEBO.com. You can also take a quiz here, and print out the results to discuss with your eye doctor.

The important thing to remember is that you don't have to live with dry eye symptoms. There are options for relief. Talk to your eye doctor to find out what's best for you.

INDICATION

MIEBO^® (perfluorohexyloctane ophthalmic solution) is used to treat the signs and symptoms of dry eye disease.

IMPORTANT SAFETY INFORMATION

• Do not use if you are allergic to MIEBO
• Remove contact lenses before using MIEBO and wait for at least 30 minutes before reinserting
• It is important to use MIEBO exactly as prescribed
• It is not known if MIEBO is safe and effective in children under the age of 18
• In pivotal trials, the most common eye side effect seen in studies was blurred vision (1% to 3% of patients reported blurred vision and eye redness)

Click here for full Prescribing Information for MIEBO.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

*The 2024 State of Dry Eye Harris Poll surveyed 2,003 U.S. adults on their understanding of, and experiences with, dry eye. Of those, 461 disclosed that they often/always experience eye dryness and/or have been diagnosed with dry eye disease (referred to as "sufferers") and 1,542 non-sufferers. "Respondents" or "Americans" refers to all 2,003 survey participants.

© 2026 Bausch + Lomb.

MBO.0150.USA.26

Personalizing care with digital twins

You're one of a kind. But someday, you could have a digital twin — a virtual version of you that helps clinicians personalize care and predict health outcomes.

How? By combining clinical, physiological, and lifestyle data, a digital twin can mirror the unique characteristics of individual patients.

While a comprehensive human digital twin hasn't been created yet, patients are already beginning to benefit from this technology. Doctors can now "rehearse" a heart valve replacement using a digital replica of the patient's heart, predicting how the body may respond to the procedure.

Medtronic is also exploring how digital twins could help develop safe therapies faster.

"A digital twin can help us accelerate research, reduce the need for animal testing, and avoid exposing humans to unnecessary risks," said Dr. Nathalie Virag, Vice President and General Manager at the Medtronic Bakken Research Center. "Many early-stage experiments can be conducted on a computer before moving to animal or human testing."

What's next? Digital twins will become smarter and help clinicians move from reacting to patient health challenges to predicting individual health risks before symptoms appear.

Using AI to answer health questions

You've likely asked "Dr. Google" medical questions. But how we find answers is changing. More people are using generative AI to learn about their health concerns, turning to AI overviews and chatbots before seeing a doctor.

While AI can offer quick, personalized answers, it should be used as a tool for learning rather than diagnosing. This is especially true for health conditions like heart disease, which can present differently in women than in men.

"AI can be a great starting point, but it should never replace a conversation with a healthcare professional," said Dr. Kendra Grubb, Vice President and Chief Medical Officer of Structural Heart at Medtronic. "It doesn't understand your lifestyle, family history, or clinical signs the way a physician does."

What's next? AI could become more connected to wearable devices.

By tracking real-time health data like heart rate and blood pressure, AI-assisted wearables could help identify early warning signs before symptoms start. This could empower patients to seek care sooner and give clinicians insights to personalize treatment.

Soft tech meets the soft life movement

This new partnership combines Foster Grant's proven expertise and originality in eyewear design with the innovative, user-friendly tech approach of Sharper Image. By joining forces, the brands have created elegant, everyday solutions for readers people need for work as well as for simply enjoying their daily lives. Their new readers are perfect not just for engaging with digital devices, but also for slowing down and reading, doing crafts or engaging in other hobbies involving near-vision tasks.

Advanced technology that makes life easier

These trusted leaders in their respective industries have developed four new collections of readers to meet the moment by satisfying both form and function, using cutting-edge tech and intentional design to combine ease of use with a definite sense of style.

• Reader with Flashlight Case: It will be easy to protect your wearable and slim new reading glasses, because they come with an efficiently designed, protective hard case. Even better, you'll help protect your vision thanks to the case's built-in compact flashlight that's perfect for reading in low lighting.
  
  
• Reader with Magnetic Sun Clip: You'll get double your value with these sleek clip-on sunglasses. Their quick-and-easy magnetic design makes it easy to switch from your readers to polarized shades while you're out and about.
  
  
• Compact Reader: When you're on the go, it's easy to worry about losing or breaking your readers. Worry no more, as these slim foldable readers come with an innovative, ultra-thin case. The glasses snap into the case for added security, making these glasses easy to carry — and they're great for travel.
  
  
• Tech Reader: Designed to tie back to the Sharper Image philosophy to make health and self-care effortless and intuitive in everyday life by merging thoughtful design with clever functionality, these stylish frames incorporate contemporary design with an emphasis on material and innovative frame features. Their memory metal and flex stainless steel elements ensure an optimal fit and comfort for wearers.

"We're always exploring new ways to push the limits of eyewear and meet the needs of the current moment, and we saw those same values reflected in Sharper Image," said Mark Flanagan, Director of Design, Foster Grant. "We combined Foster Grant's expertise in the eyewear space with the decades of experience Sharper Image has in integrating technology into everyday life and wellness. These new reader styles result from an optimal combination of technology and design, creating stylish, functional products to enhance your life."

These new tech-enhanced options mean you'll never look at your readers the same way again. Learn more about the innovative features and seamless tech integration of the Sharper Image x Foster Grant collaboration, including where you can find these new readers, at https://www.fostergrant.com/collections/sharper-image-x-foster-grant.

"I'm very proactive about getting mammograms and colonoscopies," she said. So, when Patty learned about the Galleri^® test, a blood test that can detect a signal for over 50 cancer types — including those that don't have routine screenings^1,2 — she thought, "What the heck, I'll give it a whirl."

Cancer can stay hidden in the body for months or years, but many cancers leave clues in the blood — in the form of DNA released by the cancer cells — long before they cause symptoms.^3,4 When Galleri detects a cancer signal, it provides a predicted origin in the body with high accuracy to help guide an efficient diagnostic work-up.^3,4,5 The Galleri test does not predict future cancer risk.

For Patty, the test came in the nick of time.

"There was a signal detected from the Galleri test — it was a lymphoma lineage," she recalled. "I was diagnosed with a rare form of non-Hodgkin large B-cell lymphoma."*

A Proactive Approach

Patty's decision to test for cancers did not occur in a vacuum. Her employer, Seyfarth Shaw, had been looking for ways to encourage workers to be more proactive with their health.

Encouraging employees to take health precautions was in keeping with a culture that Patty appreciated even before her diagnosis.

"The people here are genuine; everyone pitches in, which is phenomenal," she said.

Mark Coffin, a partner and former chair of the Benefits Committee at the firm, said the team was prioritizing tools that would enable employees to more effectively manage their health.

"We eventually came across GRAIL and the Galleri test, and it was just the kind of thing we were hoping we'd find," he said.

The Benefits of Early Diagnosis

Though Patty caught her cancer early, she was still facing an aggressive form of cancer. By the time she had her PET-CT scan, about a month after diagnosis, the tumor had grown in size and had affected additional lymph nodes.

"I learned that the earlier anything can be detected, especially if you have no symptoms, the better the treatment options are," Patty said.

The standard treatment for Patty's type of lymphoma was six rounds of chemotherapy.

"After the third cycle, I had another PET scan done and the mass was gone. It was completely obliterated," she said. Since completing all rounds of chemotherapy, three additional scans have come back clean.

Patty was not alone in her gratitude for catching the cancer early.

"It's wonderful to be reminded that if you do things for the right reasons and you care about your colleagues and teammates, that can come back in unexpected ways," Coffin said.

* The overall sensitivity in study participants with lymphoma was 56.3% (27.3% for stage I, 58.3% stage II, 71.7% stage III, 60.9% stage IV).

Learn More

The Galleri test must be prescribed by a healthcare provider and should be used in addition to recommended cancer screenings such as mammography, colonoscopy, prostate specific antigen (PSA) test and/or cervical cancer screening. It is intended for use in adults with an elevated risk for cancer, such as those aged 50 or older.

The Galleri test does not detect a signal for all cancers, and not all cancers can be detected in the blood. False­-positive and false-negative results do occur.

The overall sensitivity in study participants with lymphoma was 56.3% (27.3% for stage I, 58.3% stage II, 71.7% stage III, 60.9% stage IV).

Learn more at Galleri.com.

Important Safety Information

The Galleri test is recommended for use in adults with an elevated risk for cancer, such as those aged 50 or older. The Galleri test does not detect all cancers and should be used in addition to routine cancer screening tests recommended by a healthcare provider. Galleri is intended to detect cancer signals and predict where in the body the cancer signal is located. Use of Galleri is not recommended in individuals who are pregnant, 21 years old or younger, or undergoing active cancer treatment.

Results should be interpreted by a healthcare provider in the context of medical history, clinical signs and symptoms. A test result of "Cancer Signal Not Detected" does not rule out cancer. A test result of "Cancer Signal Detected" requires confirmatory diagnostic evaluation by medically established procedures (e.g. imaging) to confirm cancer. Results should be interpreted by a healthcare provider in the context of medical history, clinical signs and symptoms.

If cancer is not confirmed with further testing, it could mean that cancer is not present or testing was insufficient to detect cancer, including due to the cancer being located in a different part of the body. False­-positive (a cancer signal detected when cancer is not present) and false­-negative (a cancer signal not detected when cancer is present) test results do occur. Rx only.

Laboratory/Test Information

GRAIL's clinical laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIA) and accredited by the College of American Pathologists. The Galleri test was developed, and its performance characteristics were determined, by GRAIL. The Galleri test has not been cleared or approved by the U.S. Food and Drug Administration. GRAIL's clinical laboratory is regulated under CLIA to perform high complexity testing. The Galleri test is intended for clinical purposes.

1. Klein EA, Richards D, Cohn A, et al. Clinical validation of a targeted methylation-based multi-cancer early detection test using an independent validation set. Ann Oncol. 2021. Sep;32(9):1167-77. doi: 10.1016/j.annonc.2021.05.806
2. Preventive Services Task Force. A, B, and C grade recommendations, cancer, screening [cited 2025 Mar 18].
3. Schrag D, Beer TM, McDonnell CH, et al. Blood-based tests for multi-cancer early detection (PATHFINDER): a prospective cohort study. Lancet. 2023;402:1251-1260. doi: 10.1016/S0140-6736(23)01700-2.
4. Hackshaw A, et al. Cancer Cell. 2022;40(2):109-13.
5. GRAIL, Inc. Enhanced Cancer Signal Origin prediction. [Data on file: VV-TMF-59592].

Longer days and more time outdoors can be a welcome change, but for many people, they also bring uncomfortable eye symptoms like dryness, burning, and irritation which can arise from dry air, wind, or smoke. While these issues are often dismissed as temporary or environmental, they may actually be indicative of dry eye, one of the most common eye conditions, with symptoms affecting over 35.5 million Americans.¹

Dry eye occurs when your eyes don't produce enough tears, when those tears aren't sufficient to keep the surface of the eye properly lubricated, or your tears evaporate too quickly. Recognizing the symptoms is the first step toward finding lasting relief.

Know the Symptoms: What Dry Eye Really Feels Like

1. Dry, Discomforting Feeling

If your eyes feel like there's sand or grit in them, it may be more than just low humidity, or wind. The sensation happens when the tear film isn't able to properly lubricate and protect the eye's surface, leading to ongoing discomfort associated with dry eyes^.2

2. Burning or Stinging Sensation

A burning or stinging feeling is another common symptom.³ Environmental factors like wind, sun exposure, and increased screen time can make this irritation more noticeable, especially throughout the day.

3. Eye Discomfort In Day-to-Day Life
Dry eye symptoms can show up during everyday activities — like reading, using digital devices or spending time outdoors — making your eyes less comfortable^.4 This type of ongoing eye discomfort is a common way dry eye may show up in day-to-day life.

4. A Feeling of Irritated Eyes
Eyes may feel irritated, especially after long periods of screen use or time spent in dry or windy environments.⁵ These sensations can be linked to factors that contribute to dry eye symptoms.

Finding Relief That Works for You

The good news: Dry eye is manageable with the right approach. For many, over-the-counter eye drops are a simple and effective first step.

One option is REFRESH OPTIVE MEGA-3^® Multi-Dose Preservative Free, part of the trusted REFRESH portfolio and #1 doctor-recommended brand of artificial tears⁶. Designed for dry, burning, and irritated eyes, this preservative-free formula helps maintain hydration and works to prevent tears from evaporating.

Its triple-action formulation combines three lubricating ingredients with CMC, Glycerin, and Polysorbate 80 to help lock in moisture and provide long-lasting comfort, with relief that can last 10+ hours.^7,* The multidose bottle is also designed for ease of use, delivering a consistent drop while keeping the formula sterile without preservatives, an important consideration for people with sensitive dry eyes.

In addition to using artificial tears to relieve dry eye symptoms, the American Academy of Ophthalmology also recommends lifestyle adjustments like limiting exposure to wind and dry air and taking breaks from screens.

A More Comfortable Way Forward

Dry eye discomfort doesn't have to be something you simply put up with. By recognizing the symptoms of dry eye, you can take simple steps toward lasting relief.

If your symptoms are ongoing or worsening, it's important to consult an eye care professional. Dry eye can vary in severity, and personalized treatment can make a meaningful difference.

REFRESH OPTIVE MEGA-3^®can be found at major retailers nationwide and in select retail locations where over-the-counter eye drops are sold.

To learn more, visit RefreshEyeDrops.com and purchase REFRESH OPTIVE MEGA-3^® directly here.

*Results may vary.

1. Data on file; US-MULT-240462 2024 Update: Dry Eye Disease State Summary PPT deck; AbbVie; 05/22/2024
2. Dry Eye, National Eye Institute. Published 2025, Accessed March 25, 2026. https://www.nei.nih.gov/eye-health-information/eye-conditions-and-diseases/dry-eye
3. Dry Eyes, Cleveland Clinic, Published 2025, Accessed March 25, 2026. https://my.clevelandclinic.org/health/diseases/24479-dry-eye
4. Staff. "Dry Eyes." Mayo Clinic, 23 Sept. 2022, www.mayoclinic.org/diseases-conditions/dry-eyes/symptoms-causes/syc-20371863.
5. Staff. "Causes of Dry Eye." National Eye Institute, 6, Dec. 2024, https://www.nei.nih.gov/learn-about-eye-health/eye-conditions-and-diseases/dry-eye/causes-dry-eye
6. Data on file, AbbVie, Inc. REF-113774
7. Data on file, AbbVie, Inc. REF-136415

The experience left Azhia with profound psychological and physiological trauma, including distressing memories and fears. The idea of another pregnancy felt overwhelming. She and her husband, Brent, wanted a second child, but as Sloane approached her first birthday, Azhia realized she needed support to process her delivery experience. She found help through trauma-informed care provided by obstetric anesthesiologist Tracey Vogel, M.D., director of the Perinatal Trauma-informed Care Clinic at Allegheny Health Network, Pittsburgh. Dr. Vogel screened Azhia for anxiety and post-traumatic stress disorder (PTSD), with which she was ultimately diagnosed; helped identify triggers from her experience; and connected her to peer support and a program that supported healing through music therapy called the Lullaby Project. She worked closely with Azhia's obstetrics team, who understood her past trauma and saw her more frequently in the early stages of her second pregnancy.

"I don't think I would have gotten pregnant again without Dr. Vogel's support," said Azhia, a lawyer and mother to Sloane, who is now 3, and Hayes, 1. "She gave me the tools to face another delivery with confidence instead of fear, and my son's birth was completely different."

"Anesthesiologists are physicians who are trained to manage high-risk, high-stress situations, which puts us in a unique position to help patients not just physically, but emotionally, when they're at their most vulnerable," said Dr. Vogel. "Trauma-informed care starts with listening to each patient to identify what they've been through, what triggers their fear, and then building a plan with them and their care teams so they can move through their medical care feeling supported and in control."

Trauma-informed care recognizes that past experiences can negatively impact a patient's response to medical care. These may include childhood abuse, intimate partner violence, military service or prior medical trauma — such as poorly managed pain or feeling a loss of control. Trauma can also stem from difficult or emergency births, complications like excessive bleeding, anesthesia challenges or the loss of a baby. Because these experiences can heighten anxiety and trigger stress responses, trauma-informed care focuses on understanding each patient's emotional and physical needs and emphasizes clear communication, patient choice and step-by-step guidance, creating a sense of safety and control throughout the medical experience.

Understanding Trauma and Building Care Around the Patient

As an anesthesiologist providing anesthesia and pain management during and after labor, Dr. Vogel noticed how often past traumas affected women's birth experiences. Many carried emotional scars that influenced their response to pain, stress and medical care. Wanting to better support them, she trained in sexual assault counseling and created a specialized clinic to support patients with a history of trauma.

Dr. Vogel has worked with more than 1,000 patients and trained hundreds of clinicians in trauma-informed care. She also supports patients with a history of trauma who have other types of medical procedures, such as surgery, helping them identify triggers, understand what to expect and feel more in control throughout their care.

A Much Better Birth Experience

For Azhia, trauma-informed care made all the difference. When Hayes was born in April 2025, Azhia felt calm, informed and in control, a stark contrast to her first experience. Getting ready for his birth, she was able to ask questions, share her preferences and feel supported throughout her scheduled delivery.

"During my first delivery, I felt scared and completely alone because no one was explaining what was happening," said Azhia. "This time, Dr. Vogel walked me through every step, including what I would feel, what was happening and what would come next. I learned that I could ask questions and advocate for myself without interfering with my care. That gave me the confidence to be part of the process."

To learn more about how anesthesiologists keep patients safe during childbirth and before, during and after surgery, visit the American Society of Anesthesiologists at: https://www.asahq.org/madeforthismoment/.

Photo courtesy of Harley Steed Photography.

A nurse's personal insight

"After 20 years in nursing, I had a wide range of clinical experience, but my exposure to cleft care was limited in my training," said Carrie Alajoki, family nurse practitioner and nursing professor.

"Through my advocacy and involvement with Smile Train, including initiatives like Team Empower and the Cleft Community Advisory Council, I have been proud to support the organization's efforts to raise awareness and address gaps in cleft education, including having the opportunity to bring a group of my nursing students to experience the organization's programs firsthand in the Philippines."

How Smile Train is bridging the gap

Smile Train, the world's largest cleft-focused organization, is committed to continuously advancing and improving cleft care around the world. By partnering with local hospitals and medical professionals, the organization supports patients to receive free cleft surgeries in their own communities. Through training and funding support, Smile Train also empowers local medical professionals to deliver comprehensive cleft care services, including feeding and nutrition care, speech therapy and psychosocial support. These programs help to educate and equip parents with the tools they need to ensure their child's success and well-being.

"We know that empowering nurses and healthcare professionals with knowledge and hands-on experience transforms care for children with clefts," said Sara Horne, Smile Train's Director of Education and Training. "By investing in education and training, we ensure that cleft-affected families worldwide receive compassionate, informed support prenatally through adulthood."

What families and communities can do

• Learn about cleft care resources and advocate for proper support from healthcare providers.
• Share information to raise awareness about clefts and the challenges families face.
• Support organizations like Smile Train to expand access to cleft care and education worldwide.

By addressing the gaps in cleft education, healthcare providers and communities can make a meaningful difference in the lives of children born with clefts and their families. Every informed caregiver and supportive community brings everyone closer to a world where every child can thrive.

• A win-win for health & planet: A plant-powered diet supports your personal health with essential nutrients while also helping to reduce greenhouse gas emissions and conserve natural resources.
• Embrace smart protein: Prioritize complete plant-based proteins, like soy, which have all nine essential amino acids in the right amounts, and combine other sources (beans, nuts, grains) for a well-rounded intake.
• Focus on fiber: Aim for a variety of plants to get the key types of fiber — insoluble and soluble — which help support regularity, heart health and gut health.
• Flexitarianism is key: Adopting a flexible approach that prioritizes plant-based foods without complete restriction makes sustainable eating more realistic and achievable in the long term.

Ever wonder about the power of the food on your plate? Enjoying a variety of plant-based foods like fruits, vegetables, whole grains and legumes has been linked to a wide range of health benefits, from boosting the nutrient density of your diet to supporting heart health, metabolic health, gut health and more. Packed with fiber, protein, vitamins and healthy fats essential for overall wellness, plants are nutrient powerhouses — and their benefits don't stop there!

Choosing a plant-forward diet is also one of the most positive actions we can take for the environment as it's one of the most effective ways to reduce greenhouse gas emissions and conserve natural resources.

So how do you get the most out of a plant-powered diet? Registered dietitian Kristie Leigh, Director of Nutrition & Scientific Affairs at Danone U.S, shares her top three strategies:

1. Diversify your protein sources

Protein is a power player when it comes to your health, needed for everything from muscle and immune health to hormone production and more. But not all protein sources are created equal. Many plant-based protein sources are considered incomplete because, unlike animal sources, they don't have adequate amounts of all nine essential amino acids (aka protein building blocks) that our bodies need but can't make on their own.

There are some exceptions though, one of which is soy. Soy-based foods like soymilk, tofu, edamame and tempeh are excellent, sustainable sources of complete plant-based protein for a more plant-forward diet. Other plant-based protein sources, like beans, nuts, seeds and whole grains, can be great, too, and can be mixed and matched to get all the amino acids your body needs.

2. Get fiber from a variety of different plant foods

Ninety-five percent of U.S. adults don't get enough fiber, and eating more plant-based foods is a great way to help close that gap. To maximize fiber's benefits, aim to get fiber from a variety of different sources to help ensure you're getting different types. Insoluble fiber has been shown to promote regularity when consumed in adequate amounts, while soluble fiber can help lower LDL cholesterol and help promote more stabilized blood sugar levels. There are even fibers that act as food for the good bacteria in your gut called prebiotic fibers.

Lots of plants contain more than one type of fiber, but some especially good sources of insoluble fiber are whole grains, nuts, cauliflower and green beans and some especially good sources of soluble fiber are oats, beans, avocados, apples and bananas. The most common food sources of prebiotic fiber are foods like garlic, onions, berries and oats. You can also find foods fortified with prebiotic fiber, like certain yogurts and protein shakes.

One rule of thumb that can help ensure you get all of these is the "rule of 30." Research from the American Gut Project found people who eat 30 different types of plants a week have greater gut bacteria alpha diversity, a potential indicator of good gut health, compared to those who consume 10 or fewer.

3. Mind the potential nutrient gaps

A plant-based diet can add lots of essential nutrients to your diet, but it can also make it more challenging to get nutrients more commonly found in animal foods, like vitamin B12 and iodine. That's why it's important to build variety into your day, emphasizing a variety of nutrient-rich foods for a well-rounded intake of vitamins and minerals.

Fortified plant-based foods also play a valuable and sustainable role in a modern diet. Many options — such as Silk Protein, which offers 13g of complete plant protein per serving — are thoughtfully fortified with key nutrients like vitamin B12, iodine, calcium, vitamin D and potassium to help fill these gaps.

Make sustainable eating a sustainable habit

"One way to bring these strategies together is to follow a flexitarian eating pattern," said Leigh. "This style of eating prioritizes plant-based foods without completely eliminating nutrient-rich animal foods like yogurt, cheese, eggs, lean meats and seafood — all of which can be easy sources of high-quality protein and other nutrients you need. For many, this flexible style can be more realistic and sustainable than completely plant-based diets, making it easier to reap the rewards of plant-forward eating in the long-term without rigid rules or feeling restricted."

The best way to start adopting a more plant-forward diet is with some easy swaps. Give your next taco night a twist by replacing half of the ground meat with beans, make a tofu and veggie scramble instead of scrambled eggs, or use soymilk as your base in smoothies. The more you experiment and find what you like, the more natural it will become!

• Spring offers a natural opportunity to refresh daily routines, starting with informed choices in personal care.
• Simplify your routine by taking stock of your current products and prioritizing fewer, more intentional and transparent options.
• Understanding certifications like B Corp empowers smart shopping.
• Navigating "free from" claims empowers consumers to make choices aligned with their health and values.

As the days grow longer and nature awakens, spring offers the perfect opportunity to refresh. We clear out closets and swap heavy layers for lighter ones, but forget that the bathroom shelf is just as worthy of a second look. Personal care is one of those categories where options can feel endless but knowing what to look for can help you feel more confident about what you're choosing.

Start with what you already have

Before diving in, it's worth doing a quick check of what you already have. Check expiration dates. Toothpaste, deodorant and other daily staples may lose effectiveness over time.

And in many cases, the most intentional choice is simply using up what you already own before reaching for something new.

Take stock of your routine

Once you've checked expiration dates and confirmed everything is still good to use, take a closer look at what you have. Which of them are part of your daily routine? Which ones have been sitting untouched and taking up space? What ingredients are used in them? And are they free from the ingredients that are important for you to avoid?

This quick look can help you identify what's working, what's not and where it might be time to make a change, without overhauling everything at once.

Check the product — and the brand behind it

Once you know what you actually need, the next step is reviewing your options. As you evaluate a new product, consider not just what's in it, but the brand behind it — whether they are transparent about how they operate and the impact they have.

One of the clearest indicators of a brand's accountability is B Corp Certification, overseen by the nonprofit B Lab, which evaluates a company across governance, workers, customers, community and environment — and audits it every three years. This matters because it shows that a brand holds itself to a social and environmental standard, not just a product one.

Tom's of Maine is a certified B Corp and it's a distinction the brand takes seriously.

"Tom's of Maine's B Corp certification is a reflection of 50 years of deliberate choices," said Michelle Waring, Steward for Sustainability and Everyday Good at Tom's of Maine. "From sourcing naturally derived ingredients to dedicating 10% of our annual profits to protecting nature, we hold ourselves to the high standards B Lab sets because we believe business should be a genuine force for good."

Navigating the meaning of "free from" claims

From there, labels can help you refine your decision even further. "Free from" claims communicate that a product has been intentionally formulated without specific ingredients. Think of them as cues to understand what a brand chooses to prioritize and how a product was made.

Brands like Tom's of Maine take a consistent approach, putting their ingredient philosophy into practice across everything they make — every product is free from artificial flavors, synthetic fragrances, artificial colors, artificial sweeteners and preservatives.

Ultimately, the goal is to know your own needs and preferences and choose based on what matters to you.

To learn more about Tom's of Maine's ingredient sourcing, safety standards and sustainability commitments, visit www.tomsofmaine.com and www.tomsofmaine.com/pages/our-mission.

For anyone who may be facing financial hardship or illness, or who may have been impacted by a natural disaster, having a home that provides the worry-free safety and comfort of heating and cooling is crucial.

Lennox, a leading provider of reliable home comfort solutions, and the LII Lennox Foundation are kicking off their annual Feel The Love program in partnership with residential dealers across the U.S. and Canada. Through the program, Lennox donates essential heating and cooling equipment, while local Lennox dealers generously donate their time, expertise, and resources to install HVAC units for deserving homeowners, as well as nonprofit organizations. The LII Lennox Foundation, established in 2023, sponsors Feel The Love and other charitable initiatives that help support the communities where Lennox employees live and work.

How Feel the Love helps provide reliable heating and cooling where it's needed

Since 2009, Feel The Love has installed more than 3,100 heating and cooling systems for homeowners in need across North America, including over 400 installs in 2025 alone. The Feel The Love program provides much-needed relief to those who may be struggling with uncomfortable living conditions. It also brings communities together, encouraging a spirit of generosity and support.

It's easy to get involved: Submit your nomination today

Anyone can submit their nominations for the program starting on May 1 of this year, with nominations closing on Aug. 31, 2026. During Feel The Love Week held annually each October, the selected recipients will receive a new, high-efficiency Lennox heating or cooling unit, professionally installed by participating local Lennox dealers, at no cost to them.

Do you know about a nonprofit organization that is helping your community be a better place? You can nominate them, too: Now 501(c)(3) nonprofits are also accepted as Feel The Love program nominees (though they must be able to take residential HVAC equipment).

Last year, the Feel The Love program provided four new much-needed air conditioning units for H.A.L.O.'s No Kill Animal Shelter in Sebastian, Florida, to help keep the shelter's staff and their many rescued animals feeling safe and comfortable all year long — even throughout the famously hot and humid Florida summers.

To learn more, or if you'd like to nominate a community member or nonprofit organization for this year's Feel The Love program between May 1 and Aug. 31, visit FeelTheLove.com.

"When I found out, I was shocked," Lacey recalls. "That diagnosis turned my life upside down."

Navigating a cancer that keeps coming back

LG-IR-NMIBC is a highly recurrent type of bladder cancer that develops in the bladder lining and has not spread into the muscle wall. While it is generally slow growing, it often requires ongoing treatment.^1-3 LG-IR-NMIBC affects around 82,000 people in the U.S. each year, with an estimated 59,000 cases involving recurrent disease.^1-4 Bladder cancer is most often diagnosed in older adults, many of whom are also managing other health conditions.

"Recurrence is one of the defining challenges of the disease," explains Brian Hu, MD, Associate Professor of Urology at Loma Linda University School of Medicine, and Lacey's urologist. "Even when tumors are considered lower risk, they have a strong tendency to return, which means patients may face treatment again and again."

Up to 70% of people with NMIBC will experience at least one recurrence, and patients with LG-IR-NMIBC are even more likely to face repeated recurrences over time.^5,6 The current standard of care for recurrent LG-IR-NMIBC is transurethral resection of bladder tumor (TURBT), a surgical procedure to remove tumors from the bladder.^1-3,6

"Each recurrence usually means another TURBT," Dr. Hu explains. "That often involves anesthesia, recovery time, and frequent follow-ups, which can be really taxing for many patients, especially when it happens over and over again."

For Lacey, her cancer was coming back every three months. Facing a pattern of repeat procedures and ongoing monitoring began to shape her everyday life, with the physical and emotional toll adding up.

Discovering a new treatment option

As part of her treatment discussions, Dr. Hu introduced Lacey to a clinical trial evaluating ZUSDURI™ (mitomycin) for intravesical solution, a medication used to treat adults with recurrent LG-IR-NMIBC after prior bladder surgery to remove the tumor(s) did not work or is no longer working.

ZUSDURI combines mitomycin, a chemotherapy medication, with a proprietary reverse-thermal hydrogel technology (RTGel^®). ZUSDURI is delivered directly into the bladder through a tube called a urinary catheter, typically in a doctor's office or outpatient clinic, with no need for general anesthesia or surgery. Administered as a liquid, ZUSDURI changes into a gel at body temperature and releases mitomycin into the bladder, allowing it to remain in contact with the tumor for chemoablation. It is given once-a-week for six weeks and slowly dissolves and is flushed out in urine. Patients should avoid contact with urine for at least 24 hours post-instillation.

ZUSDURI was approved for the treatment of adult patients with recurrent LG-IR-NMIBC based on the ENVISION clinical trial, which evaluated its safety and efficacy. Among recurrent LG-IR-NMIBC patients treated once-a-week for six weeks, 78% had no detectable cancer at three months and 79% of these patients remained tumor-free for at least one year later (range of 0-25+ months).⁷ The most common side effects of ZUSDURI include: increased blood creatinine levels, increased blood potassium levels, trouble with urination, decreased red blood cell counts, increase in certain blood liver tests, increased or decreased white blood cell counts, urinary tract infection, blood in your urine. You should not receive ZUSDURI if you have a hole or tear (perforation) of your bladder or if you have had an allergic reaction to mitomycin or to any of the ingredients in ZUSDURI. Read the Important Safety Information below.

Looking ahead after treatment

For Lacey, the idea of trying something new felt like a turning point.

"My first experience with the treatment process was fascinating," she says. "It was exciting because I was part of something new, something that might help me, but other people too."

After completing treatment with ZUSDURI, Lacey has been cancer-free for over two years and she reflects on her journey with gratitude for having another option.

"I really believe that good things come when science excels," she says.

To see more of Lacey's story, visit: https://www.zusduri.com/patient/resources/#patient-stories. Lacey and Dr. Hu were compensated for participating in this interview.

Individuals with LG-IR-NMIBC, including those who have experienced repeat recurrences and have previously received bladder surgery to remove tumor and it did not work or is no longer working, should talk with their doctor about all available treatments, including ZUSDURI. To learn more about ZUSDURI and access resources designed to support patients through the treatment-coordination process, visit https://www.zusduri.com/patient/ and speak with your healthcare provider.

APPROVED USE FOR ZUSDURI

ZUSDURI™ (mitomycin) for intravesical solution is a prescription medicine used to treat adults with a type of cancer of the lining of the bladder called low-grade intermediate-risk non-muscle invasive bladder cancer (LG-IR-NMIBC) after previously receiving bladder surgery to remove tumor that did not work or is no longer working.

IMPORTANT SAFETY INFORMATION
You should not receive ZUSDURI if you have a hole or tear (perforation) of your bladder or if you have had an allergic reaction to mitomycin or to any of the ingredients in ZUSDURI.

Before receiving ZUSDURI, tell your healthcare provider about all of your medical conditions, including if you:

• have kidney problems
• are pregnant or plan to become pregnant. ZUSDURI can harm your unborn baby. You should not become pregnant during treatment with ZUSDURI. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with ZUSDURI.
  Females who are able to become pregnant: You should use effective birth control (contraception) during treatment with ZUSDURI and for 6 months after the last dose.
  Males being treated with ZUSDURI: You should use effective birth control (contraception) during treatment with ZUSDURI and for 3 months after the last dose.
• are breastfeeding or plan to breastfeed. It is not known if ZUSDURI passes into your breast milk. Do not breastfeed during treatment with ZUSDURI and for 1 week after the last dose.

How will I receive ZUSDURI?

• You will receive your ZUSDURI dose from your healthcare provider 1 time a week for 6 weeks into your bladder through a tube called a urinary catheter. It is important that you receive all 6 doses of ZUSDURI according to your healthcare provider's instructions.
• If you miss any appointments, call your healthcare provider as soon as possible to reschedule your appointment.
• During treatment with ZUSDURI, your healthcare provider may tell you to take additional medicines or change how you take your current medicines.

After receiving ZUSDURI:

• ZUSDURI may cause your urine color to change to a violet to blue color. Avoid contact between your skin and urine for at least 24 hours.
• To urinate, males and females should sit on a toilet and flush the toilet several times after you use it. After going to the bathroom, wash your hands, your inner thighs, and genital area well with soap and water.
• Clothing that comes in contact with urine should be washed right away and washed separately from other clothing.

The most common side effects of ZUSDURI include: increased blood creatinine levels, increased blood potassium levels, trouble with urination, decreased red blood cell counts, increase in certain blood liver tests, increased or decreased white blood cell counts, urinary tract infection, and blood in your urine.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088. You may also report side effects to UroGen Pharma at 1-855-987-6436.

Please see ZUSDURI Full Prescribing Information, including the Patient Information, for additional information.

ZUSDURI™ is a trademark and UroGen^® is a registered trademark of UroGen Pharma, Ltd.

Copyright©2025 UroGen Pharma, Inc. All rights reserved.

1. Chevli KK, Shore ND, Trainer A, et al. Primary Chemoablation of Low-Grade Intermediate-Risk Nonmuscle-Invasive Bladder Cancer Using UGN-102, a Mitomycin-Containing Reverse Thermal Gel (Optima II): A Phase 2b, Open-Label, Single-Arm Trial. J Urol. 2022 Jan;207(1):61-69. doi:10.1097/JU.0000000000002186

2. Babjuk M, Burger M, Comperat EM, et al. European Association of Urology Guidelines on Non-muscle-invasive Bladder Cancer (TaT1 and Carcinoma In Situ). Eur Urol. 2019 Nov;76(5):639-657. doi:10.1016/j.eururo.2019.08.016

3. Simon M, Bosset PO, Rouanne M, et al. Multiple recurrences and risk of disease progression in patients with primary low-grade (TaG1) non-muscle-invasive bladder cancer and with low and intermediate EORTC-risk score. PLoS One. 2019 Feb 27;14(2):e0211721. doi:10.1371/journal.pone.0211721

4. SEER Cancer Stat Facts: Bladder Cancer. National Cancer Institute. Bethesda, MD, https://seer.cancer.gov/statfacts/html/urinb.html.

5. Bladder Cancer Stages. American Cancer Society. National Cancer Institute. Bethesda, MD, https://www.cancer.gov/types/bladder/stages.

6. Filon M, Schmidt B. New Treatment Options for Non–Muscle-Invasive Bladder Cancer. Am Soc Clin Oncol Educ Book 45, e471942(2025). doi:10.1200/EDBK-25-471942

7. Prasad SM, Shishkov D, Mihaylov NV, et al. Primary Chemoablation of Recurrent Low-Grade Intermediate-Risk Nonmuscle-Invasive Bladder Cancer With UGN-102: A Single-Arm, Open-Label, Phase 3 Trial (ENVISION). J Urol. 2025;213(2):205-216. doi:10.1097/JU.0000000000004296

US-ZUS-00307 04/2026

About half of mental health conditions start as early as age 14, a pivotal age when students are moving from middle school to high school. Today's teens face complex stressors such as academic, family and peer pressure, an isolating social media environment that can include cyberbullying, plus questions of personal identity and growth, physical development and heightened awareness of global issues.

Without intervention or treatment early on, these stressors can lead to additional emotional, psychological and physical problems as teens seek out ways to cope with difficult feelings and experiences.

"Teens need support. Untreated mental health challenges in adolescence can have lasting consequences, including chronic mental health disorders in adulthood, academic decline and increased risk of substance use," said Tramaine EL-Amin, vice president, Mental Health First Aid (MHFA).

Even more alarming, suicide is the second leading cause of death for young people, creating even more urgency for early intervention.

This Mental Health Awareness Month, take time to learn about effective ways to reach teenagers before they experience a mental health crisis.

Peer-to-peer support is crucial for teens

Research confirms what common sense suggests: Teens are far more likely to want to talk to one another than to ask for help from a mental health professional.

"Friends provide a safe, nonjudgmental space where teens can feel understood and less isolated," added EL-Amin. "By connecting with peers who have similar experiences, teens gain coping skills, self-awareness and emotional validation."

When a teen shows signs of a mental health challenge, their friends may be the first to offer help. This natural inclination to turn to peers forms the basis of Teen Mental Health First Aid (Teen MHFA), developed by the National Council for Mental Wellbeing. Designed for students in grades 9-12 (ages 14-18), the evidence-based training teaches how to identify, understand and respond to signs of mental health and substance use challenges in friends and peers, giving teens the confidence to begin difficult conversations with empathy and care.

How Teen MHFA makes a difference

Instructors in schools and organizations across the country have trained nearly 170,000 teenagers to provide peer-to-peer support. Schools, youth-serving organizations and their partners can apply to be a Teen MHFA site. Teen MHFA can be taught as a standalone course or as part of a school health curriculum.

Learners will be able to spot warning signs of mental health challenges and understand the impact of violence and bullying on mental health. Thanks to their training, they'll know how to start conversations about these topics with their friends — and recognize when they need to connect a friend with a parent, guardian or other trusted adult.

Teen MHFA has an easy-to-remember acronym, ROLE, to describe the steps to take when supporting a peer.

• Recognize signs that your friend may be going through a hard time.
• Open a conversation with your friend by asking how they are and listening.
• Link to a parent, guardian or trusted adult to provide support.
• Encourage your friend by staying connected and showing you care.

Teens who participate in the program learn how to help each other through hard times. Topics include anxiety, depression, eating disorders, bullying, social media, substance use and ADHD. In addition to learning how to recognize the signs and symptoms of mental health and substance use challenges in their peers, teens learn techniques for practicing self-care and sharing those tips with their friends.

"Most importantly, young people in Teen MHFA learn that recovery is possible," said EL-Amin. "Through that process, they help reduce the stigma that still exists around mental health treatment."

Learn how your organization can become a Teen MHFA site at MentalHealthFirstAid.org/organizations/teens.

While attending a concert, Michelle tripped on a piece of concrete and had a minor fall into the grass. To her surprise, that minor fall resulted in a fractured arm, and she realized her body might be trying to tell her something.

"I suddenly realized my arm fracture might be part of a larger, more serious issue," said Michelle. "My doctor gave me a bone density scan which revealed I had postmenopausal osteoporosis. It was frightening to hear, but I was also relieved to finally have answers, especially since postmenopausal osteoporosis wasn't unfamiliar to me — it has affected several women in my family, including my mom. These events occurred just one year after her mother Helen received her own postmenopausal osteoporosis diagnosis, a serious bone disease that increases the risk of fractures, which led to a meaningful conversation about their family's medical history.¹

"Postmenopausal osteoporosis runs in our family. All three of my sisters had it," Helen explained. She had fractured her arm and hand right before they were planning to leave for a cruise to Canada. She informed her doctor of her family history and received a bone density scan, and the doctor diagnosed her with postmenopausal osteoporosis. "At the time, I didn't realize how important it would be for my daughter to see a doctor and learn about bone-strengthening treatments available for the disease, too," Helen said. "I wish I had sooner."

You can meet Michelle, Helen and other women with postmenopausal osteoporosis by watching videos of their stories.

What do mothers and daughters need to know about postmenopausal osteoporosis?

Osteoporosis is a condition that causes bones to weaken, making them much more prone to fracture.¹ Women past the age of menopause are at the highest fracture risk, when creation of new bone doesn't keep up with bone loss.^1,2 It is often called a "silent disease," as it can progress without symptoms and may not be discovered until after one or more fractures occur.¹

"After menopause, estrogen loss can result in weaker bones and a higher risk of fracture," said orthopedic surgeon Dr. Shannon Carpenter, MD, FAAOS, founder of The Bone Health Clinic.² "In fact, osteoporotic fractures lead to more hospitalizations per year than heart attacks, strokes or breast cancer alone."³

And in some cases, women might not even notice when they have experienced a fracture, and may not know their risk of additional fractures.^4,5

"Three out of four women 55 years of age or older with postmenopausal osteoporosis at high risk for fracture will break a bone in their lifetime, and after an osteoporosis-related fracture, you're five times more likely to suffer another fracture within a year," added Dr. Carpenter.⁶ "Especially if they have a family history of osteoporosis, it's important for postmenopausal women to see their doctor to ask about their personal fracture risk level and, if they have a risk factor, request a bone density scan."^1,5

Why aren't healthy habits always enough to reduce the risk of fractures and how can bone-building treatment make a difference?

Lifestyle factors that can help keep bones strong include increasing vitamin D and calcium intake, regular exercise and avoiding tobacco and excessive alcohol.^7,9 But for many women with postmenopausal osteoporosis, lifestyle changes alone are not enough to adequately reduce their fracture risk.⁷

Fortunately, treatment options that strengthen bone are available.⁸ Commonly prescribed bone-strengthening treatments for postmenopausal osteoporosis work in one of two ways: antiresorptives slow down bone loss, while anabolics help to stimulate new bone formation.^2,10

One type of anabolic treatment option, EVENITY^® (romosozumab-aqqg), is the first and only medication that works by building new bone and helping to slow bone loss.⁸ EVENITY is a prescription medicine used to treat osteoporosis in women after menopause who are at high risk of fracture, or cannot use another osteoporosis medicine or other osteoporosis medicines did not work well.⁸

EVENITY can cause serious side effects, including increased risk of having a heart attack, stroke, or death from a cardiovascular (heart or blood vessel) problem.⁸ Please see below for further information.

Mother and daughter look forward together

By engaging her health care provider and starting EVENITY, a bone-strengthening treatment that they felt was right for her, Michelle gained peace of mind that she was reducing her risk of future fractures. And Helen was grateful she could share her own knowledge and experience with postmenopausal osteoporosis, to help empower Michelle to take charge of her own journey with the disease.

Both Helen and Michelle understand how crucial it is to talk frankly about their family health history and vowed to continue sharing what they learned with family members and friends, especially women who may not yet be aware of their risk.

"It's important to be your own advocate and have an active role in your bone treatment journey," Michelle explained. "Have you had a bone scan, talked to a doctor, asked your mom or aunt if you have osteoporosis in your family? That's an easy place to start, with your family members. And Mother's Day is a great reminder that health conversations are some of the most critical between mothers and daughters."

EVENITY has worked well for Michelle, who continues to enjoy her favorite activities like seeing live music and walking to parks with her dog with confidence. She looks forward to spending more Mother's Days with Helen, having fun cheering on their beloved Buckeyes together, and knowing their shared support system helped move them through their postmenopausal osteoporosis journey.

What can you do about postmenopausal osteoporosis and fracture risk?

Women who have been through menopause should talk to a health care provider about bone density scans and fracture risk reduction and visit BuildingYourBones.com for more information.^1,11

Important Safety Information

What is the most important information I should know about EVENITY?

EVENITY can cause serious side effects, including increased risk of having a heart attack, stroke, or death from a cardiovascular (heart or blood vessel) problem. Call your healthcare provider or get emergency help right away if you have any of these symptoms: symptoms of heart attack, which may include: chest pain or pressure; shortness of breath; feeling light-headed or dizzy; or symptoms of stroke, which may include: headache; numbness or weakness in face, arm, or legs; difficulty talking; changes in vision or loss of balance. Before you receive EVENITY, tell your healthcare provider if you have had a heart attack or stroke, especially if it has happened in the past year.

Do not receive EVENITY if you: have low blood calcium; or are allergic to romosozumab or any of the ingredients in EVENITY.

Before receiving EVENITY, tell your healthcare provider about all your medical conditions, including if you:

• have a history of other heart or blood vessel problems
• have low blood calcium
• cannot take daily calcium and vitamin D
• have kidney problems or are on kidney dialysis
• plan to have dental surgery or teeth removed

What are the possible side effects of EVENITY?

EVENITY may cause serious side effects, including:

Serious allergic reactions have happened in people who receive EVENITY. Call your healthcare provider or go to the nearest emergency room right away if you have any symptoms of a serious allergic reaction including: rash; hives; swelling of the face, lips, mouth, tongue, or throat which may cause difficulty in swallowing or breathing.

Low calcium levels in your blood (hypocalcemia). EVENITY may lower the calcium levels in your blood. Your low blood calcium should be treated before you receive EVENITY. Call your healthcare provider if you have symptoms of low blood calcium such as: spasms, twitches, or cramps in your muscles; numbness or tingling in your fingers, toes or around your mouth.

Severe jaw bone problems (osteonecrosis) may occur. Your healthcare provider should examine your mouth before you start EVENITY and may tell you to see your dentist. Ask your healthcare provider or dentist about good mouth care.

Unusual thigh bone fractures. Symptoms of this type of fracture include new or unusual pain in your hip, groin, or thigh.

The most common side effects of EVENITY include joint pain and headaches.

These are not all the possible side effects of EVENITY. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see EVENITY full Prescribing Information, including Medication Guide.

Approved Use:

EVENITY is a prescription medicine used to treat osteoporosis in women after menopause who are at high risk of fracture, or cannot use another osteoporosis medicine or other osteoporosis medicines did not work well.

© 2022 Amgen Inc. All rights reserved. USA-785-81875

References:

1. National Institute of Arthritis and Musculoskeletal and Skin Diseases. Osteoporosis. National Institutes of Health. Updated December 2022. https://www.niams.nih.gov/health-topics/osteoporosis. Accessed February 23, 2026.
2. Office of the Surgeon General (US). Bone Health and Osteoporosis: A Report of the Surgeon General. Rockville (MD): Office of the Surgeon General (US); 2004.
3. Singer A, Exuzides A, Spangler L, O'Malley C, Colby C, Johnston K, Agodoa I, Baker J, Kagan R. Burden of Illness for Osteoporotic Fractures Compared With Other Serious Diseases Among Postmenopausal Women in the United States. Mayo Clinic Proceedings. 2015;90(1):53-62. doi: 10.1016/j.mayocp.2014.09.011
4. Van Geel TA, van Helden S, Geusens PP, Winkens B, Dinant GJ. Clinical subsequent fractures cluster in time after first fractures. Ann Rheum Dis. 2009;68(1):99-102. doi:10.1136/ard.2008.092775
5. Bone Health and Osteoporosis. What is Osteoporosis and What Causes It? https://www.bonehealthandosteoporosis.org/patients/what-is-osteoporosis/. Accessed April 16, 2026.
6. Brunetti VC, Chien H, He M, He X, McDermott M, Lin T, Kim M. Lifetime Risk of Fracture Among Post-menopausal Women in the US. Poster presented at ASBMR 2024.
7. National Institute on Aging. Osteoporosis. National Institutes of Health. Updated November 2022. https://www.nia.nih.gov/health/osteoporosis/osteoporosis. Accessed February 23, 2026.
8. EVENITY^® (romosozumab-aqqg) prescribing information, Amgen.
9. LeBoff MS, Greenspan SL, Insogna KL, Lewiecki EM, Saag KG, Singer AJ, Siris ES. The clinician's guide to prevention and treatment of osteoporosis. Osteoporosis International. 2022;33:2049-2102. doi: 10.1007/s00198-021-05900-y
10. Bandeira L, Lewiecki EM. Anabolic therapy for osteoporosis: update on efficacy and safety. Archives of Endocrinology and Metabolism. 2022;66(5):707-716. doi:10.20945/2359-3997000000566
11. Camacho PM, Petak SM, Binkley N, Diab DL, Eldeiry LS, Farooki A, Harris ST, Hurley DL, Kelly J, Lewiecki EM, Pessah-Pollack R, McClung M, Wimalawansa SJ, Watts NB. American Association of Clinical Endocrinologists/American College of Endocrinology Clinical Practice Guidelines for the Diagnosis and Treatment of Postmenopausal Osteoporosis – 2020 Update. Endocrine Practice. 2020;26(1):1-46. doi: 10 .4158 /GL-2020-0524

© 2026 Amgen Inc. All Rights Reserved. USA-785-83294. 04/26

Gut health is emerging as a major area of focus in the growing pet supplement category, yet a gap remains: while interest in gut health support is higher than ever for humans, fewer than one-third of dog and cat owners give their pets supplements specifically designed to support the gut.

Why gut health matters

Gut health has been making headlines for good reason. The gut microbiome — the community of microorganisms living in the digestive system — plays an important role in many of the body's key functions, influencing immune response, skin health, mood and nutrient absorption, among other things.

The same is true for pets. When the gut is out of balance, it can show up in a variety of ways, from itching and seasonal allergies to low energy and digestive issues.

Symptoms of gut imbalance

If your four-legged family member isn't eating well, has changes in stool or bowel habits, or you notice frequent stomach gurgling, it could be a sign their gut needs additional support. Other common symptoms include gas, bloating, diarrhea, scooting and loss of appetite.

Gut disruption can have many causes, including antibiotic use, food transitions, travel, stress and tension, aging or breed-specific sensitivities, and even puppies can benefit from early microbiome support.

Fortunately, many of these digestion challenges can be addressed with the right kind of daily support. By focusing on key ingredients that promote a balanced microbiome, pet owners can help improve digestion and overall well-being. One of the most important steps is understanding the three key components of digestive health: probiotics, prebiotics and postbiotics.

The difference between probiotics, prebiotics and postbiotics

You've likely heard of probiotics, but supporting digestive health — for both humans and pets — involves three key components:

1. Probiotics are the "good bacteria" that support digestion, aid nutrient absorption and help maintain immune health. When given as a supplement, they help reinforce the population of beneficial bacteria in the gut.

2. Prebiotics act as fuel for the probiotics. These indigestible fibers nourish probiotics and help them grow and thrive.

3. Postbiotics are the beneficial compounds produced when probiotics break down prebiotics. These byproducts — such as short-chain fatty acids, enzymes and vitamins — help support a healthy gut environment and make it more difficult for harmful bacteria to survive.

Together, prebiotics, probiotics and postbiotics create a more balanced and resilient gut microbiome.

How to find good gut health supplements

Rather than waiting until a problem arises with your dog or cat's digestive system, you can be proactive by giving them the daily digestive support they need. Here's what you should look for in a digestive support supplement:

Proven ingredients: well-researched strains like Bacillus subtilis (a hardy probiotic) and Lactobacillus rhamnosus.

Balanced formulation: a combination of prebiotics, probiotics and/or postbiotics that work together to support a healthy gut microbiome.

Form your pets will take: soft chews or powders

Third-party tested: quality products with ingredients tested for stability and safety, manufactured in audited facilities.

For example, veterinarian-formulated pet supplement brand NaturVet offers a variety of products for dogs and cats to provide daily gut health support:

• Advanced Probiotics & Enzymes with PB6 Probiotic, a 2025 Product of the Year award winner*, gives your pet the gut support they deserve with a powerful blend of beneficial bacteria designed to promote healthy digestion, boost immunity and help reduce tummy troubles like gas, bloating and diarrhea. With over a billion probiotic CFUs per serving and a blend of prebiotics and enzymes, this food supplement is perfect for pets with sensitive stomachs or with advanced digestive needs. Available in Soft Chews for Dogs, Powder for Dogs and Cats and Scoopable Tiny Bites for Dogs.
  
  
• Digestive Enzymes with Pre- and Probiotic support your pet's digestive health from the inside out with a triple-action formula featuring enzymes, prebiotics and probiotics. Vet-formulated to help break down food, ease tummy troubles and promote nutrient absorption, this daily supplement supports diet changes and helps reduce occasional digestive discomfort. Available in Soft Chews for Dogs, Soft Chews for Cats, Scoopable Tiny Bites for Cats and Powder for Dogs and Cats.

"A proactive approach to digestive health can help your dog or cat thrive," said Dr. I. Craig Prior, BVSc, CVJ. "Just as many people take a daily supplement for digestive support, your pet can benefit from a proactive approach to gut health. Supporting their microbiome through their daily routine helps with better digestion, immune function and overall vitality."

Before incorporating a digestion supplement into your pet's routine, consult your veterinarian to ensure it's appropriate for their needs.

Learn more and find products to help support your pet's health and wellness at NaturVet.com.

* Winner Pet Wellness Category. Survey of 40,000 people by Kantar.

"Everything was beautiful, and I was thriving," said Gonzalez. "But one morning I woke up, and my hands were stiff — fingers aching so much that it hurt to move them. Every single note was excruciating to play."

At 18, Gonzalez's world changed as her doctors diagnosed her with lupus, a chronic autoimmune disease.

A condition that affects millions

Gonzalez is not alone — as lupus affects millions of people worldwide.

"In lupus, the same immune system that helps us defend ourselves from infections mistakenly thinks that our own body is a harmful invader and attacks," said Dr. Roberto Caricchio, Myles J. McDonough chair in Rheumatology and chief of the Division of Rheumatology at UMass Chan Medical School. "Because lupus is systemic, it can attack any organ, such as the kidneys, brain, heart, lungs, and skin, as well as blood and joints. No one's experience is the same."

Despite its prevalence, many people are unaware of what lupus is or how it impacts people with the condition. That's why this May, during Lupus Awareness Month, the Lupus Research Alliance, the world's largest private funder of lupus research, and dedicated members of the worldwide lupus community are celebrating "Hope in Action: The Future of Lupus" — increasing awareness, supporting those living with lupus, and raising funds to fuel research to treat and one day cure this debilitating autoimmune disease.

Research breakthroughs provide hope

For decades, lupus has been one of the most complex autoimmune diseases for researchers to understand and treat, largely because the disease affects each person differently and involves many immune pathways. For 50 years, there were no treatments specifically approved by the FDA for lupus.

However, since 2011, scientific momentum has been building toward today's research renaissance. Four targeted therapies are now FDA-approved across systemic lupus erythematosus (SLE) and lupus nephritis, and hundreds of clinical trials are currently underway investigating potential new treatments. Researchers are uncovering new insights into how lupus develops, identifying biomarkers for earlier detection, and advancing therapies designed to target the disease more precisely.

One organization that has been at the forefront of lupus research over the past two decades is the Lupus Research Alliance. To drive discovery and development of next-generation lupus diagnostics and curative treatments, the Lupus Research Alliance funds the most innovative research, fosters scientific talent, and drives discovery toward better diagnostics, improved treatments and, ultimately, a cure for lupus.

Since its inception, the Lupus Research Alliance has:

• Awarded more than 675 grants and invested over $284 million in lupus research grants.
• Funded or supported the only four new treatments developed specifically for lupus.
• Established Lupus Therapeutics, the clinical affiliate of the Lupus Research Alliance, which is involved in more than 25% of active lupus clinical trials.
• Launched Lupus Ventures, the world's only venture capital fund dedicated to lupus, its manifestations, and related autoimmune conditions.

The Lupus Research Alliance's work and recent progress in lupus treatments have emboldened other organizations and individuals to do their part to raise awareness of the disease and support research. For instance, because of her desire to know more about her condition and to help others, Gonzalez switched careers.

After pursuing her M.D./Ph.D. degrees at Texas A&M College of Medicine, she will soon start a neurosurgery residency in Houston. She is also an executive member of the Lupus Research Alliance Young Leaders Board.

"Back when I was first diagnosed, I asked my doctors, 'What's lupus? What does autoimmune mean? Will I get better? What's the cure?' I was always met with the same answer: 'We don't know. We need more research,'" said Gonzalez. "Eventually, you get tired of hearing that. So, I decided to go back to school, to become a doctor and be able to give other patients the answers I struggled to find."

Everyone can do their part

While curing lupus may not be a reality yet, there is hope on the horizon.

"This is an unprecedented time in lupus," said Dr. Caricchio, Vice Chair of the Lupus Clinical Investigators Network (LuCIN), overseen by the Lupus Research Alliance's clinical affiliate Lupus Therapeutics. "The next step is ensuring that these advances translate into real-world approaches and therapies that improve daily life for people living with lupus — slowing disease progression while minimizing side effects."

Realizing that future requires collective work — and everyone can play a part. There are several ways to get involved — like donating to fuel new breakthroughs, taking part in research, and taking time to learn about lupus and raising awareness.

"With still only a handful of therapies ever approved for lupus, the next wave of breakthroughs could redefine treatment for millions worldwide — and we're right at that precipice," Albert T. Roy, president and CEO of the Lupus Research Alliance, said. "By working together, we have a real opportunity to bring people living with this disease closer to a cure."

To learn more about lupus, support those living with the disease, and donate to fuel breakthroughs, visit LupusResearch.org.

Don't be intimidated. It's important for everyone to protect their income, assets and loved ones from life's uncertainties.

Life insurance has also changed drastically over the years to include new living benefits policyholders may potentially take advantage of while they are still living to help pay for costs associated with certain serious qualifying illnesses, caregiving responsibilities and other life events.

According to National Life Group, there are several key things to consider as you decide if you need coverage or should update an existing policy.

Key questions for those without life insurance:

Does anyone depend on you financially?

If so, it may be a good idea to explore life insurance options to financially support your dependents should anything happen to you.

Are you a parent/grandparent or a caregiver for dependents or elderly parents?

Parents and grandparents should plan ahead to understand what options are available for estate planning and their children's future. Additionally, caregivers of elderly parents may be able to take advantage of certain living benefits of their life insurance policy for support.

Do you have any debt you co-own or are co-signed with? (including a mortgage)

If you have a significant amount of debt you are co-signed with another party (the most common being a mortgage) without coverage, they could be left holding the bill for the entire debt.

Do you have an estate that needs protection?

It's smart to have protection in place as part of a dedicated estate plan to ensure the quick, amicable and seamless transfer of wealth from one generation to the next.

Key questions for those with life insurance:

Have you started a family or have family members that are financially dependent on you?

If you recently started a family and have an existing policy, it may be worth speaking with your agent to ensure your new family's coverage needs are met. Your dependents can include anyone from children to parents to siblings with special needs.

Have you purchased a new home, changed careers or received a change in salary?

Significant changes in your income may require a new look at your existing policy to ensure your coverage works for you.

Is your policy several years old and has not been recently reviewed?

Ask your agent to see if you are eligible for new benefits or policy riders. Insurance partners are frequently adding new benefits or features for their policyholders. If your policy isn't automatically enrolled in new features, it may be time to speak with your agent to review your current policy.

Whether you already have a life insurance policy or are considering one, answering these key questions will help as you decide if you need coverage or should update your existing policy. For more information, visit www.nationallife.com.

Living benefits are provided by no-additional-premium Accelerated Benefits Riders (ABRs). Payment of accelerated benefits will reduce the cash value and/or death benefit otherwise payable under the policy. Receipt of accelerated benefits may be a taxable event, may affect your eligibility for public assistance programs, and may reduce or eliminate other policy and rider benefits. Please consult your tax professional to determine the tax status of any benefits paid under this rider and with social service agencies concerning how receipt of such a payment could affect you.

Riders are supplemental benefits that can be added to a life insurance policy and are not suitable unless you also have a need for life insurance. Riders are optional, may require additional premium, and may not be available in all states or on all products. This is not a solicitation of a life insurance policy.

The companies of National Life Group and their representatives do not offer tax or legal advice. For advice concerning your own situation, please consult with your appropriate professional advisor.

TC8884862(0426)1

To honor their service and legacy, Carry The Load — a nonprofit that unites Americans to honor the sacrifices made by these heroes and their loved ones — invites everyone to participate in Memorial May. This monthlong movement is a call to action, inviting communities nationwide to step forward, get involved and carry the load for those who carried us.

The cost they carry

The cost of service is heavy, and it doesn't end when the uniform comes off. Military, police, firefighters and other first responders carry the weight of service every day, and so do their families.

"Most people will never experience the trauma, loss and life-or-death decision-making these heroes face head-on while serving or the numerous challenges that follow them long after they've returned home," said Stephen Holley, CEO of Carry The Load and former U.S. Navy SEAL. "And for those heroes who make the ultimate sacrifice, their families live with the weight of that sacrifice for the rest of their lives."

Two of the most common struggles these heroes face are post-traumatic stress disorder (PTSD) and suicide. Veterans and first responders have some of the highest mental-health risks in the U.S. In fact, one in three first responders develops PTSD at some point in their career, and the suicide rate among veterans is twice that of the general U.S. adult population.

While these heroes' burdens may last a lifetime, they don't have to bear this burden alone. This May, you have the opportunity to show military, first responders and their families how much their sacrifice means to you. Here are a few ways you can honor those who have given so much.

Participate in a community event

Join your community in a Memorial May community event. Across the nation, Carry The Load will host over 75 community events featuring inspirational speakers, a community walk of remembrance and connection, and post-walk neighborhood hangouts with food and refreshments. Join more than 50,000 participants at these events as they gather to honor and support our nation's heroes.

Find a community event near you here.

Share a memory of a fallen hero

For those heroes who willingly gave their lives to protect their country, there's a simple yet meaningful way to honor their sacrifice: Tell their stories. There are many ways you can share their memory, but one you can do right now is to visit Carry The Load's Tribute Wall. There, you can create a virtual storyboard that details a hero's life, service and sacrifice. When you share these stories — whether in person or online — you ensure that no one is ever forgotten.

Donate to a trusted organization

You can make a meaningful impact on the lives of heroes and their families by donating to a trusted organization that supports those who serve. For example, when you support the work of Carry The Load, you're helping provide scholarships and critical services such as counseling, suicide-prevention initiatives, adaptive training, nontraditional therapies, service-dog programs and career placement resources.

These are just a few ways that you can show military, veterans, first responders and their loved ones your appreciation and your desire to help carry the load. To learn more ways you can help, make a donation or participate in an upcoming event near you this Memorial May, visit CarryTheLoad.org.

The seemingly endless stream of notifications, emails and updates can make it difficult for your brain to turn off and rest, leading to mental fatigue. This fatigue can be the real culprit that keeps you from performing the hobbies that once brought you joy.

The good news? There's a simple way to help clear the mental fog. Take a step away from the screens and engage in a restorative, analog act: Writing with pen and paper.

Writing by hand can help ground you, encourage you to think more creatively and empower you to act on your ideas. It's the perfect way to start an energy reset and intentionally form a new habit that can feed your creativity.

Get started with these simple yet engaging practices to spark your energy and create momentum.

Ease your brain into writing with a ritual

Do you find it difficult to launch straight into a relaxing or creative project when you've just finished work for the day? It's not your fault. Your brain needs help transitioning from one task to another, especially when they're completely different types of activities. Thankfully, you can cue your brain to switch from work mode into creative mode with simple rituals that reduce the mental friction of getting started.

Create an environment that allows you to relax and leave the worries of the day behind. Turn on soft lighting, put on a curated playlist, pour a fresh cup of tea or coffee and grab a notebook that makes you feel excited to put pen to paper. It's an easy way to train your brain to reset, so you can focus and tap into your thoughts, feelings and creative ideas.

Boost your mood with intentional color choices

Color is more than just an aesthetic choice. It has the power to shift your mood, energy and mindset, and — ultimately — fuel your creativity.

This isn't speculation; it's color science. Many studies have shown that different colors can evoke different emotions and stimulate different cognitive functions. For example, blues can create a sense of calm and focus, yellows can inspire optimism and creativity, and reds can stimulate energy and action. That means that the color you choose can help you tap into the mood-boosting and focus-enhancing effects of that hue.

Activate your energy while writing by choosing sun-kissed shades like reds, oranges and yellows to fuel your vitality, motivation and ideas. A tool like the G2 Boost Energy Pack can help integrate color science into your life by giving you the power to supercharge your energy and attitude for creative ventures.

This intentionally curated energy toolkit is thoughtfully designed to support your mood and creativity. The pack features shades of red to stimulate alertness and action, orange to encourage enthusiasm and yellow to spark optimism and idea generation. By incorporating this curated set of pens into your writing ritual, you have the tools to enhance the energy and momentum of your day.

Feeling overwhelmed? Take your thoughts outdoors

In a world where stimulation is everywhere, it's easy to feel overwhelmed and distracted. Instead of trying to fight through the mental fatigue, try writing outdoors to restore your attention, mental clarity and creativity.

Connecting with nature has a grounding effect on your body and mind. In fact, studies have shown just 20 minutes in nature can significantly lower your stress hormone levels.

Take a walk in the park or nature preserve with a notebook and pen in a meaningful color and find a quiet spot. Take a moment to revel in the rejuvenating power of fresh air, sunshine and the feel of grass underneath your feet. Start by listing what you see, then write down how each item from that list makes you feel. You'll quickly find that pairing nature with writing by hand can be the perfect remedy for mental overload.

Surprise the group chat with letters

Writing letters by hand forces you to slow down and think deeply about your loved one, cultivating a deeper connection. Instead of relying solely on digital communication to keep up with friends and family near and far, try to reconnect by sending handwritten letters.

Digital communication is convenient, but it can also be impersonal and fleeting. However, when you write and send a letter, you can show the recipient that you care for them in a lasting, tangible way. Your friend or loved one will have a lasting memento that they can hold and reread again and again.

Choose stationary or notecards that feel special — whether through inviting colors such as blue that can promote productivity or green that signal a calm and balanced tone — or playful details to help you look forward to letter writing. Select vibrant pen colors like those from the G2 Boost Collection to reflect or enhance the emotional impact of your words.

Capture inspiration without digital distractions

Have you ever had a brilliant idea that you attempted to save to your notes app, but got distracted by notifications before you could capture it? Don't let your ideas fly away. Stay in the moment and capture your ideas quickly on paper.

Whether you're at your desk, in the kitchen or out running errands, keep a notebook or notepad nearby. Not only will you be able to quickly record your ideas, but the physical act of writing also strengthens your memory pathways so your ideas can stick. When you have time, you can flip through your notebook and let your ideas build creative momentum.

Build creative moments and energy with intention

Think of creativity and energy as muscles you can activate and strengthen with intentional practices like writing by hand. While it may be challenging at first, tailoring your environment and routines to prioritize writing can spark ingenuity, sharpen your focus and drive your desire to create.

To explore more energizing tools to support your writing and cultivate creative ideas, visit PowerToThePen.com.

TD is an involuntary movement disorder that is characterized by uncontrolled movements of the face, torso, limbs, fingers and toes. Learn more about TD, living with TD and how to treat TD by visiting TalkAboutTD.com.

So, when Kathy went in for what she thought was yet another routine kidney-stone procedure, something she'd dealt with since she was 30, she didn't expect anything new. This time, however, her doctor discovered something very different: a tumor in her ureter.

"I wasn't prepared for that," Kathy remembers. "All I heard was the word cancer."

Understanding a rare disease that often recurs

Most patients with urothelial cancer have tumors in the lower urinary tract — only 5% to 10% occur in the upper tract.¹ Low-grade upper-tract urothelial cancer (LG-UTUC) is uncommon, affecting approximately 6,000-7,000 patients per year,^2,3 but for those diagnosed, the road can be uniquely difficult. Tumors grow in the upper urinary tract, including the kidney — a narrow, curved passageway where tools and cameras can only reach so far.⁴ Even with kidney-sparing options like endoscopic surgery, these tumors tend to come back, often requiring repeated procedures. Many patients spend years cycling through laser ablations, scopes, and follow-ups, only to face additional recurrence.⁴

For decades, this high recurrence rate and the difficulty of completely removing tumors meant that many people faced nephroureterectomy (full kidney and ureter removal), even when their cancer was low-grade. While this surgery can be lifesaving, it also leaves patients with only one kidney and can limit future treatment options.^2-4

"These tumors can be difficult to reach and hard to completely eradicate endoscopically," says Trushar Patel, M.D., Associate Professor and Vice Chairman in the Department of Urology at the University of South Florida. "For a long time, patients needed another option that could target the tumor directly, without the need to remove the kidney."

A path forward to treating LG-UTUC

Once Kathy's diagnosis was confirmed as LG-UTUC, her doctor recommended JELMYTO^® (mitomycin) for pyelocalyceal solution.

JELMYTO combines mitomycin with a sterile hydrogel, a proprietary reverse-thermal technology (RTGel^®), which is liquid when chilled and converts to a semi-solid gel at body temperature. JELMYTO fills hard-to-reach places in the upper urinary tract and stays in the kidney for four to six hours, making chemoablation possible. Unlike systemic chemotherapy, JELMYTO is administered locally and works right where the tumor lives. Afterwards, JELMYTO is excreted through normal urine flow.

JELMYTO was approved for the treatment of LG-UTUC based on the Olympus clinical trial, which evaluated the safety and efficacy of JELMYTO. The study followed adults at different stages of their LG-UTUC journeys, including many who had been treated before and some whose tumors were too difficult to remove with standard endoscopic treatments. After six weeks of once-a-week treatment plan with JELMYTO, 58% of patients achieved complete absence of tumor lesions after three months. More than half of these patients (56%) remained tumor-free a year after.⁵ The most common side effects observed in Olympus included swelling and narrowing of the tube that carries urine from the kidney to the bladder (ureteric obstruction), bone marrow problems, urinary tract infection, blood in urine, side pain, nausea, trouble with urination, kidney problems, vomiting, tiredness, and stomach (abdomen) pain. You should not receive JELMYTO if you have a hole or tear (perforation) of your bladder or upper urinary tract. See Important Safety Information below.

"Being able to deliver treatment straight to the upper tract with JELMYTO is a major advancement," says Dr. Patel. "It means we're targeting the cancer where it is, with a non-surgical option that doesn't require major surgery."

Kathy felt relieved that there was a localized option and that her doctor believed it was right for her. When she learned that her insurance covered JELMYTO, she didn't hesitate. "Sign me up," she told her doctor.

To receive the therapy, Kathy first had a nephrostomy tube placed in her kidney. Each week for six weeks, she, her husband and daughter, went to the clinic for her outpatient treatment.

Moving forward

After Kathy completed treatment, her doctor performed a biopsy before removing the nephrostomy tube. She still remembers the relief she felt when her doctor walked in smiling. "This really accomplished the goal," he told her.

Today, Kathy describes her experience with gratitude — not only for the outcome, but for the support of her family and the care she received. "I am just so grateful for JELMYTO," she says. This treatment made a difference. To see more of Kathy's story, visit: https://www.jelmyto.com/patient/resources/#materials. Kathy was compensated for participating in this interview.

Individuals with LG-UTUC, including those who have experienced repeat recurrences and want to explore kidney-sparing options, should talk with their doctor about all available treatments, including JELMYTO. To learn more about JELMYTO and access resources designed to support patients through the treatment-coordination process, visit https://www.jelmyto.com/patient/ and speak with your healthcare provider.

Approved Use for JELMYTO

JELMYTO^® is a prescription medicine used to treat adults with a type of cancer of the lining of the upper urinary tract including the kidney called low-grade Upper Tract Urothelial Cancer (LG-UTUC).

Important Safety Information

You should not receive JELMYTO if you have a hole or tear (perforation) of your bladder or upper urinary tract.

Before receiving JELMYTO, tell your healthcare provider about all your medical conditions, including if you:

• are pregnant or plan to become pregnant. JELMYTO can harm your unborn baby. You should not become pregnant during treatment with JELMYTO. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with JELMYTO.
  Females who are able to become pregnant: You should use effective birth control (contraception) during treatment with JELMYTO and for 6 months after the last dose.
  Males being treated with JELMYTO: If you have a female partner who is able to become pregnant, you should use effective birth control (contraception) during treatment with JELMYTO and for 3 months after the last dose.
• are breastfeeding or plan to breastfeed. It is not known if JELMYTO passes into your breast milk. Do not breastfeed during treatment with JELMYTO and for 1 week after the last dose.
• Tell your healthcare provider if you take water pills (diuretic).

How will I receive JELMYTO?

• Your healthcare provider will tell you to take a medicine called sodium bicarbonate before each JELMYTO treatment.
• You will receive your JELMYTO dose from your healthcare provider 1 time a week for 6 weeks. It is important that you receive all 6 doses of JELMYTO according to your healthcare provider's instructions. If you miss any appointments, call your healthcare provider as soon as possible to reschedule your appointment. Your healthcare provider may recommend up to an additional 11 monthly doses.
• JELMYTO is given to your kidney through a tube called a catheter.
• During treatment with JELMYTO, your healthcare provider may tell you to take additional medicines or change how you take your current medicines.

After receiving JELMYTO:

• JELMYTO may cause your urine color to change to a violet to blue color. Avoid contact between your skin and urine for at least 6 hours.
• To urinate, males and females should sit on a toilet and flush the toilet several times after you use it. After going to the bathroom, wash your hands, your inner thighs, and genital area well with soap and water.
• Clothing that comes in contact with urine should be washed right away and washed separately from other clothing.

JELMYTO may cause serious side effects, including:

• Swelling and narrowing of the tube that carries urine from the kidney to the bladder (ureteric obstruction). If you develop swelling and narrowing, and to protect your kidney from damage, your healthcare provider may recommend the placement of a small plastic tube (stent) in the ureter to help the kidney drain. Tell your healthcare provider right away if you develop side pain or fever during treatment with JELMYTO.
• Bone marrow problems. JELMYTO can affect your bone marrow and can cause a decrease in your white blood cell, red blood cell, and platelet counts. Your healthcare provider will do blood tests prior to each treatment to check your blood cell counts during treatment with JELMYTO. Your healthcare provider may need to temporarily or permanently stop JELMYTO if you develop bone marrow problems during treatment with JELMYTO.

The most common side effects of JELMYTO include: urinary tract infection, blood in your urine, side pain, nausea, trouble with urination, kidney problems, vomiting, tiredness, stomach (abdomen) pain.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit http://www.fda.gov/medwatch or call 1-800-FDA-1088. You may also report side effects to UroGen Pharma at 1-855-987-6436.

Please visit www.jelmyto.com for JELMYTO Full Prescribing Information, including the Patient Information, for additional information.

JELMYTO^® and UroGen^® are registered trademarks of UroGen Pharma, Ltd.

©2021 UroGen Pharma, Inc. All rights reserved.

JEL-PT-ISI-002

1. Evmorfopoulos K, Mitrakas L, Karathanasis A, Zachos I, Tzortzis V, Vlachostergios PJ. Upper Tract Urothelial Carcinoma: A Rare Malignancy with Distinct Immuno-Genomic Features in the Era of Precision-Based Therapies. Biomedicines. 2023;11(7):1775. Published 2023 Jun 21. doi:10.3390/biomedicines11071775

2. Upfill-Brown A, Lenis AT, Faiena I, et al. Treatment utilization and overall survival in patients receiving radical nephroureterectomy versus endoscopic management for upper tract urothelial carcinoma: evaluation of updated treatment guidelines. World J Urol. 2019;37(6):1157-1164. doi:10.1007/s00345-018-2506-1

3. Cutress ML, Stewart GD, Zakikhani P, Phipps S, Thomas BG, Tolley DA. Ureteroscopic and percutaneous management of upper tract urothelial carcinoma (UTUC): systematic review. BJU Int. 2012;110(5):614-628. doi:10.1111/j.1464-410X.2012.11068.x

4. Raman J, Shore ND. Management of Low-grade Upper Tract Urothelial Carcinoma: An Unmet Need. Rev Urol. 2020;22(1):1-8.

5. JELMYTO [package insert]. Princeton, NJ: UroGen Pharma, Inc.; June 2025.

US-JEL-01040 04/2026

"For anyone who is health-conscious, eating more greens is a primary goal and sometimes a struggle," said Valerie Agyeman, RD, and Nature Made brand partner. "The good news is, it's easier than you may think to meet that goal."

Here's why eating greens is so vital, and ways to make it easier.

Why green vegetables?

While all vegetables are high in fiber, vitamins and minerals, green veggies, especially leafy greens like kale and spinach, also support your metabolism, and may reduce the risk of certain diseases. In addition, cruciferous vegetables (think broccoli, brussels sprouts and cabbage) are especially rich in nutrients and fiber, which aids gut health and provides antioxidants plus other beneficial compounds that support your overall health.

Try some of these methods to help you enjoy more greens in your daily routine.

Keep them fresh

After purchasing (or growing!) green veggies, remove wilted or rotten areas to prevent the rot from spreading. Don't wash veggies until you're ready to use them, as additional moisture can spoil them.

Dry veggies first, then store in an air-tight container or sealed plastic bag along with dry paper towel to absorb excess moisture. Keep them in the crisper drawer in your fridge, and enjoy them soon!

Switch them up

Not keen on kale? Look for other options to find what you love. Experiment with turnip greens, watercress, chard or others for more variety in flavor and texture. Veggies can be enjoyed raw, sauteed, creamed, stir-fried or steamed, so discover what methods you like best.

Pro tip: Search for recipes from cuisines that typically highlight specific veggies, like Chinese dishes featuring bok choy or Italian food with arugula.

Flex your culinary muscles

You can find plenty of ways to incorporate green veggies into foods and drinks. Love smoothies? Combine greens with fruit along with coconut water or your favorite milk to create your own unique blend. Frozen fruit or veggies create a refreshing shake-like drink you can enjoy for breakfast, lunch or as a treat.

Spruce up green salads with seasonal berries, toasted nuts or grated cheese for extra flavor, color and texture. Try new dressings to keep salads interesting, boosting flavor by adding Dijon mustard, soy sauce, rice wine vinegar or fresh minced herbs.

Finely chop greens or chiffonade (cut into thin strips) to use in pasta dishes like spaghetti and lasagna, or as pizza toppings; they'll resemble fresh basil and blend right in! Use chopped greens in soups, burgers or meat loaf, casseroles or as an extra layer of freshness for your favorite grilled sandwich or omelet.

You can easily add greens without drastically changing the taste or texture of most dishes. Avoid adding unwanted moisture with extra veggies by blanching first, then squeezing out extra moisture. Adding a more bitter veggie like arugula, broccoli rabe, collard greens or chard? Reduce bitterness with additional salt, healthy fats like olive oil, more acid (lemon juice or vinegar) or aromatics such as garlic and onions. Taste your food as you cook and adjust as needed!

Pro tip: Most greens reduce a lot in volume when cooked, so you can add more than you think!

Supplement your greens intake

For busy people seeking a boost,* get more greens into your daily regimen by adding Nature Made SuperGreens supplements, available in a drink powder or capsule form.

SuperGreens with Prebiotic Powder Drink Mix contains one cup of green vegetables (kale, spinach and broccoli) in each daily serving.* Each super greens serving offers a simple, tasty way to enjoy a good source of prebiotic fiber to support digestive health, plus 12 essential nutrients to support energy,** immune and whole body health.†

SuperGreens Capsules with Probiotics is made with a half cup of real green vegetables (kale, spinach and broccoli) and 2 billion CFU (Colony Forming Units) of probiotics per 3 capsules to support digestive health, plus 12 essential nutrients to support energy,** immune and whole body health.†

"Remember, SuperGreens powder or capsules are meant to complement your daily diet, so it's important to keep enjoying plenty of fresh vegetables throughout the day," added Valerie Agyeman, RD.

To learn more and shop the line of Nature Made SuperGreens products and more, visit NatureMade.com.

* Consume in addition to your daily intake of vegetables.
** B vitamins help convert food into cellular energy.
† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Joe was just nine years old when he realized he wanted to play guitar. The youngest of eight children in a music-filled household, he grew up listening to records, and the songs replayed in his mind all day long. By his teenage years, Joe was performing professionally and mastered nearly every genre alongside his band: country, rock, R&B, blues and gospel. For Joe, guitar has never been about making a living — it's a part of who he is.

Then, at age 60, Joe started experiencing unfamiliar symptoms that began affecting the very thing that he relied on most to play: his hands. At this time, Joe was diagnosed with moderate-to-severe atopic dermatitis (eczema), which can cause itching and painful skin cracking and bleeding. With the symptoms primarily on his hands, Joe found himself struggling to play guitar and feeling concerned that he might not be able to continue.

Eczema is a chronic skin condition characterized by intense itching, dry skin and inflammation that can result in affected skin cracking, weeping or oozing, and becoming scaly over time. Approximately seven percent of adults in the U.S. live with eczema and 40% of them have moderate-to-severe disease, and these rates are even higher in children ages 12 to 17: more than 9% have eczema and 50% experience moderate-to-severe disease. Eczema inflammation may cause symptoms to pop up anywhere on the body with little warning.

An Off-Beat Interruption

It was June 2022 when Joe first realized the impact of his eczema symptoms. He was performing with a local gospel band when he noticed, "fissures and tears [had] developed while I played. I had blood running down onto my guitar," said Joe.

After years of trial and error and cycling through a variety of topical prescriptions and home remedies, Joe was still struggling to manage his symptoms. "Being diagnosed with eczema late in life was already shocking, but when I realized that playing my guitar was getting hard, I felt disheartened." Finally, Joe's bandmate spoke up and encouraged him to raise his concerns to a dermatologist, and Joe decided it was time to take action.

Finding His Rhythm

For people living with eczema, having a conversation with a dermatologist is a crucial step in finding relief. When Joe voiced his worries about how eczema was impacting his ability to perform, he finally found the care he was looking for — a dermatologist who listened to him and understood his symptoms. He was then introduced to EBGLYSS^® (lebrikizumab-lbkz) injection 250mg/2mL, which is approved as a first-line biologic treatment for adults and children 12 years and older who weigh at least 88 pounds with moderate-to-severe atopic dermatitis after topical prescription therapies. When taken as directed, EBGLYSS works around the clock to target eczema inflammation from the inside out. EBGLYSS can be taken at home with a pre-filled pen once-monthly after taking EBGLYSS every two weeks for four months (or later once achieving adequate clinical response) and can be used with or without topical corticosteroids. Do not use if you are allergic to EBGLYSS or any of its ingredients. See full Safety Summary below, including information regarding severe allergic reactions, eye problems, parasitic infections, and vaccinations.

"My dermatologist looked at my hands and said he had a medication for me that could help me control my symptoms," said Joe. He began to see improvement within a few weeks of starting treatment, and he felt comfortable playing guitar again. "Now, I don't always have to rely on topical prescriptions to treat my eczema. I take an injection of EBGLYSS once a month, which helps with my symptoms. I feel very lucky."

With EBGLYSS, Joe experienced fewer flares. The efficacy of EBGLYSS was studied in two clinical trials of adults and children (children were ages 12+ and weighed at least 88 pounds) with moderate-to-severe eczema that was not well controlled with topical medicines. The studies also measured the safety and efficacy of EBGLYSS at one year. Some people taking EBGLYSS saw clear or almost-clear skin at 4 weeks. In an average of the two studies, 38% of people achieved clear or almost-clear skin with EBGLYSS at 16 weeks vs 12% who received placebo. Of the people who experienced clear or almost-clear skin at 16 weeks, 77% still saw clearance at 1 year compared with 48% of people who stopped EBGLYSS at week 16 and were then treated with placebo.

Helping Others Find Their Way Back to the Music

Since getting back to everyday life and playing guitar without having his eczema symptoms top of mind, Joe hopes to encourage others to find a treatment that can work for them.

"Through this journey, I've learned that there's real help out there for eczema. I would encourage anybody going through what I experienced to speak with their doctor on how to help take control of their symptoms."

Lilly is committed to helping people living with dermatological conditions, like Joe. If you have moderate-to-severe eczema, talk to your doctor about your specific symptoms and ask if EBGLYSS could be the right treatment for you. Visit EBGLYSS.lilly.com to learn more.

INDICATION AND SAFETY SUMMARY
EBGLYSS^® (EHB-glihs) is an injectable medicine used to treat adults and children 12 years of age and older who weigh at least 88 pounds (40 kg) with moderate-to-severe eczema (atopic dermatitis) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. EBGLYSS can be used with or without topical corticosteroids.

It is not known if EBGLYSS is safe and effective in children less than 12 years of age or in children 12 years to less than 18 years of age who weigh less than 88 pounds (40 kg).

Warnings - Do not use EBGLYSS if you are allergic to lebrikizumab-lbkz or to any of the ingredients in EBGLYSS. See the Patient Information leaflet that comes with EBGLYSS for a complete list of ingredients.

Before using
Before using EBGLYSS, tell your healthcare provider about all your medical conditions, including if you:

• Have a parasitic (helminth) infection.
• Are scheduled to receive any vaccinations. You should not receive a "live vaccine" if you are treated with EBGLYSS.
• Are pregnant or plan to become pregnant. It is not known if EBGLYSS will harm your unborn baby. If you become pregnant during treatment with EBGLYSS, you or your healthcare provider can call Eli Lilly and Company at 1-800-LillyRx (1-800-545-5979) to report the pregnancy.
• Are breastfeeding or plan to breastfeed. It is not known if EBGLYSS passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Possible side effects
EBGLYSS can cause serious side effects, including:

• Allergic reactions. EBGLYSS can cause allergic reactions that may sometimes be severe. Stop using EBGLYSS and tell your healthcare provider or get emergency help right away if you get any of the following signs or symptoms:
  • breathing problems or wheezing
  • swelling of the face, lips, mouth, tongue or throat
  • hives
  • itching
  • fainting, dizziness, feeling lightheaded
  • skin rash
  • cramps in your stomach area (abdomen)
• Eye problems. Tell your healthcare provider if you have any new or worsening eye problems, including eye pain or changes in vision, such as blurred vision.

The most common side effects of EBGLYSS include:

• eye and eyelid inflammation, including redness, swelling, and itching
• injection site reactions
• shingles (herpes zoster)

These are not all of the possible side effects of EBGLYSS. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

How to take

• See the detailed "Instructions for Use" that comes with EBGLYSS for information about how to prepare and inject EBGLYSS and how to properly store and throw away (dispose of) used EBGLYSS prefilled pens and prefilled syringes.
• Use EBGLYSS exactly as prescribed by your healthcare provider.
• EBGLYSS is given as an injection under the skin (subcutaneous injection).
• If your healthcare provider decides that you or a caregiver can give the injections of EBGLYSS, you or a caregiver should receive training on the right way to prepare and inject EBGLYSS. Do not try to inject EBGLYSS until you have been shown the right way by your healthcare provider. In children 12 years of age and older, EBGLYSS should be given by a caregiver.
• If you miss a dose of EBGLYSS, inject the missed dose as soon as possible, then inject your next dose at your regular scheduled time.

Learn more
EBGLYSS is a prescription medicine available as a 250 mg/2 mL injection prefilled pen or prefilled syringe. For more information, call 1-800-545-5979 or go to ebglyss.lilly.com.

This summary provides basic information about EBGLYSS but does not include all information known about this medicine. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking to your doctor. Be sure to talk to your doctor or other healthcare provider about EBGLYSS and how to take it. Your doctor is the best person to help you decide if EBGLYSS is right for you.

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EBGLYSS^® and its delivery device base are trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.

CMAT-14119 04/2026 © Lilly USA, LLC 2026. All rights reserved.

ALYFTREK is a prescription medicine for people six years and older who have a diagnosis of CF and at least one genetic change (variant) in the CFTR gene that is responsive to ALYFTREK or results in protein production.⁶ Talk to your healthcare provider to learn if you have an indicated CF gene variant. If your genotype is unknown, an FDA-cleared CF variant test should be used to confirm the presence of the indicated variant(s).⁶

Advancing treatment for cystic fibrosis

Cystic fibrosis is a rare, life-shortening, progressive genetic disease caused by variants in the CFTR gene that affect the respiratory system, digestive system and other organs.^8,9 This gene was only discovered in 1989, leading to innovative work in the CF space that focused on targeting the underlying gene dysfunction.¹ This led to the development of a new class of medicine—CFTR modulator therapies.^1,10

Today, CFTR modulator therapies from Vertex Pharmaceuticals, including ALYFTREK, are treating over 75,000 people with CF in over 60 countries on six continents.^11,12 This population represents approximately two-thirds of diagnosed people with CF who are eligible for CFTR modulator therapies.¹¹

"With more than 2,000 variants of the CFTR gene that cause cystic fibrosis, this label expansion brings ALYFTREK, our most advanced and our only once-daily therapy, to even more people with CF variants," said Meg Duncan, Head of U.S. Medical Affairs-CF at Vertex.^6,13 "This is the heart of our ambition—to serially innovate in hopes of bringing our transformative therapies to more people living with CF and give them the opportunity to live life without limits."

A novel approach for rare disease innovation

While there are thousands of CFTR variants, over 80% of CF patients have one in common—known as a F508del variant.¹ There are another 10% to 18% of patients who have a rare CFTR variant.^1,4 In most cases, there are so few patients with each rare variant that a clinical trial is incredibly difficult to organize. A final approximately 7% do not make CFTR protein at all, making this population even more challenging to reach.⁴

In an effort to bring transformative therapies to more people living with CF, Vertex developed assays of Fischer Rat Thyroid (FRT) cells to replicate these rare variants, which allows them to study how the medicines could work for these different patient groups.¹⁴

"For 25 years, we've been dedicated to CF research, including the last decade focused on rare variants, all in partnership with the incredible CF community. Their stories have inspired us to push boundaries, expand the reach of our medicines and make meaningful progress toward helping even more patients," said Duncan. "We're deeply grateful for their role in this journey and remain committed to advancing together."

To learn more about ALYFTREK and treatment eligibility, visit ALYFTREK.com or talk to your doctor.

This article was sponsored by Vertex Pharmaceuticals Incorporated.

What is ALYFTREK (vanzacaftor/tezacaftor/deutivacaftor)?

ALYFTREK is a prescription medicine for people 6 years and older who have a diagnosis of cystic fibrosis (CF) and at least 1 genetic change (variant) in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that is responsive to ALYFTREK or results in protein production.

Talk to your healthcare provider to learn if you have an indicated CF gene variant.

It is not known if ALYFTREK is safe and effective in children under 6 years.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about ALYFTREK?

Elevated liver enzymes have been observed in patients taking ALYFTREK. Cases of serious liver damage and liver failure leading to transplantation and death have been seen in some people with or without a history of liver problems taking elexacaftor/tezacaftor/ivacaftor (TRIKAFTA), a medicine which has the same or similar active ingredients as ALYFTREK.

• Your healthcare provider will do blood tests to check your liver:
  • before you start ALYFTREK
  • then every month during your first 6 months
  • then every 3 months during the next 12 months
  • then at least every year while taking ALYFTREK
    
    

• Your healthcare provider may do blood tests to check the liver more often if you have had high liver enzymes in your blood in the past or are experiencing signs or symptoms of liver injury.
  
  

• Stop taking ALYFTREK and call your healthcare provider right away if you have any of the following symptoms of liver problems:
  • pain, swelling, or discomfort in the upper right stomach (abdominal) area
  • yellowing of your skin or the white part of your eyes
  • mental changes
  • nausea or vomiting
  • dark, amber-colored urine
  • loss of appetite
  • fluid in your stomach area (ascites)

What should I tell my healthcare provider before taking ALYFTREK?

Before taking ALYFTREK, tell your healthcare provider about all of your medical conditions, including if you:

• have or have had liver problems
• are allergic to ALYFTREK or any ingredients in ALYFTREK. See the end of the Medication Guide for a complete list of ingredients in ALYFTREK
• have taken another medicine with elexacaftor, tezacaftor, or ivacaftor before and temporarily or permanently stopped because of side effects. Your healthcare provider may want to see you more often
• have kidney problems
• have or have had mental health problems
• are pregnant or plan to become pregnant. It is not known if ALYFTREK will harm your unborn baby. You and your healthcare provider should decide if you will take ALYFTREK while you are pregnant
• are breastfeeding or planning to breastfeed. It is not known if ALYFTREK passes into your breast milk. You and your healthcare provider should decide if you will take ALYFTREK while you are breastfeeding

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

ALYFTREK may affect the way other medicines work, and other medicines may affect how ALYFTREK works. The dose of ALYFTREK may need to be adjusted when taken with certain medicines. Ask your healthcare provider or pharmacist for a list of these medicines if you are not sure.

Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

What should I avoid while taking ALYFTREK?

• Avoid food or drink that contains grapefruit while you are taking ALYFTREK

What are the possible or reasonably likely side effects of ALYFTREK?

ALYFTREK can cause serious side effects, including:

• See "What is the most important information I should know about ALYFTREK?"
  
  

• Serious allergic reactions can happen to people who are treated with ALYFTREK. Call your healthcare provider or go to the emergency room right away if you have any symptoms of an allergic reaction. Symptoms of an allergic reaction may include:
  • rash or hives
  • tightness of the chest or throat or difficulty breathing
  • light-headedness or dizziness
    
    

• Increased pressure around the brain (intracranial hypertension) has happened in people treated with medicines containing the same or similar ingredients as ALYFTREK. If you experience an unusual headache, blurred vision, double vision, or vision loss, call your healthcare provider right away
  
  

• Serious mental health problems, such as anxiety, depression, suicidal thoughts and behaviors, and trouble sleeping, have happened in people treated with ALYFTREK. If you experience new or worsening mental health problems, call your healthcare provider right away
  
  

• Abnormality of the eye lens (cataract) has happened in some children and adolescents treated with ALYFTREK. If you are a child or adolescent, your healthcare provider should perform eye examinations before and during treatment with ALYFTREK to look for cataracts

The most common side effects of ALYFTREK include:

• cough
• pain or swelling of your nose or throat (nasopharyngitis)
• upper respiratory tract infection (common cold), including stuffy and runny nose
• headache
• mouth or throat pain
• flu (influenza)
• tiredness
• increase in liver enzymes
• rash
• sinus congestion

Your healthcare provider should monitor you during treatment with ALYFTREK. You may require additional monitoring if your treatment with a medicine that works like ALYFTREK has been previously stopped or interrupted because of side effects.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of ALYFTREK. For more information, ask your healthcare provider or pharmacist. Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Please see full Prescribing Information, including Medication Guide with Important Warning.

(BPT) - Imagine what it would be like if your body was constantly battling infections, without a clear cause or diagnosis. This difficult search for answers and care is a daily reality for many living with Primary Immunodeficiencies (PI), a group of rare conditions that weaken the immune system.¹

An estimated 6 million people worldwide are impacted by PI, yet a staggering 70-90% remain undiagnosed.¹ This World PI Week, observed from April 22-29, the global community is uniting under the powerful call to action, "We Can't Wait" — championing for faster diagnoses and access to innovative care options.²

The Long Road to Diagnosis

For many individuals living with PI, the journey can be a long cycle of frequent, severe and prolonged infections, compounded by years of unexplained symptoms, doctor visits and misdiagnoses.¹ This frustrating path can delay essential care and leave patients feeling isolated as they navigate a condition that is often rare, unfamiliar and difficult to recognize.

Finding a Path Forward

Ewa, a dedicated teacher, navigated this persistent pattern of illness for years. A pivotal moment came when she received a PI diagnosis at 28 years old which finally provided the answers she sought. This opened the door to understanding her condition and accessing the specialized support and therapies needed to manage it.

The Power of Plasma

For a majority of PI patients like Ewa, treatments made from human plasma are not just an option, but rather the only available path to providing the vital immune support their bodies cannot naturally produce.³ Plasma cannot be created in a lab and comes solely from donations from healthy people.⁴

Organizations like BioLife Plasma Services, part of Takeda, play a crucial role in collecting this essential plasma, which Takeda then develops into critical therapies. It's a remarkable chain of human connection — turning one person's generosity into another's crucial support.

A Collective Call to Action: "We Can't Wait"

As World PI Week reminds us, "We Can't Wait" for progress, when answers and critical care options are within reach. By raising awareness and supporting diagnostic efforts, we can collectively empower those living with PI to find their path forward and access the crucial care they deserve.

To learn more about PI and the power of plasma-derived therapies, watch the video above and read Ewa's full story at Takeda.com.

As a film editor, there's no such thing as a typical day. One day might be spent combing through hours of footage to find the perfect soundbite, while another is spent brainstorming with a director to find the heart of a story. For Michael, though, the unpredictable moments of daily life go beyond his job as a film editor.

Michael is one of approximately 7,000 people in the U.S. living with hereditary angioedema (HAE), a rare and potentially life-threatening genetic condition that involves recurring and unpredictable attacks of severe swelling, or angioedema, in various parts of the body like the hands, feet, stomach, face and/or throat.^1-3 Some attacks can be life-threatening, and not knowing when they might happen can lead to feelings of anxiety and fear, making simple daily tasks more difficult.¹

HAE attacks are unpredictable, and triggers vary from person to person.¹ For Michael, the unpredictable nature of sudden attacks meant that it was a constant challenge for him to fully participate at work, in his friendships or in his relationships with family.

Life with HAE

"Growing up, it felt like I was constantly balancing on a tightrope, always on the lookout for attacks. I remember school talent shows and other social events that quickly turned into embarrassing and isolating experiences if I had an attack," reflects Michael. "Some attacks aren't immediately visible to other people, so it was often difficult to explain. Not knowing when the next attack might come kept me on edge, and I often felt like I would get sick at the worst possible time, forcing me to cancel plans at the last minute. It was incredibly isolating."

For those living with HAE, the unpredictability of attacks can often come with a series of lifestyle tradeoffs.¹ An Ionis-sponsored Harris Poll* revealed that 72% of patients surveyed reported they make tradeoffs in their daily lives due to the unpredictability of attacks.⁴ In addition, 89% reported missing or avoiding events like work, cookouts, concerts, dates and even altering travel plans in the past 12 months due to their HAE.⁴

"Even in times that I considered my HAE to be well managed, I was still experiencing minor swells that would impact my ability to go about my usual daily activities," says Michael. "If my hands swell, for example, it can make my job incredibly difficult."

Finding a treatment option that works for you

After years of struggling to manage his HAE and cycling through different treatment options, Michael's doctor introduced him to DAWNZERA™ (donidalorsen). DAWNZERA is a prescription medicine used to prevent hereditary angioedema (HAE) attacks in adults and children 12 years of age and older. It is not known if DAWNZERA is safe and effective in children under 12 years of age.⁵ Do not use DAWNZERA if you have had a serious allergic reaction, including anaphylaxis, to donidalorsen or any of the ingredients in DAWNZERA.

"Since starting on DAWNZERA, I've experienced fewer HAE attacks, even during times of stress that used to be a trigger for me. Now, I can show up more reliably for my team at work, my friends and myself," shares Michael. "Having my HAE better under control has made me realize how much extra effort I was putting in to fulfill my responsibilities when I was having more regular attacks."

Disconnects in the doctor's office

While Michael's experience with DAWNZERA is encouraging, finding the right treatment option for you can be a complex journey for many people living with HAE. In fact, many find it difficult to fully communicate the impact of their HAE, including in conversations with their doctor.

Open dialogue is crucial to help bridge the gap between people with HAE and their doctors. Although 85% of physicians surveyed reported they felt they understood how much HAE impacts their patients' day-to-day lives, more than half of patients expressed a desire for their doctors to better grasp their true realities. This disconnect can affect a provider's perception of disease control and contribute to differences in how patients and providers view attack frequency, impact on quality of life and the effectiveness of the patient's current treatment.⁴

"Putting your HAE experience into words can be a challenge. We see that patients may be hesitant to share the full extent of their disease burden with their doctor if they feel they've exhausted all options. As a result, some physicians may be overestimating patients' level of disease control with their current treatment," says Dr. William Lumry, M.D., clinical professor of Internal Medicine, University of Texas Southwestern Medical School. "In my practice, I've found that using a standardized tool or questionnaire can help by providing a simple way for patients to evaluate and communicate their disease burden and supporting informed conversations about treatment options."

Flipping the switch on treatment expectations

According to the same survey, nearly two-thirds of patient respondents said they have not yet found what they considered to be the best treatment for them.⁴

For Michael, finding a treatment option that worked for him marked a turning point in his life. "For me, it's just easy – easy to take, easy to incorporate into my life and it helps prevent my attacks," says Michael.

With multiple treatment options available, like DAWNZERA, patients like Michael can flip the switch on their HAE treatment plan.

Please see full Prescribing Information and Patient Information for DAWNZERA, also available at DAWNZERA.com.

Michael is a real DAWNZERA patient and a paid consultant for Ionis Pharmaceuticals. His experience is individual to him; results may vary from person to person.

*The survey was sponsored by Ionis Pharmaceuticals and conducted online in the U.S. by The Harris Poll among two groups: 150 U.S. adults aged 18 and older who have been diagnosed with HAE by a HCP, and 228 licensed and board-certified allergists or immunologists aged 18 or older, practicing in the U.S., who have been in practice between 3 and 35 years, spend at least 60% of their professional time treating patients, have treated at least 3 patients living with HAE in the past 12 months and have at least 1 HAE patient on prophylactic therapy. The patient survey was conducted from November 13–December 5, 2024, using a 70-question questionnaire, and the HCP survey was conducted from November 12–December 20, 2024, using a 56-question questionnaire; both surveys consisted primarily of closed-ended pick-list and scale questions. Full research methodology for both surveys is available upon request.

IMPORTANT SAFETY INFORMATION & INDICATION

Do not use DAWNZERA if you have had a serious allergic reaction, including anaphylaxis, to donidalorsen or any of the ingredients in DAWNZERA.

Before using DAWNZERA, tell your healthcare provider about all of your medical conditions, including if you are pregnant or plan to become pregnant, are breastfeeding or plan to breastfeed. It is not known if DAWNZERA can harm your unborn baby, or if it passes into your breast milk and if it can harm your baby.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of DAWNZERA?
DAWNZERA can cause serious side effects including allergic reactions. Allergic reactions can include rash, trouble breathing, chest pain, fainting, dizziness, feeling lightheaded, swelling of the face, lips or tongue, and itching. Stop using DAWNZERA and call your healthcare provider or get emergency help right away if you have any of these symptoms.

The most common side effects of DAWNZERA include injection site reactions (such as redness or pain at the injection site), upper respiratory tract infection, urinary tract infection and abdominal discomfort.

These are not all the possible side effects of DAWNZERA. Tell your healthcare provider or treatment team about any side effects you may have.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call 1-800-FDA-1088.

INDICATION

DAWNZERA™ (donidalorsen) is a prescription medicine used to prevent hereditary angioedema (HAE) attacks in adults and children 12 years of age and older.

It is not known if DAWNZERA is safe and effective in children under 12 years of age.

Please see full Prescribing Information and Patient Information for DAWNZERA.

References:

1. Banerji A, Davis KH, Brown TM, et al. Patient-reported burden of hereditary angioedema: findings from a patient survey in the United States. Ann Allergy Asthma Immunol. 2020;124(6):600-607. doi:10.1016/j.anai.2020.02.018.
2. Maurer M, Magerl M, Betschel S, et al. The international WAO/EAACI guideline for the management of hereditary angioedema - The 2021 revision and update. Allergy. 2022;77(7):1961-1990. doi:10.1111/all.15214.
3. Busse PJ, Christiansen SC. Hereditary angioedema. N Engl J Med. 2020;382(12):1136-1148. doi:10.1056/NEJMra1808012.
4. Ionis. New Harris Poll findings reveal HAE patients are unsatisfied with current prophylactic treatment options, with over 90% interested in trying new therapies. Available at: https://ir.ionis.com/news-releases/news-release-details/new-harris-poll-findings-reveal-hae-patients-are-unsatisfied.
5. DAWNZERA. Prescribing information. Ionis Pharmaceuticals.

US-DONI-2600040 v1.0 03/2026

Here are five ideas for living a little greener this Earth Day, and every day. Each one is good for the planet — and your wallet.

1. Opt for a solar generator

As AI data centers, smart devices and connected home systems drive electricity demand to record highs, more and more household power draw is tied to the digital world — making clean, renewable home energy solutions a smart choice for eco-conscious consumers. With extreme weather events becoming more frequent across the country — from wildfires on the West Coast to hurricanes along the Gulf Coast and ice storms in between — having a reliable solar-powered backup isn't just a green choice. It's a practical emergency preparedness strategy for your whole family.

Be ready to power your entire home or key appliances during an outage with a quiet, reliable and emission-free solar generator. For example, the Jackery Solar Generator 5000 Plus can harness the power of the sun to keep your refrigerator, lights, medical devices, EV charger and more going — making it a true home energy backup solution. Even better, the generator has expandable capacity thanks to a battery that can be expanded up to 60 watt-hours (Wh) to grow with your household's needs.

By pairing the generator with Jackery SolarSaga panels to generate clean energy from the sun, you're further reducing your reliance on the grid to lower your carbon footprint. You can even use the stored solar energy to power heavyweight appliances such as washing machines and dryers, as well as the growing fleet of AI-enabled smart home devices — and offset costs for grid power when it is at peak pricing.

Today, AI-powered home energy management systems can even work alongside solar generators to automatically optimize when you draw from stored power versus the grid, saving money and reducing emissions at the same time. For households in high-sun states like California, Texas, Arizona and Florida, the combination of solar generation and smart energy management is fast becoming one of the most searched home improvement and emergency preparedness investments of the year.

Bonus: The Jackery Solar Generator uses LiFePO4 battery chemistry for long-lasting, stable home use, designed with safety in mind for indoor environments.

2. Eat locally sourced food

The closer to home your food is grown, the less fuel is used to transport and refrigerate it. On top of that, less packaging is needed for locally grown and sold produce. You can shop at neighborhood farmers markets, or when you're at the grocery store, look for items labeled as grown in your home state. Supporting local farms also makes an impact because smaller-scale production is likely to use beneficial farming techniques like crop rotation, composting and more efficient irrigation. This kind of slow, intentional approach to food — buying less processed, more local — is at the heart of the growing "slow living" movement, which prioritizes quality and sustainability over convenience.

Love going out to eat? Look for restaurants that have a strong farm-to-table practice featuring locally sourced food.

Bonus: Eating local, seasonal food usually tastes better! You're eating food that's at peak ripeness and freshness. And with grocery prices still top of mind for most households, buying seasonal and local is one of the easiest ways to eat well while spending less.

3. Minimize kitchen waste

Similarly, finding ways to reduce and reuse kitchen waste at home can also impact the environment in many positive ways, including reducing the amount of methane released by rotting foods, which is a powerful greenhouse gas that contributes to climate change. In a time when more people are embracing "underconsumption" — the idea of using what you already have before buying more — the zero-waste kitchen has become one of the most searched sustainable lifestyle topics online.

To cut down on kitchen waste, plan your grocery shopping and meal preparation more intentionally, and seek creative ways to use leftovers. Store produce correctly to avoid food items going bad, and try to use them quickly (or freeze if possible). When you do have kitchen scraps, they can be easily composted to help fertilize your garden, where you can grow a little of your own produce for the ultimate locally sourced food. Composting is also one of the most beginner-friendly eco swaps out there, with many cities now offering curbside compost pickup alongside regular recycling.

Pro tip: Some kitchen scraps, like the skins, peels or cut-off ends of onions, carrots and other produce, can be used to make vegetable broth. Just simmer with water and your favorite seasonings for 1-2 hours, then strain through a sieve for a tasty broth that's better than store bought!

4. Switch to reusable bags

Whenever you're shopping for groceries or other items, use reusable bags (like those free tote bags collecting in your closets) to significantly reduce plastic pollution and minimize the need to cut down trees to make more paper bags. This is one of the simplest examples of the "buy less, use more" mindset that's gaining traction across sustainable lifestyle communities on social media — small, consistent habits that add up to real change over time.

Pro tip: Keep a stash of reusable bags near the front door and in your car so you'll always have some handy.

5. Choose low-waste cleaning products

You can minimize the environmental impact of plastic by opting for products that don't come in single-use plastic containers. Compared to using conventional cleaning products, this can help lower your carbon footprint, while reducing both plastic pollution and water pollution. Easy swaps to look for include choosing natural sponges, reusable or compostable containers, concentrated formulas like soap blocks, tablets and laundry sheets, plus cleaners that come in refillable glass spray bottles. These swaps also tend to be more cost-effective in the long run — concentrated formulas and refillable options mean you're buying less packaging and spending less per use, which matters when household budgets are stretched.

Pro tip: Prefer a certain cleaner that only comes in plastic spray bottles? Buy a large refill bottle so you can reuse that bottle as many times as possible.

Any one of these simple steps can make a big difference. And if climate news ever starts to feel paralyzing, remember: doing something — anything — is always better than doing nothing. Start with one until it becomes a habit, then try another. You'll feel good knowing you're doing your part to help protect the environment.

Learn about more ways to live a lifestyle that can benefit the planet at Jackery.com.

Taking a closer look at what's actually in your pet's bowl can make a meaningful difference. Research shows that a whole-food, natural, high-meat diet supports overall vitality, including improved energy, digestion, skin and coat health. Avoiding unnecessary fillers will ensure your pet gets the nutrients and nutrition they need, just as nature intended.

Often, this is where pet parents' research ends. However, it doesn't matter what's in your pet's food if you don't know where the food comes from. This means having full transparency into how ingredients are grown, the way animals are raised, and what happens to the ingredients at every stage. A farm-to-bowl approach ensures that what your pet is eating is not only good for them, but also good for others and the planet.

Raising the bar on transparent sourcing

Brands in the pet food industry are raising the bar by clearly outlining where their ingredients come from and how they are made. One company in particular, Natural Pet Food Group (NPFG), the New Zealand-based company behind the K9 Natural and Feline Natural brands, are focused on doing things differently by committing to only using high quality ingredients from vetted sources, earning them B Corporation Certification. In doing so, it became just one of three pet food companies in New Zealand to attain this certification.

Certified B Corporations go beyond typical industry practices to meet verified international standards of social and environmental performance, accountability and transparency, achieved through a rigorous assessment across governance, workers, community, the environment and customers.

Rooted in New Zealand's strong agricultural and seafood sectors, K9 Natural and Feline Natural's whole-food ingredients are ethically sourced and traceable. By partnering with local farmers and fisheries that share a commitment to animal welfare, sustainability and ingredient integrity, the brand offers pet nutrition you can trust.

"Before we partner with new suppliers, we get into the details," said Natural Pet Food Group CEO Brett Henshaw. "How animals are farmed, where fish comes from, how it's caught, how suppliers look after their people. There's real substance behind our sourcing, and this achievement reflects the strength of our long-standing partnerships with farmers and seafood suppliers across New Zealand and beyond."

Almost all the ingredients that go into both K9 Natural and Feline Natural pet food products are sourced in New Zealand from grass-fed, free-range and pasture-raised animals, cage-free chicken, sustainable seafood and fertile soil-grown vegetables. No unnecessary ingredients, fillers or additives are used.

Doing good beyond the bowl — prioritizing environmental impact

A meaningful shift has been made by pet brands, including K9 Natural and Feline Natural, to reduce their environmental impact by prioritizing not only responsibly sourced ingredients but also improving packaging and production practices. As a newly B Corp Certified brand, K9 Natural and Feline Natural demonstrates the brand's commitment to the environment's health by:

• Powering all its offices in New Zealand with 100% renewable energy
• Prioritizing sea freight to reduce emissions
• Increasing recycled content and removing unnecessary plastics in packaging
• Donating 8,518 kilograms of pet food to 19 food hubs in the last year
• Creating strong health and safety systems

"If we make food to help pets thrive, the way we run our business must support people, communities and the environment too," said Henshaw. "Certification affirms the progress we've made and raises the bar for what great looks like in pet nutrition."

Supporting pets, people and the planet

Ensuring your pet's food helps them live long, high-quality lives can help others live that way, too. To learn more about K9 Natural and Feline Natural visit K9FelineNatural.com.

(BPT) - Article is sponsored and developed by Sanofi. Chris was compensated by Sanofi.

Each year on April 17, World Hemophilia Day shines a light on the experiences of people living with bleeding disorders — and the meaningful progress being made in treatment and care. For Chris, who has lived with hemophilia A since childhood, managing his condition has always been woven into the fabric of everyday life. Like many living with the condition, his treatment schedule once shaped everything from travel plans to family time.

"I've always tried to live an active life," said Chris. "Growing up, hemophilia was always something I had to manage — from learning how to treat bleeds at a young age to staying on top of my infusions as I got older. I bowl competitively and travel quite a bit, so treatment has always been something I had to plan around. For me, it was important that my infusion schedule didn't impact my ability to do the things that I loved."

Understanding Hemophilia

Hemophilia is a rare genetic bleeding disorder that affects the body's ability to form blood clots. In the United States, approximately 33,000 males live with hemophilia.¹ In both main types — hemophilia A and B — the blood does not clot properly, which can lead to spontaneous internal bleeding as well as excessive bleeding after injuries or surgery.¹

Managing hemophilia typically requires lifelong care to help prevent bleeding episodes. Historically, many treatment regimens required frequent — sometimes daily — dosing, often involving intravenous infusions with specific requirements for storage, preparation and administration.² Over time, these routines could add up to a significant burden, influencing work schedules, travel plans and the rhythms of daily life.

A Different Approach

For Chris, those challenges became increasingly real as he moved from childhood into adulthood and navigated different treatment approaches over the years.

"One of my earliest memories was learning the hard way how important it is to stay on top of treatment," he said. "I had a serious bleed when I was younger that required hospitalization, and that really stuck with me."

That experience stayed with him as he got older and took on more responsibility for managing his care. Over time, the demands of frequent infusions became harder to maintain.

"At one point my schedule required infusions five days a week," he said. "That's when I started missing infusions. It can be a lot to keep up with, and over time it really takes a toll on your veins."

As his treatment schedule became harder to manage, Chris began exploring whether there might be a different path forward, one that could better fit his lifestyle.

After learning about other options and discussing them with his doctor, Chris decided to try Qfitlia^® (fitusiran), a therapy designed for routine prophylaxis in people 12 years and older with hemophilia A or B with or without inhibitors. Qfitlia can cause serious side effects, including abnormal blood clotting (thrombotic events), gallbladder disease, and liver problems. The most common side effects of Qfitlia include viral infection, common cold symptoms, and bacterial infection. Patients should talk with their healthcare provider about the benefits and risks of treatment.

Qfitlia works by lowering antithrombin, a protein that normally slows blood clotting. By reducing antithrombin levels, the therapy helps increase thrombin generation and restore the body's ability to form clots. The treatment uses small-interfering RNA technology and may be administered as few as six times per year using a prefilled pen or vial and syringe.³

For Chris, one of the most noticeable differences has been how his treatment schedule fits into daily life.

"I travel a lot for bowling tournaments and to visit family," Chris said. "There were times in the past when I needed an entire suitcase just to bring my treatment supplies. While the mental load was something that I was used to, the physical burden of traveling with that much baggage was tough to deal with."

Today, he says planning around treatment feels simpler and more flexible.

"When you don't have to think about preventative treatment as often, it gives you more freedom to focus on the things you enjoy," he said. "Knowing I may only need preventative treatment as few as six times a year makes a big difference — especially when I'm traveling."

This summer, he's looking forward to taking trips with his daughter without having to pack and plan around multiple preventative doses or carry the extra supplies that once filled an entire suitcase.

Looking Towards the Future

Chris believes progress in hemophilia care is helping people live fuller, more active lives.

"I think everyone in the hemophilia community is hoping to minimize the impact treatment has on their lives as much as possible," he said. "The fewer times you have to stop and think about preventative treatment, the more you can focus on living your life."

His experience has also shaped the way he talks about hemophilia with his daughter, who is also living with the condition.

Chris also urges others living with hemophilia to feel comfortable talking with their healthcare team about treatment options.

"Everyone's situation is different," he said. "But talking openly with your doctor about your treatment plan can help you find something that fits your life."

To learn more about Qfitlia, please visit www.qfitlia.com

Indication and Important Safety Information

Indication

Qfitlia^® (fitusiran) is a prescription medicine used for routine prophylaxis to prevent or reduce the frequency of bleeding episodes in adults and children 12 years and older with hemophilia A or B with or without Factor VIII or IX inhibitors.

It is not known if Qfitlia is safe and effective in children younger than 12 years of age.

IMPORTANT SAFETY INFORMATION
Qfitlia can cause SERIOUS SIDE EFFECTS, including:

• Abnormal blood clotting (thrombotic events): Serious blood clots have occurred in people treated with Qfitlia. Qfitlia can cause blood clots to form in the blood vessels in your arms, legs, lungs, heart, brain, eyes, or head. Your risk of blood clots is greater if your antithrombin (AT) blood level is persistently less than 15% or if you have certain other conditions. Your healthcare provider (HCP) will check your AT blood levels before and during treatment with Qfitlia
• Gallbladder disease: Qfitlia can cause gallstones and inflammation of your gallbladder, which might require surgery to remove your gallbladder. Tell your HCP right away if you develop stomach pain, indigestion, nausea, or vomiting. Your HCP may temporarily or permanently stop Qfitlia if you develop any of these symptoms

What is the most important information I should know about Qfitlia?
Qfitlia helps your blood form clots. Do not stop using Qfitlia without talking to your HCP. If you miss doses or stop using Qfitlia, you may no longer be protected against bleeding.

Use of a clotting factor concentrate (CFC) or bypassing agent (BPA) to help protect against bleeding must be stopped within 7 days after your first dose of Qfitlia.

Your HCP may prescribe on-demand CFC or BPA if you bleed during treatment with Qfitlia. Carefully follow your HCP's instructions regarding when to use on-demand treatment with CFC or BPA, including the prescribed dose and timing of the CFC or BPA.

Get medical help right away if you get any of these signs or symptoms of blood clots during or after treatment with Qfitlia:

• Swelling, pain, or redness in arms or legs
• Coughing up blood
• Shortness of breath
• Severe chest pain or tightness of the chest
• Fast heart rate
• Feeling faint or passing out
• Severe or persistent headache
• Difficulty speaking or understanding language
• Feeling confused
• Numbness or weakness in your face, arms, or legs
• Sudden loss or changes in your vision, eye pain, or swelling

What are the possible side effects of Qfitlia?

• Qfitlia can cause other serious side effects, including an increase in your blood liver enzymes. Your HCP will do blood tests to check your liver function before and during treatment with Qfitlia
• The most common side effects of Qfitlia include viral infection, common cold symptoms, and bacterial infection

These are not all the possible side effects of Qfitlia.

What should I tell my HCP before using Qfitlia?

• Tell your HCP about all of your medical conditions, including if you have liver problems, a history of gallbladder disease, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed
• Females who are able to become pregnant: Hormonal birth control may increase your risk of blood clots if used during treatment with Qfitlia. Talk to your HCP about effective forms of non-hormonal birth control you can use before starting and during treatment with Qfitlia
• Tell your HCP about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements

Please see full Prescribing Information, including SERIOUS SIDE EFFECTS, and Medication Guide.

References:

1. Centers for Disease Control and Prevention. Data and Statistics on Hemophilia. https://www.cdc.gov/hemophilia/data-research/index.html. Accessed March 2026
2. World Federation of Hemophilia. WFH Guidelines for the Management of Hemophilia, 3rd Edition. 2020. https://www1.wfh.org/publications/files/ pdf-1863.pdf. Accessed March 2026.
3. Qfitlia Prescribing Information. Genzyme Corporation. Cambridge, MA.

© 2026 Sanofi. All rights reserved. Qfitlia and Sanofi are registered trademarks of Sanofi or an affiliate. MAT-US-2603143-v1.0-04/2026

For many cleft-affected patients and their families in the United States, this is a common occurrence. Being born with a cleft lip and/or palate brings not only medical needs, but also the added burden of navigating complex insurance barriers to access essential care. While cleft care is widely recognized by medical professionals as necessary for a child's health, coverage decisions don't always reflect that reality.

Clefts affect 1 in 700 births and are not resolved with a single procedure. Treatment often involves multiple surgeries over time, along with speech therapy, dental and orthodontic treatment, and psychosocial support. When any part of that care is denied or delayed, it can directly affect a child's ability to eat, speak, hear, and build confidence.

When "medically necessary" is up for debate

Cleft-affected patients and their families can frequently find themselves in difficult conversations with insurance providers over what treatments qualify for coverage. This is especially challenging when coverage decisions conflict with a doctor's medical recommendations.

Delays and denials often stem from misconceptions in which procedures that restore essential functions, such as eating, breathing, and speaking, are incorrectly classified as cosmetic rather than medically necessary.

"Living with a bilateral cleft lip and palate has affected how I speak, breathe, eat, and hear, but the hardest part has been the constant fight with insurance over medically necessary surgeries," said Toni-Elizabeth Wilkerson, a member of Smile Train's Cleft Community Advisory Council. "I've even had a procedure canceled just eight hours before I was due to go into the operating room, leaving me with physical, financial, and emotional burdens."

Stories like this are not isolated. They reflect a broader pattern of coverage delays and denials faced by cleft-affected patients and their families nationwide.

A push for change

The Ensuring Lasting Smiles Act (H.R. 3277/S.1677) aims to close this gap by requiring private insurers to cover the full range of necessary treatments for congenital anomalies such as cleft lip and palate, so doctors, not insurance companies, can determine the care children need to grow, speak, and thrive. From April 21–23, Smile Train is mobilizing to build momentum for this critical legislation by contacting legislators and raising our collective voice. We encourage everyone to #TakeAction4ELSA by reaching out to your legislator via our advocacy tool and joining our campaign kick-off event.

Every child deserves the opportunity to grow, speak, and thrive without unnecessary barriers. By working together to close gaps in coverage, we can help make that a reality for families across the country.

More than "just a rash"

Shingles is caused by the same virus that causes chickenpox, the varicella-zoster virus. According to the CDC, more than 99% of Americans born before 1980 have had chickenpox, even if they do not remember it.¹ After a person recovers from chickenpox, the virus remains dormant in the body and can reactivate years later and cause shingles. When it does reactivate, the effects can be severe.

"Shingles can lead to intense pain, complications like nerve damage, and even hospitalization," said Samantha Picking, PharmD, senior director of immunizations at Walgreens. "One of the most common complications of shingles is postherpetic neuralgia, a condition that can cause persistent, burning nerve pain long after the rash disappears. For some, this pain can interfere with sleep, work, and everyday activities, lasting months or even years."

The best defense is prevention

While shingles can have a serious impact, it is also highly preventable. The CDC recommends two doses of the shingles vaccine for adults ages 50 and older, as well as for adults 19 and older with weakened immune systems.² Studies show the vaccine is 97% effective at preventing shingles in adults 50-69 years old with healthy immune systems and 91% effective at preventing postherpetic neuralgia.

Some people may experience mild side effects after vaccination, but these typically go away within a few days.

"While some individuals may feel some discomfort after getting the shingles vaccine, such as a sore arm or fatigue, it is far less than the pain and potential complications associated with a shingles infection," said Picking.

Additionally, most insurance plans, including Medicare Part D and many private health insurance providers, cover shingles vaccines, making it accessible and often free for eligible individuals.

Beyond shingles: Other important vaccines for older adults

Staying up to date on all your routine vaccinations is one of the easiest ways to protect your health as you age.

"Beyond shingles, I recommend asking your pharmacist about additional routine vaccinations that are vital for healthy aging — it is about proactive health, not just reactive care," Picking said.

If you are 50 years or older, you may be eligible for the pneumococcal and RSV vaccines, as well as a Tdap booster. The CDC also recommends a second dose of the COVID-19 vaccine for people 65 and older, and those with weakened immune systems may be eligible for an additional dose.

"It is completely normal to have questions about vaccines," Picking said. "That is exactly why your local pharmacists are here. We are easily accessible and highly trained experts, ready to provide guidance, address your concerns and help you make informed decisions about your health."

Walgreens: Your partner in health

Staying up to date with routine vaccines can seem complicated, but Walgreens makes it easy, offering the option to schedule multiple vaccines in the same visit and with flexible appointments — including same-day, nights and weekends. Walk-ins are also welcome.

Walk in or schedule ahead at Walgreens.com/ScheduleVaccine, through the Walgreens app or by calling 1-800-WALGREENS.

According to the Autoimmune Association, approximately 50 million Americans live with an autoimmune disease, yet these conditions remain among the most underrecognized and underserved in modern medicine.

Despite a growing body of research into more than 100 known autoimmune diseases, overall awareness and understanding of these conditions is still developing.

Today in the United States, autoimmune disease treatment continues to prioritize short-term symptom relief over long-term disease control. This systemic challenge leaves patients seeking innovative solutions.

"Autoimmune diseases are complex, often chronic conditions that demand treatments for long-term safety, sustained disease control and restoration of physical function," said Peter Ulrichts, chief scientific officer of argenx, a global immunology company committed to improving the lives of people suffering from severe autoimmune diseases. "As scientific understanding continues to advance, we are focusing on translating that progress into innovative and patient-centered care for people living with autoimmune diseases."

Current standard of care and the need for steroid tapering

To date, corticosteroids have been the standard of care and first-line treatment across many autoimmune diseases because they can provide relief from inflammation, a common symptom of many of these conditions. According to Steritas, oral steroids are among the most prescribed medications in the United States.

However, clinical research has shown that long-term steroid use is associated with significant risk of toxicity that can lead to various issues like bone fractures, infections or hypertension. These side effects, layered on top of already challenging daily symptoms, underscore why tapering off steroid treatment is a priority for those developing new treatments for autoimmune diseases.

While clinical guidance recommends transitioning patients off chronic steroid use as quickly and safely as possible, non-steroid treatment options remain limited or inaccessible for many autoimmune diseases. In some conditions, effective alternatives do not yet exist; in others, available therapies may take time to work or fail to adequately control disease. As a result, many individuals remain dependent on steroids despite the risks associated with chronic use.

Innovations in autoimmune disease treatment

The continued reliance on long-term steroid use, despite the risk of toxicity-related health effects, highlights the need for innovation in the treatment and management of autoimmunity.

"Reducing steroid side effects relies on monitoring the patient not only on counting the pills," said Martha Stone, CEO at Steritas. "By measuring steroid toxicity directly in each patient, in clinical research and clinical care, doctors can personalize each steroid taper and help change what autoimmune disease management looks like."

Steroid-sparing treatments are becoming increasingly available, helping patients address some of these concerns. Continuing that progress requires an innovative approach to science and collaboration among researchers, healthcare providers and biotech industry innovators.

"At argenx, we're working to help people suffering from serious autoimmune diseases by developing therapies that can address the underlying drivers of disease and reduce patients' dependence on steroids, helping them achieve better outcomes with fewer long-term risks," said Luc Truyen, M.D., Ph.D., chief medical officer of argenx.

Learn more about the effects of long-term steroid use and tracking your journey with steroids at steroidsandme.com, and explore how argenx is advancing innovative approaches to autoimmune disease care at argenx.com.

The brand applies that performance-driven comfort DNA to one of footwear's most demanding categories: high-performance running. Skechers has a proven track record of creating award-winning running shoes, including the Skechers AERO Burst, which was honored as "Best Walk to Run" in the 2025 SELF Sneaker Awards.

Because here's the part the industry often overlooks: Most people don't quit running because they lack discipline. They quit because it starts to feel uncomfortable.

Discomfort triggers a chain reaction. It can lead to setbacks, impact motivation, and once running feels physically punishing, it becomes one of the first habits to fall away when life gets busy.

Research supports this. Studies have found that runners who perceive higher shoe cushioning and comfort experience significantly lower injury risk, up to a 65–76% reduction compared to lower-cushion footwear.

When running hurts early, people don't push through.

They stop.

That reality explains why Skechers continues to lean into performance running by doubling down on its core strength. Rather than asking runners to adapt, the company has adapted its proprietary comfort technologies to the biomechanics of running.

The result is footwear that prioritizes impact absorption, heel support and underfoot stability, especially for the majority of runners who are heel strikers.

The Skechers AERO Burst embodies that strategy.

Built with lightweight, responsive foam cushioning, it's engineered to reduce impact and fatigue, so runners feel better during and after their miles.

The shoe features Skechers' dual-density Hyper Burst Ice™ cushioning, a super critical foam designed to deliver lightweight responsiveness and enhanced comfort with every step.

Its anatomical heel design and Hyper Arc™ rocker geometry create a smoother transition from impact to toe-off without forcing unnatural stride mechanics. An Arch Fit^® system enhances support, while a Goodyear^® rubber outsole delivers durable traction across surfaces.

Select styles are also available in Skechers Hands Free Slip-ins^®, allowing runners to easily step into the shoe without bending down — an added convenience that supports everyday usability.

Designed to cut though the wind, the shoe's design helps reduce drag and allows runners to move more efficiently through their stride.

The philosophy is straightforward: Comfort is not the opposite of performance. It enables it.

Across the country, more Americans are redefining what performance means. Many are focused on consistency and their overall well-being. So, instead of asking "How much time can I shave off?" they're asking, "How can I keep going?"

Behavioral research consistently shows that reducing friction increases adherence. When movement feels manageable, repetition follows.

Skechers is betting that comfort is not a compromise, it's a retention strategy.

Not every runner defines performance the same way. For many runners, performance isn't only about finishing faster, it's about staying active long enough to feel healthier, think clearer and move confidently for years to come.

For them, performance is about comfort and durability.

And that desired combination starts underfoot.

The Skechers AERO Burst is available now.

For more information about Skechers AERO Burst go to Skechers.com.

For many children living with this condition, unrelenting food-related anxiety and constant thoughts about food can overshadow focus, play, and the simple joys of being a child. Many can't eat in the school cafeteria with other kids or even attend a family barbecue or birthday party because food is ever-present.

This is what it's been like for 15-year-old Matthew and his parents, Deahl and Adam. Matthew has Prader-Willi syndrome (PWS), a rare genetic disorder characterized by failure to thrive in infancy and a gradual transition to its defining feature, hyperphagia in early childhood. While PWS may look different from one child to another, it is characterized by a wide spectrum of physical, cognitive, and behavioral manifestations that are frequently interconnected and closely related to hyperphagia.

The constant daily challenge of living with hyperphagia in PWS

For individuals living with PWS, hyperphagia is not just a matter of increased hunger. It is a chronic and life-threatening feeling of intense, persistent hunger.

The intense focus on food can lead individuals living with hyperphagia in PWS to:

• Frequently think or talk about food
• Have feelings of anxiety around and about food
• Search for food in inappropriate places, such as the trash or storage areas
• Eat raw or non-edible items
• Get up at night to look for food
• Take food or money in an effort to obtain more food
• Hide or store food for later
• Bargain or negotiate for additional food
• Show rigidity for schedules, especially around mealtimes
• Feel upset, anxious, or overwhelmed when access to food is limited

"We had two entryways, and we put up doors, we locked everything behind the kitchen," said Matthew's mother, Deahl. "We would lock the windows because he would climb through the windows."

Because so many social activities are centered around meals, Matthew's constant fixation with food made it especially challenging for the family to enjoy typical social gatherings, outings, and celebrations together. Being denied food could trigger Matthew to become upset and anxious.

"In our experience with a child with hyperphagia in Prader-Willi syndrome, we were always ready to have our day hijacked. It could be, at any moment, taken over by Prader-Willi syndrome and the things that come along with that," said Matthew's father, Adam. "That constant sense of being on edge around food, not knowing when a situation might escalate, when routines might be disrupted, or when extra support will be needed when food is present, weighs on all of us."

New treatment offers hope

Historically, one of the only ways to manage hyperphagia in PWS was by strictly controlling access to food for that person.

A new medication, VYKAT™ XR (diazoxide choline) extended-release tablets, is the first and only FDA-approved treatment for hyperphagia with PWS. VYKAT XR is a prescription medicine used to treat extreme hunger, constant thoughts about food and constant urge to eat that cannot be satisfied with food (hyperphagia) in adults and children 4 years of age and older with PWS.

"After being on VYKAT for about 4 months, Matthew stopped talking about food as much. As a result of Matthew having fewer thoughts about food, the anxiety is now lifting off of him," said Deahl.

Matthew has experienced hypertrichosis, increased hair growth over the body as a side effect. Common side effects of VYKAT XR include increased hair growth all over the body, swelling, increased blood sugar, and rash. Please see the VYKAT XR Patient Information below for more information.

For Matthew, the medicine has offered him the ability to focus less on food, which has given him the ability to do more of the things he enjoys doing most. "I feel more confident and more independent since I have a little more control around food," Matthew said. "I love to dance and sing all the time and play with my friends."

For his parents, VYKAT XR has made a difference in their everyday lives. "We still monitor everything he eats. We still do everything we used to do, but the constant heightened tension and anxiety around the food isn't there. You can give him a plate of food and he will feel full, which I never thought 15 years ago my child would ever feel."

Families of those who have hyperphagia in PWS can find support and educational resources at VYKATXR.com/resources. You can also learn more about the condition and treatment at VYKATXR.com.

Patient Information for VYKAT™ XR (vye kat ex ar) (diazoxide choline) extended-release tablets, for oral use

What is VYKAT XR used for?

VYKAT XR is a prescription medicine used to treat extreme hunger, constant thoughts about food, and constant urge to eat that cannot be satisfied with food (hyperphagia) in adults and children 4 years of age and older with Prader-Willi syndrome (PWS).

What is the most important information I should know about VYKAT XR?

VYKAT XR may cause serious side effects, including:

• High blood sugar levels (hyperglycemia). Hyperglycemia is common during treatment with VYKAT XR and can also be severe. Hyperglycemia can lead to a condition called diabetic ketoacidosis (increased ketones in the blood) in some people who take VYKAT XR. Diabetic ketoacidosis is a serious condition that needs to be treated in a hospital and can be life-threatening
  • Your healthcare provider will:
    • check your blood sugar levels before you start VYKAT XR, during treatment and more often during treatment if you have an increased chance of getting hyperglycemia.
    • check your HbA1c before and during treatment.
  • If you get hyperglycemia during treatment with VYKAT XR, your healthcare provider may give you medicines to treat hyperglycemia, change your dose if you already take hyperglycemia medications, or your doctor may change your dose of, temporarily stop, or permanently stop VYKAT XR.

Tell your healthcare provider if you get any of the following signs and symptoms:

• • hyperglycemia: feel very thirsty, need to urinate more often than usual, have higher amounts of urine than usual, feel more hungry than usual, or weight loss
  • diabetic ketoacidosis: nausea, vomiting, stomach-area (abdominal) pain, feel weak or very tired or trouble breathing
    
    
• Too much fluid in your body or swelling (fluid overload). Swelling in the body from too much fluid is common during treatment with VYKAT XR and can also be severe. Your healthcare provider may decrease your dose or temporarily stop VYKAT XR if you get fluid overload. Tell your healthcare provider if you have trouble breathing or get any other signs or symptoms of fluid overload such as swelling of your legs, ankles, or feet, or unusual swelling anywhere in your body.

Who should NOT take VYKAT XR?

Do not take VYKAT XR if you are allergic to diazoxide, any ingredients in VYKAT XR or medicines called thiazides.

Before taking VYKAT XR, tell your healthcare provider about all of your medical conditions, including if you:

• have diabetes or prediabetes
• are sick
• plan to have surgery
• drink alcohol very often
• are dehydrated or have lost a lot of body fluid
• have heart problems or a history of swelling in your legs or other parts of your body that required medicine
• have liver or kidney problems
• are pregnant or plan to become pregnant. VYKAT XR may harm your unborn baby. Tell your healthcare provider right away if you become pregnant during treatment with VYKAT XR
• are breastfeeding or plan to breastfeed. VYKAT XR passes into your breast milk, and it is not known if it can harm your baby. Tell your healthcare provider if you plan to breastfeed during treatment with VYKAT XR

Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking VYKAT XR with certain other medicines may affect the way VYKAT XR or the other medicine works and may increase your risk of side effects. Do not change your dose or stop any medicines you take, or start any new medicines, without talking to your healthcare provider first during treatment with VYKAT XR.

What are the possible side effects of VYKAT XR?

• Increased hair growth all over the body, fluid overload or swelling, high blood sugar levels, and rash.

These are NOT all of the possible side effects of VYKAT XR.

Call your doctor for medical advice about side effects. You may report side effects to Soleno Therapeutics, Inc. at 1-833-765-3661 or to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

For further information please read the Medication Guide and full Prescribing Information for VYKAT XR.

C-US-VYK-00423 v1 03/2026

For U.S. Audiences Only

The relationship between a patient and their physician is crucial, shaped by shared decision-making, honest conversations and the steady navigation of unexpected changes. For patients managing progressive retinal diseases, like geographic atrophy (GA), this relationship may play a critical role in protecting not only retina cells, but confidence and independence as well.

For Ken, that relationship began more than a decade ago with his retina specialist, Dr. Arshad Khanani, Managing Partner, Director of Clinical Research and Director of Fellowship at Sierra Eye Associates in Reno, Nevada.

At age 77, Ken was still working as an usher at a luxury movie theater — an environment he enjoys for its social connection and daily routine. One morning in 2016, during a typical shift, he noticed something unexpected. Standing beside a large, illuminated IMAX^® sign he had seen countless times before, Ken realized he could no longer clearly see the small registered trademark symbol off to the side.

"In my right eye, I could not read the 'R' without moving my eye up and down or side to side," recalls Ken. "There were waves in my vision and I knew right away that something wasn't right. I immediately called my optometrist, and I was introduced to my new retina specialist, Dr. Khanani, by 6 p.m. that same evening."

Family history had already shaped Ken's expectations of his eyesight. Growing up, he watched his mother navigate life with dry age-related macular degeneration (AMD), so he was aware that his own vision may eventually be affected.

"When I first met Ken, I confirmed his diagnosis of dry AMD and explained the path forward when dealing with a progressive retinal disease," Dr. Khanani recalls. "By 2020, his dry AMD had advanced to geographic atrophy (GA), and he completely lost the central vision in his right eye."

What is geographic atrophy?

GA is the advanced form of dry AMD and leads to progressive, irreversible vision loss. In the U.S., GA affects an estimated 1.5 million people, many of whom remain undiagnosed due to subtle or gradual symptom onset.

"GA can begin with changes that are easy to miss," explains Dr. Khanani. "Patients may notice washed-out colors, distorted or wavy lines, blank or blurry areas in central vision, or increasing difficulty with tasks like reading, driving, or seeing in low light."

The disease can progress unpredictably, and sometimes faster than expected, which is why early diagnosis and proactive care are essential.

Ken's path to treatment

As Ken's GA progressed, Dr. Khanani discussed treatment options with him, outlining both benefits and risks. In 2023, Ken began treatment with IZERVAY^® (avacincaptad pegol intravitreal solution), an FDA-approved prescription eye injection proven to help slow the progression of GA.

"While there currently is no cure for GA, IZERVAY targets overactive components of the immune system that may contribute to retinal cell damage," says Dr. Khanani. "The goal is to slow disease progression and help preserve remaining vision for as long as possible."

In two clinical trials involving 624 participants, IZERVAY demonstrated an 18%-35% reduction in GA progression over one year compared to those who were untreated. Individual results may vary.

Do NOT receive IZERVAY if you have an infection in or around your eye, or if you have active swelling in or around your eye that may include pain and redness. Please see additional Important Safety Information below.

For Ken, the concept of preservation was meaningful. "Because of Dr. Khanani's transparency and guidance, I felt confident that I was receiving excellent care with the latest advancements," he says. He remains committed to regular appointments and proactive management. "I see every step I take now as an investment in the future," he says. "It's about choosing action and staying hopeful."

The importance of proactive care

"Proactivity is key — everyone should get their eyes checked annually. Luckily, we now have treatments for GA that may help slow the disease progression," says Dr. Khanani. "My goal with Ken, and all my patients, is to redefine the mindset around GA care, navigate their journey alongside them and truly understand the emotional significance behind each treatment decision."

Ken's experience underscores the impact of early detection, consistent care, and a strong patient-physician partnership. "Being diagnosed early has made all the difference," he reflects. "I often think about how different things could have been for me if I had waited."

Ken has never measured life by age. Now age 88, he moves through life with intention and chooses to share his story to give others confidence of their own. As he approaches his 90th birthday celebration with family and friends, he's already looking forward to a night full of laughter and storytelling. "Because life isn't about slowing down," he says. "It's about savoring every moment, believing in what comes next."

This article reflects Ken's experience at the time of printing. Dr. Khanani and Ken were both compensated for their participation in this article.

IMPORTANT SAFETY INFORMATION AND USE

Do NOT receive IZERVAY^® (avacincaptad pegol intravitreal solution) if you:

• Have an infection in or around your eye
• Have active swelling in or around your eye that may include pain and redness

IZERVAY can cause serious side effects including:

• Eye Infection and Retinal Detachment: Eye injections like the one for IZERVAY can cause an eye infection (endophthalmitis) or separation of layers of the retina (retinal detachment).
• Wet Age-Related Macular Degeneration (AMD): There is a risk of developing wet age-related macular degeneration (AMD) with IZERVAY. You should report any symptoms (visual distortions such as straight lines seeming bent, deterioration in vision, dark spots, loss of central vision) to your healthcare provider to monitor.
• Increase in Eye Pressure: IZERVAY may cause a temporary increase in eye pressure after the injection. Your healthcare provider will monitor this after each injection.

Call your healthcare provider right away if you have redness of the eye, eye pain, increased discomfort, worsening eye redness, blurred or decreased vision, an increased number of small specks floating in your vision, flashes of light, or increased sensitivity to light.

Before receiving IZERVAY tell your healthcare provider about all of your medical conditions including if you:

• Have a history of seeing flashes of light or small specks floating in your vision and if you have a sudden increase of size and number of these specks.
• Have high pressure in the eye or if you have glaucoma.
• Are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.
• Are taking any medications, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Tell your healthcare provider about any medicine you take.

What should I avoid while receiving IZERVAY?

• Your vision may be impaired after receiving an eye injection or after an eye exam. Do not drive or use machinery until your vision has recovered sufficiently.

What are the most common side effects of IZERVAY?

• Blood in the white of the eye
• Blurred vision
• Increase in eye pressure
• Wet AMD
• Mild corneal irritation
• Eye pain

These are not all the possible side effects of IZERVAY. Tell your healthcare provider about any side effect that bothers you or that does not go away.

Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

What is IZERVAY?

IZERVAY is a prescription eye injection, used to treat geographic atrophy (GA), the advanced form of dry AMD.

Please click here to see accompanying full Prescribing Information.

• Physical inactivity costs Americans billions each year. Prioritizing your health today pays dividends in longevity, energy and reduced healthcare costs.
• The U.S. Army is experiencing the benefits of investing in Soldier health through programs like the Holistic Health and Fitness (H2F) system. For every $1 invested in H2F Performance Teams, the Army sees a return of over $8 in force readiness improvements.
  
• The performance triad — consisting of daily movement, quality nutrition and restorative sleep — can build a strong foundation for long-term health.

At the start of spring, many Americans are planning for the long term by reviewing and refreshing their financial portfolios, but there is one critical investment that many overlook: their own health. A recent study showed that physical inactivity costs the United States roughly $192 billion annually in healthcare expenses — an $80 billion increase from 2015 — proving that early investment in health is one expense guaranteed to pay dividends for years to come.

One organization committed to this practice is the U.S. Army. With the launch of the Holistic Health and Fitness (H2F) system, the Army made its largest-ever investment into the well-being of Soldiers, aimed at offering the education, resources and expert guidance needed to optimize their physical, mental, nutritional, sleep and spiritual health. The results speak for themselves, with every $1 invested in H2F Performance Teams returning over $8 in force readiness improvements.

Many of the techniques used by Soldiers can be applied to anyone looking to invest in their own well-being. And while countless "quick fixes" clutter the health and fitness space, breaking it down to the fundamentals of the "performance triad" — building physical and cardiovascular readiness, ensuring proper nutrition intake and maintaining quality rest and recovery practices — often delivers the greatest impact. When combined, individuals can build a solid base for their health and fitness and improve long-term health and longevity.

Ready to invest in your future in a new way? Read on to learn how you can incorporate the performance triad into your routine:

Move your body every day to improve cardiovascular strength

Consistent daily movement is fundamental in establishing a routine that strengthens and maintains the body's cardiovascular system — a key indicator in overall health and longevity. "Staying active is the cheapest doctor's visit you can get a prescription for," says Lt. Col. Jason Barber, high-performance coordinator for the Army's World Class Athlete Program, which trains Soldier-athletes to perform at the highest level of international competition.

One way to track cardiovascular improvement is through VO2 max, the maximum amount of oxygen your body can utilize during exercise. Barber notes that higher levels are usually associated with reduced risks of chronic diseases and improved longevity.

Barber recommends prioritizing high-intensity interval training (HIIT) workouts to improve VO2 max. "HIIT workouts are designed to push the cardiovascular system for short periods followed by recovery. The alternation of these intensities stimulates adaptations in your heart, lungs, muscles and bloodstream, thereby increasing your ability to utilize oxygen efficiently." To incorporate a HIIT workout into your routine, he suggests:

• Warm up with dynamic stretching or a light jog.
• Alternate between 30 seconds of a sprint, bike or row at maximum effort, followed by 90 seconds of an active recovery, like walking.
• Repeat the sequence 6-8 times.
• End with a cooldown and static stretching.

Nutrition is one of the most powerful tools for improving health, energy levels and longevity, and eating a heart-healthy diet composed of lean proteins, vegetables, fruits and whole grains will compound the work being done in the gym.

A heart-healthy diet also doesn't mean deprivation or extreme restrictions. Maj. Kelly Kaim, lead sports dietitian for the Army's World Class Athlete Program, says, "A very common myth is if you keep decreasing calories, you will lose weight." Alternatively, she encourages individuals who are interested in losing weight to find their Resting Metabolic Rate (RMR), or the number of calories an individual burns for their body to function at rest. "Try not to go below this number. Doing so will often break down muscle and burn fewer calories, which in turn, can make weight loss even more difficult."

Kaim encourages individuals to identify their RMR and track their calorie intake for a few days to see where there can be minor, sustainable modifications. "One of the first things I look at is high-calorie beverages. If someone is drinking their calories, creating a healthy deficit can be as easy as removing soda and substituting for flavored water."

Develop a nighttime routine for a strong foundation

The third component of the performance triad is often the most overlooked. Healthy sleep hygiene is not just a nice-to-have — it is the foundation to maintaining an effective holistic routine. Without adequate sleep, your physical, nutritional and mental readiness deteriorates, with some studies suggesting that inadequate sleep can raise the risk of heart attack, dementia and diabetes, among other health conditions.

Maj. Lina Ochoa, occupational therapist and sleep domain lead for the H2F system, says, "Just like physical training and nutrition, sleep must be planned and protected. The most important factors for better sleep are consistency and routine." While there are endless hacks for getting better sleep, Maj. Ochoa suggests five strategies:

• Find your anchor: Pick a consistent time to go to bed and wake up each day. Keeping this routine steady helps your body know when it's time to sleep and recover.
• Be disciplined with light: Expose yourself to bright light within 30 minutes of waking and dim the lights 90 minutes before bed. A tip for night shift workers is to wear sunglasses during morning commutes home.
• Time your caffeine consumption: Try not to have caffeine within 8 hours of intended sleep.
• Drop the temperature: Keep your bedroom temperature around 60-67 degrees.
• Wind down: Take 5-10 minutes to do parasympathetic breathing (inhale for 4 seconds, exhale for 8 seconds), and limit exposure to any emotionally activating content — in other words, avoid late-night phone scrolling.

Bonus: Invite others along for maximum impact

The World Health Organization has reported that 1 in 6 people worldwide is affected by loneliness, leading to significant impacts on health and well-being. The performance triad is powerful, but it becomes truly transformative when practiced with others. Seek out communities around movement — whether that's a running club, gym or training partner, and share intentional meals with loved ones rather than eating in front of the TV.

In the Army, camaraderie and connection is key to succeeding in every mission. Lt. Col. Rebecca Shanahan, clinical psychologist and mental readiness lead for the H2F system, says, "Humans need other people for survival. Often when you get stressed, you stop engaging in social support and personal networks. When you isolate and pull away from interpersonal connectivity, it can be very detrimental."

She recommends reserving five minutes for a family or friend check-in every day. Ask each other what went well throughout your day, what went wrong, where you can use help and what you're looking forward to tomorrow. She notes, "The intent is to be consistent, tangible, and five minutes or less."

Unlike other long-term investments, the performance triad can lead to big payoffs quickly, with sustained benefits for years to come. This spring, make the choice to allocate your time and attention to the one asset that makes everything else possible: your health. Learn more at GoArmy.com.

Value-based care is here to stay

The human impact of coordinated care has never been more evident, with 14.3 million Medicare beneficiaries now estimated to receive care coordinated by ACOs in 2026.² This patient-first approach is proving its sustainability: In 2024, the MSSP achieved its highest savings to date, totaling $2.5 billion in Medicare savings and $4.1 billion in performance payments.³ While 75% of all ACOs earned shared savings, some networks saw even higher levels of physician success. Ninety-three percent of Aledade's member ACOs achieved shared savings, proving that high-quality care and financial health go hand-in-hand.⁴ To ensure this momentum continues, the Centers for Medicare and Medicaid Services (CMS) continues to support and incentivize value-based care, most recently evidenced by new models like ACCESS and LEAD, designed to further increase physician success in value-based care.

Partnerships are the key, Aledade leads the way

Success in value-based care is not guaranteed by participation alone. For primary care organizations, partnerships are key, and the right one requires tailored solutions rather than a one-size-fits-all approach. Aledade offers a national footprint, local market expertise, customized support and advanced technology to help primary care organizations thrive in value-based care. These organizations retain full clinical autonomy and ownership while benefiting from Aledade's resources.

Today, Aledade supports more than 3,000 primary care organizations across 46 states and the District of Columbia, caring for more than 3 million patients in value-based care programs. The results speak for themselves: In 2024, Aledade's ACOs saved Medicare more than $1 billion, generating nearly 20% of the entire program's shared savings while caring for just 11% of its beneficiaries.

On average, Aledade partners earned $390,000 in shared savings payments in 2024 alone. These payments allow primary care organizations to invest back into their staff, businesses and communities.

"The financial benefits of obtaining shared savings are significant. These resources have enabled us to hire and retain staff, strengthening our ability to support our patients and enhance the services we provide. Shared savings has been vital in helping our private practice remain independent while continuing to deliver high-quality care to our communities," said Jennifer Boyer, director of operations, Integrated Medical Group, PC, Pottsville, Pennsylvania.

AI-enabled insights and expert support

Aledade's success is built on a foundation of future-forward technology and human-led support. Experienced, dedicated teams provide tailored, readily available guidance to primary care organizations of all types, from independent private practices and community health centers to larger health systems.

Alongside tailored support, Aledade's AI-enabled technology unifies data from electronic health records (EHRs), hospitals, labs and pharmacies into a single, intuitive platform. The platform surfaces actionable data at the point of care to actively identify patients in need of preventive care or crucial follow-ups, driving earlier interventions and smarter care coordination.

"Having the ability to look and see care gaps, who is eligible for chronic care, who's recently been in the emergency room, who's recently been hospitalized — those things are huge," said Jennifer Richardson, PA-C, Emerald Coast Medical Group, Pensacola, Florida. "It's not only important for patient care and their long-term outcomes, but it's also beneficial to the practice as a whole."

With the right tools and resources, preventive care saves lives: Aledade partners prevented nearly 263,000 avoidable hospitalizations and emergency department visits in 2024. Additionally, partners who have worked with Aledade for two years or longer achieved an 83.3% average for hypertension control, outperforming some of the most prestigious academic medical centers in the nation.⁴

A perfect balance of scale and service

Aledade's performance, as measured by KLAS Research, reflects strong customer satisfaction with both its national scale and level of support. In the 2026 Best in KLAS: Software & Services report, Aledade received an overall performance score of 95.7 (out of 100) in the Value-Based Care Enablement Services segment. Aledade received "A+" grades across several critical categories in the KLAS Value-Based Care Enablement Services 2026: Customer Validations of Firm Offerings report:

• Loyalty: 100% of interviewed clinicians indicated they would choose to partner with Aledade again.
• Relationship: Partner feedback reflects executive involvement and strength of partnership.
• Services: Partner feedback reflects the quality of strategic guidance and expertise provided.

"Aledade feels like a secondary office that's taking care of our patients right behind us. They make sure that your patients are what comes first," said Makaila Cornelius, medical assistant at Physicians Care Group of West Georgia, Carrollton, Georgia.

An Aledade partnership is the path forward

The transition to value-based care is no longer a question of "if," but "how." Success requires choosing a partner that understands the clinical and administrative workloads they face.

Aledade offers a proven path, combining over a decade of experience, national scale, local knowledge and award-winning technology and services to ensure that doctors can get back to what they do best: practicing medicine.

Visit aledade.com/more-information to get started.

¹ 2025 APM Measurement

² 2026 Medicare Accountable Care Organization Initiatives Participation Highlights

³ Medicare Shared Savings Program Accountable Care Organizations Updated Performance Year 2024 Financial and Quality Results

⁴ Performance Year Financial and Quality Results, Data.CMS.gov. The individual performance of non-Aledade ACOs may be better or worse than the average.

(BPT) - This sponsored article is presented by Bristol Myers Squibb

Colorectal cancer (CRC) is emerging as a critical health concern, particularly due to a concerning rise in diagnoses among younger individuals. Colorectal cancer (CRC), developing in the colon or rectum, is projected to impact more than 154,000 Americans in 2025, making it the third most diagnosed form of cancer. Particularly troubling trends show an increasing incidence in individuals younger than 50, alongside rising mortality rates in those under 55 since the mid-2000s. These trends underscore an urgent and growing need for enhanced awareness, early detection and effective treatment options.

Fortunately, continued scientific research is opening additional options for treatment. For certain patients, treatment with immunotherapy, which harnesses the body's own immune system to help fight disease, may offer a promising path forward. Some patients may be eligible to receive dual immunotherapy, combining two immunotherapy treatments that can help attack cancer cells by targeting different immune checkpoints.

One such dual immunotherapy treatment is Opdivo^® (nivolumab) plus Yervoy^® (ipilimumab). This combination is approved by the U.S. Food and Drug Administration to treat adults and children 12 years of age and older with a specific type of colorectal cancer that cannot be removed with surgery, or has spread, and is microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR). MSI-H and dMMR are biomarkers, which indicate the status of DNA stability in a tumor, and occur in approximately 15% of CRC tumors. Of the 15%, 4-5% of tumors are metastatic. Biomarker testing is strongly recommended for anyone with CRC and can help determine appropriate treatment options.

"Opdivo plus Yervoy is the first FDA-approved combination of two immunotherapies, representing a distinct approach different from chemotherapy," said Heinz-Josef Lenz, MD, CheckMate-8HW investigator and Deputy Director for Research Programs and Head of the Gastrointestinal Cancers Program at the USC Norris Comprehensive Cancer Center.* "When these immunotherapies are used in combination, these treatments work with your immune system to allow your immune cells to help fight the cancer. This immune response may be greater when both immune therapies are combined than when either is used alone."

It's also important to understand that while doing so, this immunotherapy combination can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become serious or life threatening and can lead to death. These problems may happen anytime during treatment or even after treatment has ended. You may have more than one of these problems at the same time. Some of these problems may happen more often when Opdivo is used in combination with Yervoy.

Serious side effects may include lung problems; intestinal problems; liver problems; hormone gland problems; kidney problems; skin problems; eye problems; problems in other organs and issues; and complications of stem cell transplant, including graft-versus-host disease (GVHD), that uses donor stem cells (or allogeneic). Call or see your healthcare provider right away for any new or worsening signs or symptoms. Opdivo is associated with severe infusion reactions. Please see additional Important Safety Information below.

Opdivo plus Yervoy is an FDA-approved combination of two immunotherapies that has demonstrated benefit for certain patients with advanced CRC. In the CheckMate-8HW trial, this combination helped patients live significantly longer without their cancer progressing compared to certain other treatment groups in the clinical trial.

The clinical trial included 839 people with advanced MSI-H/dMMR colorectal cancer, and compared Opdivo plus Yervoy to either Opdivo alone or investigator's choice of certain chemotherapies with or without targeted therapy. People who received Opdivo plus Yervoy lived significantly longer without their cancer spreading, growing, or worsening compared to those on investigator's choice of chemotherapy. At an approximately 2.5 year follow-up, more than half the people went without their cancer spreading, growing, or getting worse in the Opdivo plus Yervoy group, compared to the investigator's choice of chemotherapy group where at 6 months, half of the people went without their cancer spreading, growing, or getting worse. This translated to a 79% lower risk of cancer progression for the Opdivo plus Yervoy group compared to chemotherapy. Furthermore, against Opdivo alone, patients treated with Opdivo plus Yervoy lived significantly longer without disease progression. At an approximately 4 year follow-up, more than half the people went without their cancer spreading, growing, or getting worse. This translated to a 38% lower risk of cancer progression compared to the Opdivo alone group, where at approximately 40 months, half of the people went without their cancer spreading, growing, or getting worse.

"With the CRC cases unfortunately rising, especially among younger populations, understanding treatment options available for advanced-stage MSI-H/dMMR CRC is more important than ever," said Heinz-Josef Lenz, MD. "If you or a loved one is facing a diagnosis with advanced CRC, I encourage you to have an open conversation with your healthcare team about biomarker testing to find out if Opdivo plus Yervoy could be a treatment option for you."

To learn more about Opdivo + Yervoy, please visit Opdivo.com.

*Dr. Lenz was contracted with Bristol Myers Squibb for this article but did not receive any compensation for sharing his perspective for this story.

Indications

OPDIVO^® (nivolumab) is a prescription medicine that may be used in combination with YERVOY^® (ipilimumab) to treat adults and children 12 years of age and older, with a type of colon or rectal cancer (colorectal cancer) that cannot be removed with surgery, or has spread, and is microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR).

OPDIVO^® (nivolumab) is a prescription medicine that may be used alone to treat adults and children 12 years of age and older with a type of colon or rectal cancer (colorectal cancer) that has spread, and is microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR), and you have received treatment with a fluoropyrimidine, oxaliplatin, and irinotecan, and it did not work or is no longer working.

It is not known if OPDIVO is safe and effective in children younger than 12 years of age with melanoma or MSI-H or dMMR metastatic colorectal cancer.

It is not known if OPDIVO is safe and effective in children for the treatment of any other cancers.

Important Safety Information for OPDIVO^® (nivolumab) + YERVOY^® (ipilimumab)

What is the most important information I should know about OPDIVO + YERVOY?

OPDIVO and YERVOY are medicines that may treat certain cancers by working with your immune system. OPDIVO and YERVOY can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. These problems may happen anytime during treatment or even after your treatment has ended. You may have more than one of these problems at the same time. Some of these problems may happen more often when OPDIVO is used in combination with another therapy.

Call or see your healthcare provider right away if you develop any new or worsening signs or symptoms, including:

• Lung problems: cough; shortness of breath; chest pain
• Intestinal problems: diarrhea (loose stools) or more frequent bowel movements than usual; stools that are black, tarry, sticky, or have blood or mucus; severe stomach-area (abdominal) pain or tenderness
• Liver problems: yellowing of your skin or the whites of your eyes; severe nausea or vomiting; pain on the right side of your stomach area (abdomen); dark urine (tea colored); bleeding or bruising more easily than normal
• Hormone gland problems: headaches that will not go away or unusual headaches; eye sensitivity to light; eye problems; rapid heart beat; increased sweating; extreme tiredness; weight gain or weight loss; feeling more hungry or thirsty than usual; urinating more often than usual; hair loss; feeling cold; constipation; your voice gets deeper; dizziness or fainting; changes in mood or behavior, such as decreased sex drive, irritability, or forgetfulness
• Kidney problems: decrease in your amount of urine; blood in your urine; swelling in your ankles; loss of appetite
• Skin problems: rash; itching; skin blistering or peeling; swollen lymph nodes; painful sores or ulcers in the mouth or nose, throat, or genital area; fever or flu-like symptoms
• Eye problems: blurry vision, double vision, or other vision problems; eye pain or redness.

Problems can also happen in other organs and tissues. These are not all of the signs and symptoms of immune system problems that can happen with OPDIVO and YERVOY. Call or see your healthcare provider right away for any new or worsening signs or symptoms, which may include:

• Chest pain; irregular heartbeat; shortness of breath; swelling of ankles
• Confusion; sleepiness; memory problems; changes in mood or behavior; stiff neck; balance problems; tingling or numbness of the arms or legs
• Double vision; blurry vision; sensitivity to light; eye pain; changes in eyesight
• Persistent or severe muscle pain or weakness; muscle cramps
• Low red blood cells; bruising

Rejection of a transplanted organ or tissue. Your healthcare provider should tell you what signs and symptoms you should report and monitor you depending on the type of organ transplant that you have had.

Getting medical help right away may help keep these problems from becoming more serious. Your healthcare team will check you for these problems during treatment and may treat you with corticosteroid or hormone replacement medicines. Your healthcare team may also need to delay or completely stop your treatment if you have severe side effects.

Possible side effects of OPDIVO + YERVOY

OPDIVO and OPDIVO + YERVOY can cause serious side effects, including:

• See "What is the most important information I should know about OPDIVO + YERVOY?"
• Severe infusion reactions. Tell your healthcare team right away if you get these symptoms during an infusion of OPDIVO or YERVOY: chills or shaking; itching or rash; flushing; shortness of breath or wheezing; dizziness; feel like passing out; fever; back or neck pain
• Complications, including graft-versus-host disease (GVHD), of bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). These complications can be serious and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with OPDIVO or YERVOY. Your healthcare provider will monitor you for these complications.

The most common side effects of OPDIVO, when used alone, include: feeling tired; rash; pain in muscles, bones, and joints; itching; diarrhea; nausea; weakness; cough; shortness of breath; constipation; decreased appetite; back pain; upper respiratory tract infection; fever; headache; stomach-area (abdominal) pain; vomiting; and urinary tract infection.

The most common side effects of OPDIVO, when used in combination with YERVOY, include: feeling tired; diarrhea; rash; itching; nausea; pain in muscles, bones, and joints; fever; cough; decreased appetite; vomiting; stomach-area (abdominal) pain; shortness of breath; upper respiratory tract infection; headache; low thyroid hormone levels (hypothyroidism); constipation; decreased weight; and dizziness.

These are not all the possible side effects. For more information, ask your healthcare provider or pharmacist. You are encouraged to report side effects of prescription drugs to the FDA. Call 1-800-FDA-1088.

Before receiving OPDIVO or YERVOY, tell your healthcare provider about all of your medical conditions, including if you:

• have immune system problems such as Crohn's disease, ulcerative colitis, or lupus
• have received an organ transplant, including corneal transplant
• have received or plan to receive a stem cell transplant that uses donor stem cells (allogeneic)
• have received radiation treatment to your chest area in the past and have received other medicines that are like OPDIVO
• have a condition that affects your nervous system, such as myasthenia gravis or Guillain-Barré syndrome
• are pregnant or plan to become pregnant. OPDIVO and YERVOY can harm your unborn baby.
• are breastfeeding or plan to breastfeed. It is not known if OPDIVO or YERVOY passes into your breast milk. Do not breastfeed during treatment with OPDIVO or YERVOY and for 5 months after the last dose of OPDIVO or YERVOY.

Females who are able to become pregnant:

• Your healthcare provider should do a pregnancy test before you start receiving OPDIVO or YERVOY.
• You should use an effective method of birth control during your treatment and for 5 months after the last dose of OPDIVO or YERVOY. Talk to your healthcare provider about birth control methods that you can use during this time.
• Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with OPDIVO or YERVOY.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Please see U.S. Full Prescribing Information and Medication Guide for OPDIVO and YERVOY.

© 2026 Bristol-Myers Squibb Company.

OPDIVO^®, YERVOY^® and the related logos are registered trademarks of Bristol-Myers Squibb Company

1. Choose recipes that resonate

A shared meal can feel even more special when it reflects your family's story. Consider preparing dishes that reflect your family's heritage, honor traditions or bring back favorite memories. You can ask relatives to share beloved recipes or explore cookbooks to discover something new together that still feels personal to your family.

2. Make it a family affair

Bringing everyone into the kitchen helps turn meal prep into part of the celebration. Invite kids into the kitchen to take the burden off mom as you get ready for your celebration by taking on simple, age-appropriate tasks like mixing, assembling ingredients or helping set up and decorate the table. Not only does this ease the workload, but it also creates meaningful moments along the way.

"Nothing makes me happier than sharing recipes with my kids," said Jinich. "And I appreciate it even more when they take over in the kitchen and prepare me one of their favorite dishes, because then they are bringing their stories into our home."

3. Go with the flow

Create a more relaxed, flexible approach to your get-together so you can really enjoy the day. Rather than sticking to a strict schedule, consider a format that allows guests to gather and connect easily. Whether you offer your guests a casual brunch, grazing table, light bites or a dessert later on, keeping things flexible helps ensure the focus stays on spending time together.

4. Prep dishes ahead to save time

Incorporating a make-ahead recipe can help simplify the day and ensure there's something special ready to enjoy. This takes away some of the stress from your preparations and saves time, too. A recipe like this Mango Key Lime Tart made with Eggland's Best eggs offers a bright, flavorful dessert that can be prepared in advance.

"The best thing is, you can make it the day before and keep it in the fridge overnight, so it's ready to go whenever you need it," said Jinich.

When preparing your Mother's Day menu, choosing high-quality ingredients can help support both flavor and nutrition. You can feel good knowing that Eggland's Best eggs contain 10 times more Vitamin E compared to ordinary eggs, which acts as an antioxidant in the body to reduce oxidative stress and protects the cells from damage. In addition, Eggland's Best eggs are an excellent source of Vitamin B5, which helps maintain a healthy digestive system and assists the body in using other vitamins.

Mango Key Lime Tart

Prep time: 10 minutes; Cook time: 40 minutes
Yield: 8 servings

Ingredients:

• 3 Eggland's Best eggs, large (egg yolks only will be used)
• 6 ounces Maria cookies, ground to a fine crumb, about 2 cups cookie crumbs
• 8 tablespoons unsalted butter, melted
• 1/2 cup granulated sugar divided
• 1/2 teaspoon kosher or sea salt
• 1 large ripe mango peeled, cored and cut into chunks (about 1-1 1/2 cups)
• 1/3 cup freshly squeezed lime juice
• 1 14-ounce can sweetened condensed milk
• 1 cup heavy cream, divided
• 1/4 cup cream of coconut

Directions:

Preheat the oven to 350°F. In the bowl of a food processor, or in a medium mixing bowl, pulse or stir together the cookie crumbs, butter, 1/4 cup of the sugar and salt until completely combined.

Press the mixture into a 9-inch tart pan so that it covers the bottom and the sides completely. Place on a baking sheet and bake for 10 minutes.

Remove from the oven and baking sheet and cool on a rack until ready to use.

Add the mango chunks and lime juice to a blender and puree until very smooth. Add the egg yolks from the Eggland's Best eggs and the remaining 1/4 cup sugar and pulse a few times to combine. With blender running, steadily stream in the sweetened condensed milk until all is combined.

Pour the mixture into the cooled tart shell and bake for 20 to 25 minutes, or until the center is set.

Allow to come to room temperature on a rack, then chill in the refrigerator for at least 1 hour before serving.

While the tart is chilling, in a small bowl, whisk the cream of coconut with 2 tablespoons of the heavy cream until the cream of coconut is dissolved. Add the coconut mixture and the remaining heavy cream to the bowl of a stand mixer, set with the whisk attachment. Whip until soft peaks form. Chill until ready to serve.

When ready to serve, remove the tart from the pan and top with the coconut whipped cream. Slice and serve.

Find more recipe inspiration at Egglandsbest.com/recipes and learn more about the nutrition provided by Eggland's Best eggs at EgglandsBest.com.

Subcutaneous administration may help address an important need for patients facing a cancer diagnosis. The cancer patient population continues to evolve, now including younger patients who may seek treatments that have faster administration time. For appropriate patients, having the option of a subcutaneous immunotherapy could meet these patient needs. Additionally, eligible patients with difficult-to-find veins may find this to be an appropriate treatment method.

An example of this evolution is Opdivo Qvantig™ (nivolumab and hyaluronidase-nvhy), the first approved subcutaneous PD-1 inhibitor immunotherapy option that is indicated to treat certain cancers, such as in adult patients with advanced RCC who have received prior anti-angiogenic therapy. Opdivo Qvantig is an injection administered under the skin that is delivered in as little as 3-5 minutes* compared to a 30-minute infusion time of Opdivo^® IV. This subcutaneous treatment is an immunotherapy that is delivered differently than IV. Both are designed to work with the immune system in the same way, but Opdivo Qvantig doesn't need to be administered at an infusion center and may be given by a healthcare professional at a doctor's office or a site closer to home. This treatment works with the immune system to help fight cancer.

Opdivo and Opdivo Qvantig are associated with the following Warnings and Precautions: severe and fatal immune-mediated adverse reactions including pneumonitis, colitis, hepatitis and hepatotoxicity, endocrinopathies, nephritis with renal dysfunction, dermatologic adverse reactions, other immune-mediated adverse reactions; complications of allogeneic hematopoietic stem cell transplantation (HSCT); embryo-fetal toxicity; and increased mortality in patients with multiple myeloma when Opdivo or Opdivo Qvantig are added to a thalidomide analogue and dexamethasone, which is not recommended outside of controlled clinical trials. Opdivo is associated with infusion related reactions. Please see Important Safety Information below.

Choosing the most appropriate treatment is an important decision that should always be made in close consultation with your healthcare team. By offering an additional administration method for certain cancers, Opdivo Qvantig is helping to redefine the patient experience in cancer care, empowering eligible individuals with a patient-centric treatment option that may offer the flexibility to receive treatment closer to home. Ask your doctor if a subcutaneous injection may be right for you or your loved one, and visit OpdivoQvantig.com to learn more.

*This does not account for all aspects of treatment. Does not include observation time. Actual clinic time may vary.

INDICATIONS

OPDIVO QVANTIG™ (nivolumab and hyaluronidase-nvhy) is a prescription medicine used alone as a first treatment for certain adults with kidney cancer that has spread (advanced renal cell carcinoma), after completing combination treatment with intravenous nivolumab and ipilimumab.

OPDIVO QVANTIG is a prescription medicine used in combination with cabozantinib as a first treatment for adults with kidney cancer that has spread (advanced renal cell carcinoma). Please read the Patient Information that comes with cabozantinib.

OPDIVO QVANTIG is a prescription medicine used to treat adults with kidney cancer (renal cell carcinoma) when your cancer has spread after treatment with other cancer medications.

OPDIVO QVANTIG is a prescription medicine used alone to treat adults and children 12 years of age and older who weigh 66 pounds (30 kg) or more with a type of skin cancer called melanoma that has spread or cannot be removed by surgery (advanced melanoma).

OPDIVO QVANTIG is a prescription medicine used alone to treat adults and children 12 years of age and older who weigh 66 pounds (30 kg) or more with a type of skin cancer called melanoma that has spread or cannot be removed by surgery (advanced melanoma), after completing combination treatment with intravenous nivolumab and ipilimumab.

OPDIVO QVANTIG is a prescription medicine used to treat a kind of skin cancer called melanoma. It may be used alone in adults and children 12 years of age and older who weigh 66 pounds (30 kg) or more with Stage IIB, Stage IIC, Stage III or Stage IV melanoma to help prevent melanoma from coming back after it has been completely removed by surgery.

OPDIVO QVANTIG is a prescription medicine used in combination with chemotherapy that contains platinum and another chemotherapy medicine, before you have surgery, for adults with early-stage lung cancer (called non-small cell lung cancer).

OPDIVO QVANTIG is a prescription medicine used in combination with chemotherapy that contains platinum and another chemotherapy medicine, before you have surgery, for adults with early stage lung cancer (called non-small cell lung cancer) that does not have an abnormal EGFR or ALK gene and then may be continued alone after surgery to help prevent your lung cancer from coming back.

OPDIVO QVANTIG is a prescription medicine used alone to treat adults with a type of advanced stage lung cancer (called non-small cell lung cancer) that has spread and you have received chemotherapy that contains platinum, and it did not work or is no longer working. If your tumor has an abnormal EGFR or ALK gene, you should have also received a FDA-approved therapy for tumors with these abnormal genes, and it did not work or is no longer working.

OPDIVO QVANTIG is a prescription medicine used alone to treat adults with head and neck cancer (squamous cell carcinoma) that has come back or spread and you have received chemotherapy that contains platinum and it did not work or is no longer working.

OPDIVO QVANTIG is a prescription medicine used alone to treat adults with cancer of the lining of the urinary tract (including the bladder, ureters, or renal pelvis) [urothelial carcinoma] to help prevent cancer of the urinary tract from coming back after it was removed by surgery.

OPDIVO QVANTIG is a prescription medicine used in combination with chemotherapy medicines cisplatin and gemcitabine, as a first line treatment for adults whose urinary tract cancer has spread (metastatic) or cannot be removed by surgery.

OPDIVO QVANTIG is a prescription medicine used alone to treat adults with cancer of the lining of the urinary tract (including the bladder, urethra, ureters, or renal pelvis) [urothelial carcinoma] when it has spread (locally advanced or metastatic) and you have received chemotherapy that contains platinum, and it did not work or is no longer working or your cancer worsened within 12 months of treatment with chemotherapy that contains platinum, either before or after surgery to remove your cancer.

OPDIVO QVANTIG is a prescription medicine used alone to treat adults and children 12 years of age and older who weigh 66 pounds (30 kg) or more with a type of colon or rectal cancer (colorectal cancer or CRC), after completing combination treatment with intravenous nivolumab and ipilimumab, when your cancer cannot be removed with surgery, or has spread, and is microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR).

OPDIVO QVANTIG is a prescription medicine used alone to treat adults and children 12 years of age and older who weigh 66 pounds (30 kg) or more with a type of colon or rectal cancer (colorectal cancer or CRC) that has spread, is microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR), and you have received treatment with a fluoropyrimidine, oxaliplatin, and irinotecan, and it did not work or is no longer working.

OPDIVO QVANTIG is a prescription medicine used alone as a first treatment for adults with a type of liver cancer called hepatocellular carcinoma (HCC) after completing combination treatment with intravenous nivolumab and ipilimumab, when your cancer cannot be removed with surgery or has spread.

OPDIVO QVANTIG is a prescription medicine used alone to treat adults with a type of liver cancer called hepatocellular carcinoma (HCC) after completing combination treatment with intravenous nivolumab and ipilimumab when your cancer cannot be removed with surgery or has spread), and you have received prior treatment with sorafenib.

OPDIVO QVANTIG is a prescription medicine used in adults to help prevent cancer of the tube that connects your throat to your stomach (esophageal cancer) or cancer where the esophagus joins the stomach (gastroesophageal junction cancer) from coming back after it has been treated with chemoradiation followed by surgery to completely remove the cancer, but some cancer cells were still present in the removed tumor or lymph nodes.

OPDIVO QVANTIG is prescription medicine used in combination with chemotherapy that contains fluoropyrimidine and platinum as a first treatment to treat adults with cancer of the tube that connects your throat to your stomach (esophageal cancer) when your cancer is a type called squamous cell carcinoma and cannot be removed with surgery or has spread and your tumors are positive for PD-L1.

OPDIVO QVANTIG is a prescription medicine used alone to treat adults with cancer of the tube that connects your throat to your stomach (esophageal cancer) if your esophageal cancer is a type called squamous cell carcinoma, and cannot be removed with surgery, and has come back or spread after you have received chemotherapy that contains fluoropyrimidine and platinum.

OPDIVO QVANTIG is a prescription medicine used in combination with chemotherapy that contains fluoropyrimidine and platinum to treat adults with cancer of the stomach (gastric), junction between the stomach and esophagus (gastroesophageal junction), and esophagus that is a type called esophageal adenocarcinoma and cannot be removed with surgery or has spread and your tumors are positive for PD-L1.

OPDIVO^® (nivolumab) is a prescription medicine used to treat adults and children 12 years of age or older with a type of skin cancer called melanoma that has spread or cannot be removed by surgery (advanced melanoma).

OPDIVO is a prescription medicine used in combination with YERVOY^® (ipilimumab) to treat adults and children 12 years of age or older with a type of skin cancer called melanoma that has spread or cannot be removed by surgery (advanced melanoma).

OPDIVO is a prescription medicine used to treat a kind of skin cancer called melanoma. It may be used alone in adults and children 12 years and older with Stage IIB, Stage IIC, Stage III or Stage IV melanoma to help prevent melanoma from coming back after it has been completely removed by surgery.

OPDIVO is a prescription medicine used in combination with chemotherapy that contains platinum and another chemotherapy medicine, before you have surgery, for adults with early-stage lung cancer (called non-small cell lung cancer).

OPDIVO is a prescription medicine used in combination with chemotherapy that contains platinum and another chemotherapy medicine, before you have surgery, for adults with early stage lung cancer (called non-small cell lung cancer) that does not have an abnormal EGFR or ALK gene and then may be continued alone after surgery to help prevent your lung cancer from coming back.

OPDIVO is a prescription medicine used in combination with YERVOY as a first treatment for adults with a type of advanced stage lung cancer (called non-small cell lung cancer) when your lung cancer has spread to other parts of your body (metastatic) and your tumors are positive for PD-L1, but do not have an abnormal EGFR or ALK gene.

OPDIVO is a prescription medicine used in combination with YERVOY and 2 cycles of chemotherapy that contains platinum and another chemotherapy medicine, as a first treatment for adults with a type of advanced stage lung cancer (called non-small cell lung cancer) when your lung cancer has spread or comes back, and your tumor does not have an abnormal EGFR or ALK gene.

OPDIVO is a prescription medicine used to treat adults with a type of advanced stage lung cancer (called non-small cell lung cancer) that has spread and you have received chemotherapy that contains platinum, and it did not work or is no longer working. If your tumor has an abnormal EGFR or ALK gene, you should have also received an EGFR or ALK inhibitor medicine and it did not work or is no longer working.

OPDIVO is a prescription medicine used in combination with YERVOY as a first treatment for adults with a type of cancer that affects the lining of the lungs and chest wall called malignant pleural mesothelioma which cannot be removed by surgery.

OPDIVO is a prescription medicine used in combination with YERVOY as a first treatment for certain adults with kidney cancer that has spread (advanced renal cell carcinoma).

OPDIVO is a prescription medicine used in combination with cabozantinib as a first treatment for adults with kidney cancer that has spread (advanced renal cell carcinoma). Please read the Patient Information that comes with cabozantinib.

OPDIVO is a prescription medicine used to treat people with kidney cancer (renal cell carcinoma) when your cancer has spread after treatment with other cancer medications.

OPDIVO is a prescription medicine used to treat people with head and neck cancer (squamous cell carcinoma) that has come back or spread and you have received chemotherapy that contains platinum and it did not work or is no longer working.

OPDIVO is a prescription medicine used to treat adults with cancer of the lining of the urinary tract (including the bladder, urethra, ureters, or renal pelvis) [urothelial carcinoma] when it has spread (locally advanced or metastatic) and you have received chemotherapy that contains platinum, and it did not work or is no longer working or your cancer worsened within 12 months of treatment with chemotherapy that contains platinum, either before or after surgery to remove your cancer.

OPDIVO is a prescription medicine used to treat adults with cancer of the lining of the urinary tract (including the bladder, ureters, or renal pelvis) [urothelial carcinoma] to help prevent cancer of the urinary tract from coming back after it was removed by surgery.

OPDIVO is a prescription medicine used in combination with chemotherapy medicines cisplatin and gemcitabine, as a first line treatment when your urinary tract cancer has spread (metastatic) or cannot be removed by surgery.

OPDIVO is a prescription medicine that may be used in combination with YERVOY to treat adults and children 12 years of age and older, with a type of colon or rectal cancer (colorectal cancer) that cannot be removed with surgery, or has spread, and is microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR).

OPDIVO is a prescription medicine that may be used alone to treat adults and children 12 years of age and older with a type of colon or rectal cancer (colorectal cancer) that has spread, and is microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR), and you have received treatment with a fluoropyrimidine, oxaliplatin, and irinotecan, and it did not work or is no longer working.

OPDIVO is a prescription medicine used in combination with YERVOY as a first treatment for adults with a type of liver cancer called hepatocellular carcinoma that cannot be removed by surgery or has spread.

OPDIVO is a prescription medicine used in combination with YERVOY to treat adults with a type of liver cancer called hepatocellular carcinoma (HCC) when your liver cancer cannot be removed by surgery or has spread, and you have received prior treatment with sorafenib.

OPDIVO is a prescription medicine used to treat adults with cancer of the tube that connects your throat to your stomach (esophageal cancer) if your esophageal cancer is a type called squamous cell carcinoma, and cannot be removed with surgery, and has come back or spread after you have received chemotherapy that contains fluoropyrimidine and platinum.

OPDIVO is a prescription medicine that may be used in adults to help prevent cancer of the tube that connects your throat to your stomach (esophageal cancer) or cancer where the esophagus joins the stomach (gastroesophageal junction cancer) from coming back after it has been treated with chemoradiation followed by surgery to completely remove the cancer, but some cancer cells were still present in the removed tumor or lymph nodes.

OPDIVO is a prescription medicine used in combination with chemotherapy that contains fluoropyrimidine and platinum as a first treatment to treat adults with cancer of the tube that connects your throat to your stomach (esophageal cancer) when your cancer is a type called squamous cell carcinoma and cannot be removed with surgery or has spread, and your tumors are positive for PD-L1.

OPDIVO is a prescription medicine used in combination with YERVOY as a first treatment to treat adults with cancer of the tube that connects your throat to your stomach (esophageal cancer) when your cancer is a type called squamous cell carcinoma and cannot be removed with surgery or has spread, and your tumors are positive for PD-L1.

OPDIVO is a prescription medicine used in combination with chemotherapy that contains fluoropyrimidine and platinum to treat adults with cancer of the stomach (gastric), junction between the stomach and esophagus (gastroesophageal junction), and esophagus that is a type called adenocarcinoma and cannot be removed with surgery or has spread, and your tumors are positive for PD-L1.

It is not known if OPDIVO or OPDIVO QVANTIG is safe and effective in children younger than 12 years of age with melanoma or MSI-H or dMMR metastatic colorectal cancer.

It is not known if OPDIVO or OPDIVO QVANTIG is safe and effective in children for the treatment of any other cancers.

IMPORTANT SAFETY INFORMATION FOR OPDIVO QVANTIG (nivolumab and hyaluronidase-nvhy), OPDIVO (nivolumab), and YERVOY (ipilimumab)

What is the most important information I should know about OPDIVO QVANTIG, OPDIVO, and YERVOY?

OPDIVO QVANTIG, OPDIVO, and YERVOY are medicines that may treat certain cancers by working with your immune system. OPDIVO QVANTIG, OPDIVO, and YERVOY can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or can lead to death. These problems may happen anytime during treatment or even after your treatment has ended. You may have more than one of these problems at the same time. Some of these problems may happen more often when OPDIVO QVANTIG or OPDIVO are used in combination with another therapy.

Call or see your healthcare provider right away if you develop any new or worsening signs or symptoms, including:

Lung problems: cough; shortness of breath; chest pain

Intestinal problems: diarrhea (loose stools) or more frequent bowel movements than usual; stools that are black, tarry, sticky, or have blood or mucus; severe stomach-area (abdominal) pain or tenderness

Liver problems: yellowing of your skin or the whites of your eyes; severe nausea or vomiting; pain on the right side of your stomach area (abdomen); dark urine (tea colored); bleeding or bruising more easily than normal

Hormone gland problems: headaches that will not go away or unusual headaches; eye sensitivity to light; eye problems; rapid heartbeat; increased sweating; extreme tiredness; weight gain or weight loss; feeling more hungry or thirsty than usual; urinating more often than usual; hair loss; feeling cold; constipation; your voice gets deeper; dizziness or fainting; changes in mood or behavior, such as decreased sex drive, irritability, or forgetfulness

Kidney problems: decrease in your amount of urine; blood in your urine; swelling of your ankles; loss of appetite

Skin problems: rash; itching; skin blistering or peeling; swollen lymph nodes, painful sores or ulcers in mouth or nose, throat, or genital area; fever or flu-like symptoms

Eye problems: blurry vision, double vision, or other vision problems; eye pain or redness

Problems can also happen in other organs and tissues. These are not all of the signs and symptoms of immune system problems that can happen with OPDIVO QVANTIG, OPDIVO, and YERVOY. Call or see your healthcare provider right away for any new or worsening signs or symptoms, which may include:

• Chest pain, irregular heartbeat, shortness of breath or swelling of ankles
• Confusion, sleepiness, memory problems, changes in mood or behavior, stiff neck, balance problems, tingling or numbness of the arms or legs
• Double vision, blurry vision, sensitivity to light, eye pain, changes in eyesight
• Persistent or severe muscle pain or weakness, muscle cramps
• Low red blood cells, bruising

Rejection of a transplanted organ or tissue. Your healthcare provider should tell you what signs and symptoms you should report and monitor you depending on the type of organ or tissue transplant that you have had.

Getting medical treatment right away may help keep these problems from becoming more serious. Your healthcare provider will check you for these problems during treatment with OPDIVO QVANTIG, OPDIVO, and YERVOY. Your healthcare provider may treat you with corticosteroid or hormone replacement medicines. Your healthcare provider may also need to delay or completely stop treatment with OPDIVO QVANTIG, OPDIVO, or YERVOY, if you have severe side effects.

What are the possible side effects of OPDIVO QVANTIG, OPDIVO, and YERVOY?

OPDIVO QVANTIG, OPDIVO, and YERVOY can cause serious side effects, including:

• See "What is the most important information I should know about OPDIVO QVANTIG, OPDIVO, and YERVOY?"
• Complications, including graft-versus-host-disease (GVHD), in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). These complications can be severe and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with OPDIVO QVANTIG, OPDIVO, or YERVOY. Your healthcare provider will monitor you for signs of complications if you have an allogeneic stem cell transplant.

OPDIVO and YERVOY can cause serious side effects, including:

• Severe infusion reactions. Tell your healthcare team right away if you get these symptoms during an infusion of OPDIVO or YERVOY: chills or shaking; itching or rash; flushing; shortness of breath or wheezing; dizziness; feel like passing out; fever; back or neck pain.

The most common side effects of OPDIVO QVANTIG when used alone in people with renal cell carcinoma include: pain in muscles, bones, and joints; feeling tired; itching; rash; low thyroid hormone levels; diarrhea; cough; stomach-area (abdominal) pain.

The most common side effects observed with nivolumab given into the vein (intravenous nivolumab), which may be experienced with OPDIVO QVANTIG, are shown below.

The most common side effects of OPDIVO, when used alone, include: feeling tired; rash; pain in muscles, bones, and joints; itching; diarrhea; nausea; weakness; cough; shortness of breath; constipation; decreased appetite; back pain; upper respiratory tract infection; fever; headache; stomach-area (abdominal) pain; vomiting; and urinary tract infection.

The most common side effects of OPDIVO, when used in combination with cabozantinib, include: diarrhea; feeling tired; liver problems; rash, redness, pain, swelling or blisters on the palms of your hands or soles of your feet; mouth sores; rash; high blood pressure; low thyroid hormone levels; pain in muscles, bones, and joints; decreased appetite; nausea; change in the sense of taste; stomach-area (abdominal) pain; cough; upper respiratory tract infection.

The most common side effects of OPDIVO, when used in combination with a platinum-containing chemotherapy and chemotherapy, include: nausea; feeling tired; pain in muscles, bones, and joints; constipation; decreased appetite; rash; vomiting; numbness, pain, tingling, or burning in your hands, and feet.

The most common side effects of OPDIVO when used in combination with platinum-containing chemotherapy and another chemotherapy medicine before having surgery for NSCLC include: nausea; constipation; feeling tired; decreased appetite; rash.

The most common side effects of OPDIVO, when used in combination with YERVOY, include: feeling tired; diarrhea; rash; itching; nausea; pain in muscles, bones, and joints; fever; cough; decreased appetite; vomiting; stomach-area (abdominal) pain; shortness of breath; upper respiratory tract infection; headache; low thyroid hormone levels (hypothyroidism); constipation; decreased weight; and dizziness.

The most common side effects of OPDIVO, when used in combination with YERVOY and a platinum-containing chemotherapy and another chemotherapy, include: feeling tired; pain in muscles, bones, and joints; nausea; diarrhea; rash; decreased appetite; constipation; and itching.

The most common side effects of OPDIVO when used in combination with fluoropyrimidine and platinum-containing chemotherapy include: nausea; numbness, pain, tingling, or burning in your hands or feet; decreased appetite; feeling tired; constipation; mouth sores; diarrhea; vomiting; stomach-area (abdominal) pain; pain in muscles bones, and joints.

These are not all the possible side effects. For more information, ask your healthcare provider or pharmacist. You are encouraged to report side effects of prescription drugs to FDA. Call 1-800-FDA-1088.

Before receiving OPDIVO QVANTIG or OPDIVO or YERVOY, tell your healthcare provider about all of your medical conditions, including if you:

• have immune system problems such as Crohn's disease, ulcerative colitis, or lupus.
• have received an organ or tissue transplant, including corneal transplant.
• have received or plan to receive a stem cell transplant that uses donor stem cells (allogeneic).
• have received radiation treatment to your chest area in the past and have received other medicines that are like OPDIVO, YERVOY, or OPDIVO QVANTIG.
• have a condition that affects your nervous system, such as myasthenia gravis or Guillain-Barré syndrome.
• are pregnant or plan to become pregnant. OPDIVO QVANTIG, OPDIVO, and YERVOY can harm your unborn baby.
• are breastfeeding or plan to breastfeed. It is not known if OPDIVO QVANTIG, OPDIVO, or YERVOY pass into your breast milk. Do not breastfeed during treatment and for 5 months after your last dose of OPDIVO QVANTIG, OPDIVO, or YERVOY.

Females who are able to become pregnant:

• Your healthcare provider should do a pregnancy test before you start receiving OPDIVO QVANTIG, OPDIVO, or YERVOY.
• You should use an effective method of birth control during treatment and for 5 months after your last dose of OPDIVO QVANTIG, OPDIVO, or YERVOY. Talk to your healthcare provider about birth control methods that you can use during this time.
• Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with OPDIVO QVANTIG, OPDIVO, or YERVOY.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Please see U.S. Full Prescribing Information and Medication Guide for OPDIVO QVANTIG. Please see U.S. Full Prescribing Information and Medication Guide for OPDIVO and YERVOY.

© 2026 Bristol-Myers Squibb Company.

OPDIVO^®, OPDIVO Qvantig™, and the related logos are trademarks of Bristol-Myers Squibb Company.

• Staying up-to-date on vehicle safety recalls should top every driver's maintenance checklist.
• It's easy to check for open recalls at CheckToProtect.org.
• An authorized dealership can complete your recall repair at no cost to you.

Just as staying on top of regular oil changes, tire rotations and other essential vehicle maintenance helps ensure driver and passenger safety, it's vital to make sure your car or truck is recall-free. However, many drivers don't realize there's an easy way to check. According to a survey by Stellantis, nearly half (43%) of American drivers don't know where to find out if their vehicle has an open safety recall.

There's an easy solution: Any driver can see if their vehicle has a recall by visiting the National Safety Council's CheckToProtect.org. Whether you're planning a road trip or just want to be sure your vehicle is safe for you and your family, checking for recalls can give you peace of mind.

How do you check for recalls?

Simply enter or upload a photo of your license plate number or the 17-character vehicle identification number (VIN) into the search tool on CheckToProtect.org. If your vehicle has a recall, you can contact an authorized dealership in your area to schedule a free recall repair.

While it's especially important for owners of used or older vehicles, or for anyone who changed their address since purchasing their car or truck, all drivers should ensure their vehicle is safe for themselves and their passengers by checking for recalls.

Why do vehicle recalls matter?

Safety recalls may be issued by an automaker when a part stops functioning properly as it ages, or when a group of vehicle owners experience a similar problem. Safety recalls can affect everything from brakes and steering to batteries and airbags.

Research commissioned by automaker Stellantis found that 40% of drivers believe a recall is fine as long as it doesn't affect a vehicle's performance. However, while some recalls may not change the way a vehicle drives, they can still present a safety risk. For example, if a recalled Takata airbag deploys in a crash, the airbag's inflator can break apart, sending shrapnel throughout the vehicle that could severely injure or kill vehicle occupants.

Another example relates to car seat anchors. CARFAX released new data showing that nearly one million vehicles have open safety recalls for child car seat anchors, a critical safety feature that secures car seats firmly in place.

According to CARFAX, as many as 57 million vehicles currently on the road have an unrepaired safety recall — that's about 1 in every 5 vehicles. Any driver can take the proactive step to check their vehicle's recall status. This is especially important for those with older, used vehicles or who have changed addresses, because manufacturers may not have updated contact information to notify them of recalls.

HAE causes repeat attacks of severe swelling in the body, especially the face, arms, legs, intestinal tract and airway. This can be especially dangerous for children, as their small airways can close quickly during laryngeal attacks.

Previously, children under age 12 with this rare condition only had treatment options that required injections or infusions, which can be difficult and uncomfortable for kids and their caregivers.

But the U.S. Food and Drug Administration (FDA) recently approved ORLADEYO^® (berotralstat) oral pellets, the first oral preventative treatment for children ages 2 to less than 12. Taken daily, the treatment helps to prevent HAE swelling episodes, or attacks, before they start. ORLADEYO is not approved for the treatment of acute attacks.

An impactful and burdensome rare disorder

HAE often begins in childhood, and about 40% of children with HAE experience their first swelling episode by age 5. Uncontrolled HAE can significantly interfere with the ability to live a normal life, and children with HAE often miss school, extracurricular activities and other opportunities, like travel.

Regardless of age, HAE can be burdensome both physically and psychologically, and it can have a significant impact on quality of life, mental health and other developmental elements.

Treatment administration can present additional challenges

Managing the treatment of HAE can also be burdensome for families.

HAE caregiver Lisa Moore knows these challenges firsthand. Her adult son and his father were both diagnosed with HAE, and her granddaughter, Letty, age 8, was diagnosed around age 1.

"Letty was so young when she had her first attack, and it was very hard to deal with," said Moore.

There was no oral preventative treatment available at the time, and the experience of injectable medication administration was difficult for all of them. According to Lisa, Letty would run away and try to avoid it.

"The needle was the biggest thing for her," Moore said. "They had to hold her down, and it was just very hard."

A welcome oral option designed for kids

ORLADEYO oral pellets are sprinkle-like in appearance and were developed by their manufacturer, BioCryst Pharmaceuticals, to be easy for kids to take. The pellets can be poured directly into the mouth and swallowed immediately with a non-acidic liquid such as water or milk, or sprinkled over a spoonful of soft, non-acidic food.

Moore sees this as a big advance.

"To have the option of a preventative medicine in oral form for kids is wonderful. To not have to go through the trauma of being held down, being stuck with a needle, and being fearful when it comes time to have their medication will be so much easier on children and their caregivers," she said.

Clinical findings

In the largest clinical trial of a long-term preventative treatment for HAE in children ages 2 to less than 12, ORLADEYO was generally well tolerated, had a safety profile consistent with trials in people ages 12 and older, and resulted in an early and consistent decrease in HAE attacks. The most commonly reported side effect was upper respiratory infection (nasopharyngitis).

Talk with your doctor

In addition to the new oral pellet formulation, an FDA-approved capsule formulation of ORLADEYO has been available for people with HAE aged 12 and older for more than five years.

If you or someone you know has HAE, it is important to talk to a healthcare provider about treatment options. Learn more by visiting ORLADEYO.com.

Indication and Important Safety Information

WHAT IS ORLADEYO^® (berotralstat)?

ORLADEYO (or-luh-DAY-oh) is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in adults and children 2 years of age and older. It is not known if ORLADEYO is safe and effective in children under 2 years of age.

It is not known if ORLADEYO is safe and effective to treat an acute HAE attack, therefore ORLADEYO should not be used to treat an acute HAE attack.

Do not take more than 1 dose of ORLADEYO per day because extra doses can cause heart rhythm problems.

IMPORTANT SAFETY INFORMATION

Before taking ORLADEYO, tell your healthcare provider about all of your medical conditions, including if you

• have liver problems or kidney problems.
• are pregnant or planning to become pregnant. It is not known if ORLADEYO can harm your unborn baby.
• are breastfeeding or plan to breastfeed. It is not known if ORLADEYO passes into your breastmilk. Talk to your healthcare provider about the best way to feed your baby while taking ORLADEYO.

Tell your healthcare provider about all of the medicines you take, including other medicines for HAE, prescription and over-the-counter medicines, vitamins, and herbal supplements.

Taking ORLADEYO with certain other medicines may affect the way other medicines work and other medicines may affect how ORLADEYO works.

Know the medicines you take and keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

What are the possible side effects of ORLADEYO?

Taking more than 1 dose of ORLADEYO per day may cause serious side effects, including heart rhythm problems. A heart rhythm problem called QTc interval prolongation can happen in people who take more than 1 dose of ORLADEYO per day. This condition can cause an abnormal heartbeat. Do not take more than 1 dose of ORLADEYO per day.

The most common side effects of ORLADEYO include abdominal pain, vomiting, diarrhea, back pain, and heartburn. These are not all of the possible side effects of ORLADEYO. For more information, ask your healthcare provider or pharmacist.

Talk to your healthcare provider for medical advice about side effects.

You are encouraged to report side effects of prescription drugs to BioCryst Pharmaceuticals, Inc. at 1-833-633-2279 or to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088.

For more information, please see the full Prescribing Information including the Patient Information.

© 2026 BioCryst Pharmaceuticals, Inc. All rights reserved. US.ORL.03216. 3/26

BioCryst and ORLADEYO are registered trademarks of BioCryst Pharmaceuticals, Inc.

• This Earth Month, you can make a difference by starting with individual actions.
• From spending time outside to choosing the right personal care products, change starts with simple actions.
• Learn more about one company making a difference at www.tomsofmaine.com.

When it comes to the environment and supporting the planet, people often think of big, sweeping changes — climate policy, global emissions, renewable energy. But change doesn't always start at that scale. More often, it begins with everyday decisions: what we eat, how we support our community and the products we bring into our homes. Individual actions can feel small, but multiplied across millions of people, they become something else entirely.

Here are four ways those everyday choices can make a difference for Earth Month 2026.

First, spend more time outside

Beyond the well-documented effects on mood and stress, time in nature has been shown to shift behavior — making people more considerate of those around them and more likely to take action to protect the environment.

It reflects something intuitive. The more time people spend outside — whether hiking, biking or simply walking through a park — the more invested they become in protecting those spaces.

That mindset also shapes the choices they make at home.

How to think about plastic circularity

Not all plastic is created equal, and not all of it has to end up in a landfill. The concept of plastic circularity is about keeping materials in use for as long as possible, through products designed to be reused, refilled or recycled; and through better systems for recovering them at end of life.

At home, that can look like prioritizing products made from recycled content, choosing packaging that's designed to be recycled and taking advantage of take-back programs for items your curbside bin won't accept. Tom's of Maine builds this thinking into its products with recyclable toothpaste tubes and a free TerraCycle program for hard-to-recycle personal care containers.¹

Look beyond labels when choosing personal care products

Personal care products are often bought on autopilot. A quick stop at the store, the same familiar brand tossed in the cart and the decision is done. But sourcing and formulation decisions behind those products have implications.

Tom's of Maine was founded in 1970, the same year as the first Earth Day. Not a coincidence so much as a reflection of the same shift: the belief that responsible practices weren't optional extras but the right way to do business. The company's Stewardship Model guides every sourcing and formulation decision, evaluating not just what an ingredient does but where it comes from and how it gets there.

Take peppermint oil or lavender oil. When Tom's of Maine refers to a naturally sourced ingredient, it means something that hasn't changed much from how you'd find it in its original state, removed and concentrated, but otherwise much the same.

"Tom's of Maine was founded on the idea that personal care shouldn't come with compromises. We're thoughtful about every step of the process, starting with where our ingredients come from — choosing only naturally sourced or derived ingredients and leaving out artificial flavors and fragrances altogether," said Michelle Waring, Steward for Sustainability and Everyday Good at Tom's of Maine.

Support organizations doing the work

American Forests, the oldest national forest conservation organization in the country, reforested more than 240,000 acres in 2024 alone. Additionally, their Tree Equity movement has expanded to more than 1,000 U.S. communities, working to ensure everyone has equitable access to green spaces and the benefits trees provide.

Tom's of Maine is backing that work through a three-year partnership with American Forests, reflecting the brand's broader commitment to protecting nature for generations to come. Finding an organization with a mission aligned with your values and supporting it — as Tom's has — is how a personal value becomes collective impact.

Small choices, real impact

Everyday decisions don't always feel like environmental actions. But collectively, they shape the world around us — and when millions of people make them with intention, progress adds up.

To learn more about Tom's of Maine's ingredient sourcing, safety standards and sustainability commitments, visit www.tomsofmaine.com and www.tomsofmaine.com/pages/our-mission.

¹ Tube recyclability varies by community; check locally. TerraCycle program participation is limited.

"As we age, maintaining independence often becomes a top priority. The best way to do that is by staying healthy and active. Spending time outdoors is a powerful tool we can use to help do just that," said Doug Armstrong, vice president, Health Products at AARP Services Inc. "Time outside engages your mind and body, offering a significant boost to your physical and mental health and keeping you feeling your best."

Fortunately, AARP member benefits provide a wealth of resources to help you take that first step toward a healthier, more active lifestyle while saving money in the process.

Take in the sights

The best way to appreciate nature's beauty and serenity is with clear vision. Whether you are driving to a park, reading trail markers, or navigating a rocky hiking path, seeing clearly also keeps you safe and confident.

Regular eye exams are a simple but vital way to prevent accidents and catch serious health conditions early. To stay up to date on regular vision checks, AARP members can learn more about vision insurance options with plans that offer access to a large, nationwide network of eye doctors, generous allowances for glasses or contacts, savings on lens enhancements (like progressives and anti-reflective coatings) and more.

AARP members can also explore and enjoy natural destinations more clearly with a new pair of prescription glasses or sunglasses. Members can get 20% off designer frames + 50% off prescription lenses with the purchase of a complete pair of eyewear and 30% off sunglasses at LensCrafters.

Enjoy the sounds of nature

Much of nature's healing qualities come from the sensory experience — the sound of birds chirping, the rustle of leaves in the wind, or the voices of friends during a group hike. Hearing not only allows you to enjoy your surroundings, but it is also a vital component of staying safe and connected while outside.

With AARP^® Hearing Solutions™ provided by UnitedHealthcare^® Hearing members have access to savings on hearing aids and hearing care. AARP members can save up to 50% on prescription hearing aids and up to $200 off over-the-counter hearing aids. Members also receive a free hearing exam and consultation, with personalized support through a large nationwide network of hearing providers. No insurance is needed to use the program.

Staying proactive with your hearing allows you to enjoy the subtle cues of the natural environment and remain alert to your surroundings, which is essential for safety during outdoor excursions.

Get moving

A critical benefit of being outdoors is that it encourages physical activity. While being active helps maintain health, you also need to be in good health to stay active. Regular visits with a primary provider can help you feel your best and formulate a plan to stay resilient for years of future adventures.

Oak Street Health provides personalized care for older adults on Medicare, designed to help you stay healthy and independent. AARP members and non-members get same-day/next-day appointments where available, a dedicated care team, and a 24/7 patient support line. Oak Street Health has over 200 primary care doctor offices across 27 states, making it easier to address health concerns before they interfere with your active lifestyle.

Supplement wellness with savings

As we get older, ongoing prescription medications may become part of our daily routine. Saving money on these recurring costs can add up significantly over time, freeing up funds for leisure activities like travel or outdoor gear.

AARP^® Prescription Discounts provided by Optum Rx^® offers a free prescription discount card that can be used at 66,000 pharmacies nationwide for savings on FDA-approved medications. The program is open to anyone, whether you're an AARP member or not — but AARP members get additional benefits, including deeper discounts on medications, home delivery, savings for your dependents and more.

For those juggling multiple medication regimens, the Hero Smart Pill Dispenser stores, sorts and dispenses up to a 90-day supply of up to 10 different medications. The connected medication management app helps you manage medication routines, track your supply and understand your adherence. AARP members get exclusive savings on a Hero subscription.

Stay safe outdoors

For those who enjoy solo walks or spending time in the yard, safety is a key consideration. With Lifeline Medical Alert Service members and their families can have peace of mind in the event of an accident or an unexpected situation. Lifeline systems connect you to a trained care specialist with just the press of a button. Members save 15% on medical alert service and get free shipping and activation. You can select the service option that fits your lifestyle and get fast, 24/7/365 access to help when you need it.

Taking small steps like adding a few extra minutes outside each day can have a greater impact on tomorrow. Utilizing these benefits can help make that even easier and allow you to stay a step ahead as you age. For more resources on how to manage your health at home and in the great outdoors, visit aarp.org/benefits.

AARP and its affiliates are not insurers, agents, brokers or producers. AARP member benefits are provided by third parties, not by AARP or its affiliates. Providers pay a royalty fee to AARP for the use of its intellectual property. These fees are used for the general purposes of AARP. Some provider offers are subject to change and may have restrictions. Please contact the provider directly for details.

Every year, thousands of people dismiss symptoms such as rectal bleeding or a change in bowel habits, chalking it up to hemorrhoids, stress or something they ate. As surgeons, we want to share a crucial message that could save your life: never ignore these symptoms, no matter your age.

For decades, colorectal cancer was considered a disease primarily affecting older adults. Today, medical understanding has shifted significantly. We have seen a concerning rise in diagnosis in people under 50, making it a leading cause of cancer deaths in this younger population. People born in 1990 now have double the risk of colon cancer and quadruple the risk of rectal cancer compared to those born in 1950. Because of their age, their symptoms are often overlooked, leading to later-stage diagnoses when the disease is harder to treat.

Research presented at the most recent American College of Surgeons Clinical Congress emphasizes this point. In patients under 50, rectal bleeding was the strongest predictor of colorectal cancer, with an 850% increase in the odds of a diagnosis. Furthermore, 70% of these young patients had no family history, and 88% scheduled their colonoscopy due to symptoms, rather than as a routine screening.

What should you do if you notice something that doesn't seem right?

• Listen to your body. Pay attention to persistent changes. This includes a change in bowel habits (like new constipation or diarrhea), narrow or ribbon-like stools, a feeling that your bowels don't empty completely, bloating, or rectal pain or discomfort.
• Don't ignore blood. If you see blood in or on your stool, on the toilet paper, or in the bowl, do not assume it's "just" hemorrhoids whether it is bright red or dark in color. Note how often it happens and whether it's mixed in with the stool. Bleeding is a key warning sign that warrants an immediate discussion with your doctor.
• Note general health changes. Unexplained weight loss, ongoing fatigue, bloating or a loss of appetite can also be signs that something is not quite right. The American College of Surgeons has a free Colon Cancer Symptom Checklist to help you track these symptoms and prepare for an informed conversation with your physician.
• Know your screening needs. If you are at average risk, begin regular screening at age 45. If you have a family history of colon cancer or polyps, or a condition like Crohn's or Ulcerative colitis, or certain other cancers, you may need to start even sooner.

Know the symptoms and when to act. By advocating for yourself, we can diagnose this disease early when it is most treatable.

Patricia L. Turner, MD, MBA, FACS is the Executive Director & CEO of the American College of Surgeons.

James W. Fleshman Jr., MD, FACS, FASCRS is a member of the Board of Regents of the American College of Surgeons and chief of surgery and Sparkman Endowed Professor and Chairman of the department of surgery at Texas A&M Health Science Center, Baylor University Medical Center.

For pet parents, that pressure can lead to tough tradeoffs, such as delaying routine veterinary visits or skipping preventive care. While those decisions may ease short-term financial strain, they can carry longer-term consequences for both pet health and household budgets.

Preventive care, including annual checkups, vaccinations and screenings, is widely recommended by veterinarians and plays a critical role in keeping pets healthy. Yet as everyday expenses, from groceries to healthcare, continue to climb, it can be tempting to postpone routine care, even though doing so may lead to higher and less predictable costs later on.

Thinking of preventive care as one way to safeguard your pet's well-being — and your own peace of mind — can make it easier to prioritize during financially stressful times.

Preventive Care Is Common — and Often Effective

Most veterinary visits aren't driven by emergencies. In fact, MetLife Pet Insurance's recent research found about 60% of vet visits are preventive rather than reactive, underscoring the role routine care plays in keeping pets healthy. These visits often make a real difference: 37% of pet parents say routine care helped them catch a health issue early, when treatment is typically simpler and more affordable.[i]

"Preventive exams allow veterinarians to spot subtle changes you might not notice at home," said Brian Jorgensen, CEO of MetLife Pet Insurance. "Catching issues early can reduce the likelihood of more complex, expensive complications later."

Cost Pressures Can Lead to Delays

Even when you know preventive care matters, cost can be a barrier. Seven in 10 pet parents say they've delayed or skipped veterinary visits due to expense, according to MetLife Pet Insurance research. Among those who postponed care, 35% say their pet's condition worsened — sometimes requiring more intensive treatment than if it had been addressed sooner.[ii]

Delaying care can also take an emotional toll. Nearly three-quarters of pet parents who delayed care said they felt guilty, while many also reported feeling anxious, ashamed, uncertain or helpless.[iii] As veterinary costs rise alongside everyday expenses, balancing short-term savings with long-term risk becomes increasingly difficult.

Why Preventive Care Often Costs Less

Preventive care can play an important role in helping pet parents plan and budget over time, replacing unpredictable, high-cost medical crises with more manageable, routine expenses.

One simple example is heartworm disease: According to the American Heartworm Society, a year of heartworm prevention typically costs $70 to $200, while treatment can range from $1,200 to $1,800, not including follow-up care.[iv] Dental care follows a similar pattern: a routine exam and cleaning may cost a few hundred dollars, but untreated dental disease can lead to extractions costing $500 to $2,500.[v]

"Many of the most expensive conditions affecting pets don't appear overnight," Jorgensen noted. "They develop gradually, which is why routine checkups and prevention are so important."

How Pet Insurance with Wellness Coverage Can Help

For many pet parents, the challenge isn't understanding the value of preventive care — it's fitting routine costs into a monthly budget. Pet insurance with a wellness add-on can help make these services, such as exams, vaccinations, dental cleanings and parasite prevention, more manageable by turning them into planned, predictable expenses.

That predictability can make it easier to stay on schedule with recommended care, reducing the risk that small issues become larger, more costly problems.

A Seasonal Reset with Lasting Impact

Spring is a season of renewal — for people and pets alike. Scheduling routine checkups, staying current on preventive care, and addressing small concerns early can help your pet stay healthier throughout the year, while reducing the likelihood of unexpected, high-cost medical events.

Preventive care benefits both you and your furry loved one — not only does it protect the bond you share, it also safeguards the financial well-being of your household. This spring, a simple wellness visit can be a meaningful reset, offering peace of mind that lasts long after the season changes.

While there's nothing quite like the joy of a sparkling, clean home, spring cleaning can sometimes feel like a chore, but with your favorite Lysol^® products, it can become a moment you actually look forward to.

This season, the experts at Lysol share tips to help transform your cleaning routine into a sensory experience.

Declutter before you disinfect

Take a moment to declutter your space. Removing unnecessary items instantly makes rooms feel lighter, brighter and more inviting — and helps you spot messes you didn't even realize were there.

Tackle one area at a time, like a countertop, shelf or corner. Sort items into three piles: keep, toss and donate. Be honest about what you truly need and let go of what's just taking up space.

Try Lysol Lavender & Cotton Blossom scented Disinfecting Spray to disinfect both hard and soft surfaces throughout your home. It kills 99.9% of viruses and bacteria, including cold and flu viruses*, and can be used on many frequently touched surfaces like desktops, metal door handles** and countertops.

Let fragrance refresh your cleaning routine

While cleaning and disinfecting your home, play around with the scent of the products you use to help transform cleaning from a chore into an enjoyable ritual.

The Lysol Lavender & Cotton Blossom fragrance is ideal for a spring reset, as the scent blends notes of lavender, jasmine and violet with subtle hints of energizing apple and green pear. Rich sandalwood and white musk, reminiscent of cozy cotton blossoms, round out the scent for a refreshing finish.

The product line has you covered throughout your cleaning routine, including All-Purpose Cleaner, Multi-Surface Cleaner 2X Concentrated Pour, Toilet Bowl Cleaner, Disinfectant Spray and Disinfecting Wipes. The products kill 99.9% of germs* while leaving behind a lavender scent you'll love.

Tackle the hidden spots

Once you've tackled the big, obvious areas of your home, it's time to dig into the spaces that often get ignored but can harbor a surprising amount of dust, grime and germs. Think stovetops, light switches, metal door handles and all those hard-to-reach corners where clutter collects.

Give these hidden areas the same energy you gave to the main rooms. A thorough wipe-down can make a noticeable difference, especially on hard surfaces like sinks, bathtubs, cabinets, appliance exteriors and more.

A little attention here goes a long way.

Enjoy the sound of music

Make the entire cleaning process a whole lot more fun by cranking up your favorite high-energy or uplifting music that moves you. Let the beat carry you along as you declutter, dust and refresh your home for the season ahead.

When you're finished, kick back, take a deep breath, relish in your refreshed space and enjoy the atmosphere that comes from a delightfully clean home.

Explore more tips and products to help you embrace your spring cleaning this year at Lysol.com.

*When used as directed

**Not for use on leather, rayon, silk or satin fabrics or acrylic plastics, or on brass, copper or aluminum or painted wood surfaces.

A cancer diagnosis and treatment can disrupt nearly every part of life for both the person living with cancer and their family and close friends. There is the emotional toll and side effects of the diagnosis and cancer treatment — then there are logistical and financial challenges that can accompany cancer treatment: Navigating a complicated care plan, scheduling and transportation for appointments, managing prescriptions and understanding benefits and insurance coverage.

These challenges can be daunting for both the patient and the loved ones and family members who help provide care.

The good news is that there is a growing call for expanding access to a type of cancer care called Supportive Cancer Care that bridges medical treatment with emotional, physical and practical support, putting patients and their caregivers at the center of care. However, fewer than one in five patients make use of this kind of whole-person support while going through cancer treatment.

Support is Care: Spreading the word about whole-person care

The new Support is Care campaign, powered by The Sheri and Les Biller Family Foundation, is raising awareness about Supportive Cancer Care.

Sheri and Les Biller first recognized how vital this aspect of care was after Sheri lost two of her closest friends to breast cancer.

"Watching two of my dearest friends — who were truly like sisters to me — battle cancer was devastating. We saw up close how the emotional and practical toll consumed them and their families: shock, anxiety and exhaustion around the diagnosis and prognosis, the maze of insurance, debilitating physical side effects, lost work hours and mounting bills," said Sheri Biller. "Far too many families confront the same emotional, practical and financial challenges our friends endured years ago."

Today, the mission of Support Is Care is simple: to help people living with cancer and those who love them understand Supportive Cancer Care, know that it's part of high-quality care, and that they can ask for it.

What is Supportive Cancer Care?

Supportive Cancer Care combines medical treatment for cancer — such as chemotherapy, radiation, surgery and immunotherapy — with emotional, practical and financial support. It supports the whole person while also addressing the symptoms of the disease and the side effects of treatment.

Supportive Cancer Care services can include anything from financial guidance, transportation support and help navigating insurance and billing to pain management, nutrition counseling, emotional support and counseling, plus holistic conversations about treatment options and goals. For caregivers, these services can include counseling and stress management support, as well as practical help that makes caretaking easier and brings clarity to a complicated system.

Research shows that Supportive Cancer Care improves outcomes and quality of life. For example, by proactively managing symptoms, Supportive Cancer Care helps reduce preventable emergency department visits and stays in the hospital. In fact, patients receiving supportive oncology had between 27% and 70% fewer inpatient admissions, and between 16% and 54% fewer emergency department visits compared to patients not receiving supportive oncology. Lifting some of the burden of daily stressors can help patients and their loved ones focus on what matters most: their treatment and their well-being.

"Supportive Cancer Care connects patients and caregivers to real-life support, helping people manage symptoms and side effects, find counseling, talk with their care team about goals and options, plus tackling logistical challenges like insurance, transportation or complex billing. It's no surprise that many forward-thinking employers are embracing Supportive Cancer Care as a compassionate and smart benefit for employees and their families," said Les Biller. "Crucially, this care starts early — for every diagnosis — and adapts as needs evolve during treatment, remission and even recurrence."

What you can do

If you or a loved one is undergoing cancer treatment, you can ask your health care team what Supportive Cancer Care services are available to you and your loved ones. Patients and caregivers can find guides for how to talk with your care team at SupportIsCare.org, along with other resources to provide answers to your questions about the treatment journey.

"It's time to make Supportive Cancer Care the national standard of care for everyone, no matter what stage or type of diagnosis they receive or what zip code they live in," added Sheri. "It's time to make sure everyone knows support is care. Supportive Cancer Care isn't a 'nice-to-have,' it's a 'must-have.'"

You and your loved ones don't have to go through cancer treatment alone. Learn more at SupportIsCare.org.

"The biggest mistake people make with spring allergies is waiting for the first sneeze to take action," said Dr. Fred Pescatore, M.D., a Manhattan-based natural physician and author of The Allergy and Asthma Cure. "If you wait for symptoms to show up, you're fighting an uphill battle. Preparing early is the difference between controlling your allergies and letting them control you."

Check out Dr. Pescatore's top tips for preparing for allergy season so you can enjoy spring with minimal symptoms.

Change your air filter

Your HVAC air filter works hard year-round to improve your indoor air quality by removing dust, pollen and other allergens from your home. Change the filter at the onset of spring so it is operating optimally before spring allergy season arrives.

Pro tip: If you have severe allergies, don't replace the filter yourself. The old filter will be full of allergens that can trigger your symptoms during the replacement. Instead, have another household member take on the chore and dispose of it immediately.

Manage inflammation

Leading up to allergy season, make an effort to manage inflammation before it starts. Inflammation is a normal immune response to allergens, triggering symptoms like sneezing, congestion, coughing and watery eyes.

A proactive approach can help reduce the intensity of seasonal symptoms. Foundational habits like limiting excess sugar, gluten and dairy, prioritizing sleep and managing stress all support a more balanced immune response. For those looking to add targeted nutritional support, Pycnogenol^® French maritime pine bark extract has been clinically studied for its role in helping to modulate the body's inflammatory response when taken ahead of allergy season.

While many people rely on over-the-counter antihistamines for short-term symptom relief, some prefer a more natural approach that supports overall immune health rather than simply masking symptoms.

Dr. Pescatore adds, "When recommending Pycnogenol^® to my patients, I typically suggest 50 to 100 milligrams daily starting 5-8 weeks before allergy season for best results."

Reduce pollen exposure

Pollen is one of the most common seasonal allergy triggers, so reducing your exposure is key. This is especially important now, as pollen seasons have become more intense, start earlier and last longer in recent years — largely due to climate change. Warmer weather creates the perfect environment for pollen to thrive, especially during warm days and cool nights.

Even though it's tempting to let the fresh spring air in, keep doors and windows closed to prevent pollen from entering your home and settling on surfaces. Using a high-quality air purifier with a HEPA filter can also help reduce indoor pollen levels and improve overall air quality. In addition, avoid doing yard work like mowing the lawn before noon, when pollen counts are typically highest, and try to limit outdoor activities on high pollen-count days.

Add a shower to your nighttime routine

If you don't shower at night, it's time to start. During the day, pollen settles on and clings to your hair, face and body. Rinsing off before going to bed prevents pollen from settling on your pillow and triggering allergies while you sleep. Plus, having a warm shower before bed can be incredibly relaxing, allowing you to settle into sleep and wake up refreshed to take on another day.

Don't be reactive. Be proactive.

You can't control allergens, but you can make intentional changes in your life to reduce your exposure to allergens and manage your symptoms before they start. Use these expert tips to get a jump on allergy season so you can enjoy the warmer weather to the fullest!

This was the case for Elizabeth Simms, who was 27 years old and 31 weeks pregnant. One morning, she had a hard time breathing but she brushed it off, blaming it on her pregnancy. Her husband insisted she go to her local hospital and rushed her to the emergency room, where the ER team quickly confirmed that she had a significant pulmonary embolism (PE), a blood clot that was blocking blood flow to her lungs. Her condition worsened and she was quickly medevacked to the regional hospital. Given the urgency of her condition, the doctors decided to use computer-assisted vacuum thrombectomy (CAVT™ is an advanced therapy to suction out the blood clot), which restored blood flow to her lungs. Elizabeth's condition improved quickly, with her oxygen levels returning to normal shortly after the procedure. She was discharged from the hospital the following day and eight weeks later delivered a healthy baby boy.

Elizabeth's story is just one example of how getting to the hospital and being treated appropriately and in a timely fashion can make a big difference in patient outcomes. It's important to recognize the signs and symptoms of blood clots. Here's what you need to know:

1. Blood Clots Affect Hundreds of Thousands Each Year

It's estimated that up to 100,000 Americans die of VTE each year and many others have long-term complications. VTE includes PE and deep vein thrombosis (DVT), a clot in the legs. These blood clots often go undetected due to symptoms that overlap with those of other, less serious conditions. If left untreated, blood clots can lead to complications or death.

2. Early Diagnosis is Key to Better Outcomes

Prompt diagnosis of blood clots along with timely intervention can improve outcomes significantly. Unfortunately, at times blood clots can be prone to misdiagnosis and/or delayed diagnosis due to symptoms that can be mistaken for another condition. The symptoms — swelling in the legs, chest pain, or sudden shortness of breath — are easily mistaken for other, less serious health issues, which can delay diagnosis and treatment. Dr. Venkat Tummala, a vascular and interventional radiologist in Lakeland, FL, and associate chief medical officer at Penumbra, Inc., underscores the urgency: "Time is critical when it comes to blood clots. Delays in diagnosis and treatment can result in life-threatening complications."

3. New Treatments Are Changing the Game

New technologies have led to quicker treatments for blood clots. Anticoagulation (blood thinners) are commonly used to treat blood clots. However, their effectiveness on their own may be limited. Newer methods like CAVT enable doctors to rapidly remove blood clots and are minimally invasive. A recent study found the use of CAVT with anticoagulation had better improvements in both clinical and functional outcomes in PE patients compared to anticoagulation alone.

4. Know the Signs and Symptoms

While medical technology is advancing, knowing the signs and symptoms remains crucial. Common signs to watch for include swelling in the extremities, pain or tenderness in the leg, arm or chest, skin that feels warm to the touch, fainting and unexplained shortness of breath or difficulty. Dr. Tummala stresses, "It's important for patients to be active participants in their care, especially when it comes to proven emerging treatments. Early action and communication with healthcare providers can greatly improve outcomes." Patients should feel empowered to ask questions, explore the latest treatment methods, and discuss their best options with their doctors.

5. The Future of Blood Clot Treatment Looks Bright

The future of blood clot treatment is promising, with new technologies, specialized response teams, and growing awareness. However, gaps currently remain in standardizing care protocols across healthcare systems. Reducing these gaps is a goal of the Get Out the Clot campaign, a collaborative educational initiative uniting experts to support adoption of uniform approaches to blood clot treatment to help ensure more consistent and effective care for patients nationwide.

The ongoing advancements in blood clot treatments are helping to save lives and improve recovery times for many patients such as Elizabeth. As experts continue to improve care protocols and raise awareness about blood clots, the outlook for these patients is becoming increasingly hopeful with earlier diagnoses, more effective treatments, and better long-term outcomes. If you or someone you know experiences symptoms of a blood clot, seek medical help immediately — early action could save a life.

For more information about blood clots and available treatment options, visit https://www.getouttheclot.com/patient.

(BPT) - Sponsored by Incyte

Mary was sure something wasn't right. For nearly a decade, the elementary school teacher and mother of two expressed concerns to doctors about itching, discomfort and blood in her stool, which were repeatedly dismissed as hemorrhoids. She kept pushing for answers until a PET scan finally confirmed she had stage 3C squamous cell carcinoma of the anal canal (SCAC), caused by the human papillomavirus (HPV).

Susie, a retired NFL cheerleader, and Daniel, a comedian and long-time HIV advocate, faced similar dismissals, with their symptoms initially attributed to less serious conditions before being diagnosed with stage 2 SCAC. Anal cancer has many of the same symptoms — pain, itching, a lump or mass and changes in bowel movements — as common non-cancerous conditions like hemorrhoids, which can lead to delays in diagnosis.^1,2

Mary, Susie and Daniel are anal cancer "thrivers" partnering with Incyte to share their personal stories as part of Let's Talk Anal Cancer (LTAC), a national program developed in collaboration with patients, advocates and anal cancer experts to help normalize open conversations about anal cancer. Their experiences reflect how embarrassment and social stigma can silence vital communication with healthcare professionals, delay diagnosis and leave people feeling isolated from key social supports during their cancer journey.

In Mary's case, that delay meant her cancer wasn't identified until after it had spread. For Daniel, who already faced bias and judgment as a gay Latino man, the added stigma surrounding anal cancer made the path to diagnosis even more challenging. Susie had always been healthy and had never had HPV detected through routine screenings like her annual Pap test, so learning that it was the cause of her anal cancer came as a complete shock. By elevating these lived experiences, LTAC aims to help people with anal cancer feel seen, understood and supported throughout their journey.

Although rare, more than 10,000 people in the U.S. were diagnosed with anal cancer in the past year, and cases continue to rise by approximately 3% annually.^3,4 Most of these cases are SCAC — the same diagnosis Mary, Susie and Daniel received — which accounts for approximately 85% of those diagnosed.⁴ Yet, many people are embarrassed to talk about anal cancer symptoms or its connection to HPV, a common skin-to-skin virus found in about 90% of SCAC cases.⁵

Together, we can break that silence. Stories like Mary's, Susie's, and Daniel's remind us that cancer doesn't discriminate by location — it can grow anywhere. No one should feel embarrassed or allow stigma to stand between them and the care they deserve. Don't let four letters stop an important, even life-saving, conversation with your doctor. Let's talk anal cancer.

Visit AnalCancer.com to learn more and download a guide to help navigate conversations with your doctor.

References

¹ Rao S, et al. Ann Oncol. 2020;31(4):S1170-S1171.

² Anal Cancer Foundation. Anal Cancer: Signs, Symptoms, Causes & Treatment. https://www.analcancerfoundation.org/what-is-anal-cancer/. Accessed November 25, 2025.

³ National Cancer Institute. Cancer Stat Facts: Anal Cancer. https://seer.cancer.gov/statfacts/html/anus.html. Accessed November 25, 2025.

⁴ Symer MM, Yeo HL. F1000Research. 2018;7:F1000 Faculty Rev-1572.

⁵ U.S. Centers for Disease Control and Prevention. Cancers Linked With HPV Each Year. https://www.cdc.gov/cancer/hpv/cases.html. Accessed November 25, 2025.

Why do you need to screen for cancer even if you feel healthy?

While cancer is the second leading cause of death within the United States, most cancers do not have a recommended screening method and can be detected too late to be treated effectively.² This includes some of the deadliest cancer types — pancreatic, ovarian, stomach and esophageal.^2,3

Finding cancer early may help increase the chances of treating and surviving cancer.¹ The sooner cancer is identified through screening like MCED testing, the sooner it can be treated.

What is Multi-Cancer Early Detection (MCED) testing?

Using a simple blood draw, MCED tests, like Cancerguard, detect cancer signals in the blood. Normal cells regularly release a small amount of healthy DNA and protein into the bloodstream. If cancer is present, cancer cells will also release altered DNA and other markers into the bloodstream. The Cancerguard test helps identify differences in these DNA and protein markers in the blood — which can be used to find cancer even in earlier stages, when it is more treatable.³

How are MCED tests different from routine screenings?

Routine single-cancer screenings look for one type of cancer at a time, while the Cancerguard test helps detect over 50 cancer types and subtypes.^3,4 U.S. Preventive Services Task Force A&B Guidelines recommend screening for only four cancer types: breast, cervical, colorectal and lung (in high-risk populations),⁵ leaving nearly 70% of annual cancers and deaths with no recommended screening options.⁶

Before symptoms even appear, MCED tests can identify cancer-associated biomarkers to help detect the presence of a range of screen-detected cancers. MCED testing is intended to be used as a complement to routine screening options.

If MCED tests are so powerful, which should you choose?

Cancerguard is the only MCED test available that analyzes multiple biomarker classes to enhance early detection potential. Exact Sciences, the makers of the Cologuard^® test, introduced the Cancerguard test which can detect over 50 cancer types and subtypes, including the 6 most deadly forms.^3,4 In addition to analyzing methylated DNA markers in the body associated with cancer, the Cancerguard test also analyzes protein biomarkers linked to cancer. It was designed to evolve and incorporate new cancer-associated biomarkers as they are discovered. Consider the Cancerguard test if:

• You are proactive about your health
• You have increased risk factors such as smoking or alcohol use
• You haven't had a cancer diagnosis in the last 3 years
• You have a family history of cancer
• Your healthcare provider thinks you are an appropriate patient for the test

This test is not recommended for individuals who have had cancer within the last three years or who are pregnant and does not replace recommended screening. Individuals interested in taking the Cancerguard test should talk to their health care provider about whether the test is right for them.

You are interested in using the Cancerguard^® test. How does the testing process work?

Screening is simple and convenient. You can request your test in one of two ways:

• By visiting Cancerguard.com, where you can request a prescription via telehealth
• By requesting the test via your healthcare provider

Once the test is ordered by a healthcare provider, have your blood sample taken at:

• Your doctor's office
• A local hospital system
• An approved blood drawing center
• Home, where a professional phlebotomist comes to you

Your sample will be shipped to Exact Sciences Laboratories for analysis. Results will be available in about two weeks to discuss with your ordering provider.

• If results are negative, continue your regular cancer screenings and consider incorporating MCED testing into your annual wellness routine.
• If results are positive, plan your next steps with your health care provider. A positive result means that the blood test identified a cancer signal that may indicate the presence of cancer. It is not a diagnosis and does not confirm that you have cancer. Imaging (radiology) scans and other medical tests are typically needed to locate and confirm a cancer diagnosis.

Exact Sciences offers Care Navigation support to help you through your next steps. Exact Sciences also offers an imaging reimbursement program that reimburses up to $6,000 for non-covered imaging costs to help reduce the financial impact for eligible patients.*

*Patients must apply. Eligibility depends on program qualifications, is not guaranteed, and is subject to change. The program will not reimburse any covered imaging costs, including copay, coinsurance and/or deductible amounts determined by insurance. For more information patients should contact to apply, call 1-844-870-8870.

What should you do if you get a negative result?

The Cancerguard test does not replace routine cancer screening and tests, and it is not a diagnostic tool. Discuss with your doctor how you may use the Cancerguard test as an important tool to complement your routine screenings.

To learn more about how the Cancerguard test can expand your health screening journey, visit www.cancerguard.com.

Cancerguard, Cologuard, and Exact Sciences are trademarks of Exact Sciences Corporation.

© 2026 Exact Sciences Corporation. All rights reserved.

Disclaimer: The Cancerguard test was developed, and the performance characteristics validated by Exact Sciences Laboratories following College of American Pathologists (CAP) and Clinical Laboratory Improvement Amendments (CLIA) regulations. This test has not been cleared or approved by the US Food and Drug Administration. The test is performed at Exact Sciences Laboratories. Exact Sciences Laboratories is accredited by CAP, certified under CLIA regulations, and qualified to perform high-complexity clinical laboratory testing.

References

1. The Cancer Atlas. Early Detection. Accessed February 20, 2026. https://canceratlas.cancer.org/taking-action/early-detection/
2. Siegel RL, Kratzer TB, Giaquinto AN, et al. Cancer statistics, 2025. CA Cancer J Clin. 2025;75:10-45.
3. Cancerguard Clinician Brochure. Exact Sciences Corporation. Madison, WI.
4. Data on file. Cancerguard Cancer Subtype Analysis. Exact Sciences. Madison, WI; September 2025. [MED-REF- 01259]
5. USPSTF. A & B Recommendations. Accessed November 10, 2025. https://www.uspreventiveservicestaskforce.org/uspstf/recommendation-topics/uspstf-a-and-b-recommendations
6. Data on file. Cancers without USPSTF recommended screening. 2026. Medical Affairs, Exact Sciences, Madison, WI

For many people, skin care is as simple as applying a daily moisturizer. But a 2025 survey conducted for Aura Cacia by Suzy, a leading end-to-end market research platform, shows that consumers are asking deeper questions about what's in their products and how those ingredients support their overall well-being.

Survey respondents signaled a growing desire for skin care rooted in simplicity, transparency and ingredients closer to nature. When asked to rank their top priorities, nearly half of consumers chose "100% pure and natural ingredients" (48%), and "non-toxic or clean formulations" (45%). Others prioritized "minimal ingredient lists" (30%) and "fragrance-free" or "no synthetic fragrance" options (25%).

According to Jennifer Kellison, botanical beauty expert and director of innovation at Aura Cacia, botanical ingredients are a natural fit for these needs. "Clean beauty is less about trends and more about intention," says Kellison. "Consumers are gravitating toward ingredients they recognize and trust to support their everyday wellness."

How to get started with clean beauty

While many think of clean beauty as a trend limited to facial care, experts say the opportunity extends far beyond that. While skin care priorities may vary from hydration to protecting overall skin health, essential oils and plant-based ingredients have long been valued for their ability to support more holistic care when used intentionally.

"When formulations are kept simple and ingredients are chosen with purpose, botanicals can offer unique support for hydration, balance and overall skin wellness in a gentle, yet effective way," says Elena Mercurio, aromatherapist and educator for Aura Cacia.

Beginning a clean beauty routine doesn't have to be complicated. It starts with understanding how essential oils and carrier oils support your skin.

• Essential oils, such as lavender or tea tree essential oil, are highly concentrated plant extracts known for their aroma and targeted benefits. Because of their potency, they must always be diluted before being applied to the skin.
• Carrier oils, such as jojoba oil, sweet almond oil or castor oil, act as a base to safely dilute and apply essential oils to your skin. They contain antioxidants, vitamins and minerals that provide deep nourishment and support everyday skin needs.

Tips for everyday clean beauty needs

Thoughtfully chosen essential oils and carrier oils can transform simple daily self-care routines into nourishing rituals, particularly in skin care.

• For face: Create a nourishing and toning facial serum by diluting neroli and lavender essential oil in rosehip oil and jojoba oil. Massage a small amount into clean, slightly damp skin in the morning and before bed.
• For body: Use plant-based carrier oils and body butters as daily moisturizers. These provide easy, skin-loving hydration. For deep hydration, try jojoba oil or castor oil. Both are non-comedogenic and work well as daily moisturizers or overnight treatments depending on your skin's needs.
• For hair: Use argan oil for rejuvenating hair and scalp massages. Customize your routine by blending one to two drops of your favorite essential oil into each small dropperful of argan oil for a personalized touch.
• For nails and cuticles: Massage castor oil into your nail beds and around cuticles to lock in moisture, soften skin and support healthier-looking nails.

Mercurio notes that personalization is key when working with botanicals. "Everyone's skin and hair have different needs," she explains. "Starting with a few carefully selected plant oils allows you to build a routine that feels simple, effective and tailored to you."

This approach works whether you're at home or on the go, like singer-songwriter Avery Anna. When Avery is on tour, simplicity is key for her skin care routine. "When I'm on the road, I don't want anything complicated," she shares. "A few oils like frankincense and rosehip oil help keep my skin feeling hydrated and plump, even on my busiest days."

Behind every Aura Cacia bottle

Aura Cacia is rooted in helping you feel good inside and out, from the natural grounding effect of our products and the peace of mind that comes with knowing your choice supports ethical and socially responsible practices. According to the survey, 41% of respondents associate clean beauty with accountability: prioritizing transparent ingredient decks, third-party certifications and environmentally friendly practices.

"We understand that clean beauty also has ethical implications," says Kellison. "That's why all our products are cruelty-free, with no preservatives, artificial colors or synthetic fragrances. We also offer an extensive line of USDA Certified Organic options, reflecting our commitment to both personal wellness and broader social and environmental impact."

Central to this commitment is the Aura Cacia Positive Change Project, which is celebrating 10 years of investing in organizations that help women and girls make transformational improvements in their lives. Since its launch, the program has contributed more than $1 million to organizations supporting meaningful change across the U.S. and Canada.

Clean beauty that aligns with key values and meets personal care goals is now within reach. To explore skin care tips and discover the full range of Aura Cacia skin care products, visit https://www.AuraCacia.com.

Survey Methodology: Suzy conducted a custom survey in December 2025, among a sample of 1,005 U.S. women 19-65 years of age.

Understanding Angina: More Than Just Chest Pain

Angina pain is often a symptom of coronary artery disease (CAD), when plaque buildup occurs in the arteries supplying the oxygen-rich blood to the heart, forcing it to work harder than it should.¹ Angina may feel like pressure or squeezing in the chest, pain in the shoulders, arms, neck, jaw or back, or shortness of breath.³

Beyond physical symptoms, people with recurring, severe angina face more frequent hospital visits and healthcare costs that can double compared to those without the condition.⁴ Nearly half (45%) of people experiencing angina report episodes as extremely or moderately debilitating, with many expressing concerns about their future health.² These issues underscore the urgent need for new treatment options.

When Standard Options Aren't Enough

While medicines and a procedure to clear blocked arteries can successfully ease symptoms, 20-40% of patients continue to experience angina after revascularization, and roughly 50% continue their symptoms after medical therapy.^5,6

Clinical Research Study is Evaluating a Potential New Option

For those with recurring, chronic angina, the COSIRA II trial is currently enrolling participants in sites across the U.S.

The trial is designed to evaluate the safety and effectiveness of an investigational device for treatment of recurring, chronic angina in adults who continue to have symptoms, such as chest pain, chest pressure, or tightness, despite taking at least three medicines at the maximum doses they can tolerate.

"For people living with chronic, recurring angina who continue to experience symptoms despite medications or procedures to clear blocked arteries, clinical trials like COSIRA II can provide an important opportunity to explore innovative therapies that could help ease symptoms and improve patient outcomes," said Dr. Timothy Henry, Co-Principal Investigator of the COSIRA II Clinical Trial and Medical Director of the Carl and Edyth Lindner Center For Research And Education, Christ Hospital, Cincinnati. "If you or someone you love continues to struggle with angina symptoms, I encourage you to talk to your doctor about all available treatment options, including whether a clinical trial might be right for you."

The COSIRA II Trial is Currently Enrolling

Living with chronic, recurrent angina can feel overwhelming, but expert support can help guide your health journey. If you are interested in learning whether the COSIRA II trial might be right for you or a loved one, you can talk to your doctor or visit the COSIRA II Clinical Trial Website (Shockwave Medical, part of Johnson & Johnson MedTech) to see trial locations and get more information.

CAUTION—Investigational Device. Limited by US Law to Investigational Use.

1. Agho, A. V., Disu, F., Figueroa, A. S., Wiredu, B., Okorigba, E. M., Olanite, M., Okobi, O. E., & Noman, T. (2025). Prevalence of angina pectoris: An analysis of the National Health Interview Survey (NHIS) database. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12116826/.
2. BJCardio editorial team. (2008, July). New data highlight burden of sub-optimal management of angina. The British Journal of Cardiology, 15(3), 191–194.
3. Mayo Clinic. Angina. https://www.mayoclinic.org/diseases-conditions/angina/symptoms-causes/syc-20369373. Accessed October 2025.
4. Kempf, J., et al. (2011). Health resource utilization and direct costs associated with angina for patients with coronary artery disease in a US managed care setting. American Health & Drug Benefits, 4(6).
5. Crea, F., et al. (2019). Mechanisms and diagnostic evaluation of persistent or recurrent angina following percutaneous coronary revascularization. European Heart Journal, 40(29), 2455–2462.
6. Singh A. (2024 Oct). European Heart Journal, 28; 45 (Supplement_1): ehae666.1457

SPL-78928 Rev. A.

According to a recent MD Live by Evernorth survey, many consumers are juggling multiple health apps at once, often spending significant time responding to alerts, logging information and trying to interpret their data. In fact, more than half of Americans feel there are too many health apps to keep track of, and 45% report feeling "burnt out" on a weekly basis just from trying to stay on top of logging information in their apps.

"Most people download health apps with good intentions, but managing too many tools at once can quickly become overwhelming," says Dr. Maggie Williams, medical director of primary care at MD Live by Evernorth. "When that happens, it's important to recognize when helpful technology starts to feel more like a source of stress than support."

If you're unsure whether your health apps are supporting your goals or working against them, here are three signs it may be time to rethink your digital health routine:

1. You're tracking, but not acting on it: From sleep, calories and blood pressure to steps, heart rate and hydration, the list of tracking tools is endless, and can add up quickly. While health data can be insightful, collecting too much of it at once can make it harder to see what actually matters. If you find yourself logging numbers often but feeling unsure what to do with them, your apps may be leaving you feeling more stuck than empowered. Instead of tracking everything, prioritize the data that directly supports your current health goals and let the rest take a back seat.
2. Managing your apps feels stressful or confusing: Trying out new health apps is common, especially when friends recommend a new tool or a trend goes viral online. But juggling multiple tools — each with its own alerts, notifications and advice — can quickly become overwhelming. When reminders start piling up or conflict with one another, it can be hard to know which ones are important. If you've downloaded apps you don't use, deleted others after a short time or found yourself faced with conflicting information, it may be a sign that it's time to narrow your focus and rethink which tools truly add value to your routine.
3. Your health apps are interfering with your health goals: Health apps are meant to support healthy habits, not complicate them. If app overload has caused you to miss appointments, abandon goals or feel unsure about next steps, it may be time to simplify. A healthcare provider can help you prioritize what to track, recommend tools that work well together, and create a plan that fits into your daily life.

Managing your health tools shouldn't feel like a full-time job. Rather than abandoning digital tools altogether, consider using fewer tools more purposefully. Virtual care options, such as those available through MD Live by Evernorth, can offer a convenient way to check in with a board-certified doctor, ask questions about your health data, and get clarity on next steps without unnecessary delays.

"There is no one-size-fits-all approach to managing your health," said Dr. Williams. "Health tools can be incredibly useful, but when they're used intentionally and with the right guidance, they're more likely to have a meaningful difference on your well-being."

This may sound intimidating, but you don't have to overhaul your life to build a more nutritious routine with healthier habits. Making small changes to your daily meals can make a meaningful difference in how you feel each day. To get you started, Registered Dietitian and Nutritionist Dawn Jackson Blatner shares five simple, practical tips to help you build a better daily routine that supports steady nourishment and overall wellness.

Cut back on added sugars and refined ingredients

Have you ever experienced a sugar crash? This drop in energy can throw your day off, leaving you feeling fatigued and distracted, making it harder to power through your to-do list. Highly refined, sugary foods digest quickly, causing blood sugar to rise fast and then fall just as quickly. You don't have to eliminate these foods completely, but choosing whole, nutrient-dense options more often can help maintain steady energy so you can stay focused on work, errands and family time.

When a sugar craving hits, try Greek yogurt topped with berries, nuts and a few dark chocolate chips to provide long-lasting energy thanks to its balance of protein, fiber and healthy fats.

Boost nutrition with simple ingredient swaps

Making smarter, healthier choices to improve your nutrition doesn't mean you have to give up your favorite meals. Instead, look for simple ingredient swaps that boost the nutrition of meals you already love.

For example, the next time you're cooking pasta, pick up a box of high-protein, high-fiber pasta made of lentils or chickpeas instead of your regular white flour noodles. If you're sauteing veggies, reach for olive or avocado oil instead of butter. Instead of making sour cream dip, opt for low-fat Greek yogurt for your mix. Not only are these swaps simple, but they're also tasty!

Keep nutritious snacks on hand

Busy days often lead to grabbing whatever snack is closest, but planning ahead and keeping nutritious snacks on hand can make it easier to make better-for-you choices. Having nourishing snacks readily available can help you stay productive and avoid energy dips throughout the day.

Aim for snacks that combine protein with fiber-rich carbohydrates to promote lasting energy. Convenient options include: hard-boiled eggs and whole grain crackers, edamame and orange slices, or a cheese stick and an apple.

Add color to your plate

Did you know that the different colors of produce provide different nutritional benefits? According to Harvard Health, fruits and vegetables contain phytonutrients, which give produce its rich colors and offer a wide range of health benefits. When building your plate, aim to include at least two different-colored fruits or vegetables.

Adding multiple colors to each meal helps you cover a broader range of beneficial nutrients, without overthinking it. Plus, produce is naturally hydrating, which can support better energy throughout the day.

Meal prep nutrient-packed breakfasts

Use the weekend to prepare easy, nutrient-packed breakfasts for the week ahead. A make-ahead breakfast built with wholesome ingredients can help set a positive tone for the entire day. Start by testing out this Vegetarian Egg Casserole made with Eggland's Best eggs, for a convenient and nourishing way to kick off a productive week.

Eggland's Best eggs contain more than double the Vitamin B12 compared to ordinary eggs, which supports energy production inside your cells. Eggland's Best eggs are also an excellent source of Vitamin B5, which helps release energy from the carbs, fats and protein you eat.

Vegetarian Egg Casserole

Prep time: 10 minutes

Cook time: 35 minutes

Yield: 6

Ingredients

• 10 Eggland's Best eggs, Large
• 14 ounces ground vegetarian sausage
• 3/4 cup finely diced zucchini
• 1 finely diced red bell pepper
• 3/4 cup diced celery
• 1/2 cup 2% milk
• 1 teaspoon onion powder
• 1/2 teaspoon black pepper
• 1/2 cup shredded Asiago cheese (Feel free to use any kind of white cheese that you like. Mozzarella, parmesan or muenster would work well.)
• Optional: fresh chopped herbs

Instructions

1. In a large cast iron skillet, cook vegetarian sausage for about 5 minutes until it is cooked through, breaking it apart as it cooks.
2. Add in the zucchini, bell pepper and celery and sauté for another 3 minutes. Note: if your sausage is very low-fat, you may need to add in a tablespoon of olive oil so the sausage and veggies do not stick to the pan.
3. Meanwhile, in a large bowl, whisk together the eggs, milk, onion powder and black pepper.
4. Preheat oven to 350 degrees. Pour the egg mixture over the sausage/veggie mix.
5. Bake in the oven for 15 minutes. Remove the pan from the oven and top the eggs with shredded cheese.
6. Bake for another 10 minutes or until the eggs are cooked through.
7. Enjoy!

Pro tip: For meal prep, allow cooling before freezing. (Keeps well in the freezer for up to three months.) Alternatively, you can also skip baking and store the prepped casserole in the fridge, covered, until ready to bake. Store in fridge for up to five days.

Fueling your day doesn't have to be complicated. By focusing on small, sustainable habits, you can support steady energy and overall wellness throughout National Nutrition Month and beyond. To find more energizing recipes and nutrition tips, visit EgglandsBest.com.

The Cancerguard^® test is a simple MCED blood test that analyzes DNA and protein biomarkers and helps detect over 50 cancer types and subtypes,^1,5 supporting other standard screenings by broadening types of cancers that can be found, even at early stages. The Cancerguard test can detect some of the deadliest cancers, such as pancreatic, ovarian, liver, and esophageal — even before symptoms appear.^1,2,5

Why early detection matters

Cancer remains the second leading cause of death in the United States with roughly 600,000 deaths each year.² Early detection is one of the most effective tools we have to help improve those outcomes. MCED testing can detect signals of cancer in the body and provide insight before symptoms even appear. Finding cancer early, before it spreads, may help increase the chances of treating and potentially surviving cancer.^1,2

How the Cancerguard test works

Cancerguard is the only marketed test of its kind that uses a multi-biomarker class approach. It searches for cancer signals within several types of biological markers, not just one. With one blood sample, the test analyzes both methylated DNA markers and protein biomarkers that can indicate the presence of cancer. By combining these biomarkers, the Cancerguard test casts a wider net for detecting cancer in its early stages, including some of the deadliest types.^1,2

What you can expect with Cancerguard testing

Once a healthcare provider places your Cancerguard test order, you can schedule your blood draw where it works best for you — at your doctor's office, an approved lab or health system partner, or even in the comfort of your home. Once the sample is received at the lab, most people will get their results in about two weeks.

The Cancerguard test is designed for reliability and features a 97.4% specificity.¹ This limits false positive results to help ensure patients receive clear, dependable information.¹ If no cancer signal is detected, you should continue with screenings recommended by your provider and can consider annual MCED testing with the Cancerguard test for expanded cancer screening. If a cancer signal is detected, review your test results with your healthcare provider to plan your next steps. It is not a diagnosis and does not confirm that you have cancer. Imaging (radiology) scans and other medical tests are typically needed to locate and confirm a cancer diagnosis.

While a positive result can feel overwhelming, Exact Sciences provides support, including care navigation resources that help guide patients through next steps with comprehensive support systems. In addition, Exact Sciences offers an imaging reimbursement program which reimburses up to $6,000 for non-covered imaging costs to help reduce the financial impact for eligible patients.*

* Patients must apply. Eligibility depends on program qualifications, is not guaranteed, and is subject to change. The program will not reimburse any covered imaging costs, including copay, coinsurance and/or deductible amounts determined by insurance. For more information patients should contact to apply, call 1-844-870-8870.

Choose Cancerguard with confidence

From clear and reliable results to guided next steps, Cancerguard is built with the patient experience at the center. For adults who want to take a more proactive role in their health, Cancerguard offers a meaningful way to screen for cancers with a simple blood test, helping individuals stay empowered and informed. The Cancerguard test may benefit people who:

• Are proactive in their approach to their health
• Have increased risk factors, such as smoking, alcohol use, obesity, or are over age 50
• Haven't had a cancer diagnosis in the last three years
• Have a family history of cancer

This test is not recommended for individuals who have had cancer within the past three years or who are pregnant, and it does not replace recommended screening. Individuals interested in taking the Cancerguard test should talk to their doctor about whether the test is right for them.

Learn more at www.cancerguard.com.

Disclaimer: The Cancerguard test was developed, and the performance characteristics validated by Exact Sciences Laboratories following College of American Pathologists (CAP) and Clinical Laboratory Improvement Amendments (CLIA) regulations. This test has not been cleared or approved by the US Food and Drug Administration. The test is performed at Exact Sciences Laboratories. Exact Sciences Laboratories is accredited by CAP, certified under CLIA regulations, and qualified to perform high-complexity clinical laboratory testing.

Cancerguard and Exact Sciences are trademarks of Exact Sciences Corporation. © 2026 Exact Sciences Corporation. All rights reserved.

Of course, your pets deserve clean air, too! They spend the majority of their lives indoors, making indoor air quality critical to maintaining your furry family member's long-term health. This is especially important if your pet has allergies or lung issues.

Good indoor air quality is a key part of responsible pet ownership, protecting against preventable sickness and discomfort for all household members. The good news? You can still enjoy quality time with your furry family members and reduce allergens so you can breathe easier. All you need is to take a few proactive steps to improve your IAQ, so you can continue to curl up with your canine companions and feline friends. Check out a few suggestions below!

Install an air quality monitor

Install an air quality monitor to track dander, Volatile Organic Compounds (VOCs) and other pollutant particles. Real-time data helps you spot problems quickly and reduce pollutants in your home.

Increase ventilation throughout your home

Ventilating promotes airflow, improving IAQ for you and your four-legged friend.

To keep the air in your home balanced and fresh consider using an energy recovery ventilator (ERV) like the BalancedHome ERV. This whole-home ventilation solution is ideal for improving airflow and IAQ. Plus, the BalancedHome ERV is built to deliver high-performance ventilation, manage humidity and improve energy efficiency at a cost-effective price point for a single-family home.

Another all-in-one whole house option to consider is the WhisperGreen Select Fan, a precision solution to ventilate your bathroom, laundry room, sun room, basement or garage. With its built-in, multispeed selection, you can easily customize fan speed to meet your space's ventilation needs and improve your IAQ. Best of all, you can easily install the WhisperGreen Select yourself!

Improving your IAQ isn't just about cleanliness. It's also about maintaining a healthier living environment for everyone in the household. Using these easy tips, you can actively manage airflow and remove airborne pollutants to maintain a balanced and healthier indoor environment.

Groom your pets often

It may seem counterintuitive, but grooming your fur babies can actually help prevent pet allergens from becoming airborne. Daily brushing and weekly bathing can remove loose fur, dander and dirt, capturing these particles and preventing them from circulating in your home. This is an easy way to remove allergens that can trigger or worsen allergies, asthma and other respiratory issues, so everyone can enjoy spending time indoors.

Vacuum twice a week

Pet dander, fur and allergens can easily settle on top of your carpets, upholstered furniture and floors. To remove these particles from your home, vacuum twice a week, at least, though you may have to vacuum more frequently depending on how many furry family members you have. According to the Asthma and Allergy Foundation of America, poor-quality vacuums can put dust in the air instead of removing it. Make sure to use a vacuum with a HEPA filter to remove particles before they become airborne so you can enjoy a healthier environment with your paw-tners in crime.

Neutralize pet odors with an air purifier

Pet odors aren't just unpleasant to smell; they're a sign that dander and fur are circulating throughout your home. While grooming pets and vacuuming can do a lot for your air quality, pairing these habits with an air purifier can significantly improve your IAQ, leaving cleaner, fresher air.

Frequently wash bedding, blankets and cushions

Your pet's bed, favorite blankets and pillows easily accumulate dander, fur, saliva and skin oils, all of which can irritate your breathing. If your furry friends spend a lot of time on your bed or furniture with you, these areas can also become allergen-laden.

To remove these particles before they become airborne, make sure to regularly wash these fabric items with hot water. If your pet's bed and your furniture have removable covers, you can throw them into the wash with the bedding, blankets and pillows. If these items don't have removable covers, no worries. Vacuum the surface, spot treat stains, deodorize the fabric with baking soda and vacuum it up when you're done.

• No matter your age, investing in your brain health should be top of mind.
• Simple steps like eating brain-nourishing food, taking brain-boosting supplements like Cognizin citicoline, protecting your brain when exercising and staying social can help support your cognitive functions now and in the future.
• Boosting your brain health improves your focus and attention when you're younger and preserves your cognitive abilities when you're older.

If you're planning to take better care of your health this year, don't forget to focus on supporting one of the most important organs in your body: Your brain! Your senses, thoughts, motor skills, memory and so many more functions are ruled by your brain. That's why investing in your brain health is vital to taking care of your overall well-being.

Brain health isn't just important for older adults. Brain health and performance should be top of mind for everyone at any age. Investing in brain health when you're young can help sharpen your focus and mental energy, so you can zone in and be more productive. And, as you age, maintaining brain health can help to preserve your memory and other cognitive functions.

Not sure how to start taking care of your brain? Read on to discover just a few tips that can keep your brain working well, whether you're 18 or 80.

Fuel your thoughts with brain-boosting nutrients

Food nourishes your whole body, and that includes your brain. So, what foods can help your brain function at its best now and in the future? According to Harvard Health, your best strategy is to change your dietary habits to prioritize veggies, fruits, legumes, whole grains, fish and healthy fats. The next time you're at the store, consider buying:

• Green leafy vegetables like kale, spinach and broccoli
• Strawberries and blueberries
• Black beans and chickpeas
• Cracked wheat, oats and whole-grain couscous
• Omega-3 rich fish like salmon, cod and canned light tuna
• Olive oil and other healthy fats

Take daily brain support supplements

Supplements are a great way to optimize brain-fueling nutrients. For example, Cognizin Citicoline is a great supplement to add to your daily routine to support mental focus and memory.

What is citicoline? You may not know it by name, but it's already inside of you! Citicoline is a naturally occurring brain nutrient that protects and repairs your brain cells.

Many cognitive health ingredients on the market can enhance your brain performance. However, Cognizin Citicoline provides brain performance and comprehensive brain health support over time. Clinical trials have shown that this brain health nutrient offers cognitive benefits for young professionals and improved memory function for older adults.

Cognizin is used in over 300 products, from capsules to beverages. You can visit Cognizin.com/en/Buy-Cognizin to learn more and find the products that work best for you.

Wear a helmet when doing high-impact sports

Staying active is great for your body and brain, but don't forget to wear a helmet. Whether you bike, ski, snowboard, roller skate, skateboard, horseback ride, or participate in high-impact sports like football and hockey, wearing a helmet can reduce your risk of a head injury.

According to the Mayo Clinic, a moderate to severe TBI can lead to cognitive issues with memory, attention, concentration, communication and problem-solving.

Stay social to stay mentally sharp

Social connections are incredibly vital to your well-being throughout every stage of life and can protect your brain health. Socializing can improve a person's longevity, stress levels, mood and — most importantly — boost their thinking and memory.

How do social connections improve brain health? When you participate in social interactions, you're activating neural pathways and preserving neural plasticity. In other words, social interactions keep your brain flexible, allowing it to adapt and function well now and in your golden years.

If you're struggling to connect with others, try one (or a few) of these activities:

• Having a weekly phone or video call with an old friend
• Hosting a game night
• Meeting up with loved ones for lunch or dinner
• Planning a hike, bike ride or other activity
• Joining a book club

You're never too young or too old to take care of your brain

It's never too early or too late to invest in your brain health and function. The time and energy you spend trying these and other brain-boosting tips can help you in your personal and professional life now and keep your cognition and memory in tip-top shape in your retirement.

To learn more tips to keep your brain healthy at any age, visit Cognizin.com.

(BPT) - Did you know neurofibromatosis type 1 with plexiform neurofibromas (NF1-PN) is a rare genetic disorder that can cause tumors to grow along nerves, leading to pain, mobility challenges, and lifelong complications?¹ This rare condition affects approximately 30,000 to 50,000 people in the United States, including Austin, who has lived with NF1-PN since early childhood.^1-5

Living with NF1-PN has affected nearly every aspect of Austin's life, from repeated surgeries at a young age, to pain and other symptoms which forced him to give up his career in law enforcement. As he grew older, Austin learned to advocate for himself, working closely with his doctors to manage symptoms and explore treatment options. After consulting with his care team, Austin decided to participate in a clinical trial for what is now FDA-approved as GOMEKLI^®(mirdametinib) for treating symptomatic, inoperable PNs in adults and children with NF1. Please see important safety information and Patient Information for GOMEKLI.

Austin shares his experience to help others feel less alone and encourage those newly diagnosed to speak up, seek specialized care, and connect with the NF1-PN community for more information and resources.

Learn more: https://www.gomekli.com/

What is GOMEKLI?

GOMEKLI (mirdametinib) is a prescription medicine used to treat adults and children 2 years of age and older with neurofibromatosis type 1 (NF1) who have plexiform neurofibromas that cause symptoms and cannot be completely removed by surgery.

It is not known if GOMEKLI is safe and effective in children under 2 years of age.

IMPORTANT SAFETY INFORMATION

Before taking GOMEKLI tell your healthcare provider about all of your medical conditions, including if you:

• have eye problems
• have heart problems
• are pregnant or plan to become pregnant. GOMEKLI can harm your unborn baby.
  Females who are able to become pregnant
  
  • Your healthcare provider should check to see if you are pregnant before you begin treatment with GOMEKLI.
  • Use effective birth control (contraception) during treatment with GOMEKLI and for 6 weeks after your last dose.
  • Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with GOMEKLI.
  
  Males with Female partners who are able to become pregnant:
  
  • Use effective birth control (contraception) during treatment with GOMEKLI and for 3 months after your last dose.
  • Tell your healthcare provider right away if your female partner becomes pregnant or thinks she may be pregnant during treatment with GOMEKLI.

• are breastfeeding or plan to breastfeed. It is not known if GOMEKLI passes into your breastmilk.
  • Do not breastfeed during treatment with GOMEKLI and for 1 week after your last dose.
  • Talk to your healthcare provider about the best way to feed your baby during this time.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How should I take GOMEKLI?

• Take GOMEKLI exactly as your healthcare provider tells you to take it. Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment with GOMEKLI if you develop certain side effects.
• Take GOMEKLI twice a day, about 12 hours apart, for 21 days, followed by 7 days off treatment, to complete a 28-day treatment cycle. Your healthcare provider will decide how many treatment cycles are right for you.
• Take GOMEKLI with or without food.
• GOMEKLI comes in two different dosage forms, GOMEKLI capsules and GOMEKLI tablets for oral suspension. Your healthcare provider will decide the dosage form and dose of GOMEKLI that is right for you.
• If you take GOMEKLI capsules: Swallow each capsule whole with drinking water. If more than 1 capsule is required, swallow 1 capsule at a time. Do not open, break or chew the capsules.
• If you take GOMEKLI tablets for oral suspension, either:
  • Swallow each tablet for oral suspension whole with drinking water. If more than 1 tablet is required, swallow 1 tablet at a time.
    OR

• • Disperse the tablets for oral suspension in drinking water to make a liquid (suspension) before you take or give GOMEKLI.
    See the "Instructions for Use" that come with your medicine for instructions on how to prepare and take GOMEKLI tablets for oral suspension.

• If you miss a dose of GOMEKLI, skip the missed dose and take your next dose at your regularly scheduled time.
• If you vomit at any time after taking GOMEKLI, do not take an additional dose. Take your next dose at your regularly scheduled time.

What are the possible side effects of GOMEKLI?

GOMEKLI may cause serious side effects, including:

• eye problems. GOMEKLI may cause eye problems that can lead to blindness. Your healthcare provider will check your vision before and during treatment with GOMEKLI. Tell your healthcare provider right away if you get any of the following signs or symptoms of eye problems:
  • blurred vision
  • loss of vision
  • other changes to your vision
• heart problems. GOMEKLI may lower the amount of blood pumped by your heart, which is common in children during treatment with GOMEKLI and can also be severe. Your healthcare provider will do tests before you start GOMEKLI treatment, every 3 months during your first year of treatment, and then as needed to make sure your heart is working properly. Tell your healthcare provider right away if you get any of the following signs or symptoms of heart problems:
  • coughing or wheezing
  • shortness of breath
  • swelling of your ankles and feet
  • tiredness
  • increased heart rate
• skin problems. Skin rashes are common with GOMEKLI in both adults and children and can also be severe. GOMEKLI can also cause hair loss (alopecia). Tell your healthcare provider if you develop any of the following signs or symptoms of skin problems:
  • flat skin rash
  • raised bumps on the skin
  • skin bumps that look like acne
  • skin redness
  • itchy rash
  • peeling skin

The most common side effects of GOMEKLI in adults include:

• • diarrhea
  • nausea
  • muscle, joint, and bone pain
  • vomiting
  • tiredness

The most common severe abnormal blood tests in adults include an increased enzyme called creatine phosphokinase (CPK).

The most common side effects of GOMEKLI in children include:

• • diarrhea
  • muscle, joint, and bone pain
  • stomach (abdominal) pain
  • vomiting
  • headache
  • skin redness, swelling, or pain around the fingernails or toenails
  • nausea

The most common severe abnormal blood tests in children include decreased white blood cell (neutrophil) counts and increased CPK.

GOMEKLI may cause fertility problems in females, which may affect your ability to have children. Talk to your healthcare provider if you have concerns about fertility.

These are not all of the possible side effects of GOMEKLI. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Please click here for full Prescribing Information including Patient Information and Instructions for Use.

References:

1. Ejerskov, C., Farholt, S., Nielsen, F.S.K. et al. Clinical Characteristics and Management of Children and Adults with Neurofibromatosis Type 1 and Plexiform Neurofibromas in Denmark: A Nationwide Study. Oncol Ther 11, 97–110 (2023). https://doi.org/10.1007/s40487-022-00213-4.
2. Prada CE, Rangwala FA, Martin LJ, et al. Pediatric plexiform neurofibromas: impact on morbidity and mortality in neurofibromatosis type 1. J Pediatr. 2012;160(3):461-467.
3. Miller DT, Freedenberg D, Schorry E, Ullrich NJ, Viskochil D, Korf BR; Council on Genetics; American College of Medical Genetics and Genomics. Health supervision for children with neurofibromatosis type 1. Pediatrics. 2019;143(5):e20190660.
4. Kallionpää RA, Uusitalo E, Leppävirta J, Pöyhönen M, Peltonen S, Peltonen J. Prevalence of neurofibromatosis type 1 in the Finnish population. Genet Med. 2018;20(9):1082-1086.
5. U.S. population estimated at 332,403,650 on Jan. 1, 2022. U.S. Department of Commerce. January 6, 2022. Accessed April 16, 2024. https://www.commerce.gov/news/blog/2022/01/us-population-estimated-332403650-jan-1-2022.

Sponsored by SpringWorks: A healthcare company of Merck KGaA, Darmstadt, Germany

• Keeping up with safety recalls is an important part of vehicle maintenance.
• It's easy to check for vehicle safety at CheckToProtect.org.
• Your vehicle's recall can be repaired at an authorized dealership at no cost to you.

If you don't know how to check for vehicle safety recalls, you're not alone. According to a survey by Stellantis, nearly half (43%) of American drivers don't know how to find out if their vehicle has an open safety recall. The good news is, it's easy to see if your vehicle has a recall. Visit the National Safety Council's CheckToProtect.org.

How does it work?

Check your vehicle by entering or uploading a photo of your license plate number or the 17-character vehicle identification number (VIN) into the search tool. If your vehicle has a recall, contact an authorized dealership near you to schedule a free recall repair.

Just like getting regular oil changes, tire rotations and other essential vehicle maintenance, it's important to make sure your car or truck is recall-free.

This Vehicle Safety Recalls Week, March 2-8, 2026, is the perfect time to check your vehicle. All drivers should take this time to make sure their vehicle is safe for themselves and their passengers.

Why are vehicle recalls important?

Safety recalls are sometimes issued by an automaker when a part stops functioning properly as it ages, or when a group of vehicle owners experience a similar problem. Safety recalls can affect everything from brakes and steering to batteries and airbags.

Research commissioned by automaker Stellantis found that 40% of drivers believe a recall is fine as long as it doesn't affect a vehicle's performance. The truth is that some recalls may not change the way a vehicle drives, but they can still present a safety risk. For example, if a recalled Takata airbag deploys in a crash, the airbag's inflator can break apart, sending shrapnel throughout the vehicle that could severely injure or kill vehicle occupants.

Another example relates to car seat anchors. CARFAX released new data showing that nearly one million vehicles have open safety recalls for child car seat anchors, a critical safety feature that secures car seats firmly in place.

According to CARFAX, as many as 57 million vehicles on the road today have an unrepaired safety recall — that's roughly 1 in every 5 vehicles. Any driver can take the proactive step to check their vehicle's recall status. This is especially important for drivers of older, used vehicles and drivers who have changed mailing addresses, because manufacturers may not have their latest contact information to notify them of recalls.

Heart rhythms can tell a story with the power to change a life.

You may notice heart palpitations, sensations like fluttering, pounding or skipped beats. Heart palpitations are common¹, accounting for 16% of visits to primary care physicians, and are the second leading cause of visits to cardiologists.² While experiencing these can feel scary, these fluttery sensations are common and often harmless, caused by temporary stressors. But in some cases, they can signal an arrhythmia.

An arrhythmia is an abnormal heart rhythm where your heart may beat too quickly, too slowly or irregularly, and it's a condition that requires medical attention.

But not all arrhythmias cause noticeable symptoms. In fact, some people are asymptomatic, meaning they feel nothing at all. Up to one-third of people with atrial fibrillation, or Afib, a common arrhythmia with an irregular and often very rapid heart rhythm, are asymptomatic at the time of diagnosis.³ It is estimated that up to 27 million Americans may be at risk for undiagnosed arrhythmias.⁴

Even without symptoms, untreated arrhythmias can damage the heart, brain or other organs⁵ and may increase the risk of stroke or death.⁶

Understanding your risk and the importance of early detection

How can you do better by your heart? The good news is that arrhythmias can be highly treatable, especially when they are identified early. Taking steps to understand your heart health can make a meaningful difference. And that includes early detection and treatment of arrhythmias to reduce the burden of cardiac disease.⁷

One way to support early detection is by understanding your personal risk factors and discussing them with your healthcare provider. You can also reduce certain risk factors that are associated with arrhythmias. Risk factors for arrhythmia include heart disease, high blood pressure, obesity, diabetes, sleep apnea, alcohol use and family history.⁸

While arrhythmias and related conditions are more common in adults over age 60⁹, they're not limited to older populations. AFib, as an example, has historically been associated with aging. However, emerging research shows that there has been an increase in younger patients getting diagnosed with AFib.¹⁰

A medical evaluation may include heart rhythm monitoring to better understand what's happening with your heart. In some cases, physicians may recommend heart rhythm monitoring based on a patient's risk factors, even if noticeable symptoms are not present.

A path forward

The path to getting a diagnosis and understanding your specific arrhythmia hasn't always been easy.

Not long ago, determining whether you had an arrhythmia required a visit to a hospital or clinic for an electrocardiogram, or ECG. Because arrhythmia episodes often come and go and must be recorded while they are occurring, a brief in-clinic ECG could miss an episode. In some cases, repeat testing was needed, or the condition went undetected.

Holter monitors, wired devices introduced decades ago and typically worn for 24 to 48 hours, are sometimes still used to evaluate heart rhythm. However, because many arrhythmias occur intermittently, these shorter monitoring periods may not always capture and record an episode because some people could go days or weeks without an episode. In fact, three out of four patients who use a Holter monitor do not get a diagnosis on the first test.¹¹

Some consumer wearable devices and smartwatches can detect irregular pulse patterns and may alert you to seek medical attention. While these tools can be helpful in prompting follow-up, they do not lead to a medical diagnosis. If you receive an alert from a smartwatch or wearable device, follow up with your healthcare provider. A medical-grade ECG is typically needed for your doctor to confirm and formally diagnose or rule out an arrhythmia.

Modern medical-grade ECG monitors can now be worn at home and continuously record your heart's electrical signal for longer than 24 to 48 hours if your doctor prescribes it.

One example is the Zio^® ECG monitoring service, which includes a small wearable patch device designed to record heart rhythm data during normal daily activities without wires or battery changes during the wear period. Zio ECG monitoring devices can record heart rhythm continuously for up to 14 days, helping physicians diagnose arrhythmias more accurately.

Advances in heart rhythm monitoring are making it easier for physicians to detect arrhythmias that might otherwise go unnoticed.

Paying attention to your heart's rhythm, especially if you have symptoms or risk factors, can help ensure you receive appropriate care. If you have concerns, talk with your healthcare provider about whether further evaluation is right for you.

Your heart's story is worth knowing. With the right tools and care, it can be a long and healthy one.

Colorectal cancer is the second leading cause of cancer death in the United States, behind only lung cancer. The National Cancer Institute estimates that 154,270 people in the U.S. received a colorectal cancer diagnosis in 2025 and approximately 52,900 died from the disease.

The good news is that many colon or rectum cancers are preventable thanks to colonoscopies. This type of cancer screening allows gastroenterologists to find and remove precancerous growths called polyps before they develop into cancer. Plus, if your doctor finds cancer, they can remove it at its early stages, when treatment is more likely to be successful.

This March — during Colorectal Cancer Awareness Month — the American Association of Nurse Anesthesiology (AANA) urges you to get screened for colorectal cancer. If you're anxious about getting a colonoscopy, you're not alone, and Certified Registered Nurse Anesthetists (CRNAs) can make the procedure a pain-free experience.

Why CRNAs are key to a successful colonoscopy

CRNAs (also known as nurse anesthesiologists or nurse anesthetists) play a critical role in making colonoscopy safe, comfortable and accessible. They are advanced practice registered nurses who have extensive training in anesthesia and airway management. CRNAs safely administer more than 58.5 million anesthetics to patients each year in the United States.

CRNAs practice in:

• Hospitals
• Ambulatory surgery centers
• Rural and underserved areas

In many communities — especially rural America — CRNAs are the primary anesthesia professionals. Without them, access to colonoscopies and other procedures could be delayed or limited.

Before your procedure, your CRNA will take a full medical history, review your medications and explain your anesthesia plan.

CRNAs provide monitored anesthesia care (MAC) to keep a patient comfortable, pain-free and breathing on their own so the gastroenterologist can focus fully on the colonoscopy, improving procedural efficiency. Commonly used drugs for sedation are propofol, benzodiazepine and narcotics. Ultimately, it will be the CRNA's determination on what to use and how much to titrate to get the intended effect.

During the colonoscopy, your CRNA will remain with you through the procedure — watching over you with vigilance. They will administer one of three types of sedation:

Moderate sedation: Sometimes referred to as twilight anesthesia or conscious sedation, this type of sedation uses benzodiazepine and an opioid delivered to a patient via IV. When under moderate sedation, patients are very relaxed, sleepy and often have no memory of the procedure, though they can still respond to verbal commands.

Deep sedation: This type of sedation uses propofol — a fast-acting, short-duration medication — that is also administered via an IV. When under deep sedation, many patients sleep through the colonoscopy, are able to breathe on their own, and typically don't remember the procedure when they wake up.

General anesthesia: This type of anesthesia is rarely used for routine colonoscopies and is done in a hospital setting. Patients are fully unconscious, requiring a breathing tube.

Once you've been anesthetized, the gastroenterologist will perform the colonoscopy, and the CRNA continuously titrates the medication and monitors your vitals. If clinically appropriate, the CRNA can adjust your anesthesia for a lighter sedation. Although rare, if the moderate or deep sedation is not effective for the procedure or in the event of an emergency, the CRNA is always equipped to maintain your airway and convert your anesthetic to a general one.

Most procedures take as little as 20 minutes; however, this can vary and is patient-dependent. Once the procedure is over, the CRNA will stop administering the medication and will let it naturally wear off and allow you to wake up in recovery. You will continue to be monitored until you are fully awake. Typically, patients are discharged the same day and must have a reliable family member or friend to drive them home.

When you get screened, you're in good hands

Colonoscopies have been proven to save lives. With a CRNA administering your anesthesia, you will be comfortable and safely monitored. Schedule your colonoscopy today. You can help prevent or treat colorectal cancer before it spreads or develops.

To learn more about CRNAs and their role during colonoscopy and other surgical procedures, visit https://www.aana.com/about-us/about-crnas.

• Brain health should be a priority for adults of every age.
• There are many ways to take care of your brain, from socializing to taking brain-boosting supplements like Cognizin citicoline.
• When you invest in your brain health, you can improve your focus and attention today as well as preserve your cognitive abilities and memory down the line.

It may only weigh 3 pounds, but your brain is one of the most important organs in your body. The brain is responsible for your thoughts, feelings, memory, experiences, communication, motor skills and so many other processes. That's why it's important to invest in your brain health now.

Brain health isn't just important for older adults. Brain health and performance should be top of mind for everyone at any age. Investing in brain health when you're young can help sharpen your focus and mental energy, so you can zone in and be more productive. And, as you age, maintaining brain health can help to preserve your memory and other cognitive functions.

Not sure how to start taking care of your brain? Read on to discover just a few tips that can keep your brain working well, whether you're 18 or 80.

Eat smart to fuel your thoughts

Food nourishes your whole body, and that includes your brain. So, what foods can help your brain function at its best now and in the future? According to Harvard Health, your best strategy is to change your dietary habits to prioritize veggies, fruits, legumes, whole grains, fish and healthy fats. The next time you're at the store, consider buying:

• Green leafy vegetables like kale, spinach and broccoli
• Strawberries and blueberries
• Black beans and chickpeas
• Cracked wheat, oats and whole-grain couscous
• Omega-3 rich fish like salmon, cod and canned light tuna
• Olive oil and other healthy fats

Incorporate brain support supplements into your routine

Supplements are a great way to optimize brain-fueling nutrients. For example, Cognizin Citicoline is a great supplement to add to your daily routine to support mental focus and memory.

What is citicoline? You may not know it by name, but it's already inside of you! Citicoline is a naturally occurring brain nutrient that protects and repairs your brain cells.

Many cognitive health ingredients on the market can enhance your brain performance. However, Cognizin Citicoline provides brain performance and comprehensive brain health support over time. Clinical trials have shown that this brain health nutrient offers cognitive benefits for young professionals and improved memory function for older adults.

Cognizin is used in over 300 products, from capsules to beverages. You can visit Cognizin.com/en/Buy-Cognizin to learn more and find the products that work best for you.

Protect your brain when you exercise

Staying active is great for your body and brain, but don't forget to wear a helmet. Whether you bike, ski, snowboard, roller skate, skateboard, horseback ride, or participate in high-impact sports like football and hockey, wearing a helmet can reduce your risk of a head injury.

According to the Mayo Clinic, a moderate to severe TBI can lead to cognitive issues with memory, attention, concentration, communication and problem-solving.

Invest in social connections and reap brain benefits

Social connections are incredibly vital to your well-being throughout every stage of life and can protect your brain health. Socializing can improve a person's longevity, stress levels, mood and — most importantly — boost their thinking and memory.

How do social connections improve brain health? When you participate in social interactions, you're activating neural pathways and preserving neural plasticity. In other words, it keeps your brain flexible, allowing it to adapt and function well now and in your golden years.

If you're struggling to connect with others, try one (or a few) of these activities:

• Having a weekly phone or video call with an old friend
• Hosting a game night
• Meeting up with loved ones for lunch or dinner
• Planning a hike, bike ride or other activity
• Joining a book club

No matter your age, take care of your brain

It's never too early or too late to invest in your brain health and function. The time and energy you spend trying these and other brain-boosting tips can help you in your personal and professional life now and keep your cognition and memory in tip-top shape in your retirement.

To learn more tips to keep your brain healthy at any age, visit Cognizin.com.

Patient information is accurate as of January 2026

In the heart of Mississippi, Diana "Di" Fillhart, a vibrant 68-year-old, lives a life defined by purpose and an unwavering commitment to others. As a retired pediatric and neonatal intensive care unit (NICU) nurse, religious missionary and restaurant owner, Di's life has always been one of service.

Recently, her days have been filled with cherished companionship from her two granddaughters aged 6 and 11, friends and her church community. Di has always been one to stay in charge of her own life, a trait that would soon be tested in profound ways.

The shadow of Alzheimer's disease (AD) loomed large in Di's family history. Her father's final years, marked by a slow erosion of identity, had etched a deep fear into Di's heart. She vowed she would never become a shell of herself when her own journey with memory issues surfaced in 2022, as she found herself forgetting conversations with her grandchildren.

Driven by her fierce determination, Di sought out a neurologist. After a spinal tap and cognitive testing that same year, she received the diagnosis: mild cognitive impairment (MCI), the earliest recognizable stage of AD.

MCI may not be recognized or diagnosed right away because the symptoms can be very subtle and similar to typical signs of aging. Common symptoms of MCI, or early AD, include:

• Forgetting names or information you just learned,
• Confusion, such as asking the same question repeatedly,
• Struggling to find the right words and
• Difficulty concentrating and keeping track of household tasks.

These are not all the signs and symptoms of early AD, only a doctor can diagnose AD.

Because AD is a progressive disease, meaning it gets worse over time, it is crucial to recognize the signs, speak with a doctor and work with them to get an accurate and early diagnosis. Some treatment options for AD are only accessible during the disease's early stages.

Di's neurologist recommended that she begin treatment with LEQEMBI^® (lecanemab-irmb) as soon as possible. After the neurologist explained the potentially serious risks, Di carefully considered her options and decided to proceed with biweekly LEQEMBI intravenous (IV) treatment.

LEQEMBI is a prescription medicine used to treat people with early AD, which includes MCI or mild dementia stage of disease. After completing 18 months of intravenous (IV) infusions of LEQEMBI every two weeks, people have the option to either continue with this IV dosing regimen, transition to the once every four weeks IV maintenance dosing regimen, or transition to a weekly maintenance regimen administered at home with the subcutaneous autoinjector (SC-AI), which injects LEQEMBI under your skin.

Di's spirit remains undimmed and she feels good about her treatment. "I was determined to fight this disease and do whatever I can," she stated. "I feel like I am on the path to maintaining who I am for longer with LEQEMBI." Other people on LEQEMBI may have a different experience.

In an 18-month study of people with early AD, LEQEMBI was shown to significantly slow the progression of the disease when compared to people not taking LEQEMBI. Ongoing treatment with LEQEMBI may help prolong the benefit of therapy, helping people like Di continue doing the things they love for longer. LEQEMBI is not a cure for AD and does not stop its progression.

LEQEMBI fights AD in two ways. It removes existing amyloid-beta plaque, the clumps of protein that accumulate in the brain and contribute to disease progression, and targets harmful amyloid proteins called protofibrils, which can continue to damage brain nerve cells even after the plaque is removed.

LEQEMBI can cause serious side effects, including amyloid related imaging abnormalities (ARIA). ARIA is a side effect that does not usually cause any symptoms, but serious symptoms can occur. ARIA can be fatal. ARIA commonly shows up as temporary swelling in areas of the brain that usually goes away over time. Some people may have small spots of bleeding in or on the surface of the brain; sometimes larger areas of bleeding have occurred. Tell your doctor right away if you notice: headache, confusion that gets worse, dizziness, vision changes, nausea, difficulty walking or speaking, seizures, or muscle weakness. Talk to your doctor about testing to see if you have a genetic risk factor (homozygous apolipoprotein E gene carriers) that may cause an increased risk for ARIA. It is important to also tell your doctor about all the medicines you take, including medications to reduce blood clots from forming such as antithrombotic medicines like aspirin, which may increase the risk of developing bleeding in the brain. LEQEMBI may also cause serious allergic reactions as well as infusion- and injection-related reactions. Most common side effects include infusion-related reactions, ARIA and headaches. These are not all the possible side effects of LEQEMBI. Please see Important Safety Information below.

Di's granddaughters remain her greatest motivation and give her purpose. Since receiving an AD diagnosis, she has been able to continue doing the things she loves, including spending time with her granddaughters, swimming and being active in her church community.

Her journey is not one of quiet suffering, but of open advocacy. "Fear can get in the way of living life for people with AD, and I am outspoken about my experience to help encourage others to keep moving forward and stop letting fear rule their lives," she asserted.

Di is living, loving and leading the way forward for her family, for her community and for herself.

If you or someone you love may be living with AD, it's important to speak with a doctor. To learn more about LEQEMBI, visit www.LEQEMBI.com.

Diana Fillhart was compensated for her participation in the story.

WHAT IS LEQEMBI?

LEQEMBI is a prescription medicine used to treat people with early Alzheimer's disease, which includes mild cognitive impairment (MCI) or mild dementia stage of disease.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about LEQEMBI?

LEQEMBI can cause serious side effects, including:

ARIA (Amyloid-Related Imaging Abnormalities). ARIA is a side effect that does not usually cause any symptoms, but serious symptoms can occur. ARIA can be fatal.

• ARIA commonly shows up as temporary swelling in areas of the brain that usually goes away over time

• Small spots of bleeding in or on the surface of the brain can occur

• Less often, larger areas of bleeding in the brain can occur

• Most people with ARIA don't have any symptoms. However, some people may notice:
  • headache
  • confusion that gets worse
  • dizziness
  • vision changes
  • nausea
  • difficulty walking
  • seizures
  • difficulty speaking
  • muscle weakness

• Some people have a gene called ApoE4 that may increase the risk of ARIA. Talk to your healthcare provider about testing to see if you have this gene
  
  
• You may be at a higher risk of developing bleeding in the brain if you take medicines to reduce blood clots from forming (antithrombotic medicines) while receiving LEQEMBI. Talk to your healthcare provider to see if any of the medicines you're taking increase this risk
  
  
• Your healthcare provider will check for ARIA with MRI (magnetic resonance imaging) scans before you start LEQEMBI and during treatment
  
  
• You should carry information that says you are receiving LEQEMBI, which can cause ARIA, and that ARIA symptoms can look like stroke symptoms

Call your healthcare provider or go to the nearest hospital emergency room right away if you have any of the symptoms listed above.

Serious allergic reactions:

Do not receive LEQEMBI if you have serious allergic reactions to LEQEMBI, LEQEMBI IQLIK, or any of the ingredients.

• Tell your healthcare provider if you notice any symptoms during or after a LEQEMBI infusion, including:

• • swelling of the face, lips, mouth, or tongue
  • itchy bumps on the skin, also known as hives
  • difficulty breathing

Infusion-related reactions:

• Infusion-related reactions can occur during or after completion with LEQEMBI injection into a vein (intravenously), which can be serious. Tell your healthcare provider right away if you notice any of these symptoms:

• • fever
  • flu-like symptoms (chills, body aches, feeling shaky, joint pain)
  • nausea and/or vomiting
  • dizziness or lightheadedness
  • fast or slow heart rate, or feeling like your chest is pounding
  • difficulty breathing or shortness of breath
  • changes in blood pressure

• If you have an infusion-related reaction, your healthcare provider may give you medicines before your next infusion to lower the chance of having a reaction

Injection-related reactions:

• Injection-related reactions may occur with LEQEMBI injection under the skin (subcutaneous injection with LEQEMBI IQLIK). Tell your healthcare provider if you notice any of these symptoms during or after an injection:

• • redness, swelling, heat, pain, itching, rash, bruising, and blood collection under the skin at the injection site
  • headache, fatigue, or fever may also be observed after an injection

The most common side effects of LEQEMBI include infusion-related reactions, ARIA, and headaches.

These are not all the possible side effects of LEQEMBI. Call your doctor for more information and medical advice about side effects. You may report side effects to the FDA at www.fda.gov/medwatch or call 1-800-FDA-1088.

Before receiving LEQEMBI, tell your healthcare provider about:

• All your medical conditions, including if you are pregnant, breastfeeding, or plan to become pregnant or breastfeed. It is not known if LEQEMBI could harm your unborn or breastfeeding baby

• All the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you take medicines to reduce blood clots from forming (antithrombotic medicines, including aspirin)

LEQEMBI (lecanemab-irmb) is available as:

• Intravenous infusion: 100 mg/mL
• Subcutaneous injection: 200 mg/mL

Please see Medication Guide with Instructions for Use and full Prescribing Information, including Boxed WARNING, for LEQEMBI.

LEQE-US5042 © Eisai Inc. February 2026

Prenatal genetic screenings, in particular, can help determine whether your baby may be at risk for certain genetic or chromosomal conditions. With the help of a clinician, you'll be able to navigate genetic screening information without feeling overwhelmed and make a plan for what comes next.

What is prenatal genetic screening?

Prenatal genetic screenings use a blood sample to test the parents or the pregnancy. These screenings allow expecting parents to learn about their own genes and how those may impact their baby, or get insights into the baby's development and discover the baby's predicted sex — well before birth.

There are two types of prenatal genetic screenings:

• Carrier screening: This prenatal genetic screening lets parents know if they're carriers of a serious genetic condition and can help determine a baby's chance of having specific inherited conditions like cystic fibrosis or fragile X syndrome. It's possible to be a carrier of a genetic condition without showing any symptoms of the condition. Carrier screening can be done before or during pregnancy.
• Non-invasive prenatal screening: Cell-free DNA screening, also known as NIPS or NIPT, can help determine if a baby has a chance of having specific chromosomal conditions like Down syndrome. This screening is done during pregnancy.

Why does clear information matter?

Prenatal genetic screening can play an important role in helping expectant parents make informed decisions during pregnancy. By identifying potential genetic risks early, screening may provide valuable insight into a baby's health risks giving families time to learn, ask questions, and consider next steps such as diagnostic testing or other care options recommended by their healthcare providers. These screens can help guide conversations between families and their health care providers as well as support personalized care and informed planning during an emotionally complex time.

"Knowing medical information early in their pregnancy can give expectant parents the most options," said Dallas Reed, M.D., FACMG, FACOG, obstetrician-gynecologist and medical geneticist, and principal medical advisor of Women's Health for Myriad Genetics^®. "Normal results can provide reassurance, while positive results open the door to thoughtful conversations about next steps between families and their healthcare providers, helping them feel more prepared and supported as they make choices for their pregnancy."

A prenatal genetic screen for everyone

Any expecting parent can benefit from a genetic test, not just those who have a family history of certain inherited conditions. If you're considering having a baby, ask your doctor about the Prequel^® Prenatal Screen and the Foresight^® Carrier Screen, non-invasive blood or saliva tests designed for everyone regardless of ancestry or BMI.

The Prequel screen checks for increased risk of certain common chromosome conditions by analyzing placental DNA in the pregnant person's blood, and with most results available in seven to 10 days. This prenatal screening can be done as early as eight weeks, giving parents as much time as possible to make a plan with their healthcare provider based on the screening results. The Foresight screen can help determine whether parents carry inherited health conditions that they may pass on to their child.

While most reports deliver low-risk results, if you do want to talk them through, Myriad offers on-demand access to board-certified genetic counselors to help interpret results and answer questions about your baby's health risks.

Determining next steps

If a screen reveals a high-risk result, it's important to keep in mind that screening is just the first step. Genetic insights based on prenatal screening give you precious time to pursue diagnostic tests like amniocentesis, consult specialists, find the best-equipped medical facilities for your birth, and connect with parents who have been in your shoes.

Your healthcare provider may offer follow-up testing or a conversation with a specialist to explore results further and discuss options.

Feel empowered, not overwhelmed

Genetic testing helps parents understand what to expect, giving them insights to help make thoughtful choices for their family.

If you're pregnant or planning to become pregnant, check out Myriad's Prequel Prenatal Screen, a screen that assesses common chromosomal conditions, as well as the Foresight Carrier Screen, which looks for genetic conditions that parents might pass down to their children, and SneakPeek^® Early Gender Test, which allows parents to learn about their baby's predicted sex as early as six weeks.

Myriad Genetics also offers resources like Know More Sooner to help make the pregnancy journey clearer and more supportive for families, and debunk common myths about genetic screening.

To help you better understand the ins and outs of allergies, the experts behind Clorox™ PURE™ — a new line of daily allergen neutralizer sprays designed to stop indoor allergens like non-living pollen, dust mite matter and pet dander before they become allergies — debunk common misconceptions.

Myth number 1: Allergies only affect people in the spring

While springtime is typically peak allergy season as pollen from many varieties of plants, trees and flowers are prevalent, many people can experience allergies year-round. In the fall and winter, dust mites tend to increase once you turn on your heating, and mold tends to peak due to outdoor decomposing leaves and damp spots in the home. And while summer lends itself to warmer weather and more time spent outside, we still see pollen and dust mites working their way throughout the home.

Myth number 2: You can avoid allergies by staying indoors

Many people who experience allergy symptoms all year may be reacting to common allergens like dust mites, pet dander and mold that can live inside your home. And no matter how hard you may try, it can be impossible to keep all pollen out of your home. Whether or not you or the other members of your household currently experience allergies, you can actually develop allergies over time simply from repeated exposure to common allergens, meaning the more you are exposed, the more sensitive your immune system can become to potential allergy triggers.

To manage indoor allergens, add Clorox™ PURE™ Allergen Neutralizer Daily Air and Fabric & Carpet sprays to your daily routine. Developed with allergists, these daily sprays neutralize common household allergens like non-living pollen, dust mite matter and pet dander by changing allergens' active protein structure so they can no longer bond to receptors in your body and trigger allergies. You can use Clorox™ PURE™ Daily Air Spray in common living spaces like living rooms, bedrooms, entryways and more while Clorox™ PURE™ Fabric & Carpet Spray is designed for use on soft surfaces where allergens can lurk. Think hard-to-clean areas like carpets, upholstered furniture, curtains, pet beds and more.

Myth number 3: Most people react only to one allergen

It's common for people with allergies to be allergic to more than one thing. This can be because an overly sensitive immune system tends to overreact in multiple ways, causing allergies to appear in clusters. In other words, once allergies take hold, new sensitivities can follow. This is all the more reason to take action to neutralize allergens in your home before they become a bigger problem.

Myth number 4: If you weren't allergic to something as a child, you won't develop allergies to it later

It is entirely possible to develop allergies later in life, often without warning. New environmental exposures, lifestyle changes, like getting a pet, and immune system changes as you get older can all increase susceptibility. While you can't control every trigger, you can take control of your environment. One way to help decrease the likelihood of developing allergies is by reducing your exposure to typical indoor and outdoor allergens.

Learn more about managing indoor allergens in your home year-round at Clorox.com/PURE, and find Clorox™ PURE™ Allergen Neutralizer products nationwide at Walmart.com, Amazon and in the air-care aisle.

The swelling attacks can cause arms and hands, legs and feet, belly, genitals, face, or throat (airways) to swell,^5,6,9 sometimes resulting in difficulty breathing and, in severe cases, suffocation (asphyxiation).^7-9 Attacks can be triggered by physical trauma, such as dental work, or emotional stress (for example finals week), and even occur without a known trigger.^5-9 Attacks can last for several days if not treated.¹⁰

Living with HAE can be challenging. The unpredictable nature of attacks can significantly impact a person's quality of life, creating anxiety, fear, and even embarrassment.^3,5,7,8,11

"Living with HAE is like having your life put on hold constantly; feeling you have no control, not even on the simplest of things, not knowing when your plans are going to be interrupted," said Soraya Alvarez Diaz, who had her first HAE attack as a child, "it is physically and emotionally exhausting and can make you feel isolated."

"An attack can occur at any time or in any occasion. I even had a severe laryngeal attack on a plane while traveling to New York. It was one of the scariest moments of my life," she said.

Currently, there is no cure, but there are treatments available that can prevent or manage the symptoms of an attack. Nonetheless, unmet treatment needs remain, including the need for additional oral medicines that are effective, well-tolerated, convenient, discreet, and portable.

One company working to address those needs is Pharvaris, which is developing a potential new treatment to further address the unmet medical needs for people living with HAE.

Investigating attack prevention: the CHAPTER-4 study^12,13

The CHAPTER-4 study is a long-term, open-label study investigating Pharvaris' investigational drug, deucrictibant, an extended-release tablet for the preventative treatment of HAE attacks in adolescents and adults, ages 12 and above.

Deucrictibant has already been tested in other HAE clinical research studies, the results of which have supported further development/study, and it has shown favorable results for efficacy and safety.

Why take part in a clinical study?

Clinical studies have been, and continue to be, essential to eventually bringing new treatments to those who need them.

"For me, the main reason to participate in clinical trials, and the reason I believe others should consider doing the same, is the chance to contribute to the development of new medications to treat HAE," said Alvarez Diaz, "I have a sense of satisfaction knowing that I have contributed to help others in need."

New therapies may offer people with HAE the opportunity to further improve management of their condition and, given the hereditary nature of HAE, experience fewer unmet medical needs than previous generations.

Participating in a clinical study can be a valuable experience. Studies can represent a form of access to investigational drugs in development that may not be available outside of a study and allow participants to contribute to the advancement of medical knowledge.

"Medical breakthroughs and advances require the active participation and support of the scientific community, including patients, suffering from the conditions," said Alvarez Diaz. "Others have led the way in benefit of humankind. I do not want to be just part of the problem; I want to be part of the solution. Participating in clinical trials can help build a better future for new generations of patients, as others did for me."

Curious to find out more?

If you or a loved one are interested in learning more about the CHAPTER-4 study, please visit: https://hae-chapter.com/#about-ch4-study

Currently, deucrictibant is only available in an investigational setting as a drug currently being studied for the prevention, or treatment, of HAE attacks. Deucrictibant is an investigational product and has not been approved by the FDA for the prevention or treatment of HAE.

References

1. Castaldo AJ, et al. Ann Allergy Asthma Immunol. 2025;135(3):303-310.
2. Lumry WR. Front. Med. 2018; 5:22.
3. Lumry WR, et al. Allergy Asthma Proc. 2020;41(Suppl 1):S08-S13.
4. Christiansen SC, et al. Ann Allergy Asthma Immunol. 2023;131(6):766-774.e8.
5. Maurer M, et al. Allergy. 2022;77(7):1961-1990.
6. Betschel SD, et al. J Allergy Clin Immunol Pract. 2023;11(8):2315-2325.
7. Busse PJ et al. J Allergy Clin Immunol Pract. 2021;10(3):716-717.
8. FDA CBER, The voice of the patient – Hereditary angioedema. May 2018. https://www.fda.gov/files/about%20fda/published/The-Voice-of-the-Patient---Hereditary-Angioedema.pdf. Accessed February 9, 2026.
9. US Hereditary Angioedema Association. What is Hereditary Angioedema (HAE)? https://www.haea.org/pages/p/what_is_hae. Accessed February 9, 2026.
10. Bork K, et al. Allergy Asthma Clin Immunol. 2021;17(1):40.
11. Anderson J, et al. Allergy Asthma Clin Immunol. 2021;17(1):60.
12. CHAPTER-3. Join us. https://hae-chapter.com/. Accessed February 9, 2026.
13. Long-Term, Open-label Study of Oral Deucrictibant Extended-Release Tablet for Prophylaxis Against Angioedema Attacks in Adolescents and Adults With HAE (CHAPTER-4). 2025. ClinicalTrials.Gov NCT06679881. https://clinicaltrials.gov/study/NCT06679881. Accessed February 9, 2026.

(BPT) - This article is sponsored by Novartis and all participants have been compensated for their time. Mona and Carolyn are KISQALI patients, Amy is a former breast cancer patient, not treated with KISQALI.

Breast cancer changes everything — one in eight women will face it in their lifetime.

In a quiet studio, journalist Amy Robach listens as Carolyn, who is living with metastatic disease, shares what life looks like after the diagnosis. Beside her, Mona, diagnosed with early breast cancer, nods in solidarity, carrying her own fears of recurrence. Their stories are a reminder that life after diagnosis isn't about going back to normal; it's about finding a new way forward.

"I still worry," Mona admits. "But I'm doing everything I can to prevent that from happening." Carolyn nods, knowing worry doesn't vanish; as someone living with breast cancer, you learn to live with it. You learn to take back control, piece by piece.

This is the premise of Voices of MORE™, a YouTube series hosted by Robach, herself an early breast cancer survivor. Each episode dives into real, unfiltered conversations, because hearing others share their fears and wins can make you feel less alone. No matter how breast cancer may touch your life, honest conversations matter.

For many, the medical milestones come with clear steps: biopsies, surgery and therapy. Appointments slow down. Life feels different. Many wonder, "Can I trust my body again? How do I live with fear without letting it steer?"

Risk of recurrence: The reality behind the numbers

Those questions aren't abstract. Breast cancer touches nearly every family. And even after treatment, recurrence is a real concern: research shows more than 1 in 9 people with early-stage breast cancer may face it. Beyond those numbers, there's a deeper truth: 90% of women want to be seen as more than their diagnosis. Behind every statistic is someone navigating what comes next.

For some, that means ongoing treatment to reduce the risk of recurrence. Options include CDK4/6 inhibitors, including KISQALI^® (ribociclib), for stage II or III hormone receptor (HR)–positive, human epidermal growth factor receptor 2 (HER2)–negative breast cancer at high risk of recurrence. Others focus on healthy routines, emotional well-being and finding support that makes everyday life feel manageable.

Please see Important Safety Information below.

Voices of MORE brings these topics into the open through real conversations. Across every episode, MORE means voice, control and true stories — not perfection. For Mona, it's admitting fear and still planning a weekend away. For Carolyn, it's asking for help and showing up for milestones that matter.

These aren't sound bites; they're stories of strength and fortitude. Watch the series at VoicesofMORE.com.

Practical next steps

• If you're navigating decisions now: Talk with your oncologist about the risk of recurrence and whether options like CDK4/6 inhibitors could be appropriate for your specific diagnosis and stage.
• If you're seeking community: Bring these episodes to a support group or a friend — use them as conversation starters for the things that are hardest to say out loud.
• If you need more information: Visit Kisqali.com for official prescribing details and important safety information, and review the full Prescribing Information, including Patient Information.

What is KISQALI?

KISQALI^®(ribociclib) is a prescription medicine used to treat adults with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer:

• in combination with an aromatase inhibitor for stage II and III early breast cancer with a high risk of coming back
• that has gotten worse or has spread to other parts of the body (advanced or metastatic breast cancer) in combination with:
  — an aromatase inhibitor as the first endocrine-based therapy; or
  — fulvestrant as the first endocrine-based therapy or following disease progression on endocrine therapy

It is not known if KISQALI is safe and effective in children.

IMPORTANT SAFETY INFORMATION

KISQALI may cause serious side effects, including:

Lung problems. KISQALI may cause severe or life-threatening inflammation of the lungs during treatment that may lead to death. Tell your health care provider right away if you have any new or worsening symptoms, including:

• trouble breathing or shortness of breath
• cough with or without mucus
• chest pain

Severe skin reactions. Tell your health care provider or get medical help right away if you get severe rash or rash that keeps getting worse; reddened skin; flu-like symptoms; skin pain or burning, blistering of the lips, eyes, or mouth, blisters on the skin or skin peeling, with or without fever.

Heart rhythm problems (QT prolongation). KISQALI can cause a heart problem known as QT prolongation. This condition can cause an abnormal heartbeat and may lead to death.

• Your health care provider should check your heart and do blood tests before and during treatment with KISQALI
• Tell your health care provider right away if you have a change in your heartbeat (a fast or irregular heartbeat), or if you feel dizzy or faint

Liver problems. KISQALI can cause serious liver problems. Your health care provider should do blood tests to check your liver before and during treatment with KISQALI. Tell your health care provider right away if you get any of the following signs and symptoms of liver problems:

• yellowing of your skin or the whites of your eyes (jaundice)
• dark or brown (tea-colored) urine
• feeling very tired
• loss of appetite
• pain on the upper right side of your stomach area (abdomen)
• bleeding or bruising more easily than normal

Low white blood cell counts (neutropenia). Low white blood cell counts are very common during treatment with KISQALI and may result in infections that may be severe. Your health care provider should check your white blood cell counts before and during treatment with KISQALI. Tell your health care provider right away if you have signs and symptoms of low white blood cell counts or infections, such as fever and chills.

Your health care provider may tell you to decrease your dose, temporarily stop, or completely stop taking KISQALI if you develop certain serious side effects during treatment with KISQALI.

What should I tell my health care provider before taking KISQALI?

Before you take KISQALI, tell your health care provider if you:

• have any heart problems, including heart failure, irregular heartbeats, and QT prolongation
• have ever had a heart attack
• have a slow heartbeat (bradycardia)
• have high blood pressure that is not controlled
• have decreased thyroid gland function (hypothyroidism)
• have problems with the amount of potassium, calcium, phosphorus, or magnesium in your blood
• have fever, chills, or any other signs or symptoms of infection
• have liver problems
• have kidney problems
• are pregnant, or plan to become pregnant. KISQALI can harm your unborn baby
  — If you are able to become pregnant, your health care provider should do a pregnancy test before you start treatment with KISQALI
  — Females who are able to become pregnant and who take KISQALI should use effective birth control during treatment and for at least 3 weeks after the last dose of KISQALI
  — Talk to your health care provider about birth control methods that may be right for you during this time
• If you become pregnant or think you are pregnant, tell your health care provider right away
• are breastfeeding or plan to breastfeed. It is not known if KISQALI passes into your breast milk. Do not breastfeed during treatment with KISQALI and for at least 3 weeks after the last dose of KISQALI

Tell your health care provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. KISQALI and other medicines may affect each other, causing side effects. Know the medicines you take. Keep a list of them to show your health care provider or pharmacist when you get a new medicine.

What should I avoid while taking KISQALI?

Avoid eating grapefruit and avoid drinking grapefruit juice during treatment with KISQALI since these may increase the amount of KISQALI in your blood.

The most common side effects of KISQALI in people with early breast cancer include:

• decreased white blood cell counts
• decreased red blood cell counts
• increased liver function tests
• infections
• increased kidney function test
• decreased platelet counts
• nausea
• headache
• tiredness

The most common side effects of KISQALI in people with advanced or metastatic breast cancer include:

• decreased white blood cell counts
• decreased red blood cell counts
• increased liver function tests
• infections
• nausea
• increased kidney function test
• tiredness
• decreased platelet counts
• diarrhea
• vomiting
• headache
• constipation
• hair loss
• cough
• rash
• back pain
• low blood sugar level

KISQALI may cause fertility problems in males, which may affect your ability to father a child. Talk to your health care provider if this is a concern for you.

Tell your health care provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of KISQALI. For more information, ask your health care provider or pharmacist. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800- FDA-1088.

Please see full Prescribing Information Including Patient Information.

Novartis Pharmaceuticals Corporation has no control over third-party websites linked in this story, and makes no representation as to the accuracy, completeness, adequacy, or any other aspects of the information contained on such websites.

1/26 FA-11578334

In honor of Pet Dental Health Month, this is the perfect time to learn why your pets' teeth and gums are so vital for keeping them healthy and happy, as well as increasing their longevity. The good news is, there are many simple things you can do to care for your beloved pets' oral health throughout their lifetime.

The mouth-body connection

Why is oral health so crucial to your pet's overall well-being? The truth is, 70% of cats and a whopping 80% of dogs will suffer from some form of dental health issues by the time they are 3 years old, with their risk of dental problems increasing as they age.

These potentially painful dental health problems don't just stay in their mouth. When plaque and tartar build up on a dog or cat's teeth, they can cause gingivitis: inflammation, redness, swelling and even bleeding of the gums. Over time, gingivitis can lead to periodontal disease, where harmful bacteria invades the gums and can even enter their bloodstream, potentially damaging vital organs over time.

Oral bacteria have been linked to serious conditions including heart disease, liver problems and kidney failure in dogs, as well as sepsis, kidney, liver and heart disease in cats. One study found that dogs with severe gum disease were much more likely to develop heart issues like endocarditis or congestive heart failure.

It's not just bad breath

One early indication your pet may be experiencing oral health issues is bad breath, but there are many other signs. Dogs and cats can effectively mask their pain, and unfortunately can't tell you when something hurts them. Watch for signs like:

• Redness, swelling or bleeding of the gums
• Drooling
• Weight loss
• Taking longer to eat or having difficulty eating
• Tilting head when eating

Other changes in behavior, like being less playful or active, are worth checking out with your pet's veterinarian.

What you can do

You can take proactive steps to prevent oral health problems. Any one of these steps can help, but consistently following many of them will go even further toward ensuring your four-legged family member stays healthy for years to come. No matter your pet's age, it's never too early or too late to begin building healthy habits.

Regular tooth brushing: Use toothpaste designed for dogs or cats (not humans), with a soft brush or finger brush. Try to brush at least a few times per week, if not daily. Introduce brushing along with positive rewards like treats. Even 30 seconds of brushing can help disrupt plaque before it hardens.

Dental chews or treats: Chewing can be nature's toothbrush. Dental chew toys or treats can mechanically scrape plaque from your dog's or cat's teeth. However, some are high in calories or not very effective. Look for VOHC-accepted dental chews or veterinarian-recommended products with scientific backing, like these choices from Swedencare's ProDen PlaqueOff^® line:

• New Crunchy Dental Bites for Dogs and Crunchy Dental Bites for Cats are natural, effective supplements that support your pet's oral health, featuring the 100% natural kelp ingredient A.N ProDen^®. Clinical trials show significant reduction in plaque and tartar while improving bad breath, with noticeable improvement in 3-8 weeks when used as directed.
• Soft Chews — Dogs or Soft Chews — Cats are another option you can try, containing similar ingredients and providing similar results as Crunchy Dental Bites. They are perfect for older pets who may have difficulty eating harder chews, and can double as a reward or treat your furry friends will love.
• Dental Care Bones for Dogs are designed to satisfy your dog's natural chewing instincts while supporting dental health. Perfect for pet parents looking for an enjoyable chewing experience, they contain the same unique, clinically studied kelp ingredient A.N ProDen^® found throughout the ProDen PlaqueOff^® range.

Oral health supplements: Adding an oral health powder to your pet's diet is one of the easiest, most seamless ways to keep their teeth cleaner. These work with the animal, helping to prevent plaque from sticking and hardening through natural chemical processes in your pet's body. ProDen PlaqueOff's^® Powder for Dogs and Powder for Cats are odorless and tasteless, using the same natural, effective ingredients as other products in the ProDen PlaqueOff^® line.

The powder is also an economical choice: A 40 g bottle of Powder for cats lasts up to four months, and a 60 g bottle for dogs lasts roughly six months for a 22-pound dog. All ProDen PlaqueOff^® formats can be used daily and for long-term use, complementing each other and offering flexible options that are easy to use.

"Dental issues are some of the most common problems we see in the clinic — and they're often painful, advanced and expensive before owners even notice," said veterinarian Marie Jury. "That's why preventive care is absolutely essential. A daily product like ProDen PlaqueOff^®, which is accepted by the VOHC, can make a meaningful difference long before problems start."

Annual checkups: Your veterinarian is your best ally in protecting your pet's oral health. They can also perform services like professional dental cleanings, which may be necessary to address oral health issues.

Following these steps, you can help ensure your dog or cat maintains good oral health and overall well-being — so you can enjoy many more years of tail wagging, cuddles and play time together.

They're often signs of increased inflammation.

Inflammation affects how you move, recover and stay consistent. It's also often an underlying cause of seasonal discomfort and reduced mobility. And when inflammation goes unaddressed, it can stifle your ability to stay active, productive and independent as you age.

"The good news is that inflammation is often manageable," said Dr. Dustin DebRoy, DC, manager of education and relations at The Joint Chiropractic. "By focusing on small, supportive lifestyle adjustments, people can reduce inflammation and reset their body this winter and — more importantly — their long-term health."

Small changes with big impact

Major short-term fixes can't sustain long-term performance, mobility and healthy aging. Instead of committing to a complete life overhaul, focus on building foundational habits that help you manage inflammation so you can improve how your body feels and moves.

Here are just a few small lifestyle adjustments that can have a big impact on inflammation, allowing your body to rest and reset.

Eat an anti-inflammatory diet: What you feed your body can also feed your inflammation. According to Harvard Health, refined carbohydrates, fried foods, sweet beverages, red meat, processed meat and unhealthy fats can increase inflammation. Try to limit eating these types of food and instead incorporate anti-inflammatory options like fruits and vegetables, whole grains, lean proteins and healthy fats like olive oil.

Manage stress: Stress can take a toll on your entire body and directly contributes to inflammation. According to The Joint Chiropractic, stress elevates your cortisol levels, setting off your body's natural inflammatory response. Make time in your day to unwind by meditating, journaling, walking or doing other relaxing activities. Not only do these activities help you destress and manage your inflammation, but they also can create long-term habits that may help promote calmness, mobility and overall well-being.

Schedule chiropractic care: Your body's musculoskeletal alignment affects how you move and feel. When you're out of alignment, you may feel discomfort and stiffness, making it harder to move. By visiting a chiropractic professional and receiving regular adjustments, you may feel reduced pain and stiffness in your joints, improved mobility, reduced stress and increased blood flow, all of which can contribute to a more active lifestyle and reduced inflammation. To learn more about how chiropractic care may help and to find a chiropractic professional near you, visit TheJoint.com.

Take a few minutes to stretch: Speaking of bodily alignment, stretching is another way to support your body so you can move more with less pain. You don't need to spend a long time doing so. In as little as six minutes, you can improve your flexibility, relieve joint stiffness and reduce stress.

Realign, reset and recover in 2026 and beyond

Small, sustainable changes are the key to managing inflammation and unlocking a better-feeling you. This winter, start small and build on these and other healthy habits that will help your body realign, reset and recover not just this season, but for the rest of your life.

Dental disease is the No. 1 health issue in pets, impacting up to 70% of pets — especially small breeds and seniors — and often developing before visible symptoms.¹ However, it remains one of the most preventable health issues with consistent daily care.

Drs. Ben and Erin Schroeder, DVM, Education Partners for Wellness Pet Company, are no strangers to pet dental health issues. As the owners of Cedar County Veterinary Services and stars of National Geographic Wild's show "Heartland Docs, DVM," they've seen firsthand how daily dental care can help prevent diseased teeth and gums and keep four-legged friends happy and healthy. If you're a pet parent who wants to start investing in your cat or dog's dental care but don't know where to start, you're not alone. Check out the Schroeders' list of expert tips that can help you simply support your pet's overall well-being today, tomorrow and the rest of their lives.

Start dental care early

When it comes to lifelong dental health for your furry family members, the sooner you start dental care the better. In fact, if you adopt a puppy or kitten, you can start dental training as early as six weeks. All you need is a toothbrush and pet-friendly toothpaste to get started!

Make dental care fun with treats

You can make daily dental care easier for you and fun for your pets with delicious dental treats that help clean your pet's mouth while they enjoy a snack. A great pick for felines and canines alike is Wellness^® WHIMZEES^® Dental treats. These are favorites because they contain simple, healthy ingredients and never have any artificial flavors, colors or preservatives. The Schroeders recommend them as a daily routine that provides consistent cleaning support when given regularly.

WHIMZEES cat dental treats are designed scientifically for feline oral care, addressing common dental concerns through daily treats that support breath, plaque and tartar reduction. Their crunchy, porous texture allows cats' teeth to sink in, increasing surface contact for more effective cleaning with every bite.

For dogs, WHIMZEES dental treats are scientifically proven to support all four vet-checked areas — breath, plaque, tartar and gums — when chewed daily, helping maintain oral health between vet visits and brushing. Designed with grooves, ridges and firmer, high-fiber texture, WHIMZEES encourage longer chew time for more effective cleaning, helping reduce plaque before it hardens into tartar when chewed daily. There are even options for smaller or older dogs with sensitive teeth, like Wellness^® WHIMZEES^® Freshzees™. Available in XS, S and M sizes, this is a great option for a more comfortable chew.

Schedule your yearly vet visit and practice at home

Annual vet exams are important for every aspect of your pawed pal's well-being, including dental. During every vet exam, one of the first tasks a vet will do is look at a pet's mouth and teeth. Just by lifting a lip, they can evaluate the health of the gums, whether plaque and tartar are present and if the pet has bad breath. A great tip for helping get your pet ready for their health examinations is to practice lifting the lips (both sides), opening the mouth and gently touching the gums at home. This quick training will make future vet visits more informative for the veterinarian, less stressful for the pet, and will be a great bonding experience that your pet looks forward to daily!

Don't ignore bad breath

Speaking of bad breath, it's one of the first signs that something isn't right with your pet's health. Rotten, stinky breath (called halitosis) is one of the first signs of dental disease, along with buildup of food material (plaque); brown, yellow or gray residue (tartar); and/or red gums. If you notice bad breath or any of these other signs, don't wait to contact your vet and start implementing simple, everyday care into your pets' routines.

Aim for consistency, not perfection

No one is perfect. Aim to brush your pet's teeth every day, but don't get down on yourself if you miss every once in a while. Life is full of surprises, interruptions and last-minute obligations. Consistency, not perfection, is what makes a difference in your pet's dental and overall health and wellness.

With a little time and effort, you can make a huge difference in your cat's and dog's dental health and set them up for lifelong well-being. To find more tips and find fun treats to help your pet look forward to their dental care routine, visit https://www.wellnesspetfood.com/whimzees/.

1. World Small Animal Veterinary Association Global Dental Guidelines JSAP2020; 61:E50

For Suzanne, age 52, her work relies heavily on near vision. As a nurse practitioner (NP) and aesthetic injector, her days involve preparing syringes, reading unit markings and performing detailed injections, while maintaining eye contact and conversations with patients. Before finding a new solution, reading glasses were a constant interruption. Taking them on and off throughout the day added up, costing not just time, but momentum and confidence.

At home, it was more of the same. "I had 'cheaters' [reading glasses] all over the place. They were in every drawer," Suzanne says. Reading labels, checking her phone or applying makeup required extra steps.

Thankfully, when it comes to age-related blurry near vision, also known as presbyopia, there are now options beyond reading glasses, including prescription eye drops designed to help improve near vision.

Qlosi™ (pilocarpine HCI ophthalmic solution) 0.4% is an FDA-approved prescription eye drop for the treatment of presbyopia in adults. Designed to help improve near vision, Qlosi offers once- or twice-daily dosing, giving adults a way to address blurry near vision without relying on reading glasses.

Presbyopia doesn't just affect how clearly you see. It tends to reveal itself in routine moments where near-vision focus matters. For Suzanne, discovering that there was an option beyond reading glasses was a turning point.

Searching for a Better Fit

While Suzanne had already addressed her distance vision with laser surgery, her presbyopia remained. She continued using reading glasses, progressives and magnifying mirrors, which helped at times, but weren't flexible enough for daily life.

Suzanne wanted a non-invasive, flexible option that fit into her day and allowed her to stay focused. She's not alone. Many adults with presbyopia are looking for solutions that offer clarity without forcing them to reorganize their routines around glasses.

Discovering Qlosi

Knowing something needed to change, Suzanne reached out to her eye doctor. During that conversation, she learned that prescription eye drops, including Qlosi, could be used to manage presbyopia.

She was drawn to the idea of improving her near vision with a drop that could fit into her everyday routine. The flexible dosing made it feel adaptable to her schedule, instead of something that required her to adjust her plans. Her eye doctor prescribed Qlosi, and she hasn't looked back. "It has been absolutely life-changing for me," she says.

A New Rhythm

Once Suzanne began using Qlosi, her days became simpler. In the morning, she applies one drop in each eye while getting ready for the day — a quick, comfortable addition to her routine. Qlosi is designed with eye comfort in mind, and in clinical studies, people reported that its EyeQ Formulation™ felt as comfortable as what goes into artificial tears. Suzanne noticed the impact right away. "I no longer have to use a mirror that is [magnified] a hundred times," she says. "I can actually see putting on eyeliner."

Later in the day, she uses a second drop. "Between two and three hours later, I go ahead and use a second drop, and it gives me approximately eight hours of clear vision," she explains.

At work, the difference is noticeable. By removing the constant interruptions, Suzanne finds it easier to stay present and focused throughout her day. Tasks feel more fluid, and interactions with patients feel more natural. "Qlosi has given me back my time," she says.

She also describes a renewed sense of ease in her day-to-day routine. "It gives me visual freedom. I no longer worry about fumbling with my glasses or breaking my focus mid-injection."

Accepting age doesn't have to mean accepting disruption. For adults experiencing presbyopia, understanding available options can help daily life feel smoother — whether at work, at home or on the go.

Qlosi is provided in single-use vials for adults seeking clearer near vision on their own schedule. Its proprietary EyeQ Formulation™ was developed to deliver safety and comfort with every drop.[1] In clinical studies, most side effects were mild and resolved in a short time. The most commonly reported side effects (5% to 8%) were eye discomfort and headache.

Looking Ahead

Suzanne says she often recommends Qlosi to colleagues and friends. "I talk about it all the time. I really think it's a game changer."

If you're experiencing early signs of presbyopia and are curious if Qlosi is right for you, talk to your eye care professional. To find an eye doctor near you, visit Qlosi.com/FindaDoctor.

Uses

Qlosi (pilocarpine ophthalmic solution) 0.4% is a prescription eye drop used to treat age-related blurry near vision (presbyopia) in adults.

Important Safety Information

• Do not use Qlosi if you are allergic to any of the ingredients.
• Use caution when driving at night or performing hazardous activities in poor lighting. Qlosi may cause temporary dim or dark vision.
• Temporary problems when changing focus between near objects and distant objects may occur. Do not drive or operate machinery if your vision is not clear.
• Seek immediate medical care if you experience sudden onset of flashes of light, floaters or vision loss.
• If you wear contact lenses, they should be removed before using Qlosi. Wait 10 minutes after dosing before reinserting your contact lenses.
• Do not touch the tip of the vial to the eye or any other surface to prevent eye injury or contamination.
• If you use more than one eye medication, use each medication at least 5 minutes apart.
• The most common side effects reported with Qlosi in clinical trials were eye pain upon instillation and headache. These are not all of the possible side effects with Qlosi.

To report suspected side effects, contact Orasis Pharmaceuticals at 1-866-ORASIS-1 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please see full Prescribing Information by clicking here.

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